Precision Oncology: Emerging Technologies & Implementation (A1)
January 12-15, 2025
| Beaver Run Conference Center, Breckenridge, CO, United States
John D. Carpten, David Solit and Chanita H Hughes Halbert
Scholarship Deadline: Oct. 30, 2024 | Abstract Deadline: Dec. 20, 2024 | Early Registration Deadline: Nov. 22, 2024
| 4:00–8:00 PM |
Registration |
Colorado Ballroom Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Colorado Ballroom Foyer |
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–9:00 AM |
Welcome and Keynote Address |
Peaks 4 & 5 |
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* John D. Carpten, City of Hope Cancer Center
Session Chair |
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Elaine R Mardis, Nationwide Children's Hospital
Complex Molecular Characterization of Pediatric Cancers: Setting the Stage for Precision Diagnosis and Therapy |
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| 9:00–11:15 AM |
Targeted Therapeutics |
Peaks 4 & 5 |
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Frank S McCormick, University of California, San Francisco
Targeting Ras in Human Cancer |
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* Christine Lovly, Vanderbilt University
Sensitivity and Resistance to Kinase Inhibitors in Cancer |
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* Lillian L Siu, Princess Margaret Cancer Centre
Targeted Cytotoxics: Advances in Antibody Drug Conjugates |
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Hee Won Yang, Columbia University
Short Talk: Deciphering the Mechanism Underlying Resistance to pan-RAS Inhibitors |
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Jeff Perry, City of Hope
Short Talk: Small Molecule-Based Targeting of PCNA Protein to Develop a Cancer-Selective Chemotherapy |
|
| 9:30–9:50 AM |
Coffee Break |
Colorado Ballroom Foyer |
| 11:15–1:00 PM |
Poster Setup |
Peaks 1 - 3 |
| 11:15–4:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Peaks 1 - 3 |
| 4:30–5:00 PM |
Coffee Available |
Colorado Ballroom Foyer |
| 5:00–6:45 PM |
Clinical Trial Advances/Insights/Design |
Peaks 4 & 5 |
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David Solit, Memorial Sloan Kettering Cancer Center
Lessons from the Study of Exceptional Responders |
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* Vivek Subbiah, Sarah Cannon Research Institute
New Clinical Trial Designs for the Precision Medicine Era |
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Sunantha Sethuraman, Repare Therapeutics
Short Talk: Utility of Circulating Tumor DNA (Ctdna) to Support Early Clinical Development of the PKMYT1 Inhibitor Lunresertib (Lunre) Alone or in Combination with the ATR Inhibitor Camonsertib (Cam) in the MYTHIC Phase I Trial |
|
| 6:45–7:45 PM |
Social Hour with Lite Bites |
Peaks 1 - 3 |
| 7:15–10:00 PM |
Poster Session 1 |
Peaks 1 - 3 |
Tuesday, January 14, 2025
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–11:00 AM |
Precision Oncology and Disparities (Implementation and Discovery) |
Peaks 4 & 5 |
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Rizwana Mia, South African Medical Research Council
Remote Presentation: Precision Oncology Disparities in South Africa |
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Rick Kittles, Morehouse School of Medicine
Reimagining Health Equity in the Era of Precision Medicine |
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Clayton C. Yates, Johns Hopkins School of Medicine
Using Precision Oncology to Support Innovation in Prostate Cancer Equity |
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* Chanita H Hughes Halbert, University of Southern California
Intersection Between Social and Biological Risk Factors on the Pathway to Cancer Health Equity |
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Nick Pannunzio, University of Califormia Irvine
Short Talk: Increased AID Results in Mutations at the CRLF2 Locus Implicated in Latin American ALL Health Disparities |
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Lixing Yang, University of Chicago
Short Talk: Data-Driven Drug Discovery Targeting Transcription and Replication Collision in Cancer |
|
| 9:00–9:20 AM |
Coffee Break |
Colorado Ballroom Foyer |
| 11:00–1:00 PM |
Poster Setup |
Peaks 1 - 3 |
| 11:00–1:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Peaks 1 - 3 |
| 2:00–3:15 PM |
Symposia Spotlight: Late-Breaking research presentations selected from abstract submissions |
Peaks 4 & 5 |
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* Clayton C. Yates, Johns Hopkins School of Medicine
Session Chair |
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Tomas Babak, Leapfrog Bio
EP300 Loss of Function is a Pan-Cancer Sensitizer to BET Inhibition |
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Yaniv Kazansky, Weill Cornell Medicine
Overcoming Clinical Resistance to EZH2 Inhibition Using Rational Epigenetic Combination Therapy |
