Single-Cell Biology: Tissue Genomics, Technologies and Disease (A2)
January 21-24, 2024
| Fairmont Hotel Vancouver, Vancouver, BC, Canada
Jason Buenrostro, Lacramioara Bintu and Fei Chen
Scholarship Deadline: Oct. 26, 2023 | Abstract Deadline: Oct. 26, 2023 | Early Registration Deadline: Nov. 16, 2023
| 4:00–8:00 PM |
Arrival and Registration |
British Columbia Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
British Columbia Foyer |
| 7:00–8:00 AM |
Breakfast |
Columbia Ballroom |
| 8:00–9:00 AM |
Welcome and Keynote Address |
British Ballroom |
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Ido Amit, Weizmann Institute
Single-Cell Discovery of Disease-Associated Cell States |
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| 9:00–11:15 AM |
Genomic Regulators of Cellular Circuitry |
British Ballroom |
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Lacramioara Bintu, Stanford University
The Control of Gene Regulation at Single-Cell Resolution |
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David R. Kelley, Calico Life Sciences
Sequence-Based Deep Learning of Single-Cell Genomics |
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Michael Lorenzini, Salk Institute
Short Talk: Short Talk: Direct Readout of Genome Perturbations and Transcription Outcomes by Single-Cell Edit Capture |
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Fabian Müller, Saarland University
Short Talk: Short Talk: Dissecting the Epigenome Dynamics of Human Immune Cells Upon Pathogen Exposure at Single-Cell Resolution |
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Siddharth S. Dey, University of California, Santa Barbara
Short Talk: Short Talk: Combinatorial Quantification of 5mC and 5hmC at Individual CpG Dyads and the Transcriptome in Single Cells Reveals Modulators of DNA Methylation Maintenance Fidelity in Early Mouse Development |
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| 9:30–9:50 AM |
Coffee Break |
British Columbia Foyer |
| 11:15–1:00 PM |
On Own for Lunch |
|
| 11:15–1:00 PM |
Poster Setup |
Columbia Ballroom |
| 1:00–10:00 PM |
Poster Viewing |
Columbia Ballroom |
| 3:00–4:30 PM |
Career Roundtable |
British Ballroom |
| |
Hongkui Zeng, Allen Institute for Brain Science
Executive Vice President, Director |
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Ana Gabriela Cristancho, Children's Hospital of Philadelphia
Assistant Professor |
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Grace Zheng, Arsenal Biosciences
Senior Director of Computational Biology and Machine Learning |
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Gonçalo Castelo-Branco, Karolinska Institutet
Professor |
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| 4:30–5:00 PM |
Coffee Available |
British Columbia Foyer |
| 5:00–7:00 PM |
Multi-omic Approaches to Study Gene Regulation |
British Ballroom |
| |
Jason Buenrostro, Harvard University
Single-Cell Epigenomics |
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Peter Smibert, 10x Genomics
An Ecosystem of Complementary Technologies for Analyzing Fresh and Archived Single Cells and Tissues |
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Gonçalo Castelo-Branco, Karolinska Institutet
Multi-Omic Dynamics of Oligodendroglia in Development and Disease |
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Mattia Zaghi, Karolinska Institutet
Short Talk: Short Talk: Multi-nano Cut&Tag-RNA,a Novel Approach to Map Transcriptomic and Multiple Epigenetic Modalities from Single Cells |
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Siran Li, Cold Spring Harbor Laboratory
Short Talk: Short Talk: Associating Cancer and Stromal Genomes with Transcriptomes by High-Throughput Single-Nucleus Multiomic Sequencing |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Columbia Ballroom |
| 7:30–10:00 PM |
Poster Session 1 |
Columbia Ballroom |
Tuesday, January 23, 2024
| 7:00–8:00 AM |
Breakfast |
Columbia Ballroom |
| 8:00–11:00 AM |
Tissue Organization and Interactions |
British Ballroom |
| |
Barbara Treutlein, ETH Zürich
Reconstructing Brain Development and Regeneration with Single-cell Technologies |
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Fei Chen, Broad Institute of MIT and Harvard
Tissue Genomics Tools for Probing Cellular Interactions |
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Hongkui Zeng, Allen Institute for Brain Science
Spatial and Cellular Organization of Mouse and Human Brain |
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Cassandra Burdziak, Memorial Sloan Kettering Cancer Center
The Environment-plasticity Axis in Tumor Progression |
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Michal Polonsky, Caltech
Short Talk: Short Talk: Spatial Transcriptomics Defines Injury-Specific Microenvironments in the Adult Mouse Kidney and Novel Cellular Interactions in Regeneration and Disease |
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| 9:00–9:20 AM |
Coffee Break |
British Columbia Foyer |
| 11:00–1:00 PM |
On Own for Lunch |
|
| 11:00–1:00 PM |
Poster Setup |
Columbia Ballroom |
| 1:00–10:00 PM |
Poster Viewing |
Columbia Ballroom |
| 3:00–4:30 PM |
Workshop 1: Mapping Diseases |
British Ballroom |
| |
Samuel Cooper, Phenomic
Single-cell RNA Analysis at Scale Identifies a Conserved Wound Healing Axis in Health and Disease |
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Siyuan Wang, Yale University
A Genome-Wide Single-Cell 3D Genome Atlas of Lung Cancer Progression |
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Shreya Menon, University of California, San Francisco / Gladstone Institutes
