Inhibitory Receptors in Immune Homeostasis, Disease and Therapy (A1)
January 16-19, 2024
| Beaver Run Conference Center, Breckenridge, CO, United States
Linde Meyaard, Jonathon D. Sedgwick, Carla V. Rothlin and Alex McCarthy
Scholarship Deadline: Oct. 25, 2023 | Abstract Deadline: Oct. 25, 2023 | Early Registration Deadline: Nov. 16, 2023
Tuesday, January 16, 2024
| 4:00–8:00 PM |
Arrival and Registration |
Colorado Ballroom Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Colorado Ballroom Foyer |
Wednesday, January 17, 2024
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–9:00 AM |
Welcome and Keynote Address |
Peaks 4 & 5 |
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* Linde Meyaard, University Medical Center Utrecht
Session Chair |
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Gordon Freeman, Dana Farber Cancer Institute
Inhibitory Receptors and Microbiome Regulation of the Anti-Cancer Immune Response |
|
| 9:00–11:15 AM |
The Role of Inhibitory Receptors in the Development of Autoimmunity, Allergy and Inflammation |
Peaks 4 & 5 |
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* Ian A. Parish, Peter MacCallum Cancer Centre
Session Chair |
|
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Eric Meffre, Stanford University
CTLA-4 Blockade Drives the Naïve B Cell Repertoire Towards Autoimmunity |
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Francesca Levi-Schaffer, Hebrew University of Jerusalem
Regulation of Mast Cells and Eosinophils by Inhibitory Receptors in Allergy |
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Maria Fernandes, Université Laval
CLEC12A Regulation of Neutrophil Activation in Chronic Inflammatory Diseases |
|
| 9:30–9:50 AM |
Coffee Break |
Colorado Ballroom Foyer |
| 11:15–1:00 PM |
Poster Setup |
Peaks 1-3 |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Peaks 1-3 |
| 2:30–4:30 PM |
Workshop 1: Signaling and Function of Immune Inhibitory Receptors |
Peaks 4 & 5 |
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* Melissa Matzelle, AbbVie, Inc.
Session Chair |
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Saskia Vijver, UMC Utrecht
A Novel Bioinformatics Pipeline for the Identification of Immune Inhibitory Receptors as Potential Therapeutic Targets |
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Lindsay G Serene, Imperial College London
Streptococcus Pyogenes Interacts with the Human Inhibitory Receptor LILRB2 |
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Maximillian Robinson, UCL
CTLA-4 Transendocytosis of CD80, but Not Simple CD80-CTLA-4 Binding, Regulates PD-L1:PD-1 Interactions |
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Bastien Moës, University of Montreal - CHMR
GSK-3 Signaling Affects T-cell Homeostasis that Enables CD8 Super-armed Killers in Anti-PD-1 Immunotherapy |
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Matthew Vesely, Yale University
PD-1H/VISTA Agonism as a Potential Therapy for Autoimmune Skin Diseases |
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Waipan Chan, National Institutes of Health
TCR Ligand Potency Differentially Regulates PD-1-Mediated Inhibitions |
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Daniela Cipolletta, Seismic Therapeutic
Identification and Characterization of Inhibitory Receptor Agonists for the Treatment of Autoimmune and Inflammatory Diseases |
|
| 4:30–5:00 PM |
Coffee Available |
Colorado Ballroom Foyer |
| 5:00–7:00 PM |
Inhibitory Immune Receptors in Cancer Development and Therapy |
Peaks 4 & 5 |
| |
* Jeanine Pignatelli, Mestag Therapeutics
Session Chair |
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* Ekaterina Koroleva, University of Texas Health Science Center at San Antonio
Session Chair |
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Nicolas Poirier, OSE Immunotherapeutics
Selective Anti-SIRPa Targeting in Immuno-Oncology |
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Ricardo Fernandes, University of Oxford
Checkpoint Blockade by Phosphatase Recruitment |
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Daniel D. Kaplan, NGM Biopharmaceuticals, Inc.