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Luke Pike, Memorial Sloan Kettering Cancer Center
EGFR Alteration Subtype Predicts the Benefit Of Stereotactic Radiosurgery in Patients with NSCLC Brain Metastasis |
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Poulikos I. Poulikakos, Icahn School of Medicine at Mount Sinai
RAF/MEK Glue Mechanism on RAF Enables RAS Mutant Tumor-Selective Therapy |
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| 3:30–4:30 PM |
Career Roundtable |
Peaks 4 & 5 |
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Clayton C. Yates, Johns Hopkins School of Medicine
Professor |
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Manisha Rao, AstraZeneca
Senior Scientist |
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Peter W. Szlosarek, Barts Cancer Institute
Professor & Group Leader, Physician Scientist |
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| 4:30–5:00 PM |
Coffee Available |
Colorado Ballroom Foyer |
| 5:00–7:00 PM |
Precision Immuno-oncology / Overcoming Immune Evasion Through Combination Therapies |
Peaks 4 & 5 |
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* David Solit, Memorial Sloan Kettering Cancer Center
Session Chair |
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Padmanee Sharma, University of Texas MD Anderson Cancer Center
Advancing Immune Checkpoint Targets in Cancer |
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Marta Luksza, Icahn School of Medicine at Mount Sinai
Novel Computational Methods to Define Immunotherapy Sensitivity |
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Alona Sosinsky, Genomics England
Integrating Genome Sequencing into Clinical Practice for Cancer Patients |
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Christine Yeh, Stanford University
Short Talk: Mapping Spatial Organization and Genetic Cell-State Regulators to Target Immune Evasion in Ovarian Cancer |
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Kyuson Yun, Houston Methodist/Weill Cornell Medical College
Short Talk: A Novel Functional Precision Oncology Platform Technology: E-Slice with Intact TME for Immunotherapy and Other Cancer Therapy Response Measurements from Human Tumors |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Peaks 1 - 3 |
| 7:30–10:00 PM |
Poster Session 2 |
Peaks 1 - 3 |
Wednesday, January 15, 2025
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–11:00 AM |
Technologies for Biomarker Discovery (Discovery Through Application in the Clinic) |
Peaks 4 & 5 |
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* Christina Curtis, Stanford University
Genomic, Immune and Microenvironmental Biomarkers in Breast Cancer |
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* Colin D. Weekes, Massachusetts General Hospital
Harnessing Tumor Plasticity for Therapeutic Intent |
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Ericca Stamper, Dovetail Genomics, Part of Cantata Bio LCC
Short Talk: Linkprep™ – A Comprehensive Assay for Cancer Genome Characterization that Enables Ultra-Sensitive Detection of Structural Variants |
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Emily Madden, EpiCypher, Inc
Short Talk: Chromatin Profiling from Formalin-Fixed Paraffin-Embedded Samples for Biomarker Discovery |
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Oliver Jonas, Brigham & Women's Hospital
Short Talk: Clinical Implementation of Implantable Microdevices to Identify Highly Effective Treatment Combinations in Cancer Patients |
|
| 9:00–9:20 AM |
Coffee Break |
Colorado Ballroom Foyer |
| 11:00–4:30 PM |
On Own for Lunch |
|
| 4:30–5:00 PM |
Coffee Available |
Colorado Ballroom Foyer |
| 5:00–6:45 PM |
Data Science, Informatics, AI & Machine Learning |
Peaks 4 & 5 |
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Eliezer M. Van Allen, Dana-Farber Cancer Institute
Remote Presentation: Convergence of Machine Learning and Multi-omics for Precision Cancer Medicine |
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* David Craig, City of Hope
Informatics Strategies for Incorporating Genetic Ancestry in Precision Oncology |
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Benjamin Greenbaum, Memorial Sloan Kettering Cancer Center
Learning what the Immune System Senses in Cancer and When It Matters |
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John Paul Shen, University of Texas MD Anderson
Short Talk: Utilizing an Automated, NLP-aided Platform to Generate Large (>10,000 patient), Comprehensive Clinical & Molecular Datasets to Enable a Real-World Evidence Approach to Precision Oncology |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Peaks 4 & 5 |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Peaks 1 - 3 |
| 8:00–9:00 PM |
Cash Bar |
Peaks 1 - 3 |
| 8:00–9:00 PM |
Entertainment |
Peaks 4 - 5 |
Thursday, January 16, 2025
