Autoimmunity & Autoinflammation: Translating Basic Mechanisms into Novel Therapeutic Approaches (A2)
January 19-22, 2026
| Keystone Resort, Keystone, CO, United States
Virginia Pascual, Raphaela Goldbach-Mansky, Veit Hornung and Richard M. Siegel
Scholarship Deadline: Oct. 3, 2025 | Abstract Deadline: Dec. 30, 2025 | Early Registration Deadline: Nov. 20, 2025
| 4:00–8:00 PM |
Registration |
|
| 6:00–8:00 PM |
Welcome Mixer |
|
Tuesday, January 20, 2026
| 8:00–9:00 AM |
Welcome and Keynote Address |
|
| |
Jenny P.Y. Ting, University of North Carolina at Chapel Hill
A 360° View of the Inflammasome: Mechanisms of Activation, Cell Death, and Diseases |
|
| 9:00–11:15 AM |
Autoimmunity and Autoinflammation: The Nucleic Acid Sensing Perspective |
|
| |
Veit Hornung, Ludwig-Maximilians-University Munich
Recognition of Non-Self RNA by the Innate Immune System |
|
| |
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne
cGAS-STING in Aging-Related Inflammation and Neurodegeneration |
|
| |
Michael Crackower, Ventus Therapeutics
Novel Therapies to Target cGAS-STING |
|
| |
Short Talk(s) Chosen from Abstracts
|
|
| 9:30–9:50 AM |
Coffee Break |
|
| 11:15–1:00 PM |
Poster Setup |
|
| 11:15–2:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
|
| 2:30–4:30 PM |
Symposia Spotlight: Late-breaking research presentations selected from abstract submissions |
|
| |
Short Talks Chosen from Abstracts
|
|
| 4:30–5:00 PM |
Coffee Available |
|
| 5:00–7:00 PM |
Inflammasomes: From Basic Mechanisms to Autoinflammatory Diseases |
|
| |
Franklin Zhong, NTU LKC School of Medicine
The NLRP1 Inflammasome |
|
| |
Raphaela Goldbach-Mansky, NIAID, National Institutes of Health
Novel Mechanisms in Autoinflammatory Diseases |
|
| |
Nick Clarke, NodThera
An Update on Inflammasome Targeting |
|
| |
Short Talk(s) Chosen from Abstracts
|
|
| 7:00–8:00 PM |
Social Hour with Dinner |
|
| 7:30–10:00 PM |
Poster Session 1 |
|
Wednesday, January 21, 2026
| 8:00–11:00 AM |
Innate Immune Cell Dysregulation in Autoimmune and AutoInflammatory Diseases |
|
| |
Musa M. Mhlanga, Radboud Institute for Molecular Life Sciences
The Intersection of Epigenetics and Metabolism in Trained Immunity |
|
| |
Virginia Pascual, Cornell University
Innate Immunity Dysregulation in Human Lupus |
|
| |
Coco Chu, Tsinghua University
Neuro- and Stromal-immune Interactions in the Intestine |
|
| |
Kate L. Jeffrey, Moderna
mRNA: A New Era in Immune Therapeutics |
|
| |
Short Talk(s) Chosen from Abstracts
|
|
| 9:00–9:20 AM |
Coffee Break |
|
| 11:00–1:00 PM |
Poster Setup |
|
| 11:00–3:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
|
| 1:30–2:45 PM |
Career Roundtable |
|
| 3:00–4:30 PM |
Panel Discussion 1: Interactions with Biotech, Pharma and Venture Capital: Translating Discoveries to Novel Therapeutics |
|
| |
* Richard M. Siegel, Novartis Biomedical Research
Panel Moderator |
|
| |
Kriti Lall, Perceptive Advisors
Panelist |
|
| |
Dennis M Zaller, Curie.Bio
Panelist |
|
| |
Markus Warmuth, Monte Rosa Therapeutics Inc
Panelist |
|
| |
Michael Crackower, Ventus Therapeutics
Panelist |
|
| |
Kara Lassen, Roche
Panelist |
|
| 4:30–5:00 PM |
Coffee Available |
|
| 5:00–7:00 PM |
Adaptive Immune Cell Dysregulation in Autoimmune and Autoinflammatory Diseases |
|
| |
Francisco J. Quintana, Brigham and Women's Hospital / Harvard Medical School & Broad Institute
Disease-Associated Astrocyte Epigenetic Memory Promotes CNS Pathology |
|
| |
Carola G. Vinuesa, Francis Crick Institute
Preclinical Models of Human Monogenic Autoimmunity |
|
| |
Johann Gudjonsson †, University of Michigan Medical School
Talk Title to be Announced |
|
| |
Short Talk(s) Chosen from Abstracts
|
|
| 7:00–8:00 PM |
Social Hour with Dinner |
|
| 7:30–10:00 PM |
Poster Session 2 |
|
Thursday, January 22, 2026
| 8:00–11:00 AM |
Stromal Cells in Autoinflammation and Autoimmunity: From Basic Mechanisms to Precision Medicine |
|
| |
Shahin Rafii, Weill Cornell Medical College
Dysfunction of Tissue-specific Endothelial Cells in Triggering Auto-immunity |
|
| |
Michael B. Brenner, Harvard Medical School
Adipocyte and Fibroblast Dysfunction in Inflammatory Diseases |
|
| |
Ken H Cadwell, University of Pennsylvania
Mechanisms of Intestinal Tissue Resilience to Immune-Mediated Damage |
|
| |
Kara Lassen, Roche
Patient Stratification Towards Precision Medicine in IBD |
|
| |
Short Talk(s) Chosen from Abstracts
|
|
| 9:00–9:20 AM |
Coffee Break |
|
| 11:00–12:00 PM |
Panel: Meet the Editors |
|
| 12:00–2:30 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Panel Discussion 2: Research and Funding Opportunities from Governments, Pharma, Academia, and Foundations |
|
| |
* Virginia Pascual, Cornell University
Panel Moderator |
|
| |
Stacy E. Ferguson, NIAID, National Institutes of Health
Panelist |
|
| |
Angela Dobes, IBD Plexus at Crohn's and Colitis Foundation
Panelist |
|
| |
Hoang Nguyen, Lupus Research Alliance
Panelist |
|
| |
Veit Hornung, Ludwig-Maximilians-University Munich
Panelist |
|
| |
Richard M. Siegel, Novartis Biomedical Research
Panelist |
|
| |
Raphaela Goldbach-Mansky, NIAID, National Institutes of Health
Panelist |
|
| 4:30–5:00 PM |
Coffee Available |
|
| 5:00–6:45 PM |
Novel Disease Insights and Therapies: Lessons from Tissue Profiling |
|
| |
Tobias Lanz, Stanford University
Roadmap for Understanding Mechanisms on how Epstein-Barr Virus Triggers Multiple Sclerosis and for Developing Therapeutic Approaches |
|
| |
Shruti Naik, Icahn School of Medicine at Mount Sinai
Mapping Inflammatory Disease over Space and Time |
|
| |
Richard M. Siegel, Novartis Biomedical Research
Novel Approaches to Tissue B Cell Depletion in Autoimmune Diseases |
|
| |
Short Talk(s) Chosen from Abstracts
|
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
|
| 7:00–8:00 PM |
Social Hour with Dinner |
|
| 8:00–11:00 PM |
Entertainment |
|
