Genetic Medicines to Treat Cardiovascular Disease (A2)
January 25-28, 2027
| Keystone Resort, Keystone, CO, United States
Rick Dewey, Litsa G. Kranias and James S. Ware
Scholarship Deadline: Oct. 1, 2026 | Abstract Deadline: Jan. 5, 2027 | Early Registration Deadline: Nov. 25, 2026
| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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Tuesday, January 26, 2027
| 8:00–8:10 AM |
Welcome Remarks |
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| 8:10–9:00 AM |
Keynote Address |
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Sekar Kathiresan, Verve Therapeutics
The Human Genome as Teacher and Target: Two Decades of Genomic Discovery to Genomic Medicines |
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| 9:00–11:15 AM |
New Trailheads: Target Identification for Genetic Medicines in CV Disease |
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James S. Ware, Imperial College London
Large Scale Genomic Discovery of Causal Mechanisms in Heart Failure |
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Victoria Parikh, Stanford University School of Medicine
Genotype-Phenotype Correlation in Inherited Cardiovascular Disease |
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Rick Dewey, Versant Ventures
Target Selection for Genetic Medicines: Biobanks to Human Proof of Concept |
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Short Talk(s) Chosen from Abstracts
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| 9:30–9:50 AM |
Coffee Break |
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| 11:15–12:15 PM |
Panel Discussion 1: Development, Regulatory, Safety, and Ethical Considerations (including long-term and off-target effects of genetic medicines) |
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Rick Dewey, Versant Ventures
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Silvia G. Priori †, Foundation Salvatore Maugeri
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Laura F. Michael, Eli Lilly and Company
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| 11:15–1:00 PM |
Poster Setup |
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| 11:15–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 2:30–4:30 PM |
Symposia Spotlight 1: Emerging Biological Insights Driving the Next Generation of Genetics Medicines for CV Disease |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Mechanisms and Models: From Variation to Validation |
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Cassady Rupert, Propria LLC
Modeling Human Cardiac Biology with Multi-Dimensional Engineered Human Heart Tissues |
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Leslie A Leinwand, University of Colorado Boulder
Nature- Inspired Solutions to Common Metabolic Challenges |
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Litsa G. Kranias, University of Cincinnati
Phospholamban Cardiomyopathy: From Bedside to Bench and Back |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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Wednesday, January 27, 2027
| 8:00–11:00 AM |
Gene Silencing in Cardiovascular Disease and Promising Avenues |
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Stefanie Dimmeler †, Institute of Cardiovascular Regeneration
Deciphering Noncoding RNAs in Cardiovascular Disease for RNA Therapeutics |
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Euan A. Ashley, Stanford University
Allele-Specific Silencing in Cardiomyopathy |
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Jin Billy Li, Stanford University
Endogenous RNA Editing in CV Disease: Mechanisms and Therapeutic Applications |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–1:00 PM |
Poster Setup |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 3:00–4:30 PM |
Career Roundtable |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Therapeutic Gene Augmentation Strategies in CV Disease |
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Roger J Hajjar, Mass General Brigham
Engineering the Failing Heart: Innovations in Cardiac Gene Therapy |
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Annemieke Aartsma-Rus, Leiden University Medical Center
Exon Skipping to Restore Gene Expression in Muscle Disease |
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Farah Sheikh, University of California, San Diego
From Cell Junctional Failure to Gene Therapy in Arrhythmogenic Cardiomyopathy |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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Thursday, January 28, 2027
| 8:00–11:00 AM |
Homing for Cures: Cardiomyocyte-Directed Delivery Approaches |
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Luk H Vandenberghe, Harvard Medical School
Engineering Viral Delivery Systems |
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Anastasia Khvorova †, RNA Therapeutics Institute, UMass Chan Medical School
Novel Approaches for Oligonucleotide Delivery to Heart |
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James Dahlman, Georgia Tech / Emory Medical School
Lipid Nanoparticles: Past, Present, and Future of RNA Delivery |
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William M Flanagan, Avidity Biosciences, Inc.
Antibody-Oligo Conjugates for Striated Muscle-Enriched Delivery |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–12:00 PM |
Panel Discussion 2: Navigating the Valley of Opportunity: Moving Ideas from Idea to Products for Patients with Academia, Venture Capital, and Pharma |
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Sekar Kathiresan, Verve Therapeutics
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Roger J Hajjar, Mass General Brigham
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| 11:00–5:00 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Symposia Spotlight 2: Emerging Translational Strategies in CV Disease |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:15 PM |
Products to Patients: Therapeutic Development and Trial Design |
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Laura F. Michael, Eli Lilly and Company
Lp(a) - From Genetic Insight to Novel Biology and Breakthrough Therapy |
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Silvia G. Priori †, Foundation Salvatore Maugeri
Therapeutic Development of Genetic Medicines for Arrhythmogenic Cardiovascular Disease |
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Short Talk(s) Chosen from Abstracts
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| 6:15–7:00 PM |
Closing Keynote Address |
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Christine E. Seidman, Harvard Medical School
Modeling Cardiovascular Disease: Genetics, Cellular Systems, Human Models |
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| 7:00–7:15 PM |
Meeting Wrap-Up: Outcomes and Future Directions |
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| 7:15–8:15 PM |
Social Hour with Dinner |
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| 8:00–11:00 PM |
Entertainment |
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