Leveraging Single-cell Multi-omic Profiling to Investigate Non-coding Variants in Neurodegenerative Disease |
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Ana Gabriela Cristancho, Children's Hospital of Philadelphia
Single-nucleus Multi-omics Predicts Persistent Functional Deficits in Glutamatergic Neurons after Prenatal Hypoxic Brain Injury |
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André F Rendeiro, CeMM Research Center for Molecular Medicine
Tissue-level Prediction of Biological Age and Pathology Incidence |
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Lochlan J. Fennell, Monash University
Traversing The Colorectal Transcriptomic Landscape Through Space, Time and Disease |
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| 4:30–5:00 PM |
Coffee Available |
British Columbia Foyer |
| 5:00–7:00 PM |
Development and Cellular Dynamics |
British Ballroom |
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Cole Trapnell, University of Washington
Creating Cellular Diversity During Development |
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Samantha A. Morris, Washington University School of Medicine in St Louis
Lineage Tracing Cell Fates |
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Martin Tran, Caltech
Short Talk: Short Talk: Lineage motifs as developmental modules for control of cell type proportions |
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HaoSheng Sun, Howard Hughes Medical Institute, University of Alabama at Birmingham
Short Talk: Short Talk: Genetic Regulation of the Post-embryonic Post-mitotic Nervous System Maturation in Single Neuron Resolution |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Columbia Ballroom |
| 7:30–10:00 PM |
Poster Session 2 |
Columbia Ballroom |
Wednesday, January 24, 2024
| 7:00–8:00 AM |
Breakfast |
Columbia Ballroom |
| 8:00–8:45 AM |
Keynote Address |
British Ballroom |
| |
Emma K. Lundberg, Stanford University and Chan Zuckerberg Initiative
From Mapping to Modeling the Subcellular Proteome Architecture of Cells |
|
| 8:45–11:15 AM |
Single-Cell and Tissue Perturbation Technologies |
British Ballroom |
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Bogdan Bintu, University of California, San Diego
Spatial Transcriptomics Reveals the Activation of Quiescent Neurogenic Niches in the Aging Mammalian Brain |
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Martin Borch Jensen, Gordian Biotechnology
Pooled in vivo Testing of Therapeutics in the Environment you want them to Work |
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Jonathan S. Weissman, Whitehead Institute, HHMI, and MIT
Genome-Wide Perturbations for Defining Principles of Biological Systems |
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Grace Zheng, Arsenal Biosciences
Short Talk: Short Talk: Combinatorial High-throughput Genetic Screening of Regulators of T Cell Function to Improve Efficacy of Therapeutic Engineered T Cells |
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Ceejay Lee, Liau Lab (Harvard University)
Short Talk: Short Talk: Massively Parallel Profiling of Androgen Receptor Protein-coding Variants with SCAnnEd |
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| 9:00–9:20 AM |
Coffee Break |
British Columbia Foyer |
| 11:15–1:00 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Workshop 2: Frontiers in Computation |
British Ballroom |
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Joshua Weinstein, University of Chicago
Volumetric Imaging of an Intact Organism by a Distributed Molecular Network |
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David Wen, Gladstone Institutes/University of California, San Francisco
A Comprehensive Map of Dosage Sensitivity Across Fetal Development |
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Camilo Espinosa Bernal, Stanford University School of Medicine
Modeling Cell-type-specific Perturbations in Single-cell Omic Datasets with Attention |
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Peiyao Zhao, Allen Institute
SPARROW: A Sequential Algorithm for Cell Type Inference and Microenvironment Delineation in Spatial Transcriptomics |
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Salil Bhate, Broad Institute of MIT and Harvard
Deriving Genetic Codes for Tissues from First Principles |
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Sandeep Kambhampati, Harvard University
Connecting Spatial Organization of Tissues to Cell State and Function using Self-supervised Machine Learning |
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| 4:30–5:00 PM |
Coffee Available |
British Columbia Foyer |
| 5:00–6:15 PM |
Aging and Disease Associated Cell States |
British Ballroom |
| |
Brian D. Brown, Mount Sinai School of Medicine
Single Cell Mapping of Myeloid Cell Targets of Cancer |
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Wolf Reik, Altos Labs, Cambridge Institute of Science
Single Cell Multi-omics Landscape of Development and Ageing |
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Ailsa Jeffries, UMass Chan Medical School
Short Talk: Short Talk: The Bidirectional Relationship between the Aging Genome and Transcriptome in the Human Brain |
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| 6:15–7:00 PM |
Closing Keynote Address |
British Ballroom |
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Michael Elowitz, HHMI/California Institute of Technology
Cellular Circuitry and Dynamics |
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
British Ballroom |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
The Roof |
| 8:00–9:00 PM |
Cash Bar |
The Roof |
Thursday, January 25, 2024
