Autoimmunity & Autoinflammation: Translating Basic Mechanisms into Novel Therapeutic Approaches (A2)
January 19-22, 2026
| Keystone Resort, Keystone, CO, United States
Virginia Pascual, Raphaela Goldbach-Mansky, Veit Hornung and Richard M. Siegel
Scholarship Deadline: Oct. 3, 2025 | Abstract Deadline: Dec. 30, 2025 | Early Registration Deadline: Nov. 20, 2025
| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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Tuesday, January 20, 2026
| 8:00–9:00 AM |
Welcome and Keynote Address |
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Jenny P.Y. Ting, University of North Carolina at Chapel Hill
A 360° View of the Inflammasome: Mechanisms of Activation, Cell Death, and Diseases |
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| 9:00–11:15 AM |
Autoimmunity and Autoinflammation: The Nucleic Acid Sensing Perspective |
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Veit Hornung, Ludwig-Maximilians-University Munich
Recognition of Non-Self RNA by the Innate Immune System |
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Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne
cGAS-STING in Aging-Related Inflammation and Neurodegeneration |
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Michael Crackower, Ventus Therapeutics
Novel Therapies to Target cGAS-STING |
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Short Talk(s) Chosen from Abstracts
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| 9:30–9:50 AM |
Coffee Break |
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| 11:15–1:00 PM |
Poster Setup |
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| 11:15–2:30 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 2:30–4:30 PM |
Symposia Spotlight: Late-breaking research presentations selected from abstract submissions |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Inflammasomes: From Basic Mechanisms to Autoinflammatory Diseases |
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Franklin Zhong, NTU LKC School of Medicine
The NLRP1 Inflammasome |
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Raphaela Goldbach-Mansky, NIAID, National Institutes of Health
Novel Mechanisms in Autoinflammatory Diseases |
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Nick Clarke, NodThera
An Update on Inflammasome Targeting |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 7:30–10:00 PM |
Poster Session 1 |
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Wednesday, January 21, 2026
| 8:00–11:00 AM |
Innate Immune Cell Dysregulation in Autoimmune and AutoInflammatory Diseases |
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Musa M. Mhlanga, Radboud Institute for Molecular Life Sciences
The Intersection of Epigenetics and Metabolism in Trained Immunity |
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Virginia Pascual, Cornell University
Innate Immunity Dysregulation in Human Lupus |
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Brian Kim, Mount Sinai
Interorgan Neuroimmune Circuits |
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Kate L. Jeffrey, Moderna
mRNA: A New Era in Immune Therapeutics |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–1:00 PM |
Poster Setup |
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| 11:00–3:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 1:30–2:45 PM |
Career Roundtable |
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| 3:00–4:30 PM |
Panel Discussion 1: Interactions with Biotech, Pharma and Venture Capital: Translating Discoveries to Novel Therapeutics |
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* Richard M. Siegel, Novartis Biomedical Research
Panel Moderator |
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Kriti Lall, Perceptive Advisors
Panelist |
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Dennis M Zaller, Curie.Bio
Panelist |
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Markus Warmuth, Monte Rosa Therapeutics Inc
Panelist |
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Michael Crackower, Ventus Therapeutics
Panelist |
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Kara Lassen, Roche
Panelist |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Adaptive Immune Cell Dysregulation in Autoimmune and Autoinflammatory Diseases |
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Francisco J. Quintana, Brigham and Women's Hospital / Harvard Medical School & Broad Institute
Disease-Associated Astrocyte Epigenetic Memory Promotes CNS Pathology |
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Carola G. Vinuesa, Francis Crick Institute
Preclinical Models of Human Monogenic Autoimmunity |
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Federica Sallusto †, Università della Svizzera Italiana & ETH Zurich
Autoreactive T Cells |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 7:30–10:00 PM |
Poster Session 2 |
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Thursday, January 22, 2026
| 8:00–11:00 AM |
Stromal Cells in Autoinflammation and Autoimmunity: From Basic Mechanisms to Precision Medicine |
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Michael B. Brenner, Harvard Medical School
Adipocyte and Fibroblast Dysfunction in Inflammatory Diseases |
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Ken H Cadwell, University of Pennsylvania
Mechanisms of Intestinal Tissue Resilience to Immune-Mediated Damage |
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Kara Lassen, Roche
Patient Stratification Towards Precision Medicine in IBD |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–2:30 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Panel Discussion 2: Research and Funding Opportunities from Governments, Pharma, Academia, and Foundations |
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* Virginia Pascual, Cornell University
Panel Moderator |
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Stacy E. Ferguson, NIAID, National Institutes of Health
Panelist |
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Angela Dobes, IBD Plexus at Crohn's and Colitis Foundation
Panelist |
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Hoang Nguyen, Lupus Research Alliance
Panelist |
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Richard M. Siegel, Novartis Biomedical Research
Panelist |
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Veit Hornung, Ludwig-Maximilians-University Munich
Panelist |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:45 PM |
Novel Disease Insights and Therapies: Lessons from Tissue Profiling |
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Tobias Lanz, Stanford University
Roadmap for Understanding Mechanisms on how Epstein-Barr Virus Triggers Multiple Sclerosis and for Developing Therapeutic Approaches |
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Shruti Naik, Icahn School of Medicine at Mount Sinai
Mapping Inflammatory Disease over Space and Time |
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Richard M. Siegel, Novartis Biomedical Research
Novel Approaches to Tissue B Cell Depletion in Autoimmune Diseases |
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Short Talk(s) Chosen from Abstracts
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 PM |
Entertainment |
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