Spotlight on the Cancer Cell: Intrinsic Properties and Vulnerabilities for Therapeutics (A3)
January 26-29, 2026
| Embassy Suites by Hilton Raleigh Durham Research Triangle, Cary, NC, United States
Anwesha Dey, Laura D. Attardi and Mariam Jamal-Hanjani
Scholarship Deadline: Oct. 1, 2025 | Abstract Deadline: Jan. 7, 2026 | Early Registration Deadline: Nov. 26, 2025
| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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Tuesday, January 27, 2026
| 8:00–8:30 AM |
Poster Setup |
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| 8:15–5:00 PM |
Poster Viewing |
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| 8:30–9:30 AM |
Welcome and Keynote Address |
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Kevan M. Shokat, University of California, San Francisco
Overcoming the Undruggable Nature of the Most Common Human Oncogene K-Ras |
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| 9:30–11:45 AM |
Cancer Evolution, Tumor Heterogeneity and Metastasis |
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Mariam Jamal-Hanjani, University College London
Tumor Evolution and Metastasis Revealed through Research Autopsies in PEACE |
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Manuel Valiente, Spanish National Cancer Research Centre
Metastatic Colonization and the Development of Brain Metastasis |
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Short Talk(s) Chosen from Abstracts
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| 10:00–10:20 AM |
Coffee Break |
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| 12:30–2:30 PM |
Poster Session 1 |
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| 2:30–4:30 PM |
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions |
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Short Talk(s) Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Drugging Cancer Pathways and New Targets on the Horizon |
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Kevin Marks, Delphia Therapeutics
Exploiting Pathway Activation as a New Form of Synthetic Lethality |
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Gregory L. Verdine, Harvard University and FogPharma
Drugging Oncogenic Transcriptional Drivers |
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Anwesha Dey, Genentech, Inc.
Targeting the PI3K Pathway in Cancers |
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Peter C. Scacheri, Amgen Research
Targeting Signaling Pathway in Cancers |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
On Own for Dinner |
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Wednesday, January 28, 2026
| 8:00–8:30 AM |
Poster Setup |
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| 8:15–5:00 PM |
Poster Viewing |
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| 8:30–11:30 AM |
Cancer Cell Vulnerabilities and Therapeutic Opportunities |
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Ashok R. Venkitaraman, Cancer Science Institute
p53 and Therapeutic Vulnerabilities |
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Karen M. Cichowski, Brigham and Women's Hospital, Harvard Medical School
Chemical Synthetic Lethal Interactions for the Development of Combinatorial Therapies |
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LaQuita Jones, Cincinnati Children's Hospital Medical Center
Unexpected Resistance Mechanisms Underlying AML Targeted Therapy |
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Josh Plotnik, AbbVie, Inc.
Novel Synthetic Lethal Targets in Cancer |
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Short Talk(s) Chosen from Abstracts
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| 9:30–9:50 AM |
Coffee Break |
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| 12:30–2:30 PM |
Poster Session 2 |
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| 3:00–4:30 PM |
Career Roundtable |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Metabolic Rewiring in Cancer and Metabolic Approaches to Therapy |
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Ralph J. DeBerardinis, University of Texas Southwestern Medical Center
Cell-Intrinsic Metabolic Features Contributing to Cancer Initiation and Progression |
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Poul H Sorensen, University of British Columbia
Metabolic Adaptation Mechanisms that Confer Resistance to Oxidative Stress in Cancer Cells |
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Dohoon Kim, University of Massachusetts Medical School
Cancer Metabolism and Metabolic Toxicity |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
On Own for Dinner |
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Thursday, January 29, 2026
| 8:30–11:30 AM |
Cellular Plasticity and Cell State Changes in Cancer |
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Karuna Ganesh, Memorial Sloan Kettering Cancer Center
Regenerative Plasticity during Colorectal Cancer Metastasis |
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Cédric Blanpain, Universite Libre de Bruxelles
Stem Cell Function in Development, Homeostasis and Cancer |
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Laura D. Attardi, Stanford University School of Medicine
p53 Governs Cell State Changes in Lung and Pancreatic Cancers |
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Kate Yen, Auron Therapeutics
Targeting Drivers of Tumor Cell Plasticity |
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Short Talk(s) Chosen from Abstracts
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| 9:30–9:50 AM |
Coffee Break |
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| 11:00–2:30 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions |
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Short Talk(s) Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:45 PM |
Looking to the Future: Provocative New Themes in Cancer |
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Laura Wood, Johns Hopkins University School of Medicine
New Insights into Tumor Development from CODA 3D Reconstruction |
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Hoifung Poon, Microsoft Health Futures
Multimodal Generative AI for Precision Health |
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Short Talk(s) Chosen from Abstracts
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 PM |
Entertainment |
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