Regulation of Myeloid Cell Biology Through the ILT/LILRB Inhibitory Receptors |
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Chao Wang, UC San Diego
Short Talk: Short Talk: Degradation of Siglec-7/-9 Receptors Rejuvenates T Lymphocytes in Cancer Immunotherapy |
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Lee B. Rivera, NGM Pharmaceuticals
Short Talk: Short Talk: Identification of OSCAR as a LAIR1-Regulated Receptor Mediating Collagen-Induced Myeloid Inflammation |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Peaks 1-3 |
| 7:30–10:00 PM |
Poster Session 1 |
Peaks 1-3 |
Thursday, January 18, 2024
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–11:00 AM |
Regulation of Homeostasis by Inhibitory Receptors |
Peaks 4 & 5 |
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* Lidia Bosurgi, University Medical Center Hamburg-Eppendorf
Session Chair |
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Li Peng, Palleon Pharma
Remote Presentation: Unlocking the Therapeutic Potential of Glycobiology |
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Linde Meyaard, University Medical Center Utrecht
Inhibitory Pattern Recognition Receptors in Homeostasis |
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Lidia Bosurgi, University Medical Center Hamburg-Eppendorf
Unveiling the Power of Phagocytic Receptor Specificity to Explore Macrophage Functions |
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Carla V. Rothlin, Yale University
MERTK and TYRO3 in Retinal Homeostasis |
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Linghua Zheng, Ohio State University
Short Talk: Short Talk: The Inhibitory Role of Cell Surface PILRα–CD8α Interactions in Maintaining Cd8+ T Cell Quiescence and Homeostasis |
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Thiago Borges, Massachusetts General Hospital
Short Talk: Short Talk: Siglec-E is a Novel Co-inhibitory Receptor in the Modulation of Innate Activation after Transplantation |
|
| 9:00–9:20 AM |
Coffee Break |
Colorado Ballroom Foyer |
| 11:00–1:00 PM |
Poster Setup |
Peaks 1-3 |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Peaks 1-3 |
| 3:00–4:30 PM |
Career Roundtable |
Peaks 4 & 5 |
| |
Sourav Ghosh, Yale University School of Medicine
Associate Professor |
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Nicole Joller, University of Zurich
Professor |
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Pia P Yachi, Eli Lilly & co
Executive Director |
|
| 4:30–5:00 PM |
Coffee Available |
Colorado Ballroom Foyer |
| 5:00–7:00 PM |
Novel Computational and Biological Insights into Inhibitory Receptor Regulation and Function |
Peaks 4 & 5 |
| |
* Jacqueline E. Payton, Washington University
Session Chair |
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* Chenglong Li, University of Florida
Session Chair |
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Gavin J. Wright, University of York
Identification of Novel Inhibitory Receptor Interactions |
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Becca Asquith, Imperial College London
KIRs, T Cell Dynamics, Control of Chronic Virus Infection and Autoimmunity |
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Sourav Ghosh, Yale University School of Medicine
TREM2 and AXL in Neurodegeneration |
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Joshua Samuels, University of Virginia
Short Talk: Short Talk: SHP-1 Negatively Regulates Microglial Innate Immune Responses in Aβ Amyloidosis |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Peaks 1-3 |
| 7:30–10:00 PM |
Poster Session 2 |
Peaks 1-3 |
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–11:00 AM |
Dissecting the Role of Inhibitory Immune Receptors in Infection Biology |
Peaks 4 & 5 |
| |
* Michiel van der Vlist, University Medical Center Utrecht
Session Chair |
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Alex McCarthy, Imperial College London
Regulation of Epithelium by CEACAMs |
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Nicole Joller, University of Zurich
TIGIT Limits Immune Pathology During Viral Infections |
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Hisashi Arase, Osaka University
Immune Evasion of Plasmodium falciparum via Inhibitory Receptors |
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Meghan Morrissey, University of California, Santa Barbara
CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis |
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Hannah Dorando, Washington University in St. Louis School of Medicine
Short Talk: Short Talk: LAIR1 Prevents Excessive Inflammatory Signaling in S. Aureus Skin and Soft Tissue Infection |
|
| 9:00–9:20 AM |
Coffee Break |
Colorado Ballroom Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Workshop 2: New Concepts in Inhibitory Receptor Biology |
Peaks 4 & 5 |
| |
* David M. Sansom, University College London
Session Chair |
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Shi-Yo Jill Chen, College of Medicine, National Taiwan University
Investigation of the Role of CD300a in Epstein–Barr Virus-infected B Cells and its Potential as a Target Antigen for T Cell-redirecting Bispecific Antibodies |
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Ian A. Parish, Peter MacCallum Cancer Centre
Single Protein Mapping of Immune Checkpoints Reveals CD80 as an Antagonist of PD-L1/MHC-I Clusters |
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James Torchia, Dana-Farber Cancer Institute
Location-Specific T-cell Inhibitory Molecules (LoSTIMs) |
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Dieuwke L Marvin, University Medical Center Utrecht
Surface Removal and Degradation of PD-L1 Using SureTACs Technology |
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Yasuyuki Saito, Kobe University Graduate School of Medicine
CD47 Promotes Peripheral T Cell Survival by Preventing Dendritic Cell–mediated T Cell Necroptosis |
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Martina Damo, University of Chicago
PD-1 Safeguards Against Cutaneous Immunopathology by Local Neoantigen-specific CD8 T Cells |
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Seymour de Picciotto, Moderna, Inc.
Agonizing Multiple Inhibitory Receptors: A Potential Therapeutic Strategy for Autoimmune Diseases |
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Mariano Malamud Guillan, University of Exeter
Regulation of Neutrophil Extracellular Trap Formation by a Novel Inhibitory C-type Lectin Receptor |
|
| 4:30–5:00 PM |
Coffee Available |
Colorado Ballroom Foyer |
| 5:00–6:45 PM |
Targeting Inhibitory Receptors for Novel Therapies |
Peaks 4 & 5 |
| |
* Pia P Yachi, Eli Lilly & co
Session Chair |
|
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* Hongtao Lu, Elpiscience Biopharma, Ltd.
Session Chair |
|
| |
Ajay Nirula, Eli Lilly
Clinical Validation of Checkpoint Agonist Antibodies in Immunologic Disease |
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Lynne Anne Murray, MiroBio
Selection of Checkpoint agonist Antibodies through Understanding of Inhibitory Receptor Signaling |
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Jonathon D. Sedgwick, Abbvie
Current Status and the Future Promise for Therapeutic Inhibitory Receptor Targeting |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Peaks 4 & 5 |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Peaks 1-3 |
| 8:00–9:00 PM |
Trivia |
Peaks 1-3 |
| 8:00–9:00 PM |
Cash Bar |
Peaks 1-3 |
Saturday, January 20, 2024
