Reimagining Diabetes: From Molecular Mechanisms to Transformative Therapies (A3)
February 1-4, 2027
| Keystone Resort, Keystone, CO, United States
Anna Krook, Jennifer Green and David Moller
Scholarship Deadline: Oct. 7, 2026 | Abstract Deadline: Jan. 12, 2027 | Early Registration Deadline: Dec. 3, 2026
| 1:00–6:00 PM |
Registration |
Longs Peak Foyer |
| 3:00–3:10 PM |
Welcome Remarks |
Grays Peak |
| 3:10–4:00 PM |
Keynote Address |
Grays Peak |
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Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute
The Expanding Benefits of GLP-1 Medicines-is Weight Loss Always Critical |
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| 4:00–6:00 PM |
Fine Tuning our Understanding of Genetic Causes for Metabolic Disease |
Grays Peak |
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Ruth J Loos, University of Copenhagen
Identification of Genes and Genetic Loci Contributing to the Risk of Obesity and Related Traits |
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Melina Claussnitzer, Broad Institute, Harvard Medical School and Massachusetts General Hospital
Moving from Variant to Function to Tractable Therapeutic Hypotheses |
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Bart O Roep, LUMC
Genetic beta-Cell Protection Modulating Type 1 Diabetes |
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Short Talk(s) Chosen from Abstracts
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| 6:00–8:00 PM |
Welcome Reception with Heavy Apps |
Longs Peak Foyer |
Tuesday, February 2, 2027
| 7:00–8:00 AM |
Breakfast |
Longs Peak |
| 8:00–11:00 AM |
Breakthrough Opportunities for Type 1 Diabetes and Preservation of Pancreatic B-Cell Mass-Function |
Grays Peak |
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Matthias Hebrok, Technical University Munich and Helmholtz Center Munich
Advances toward Realizing the Goal of Stem Cell-Derived Islet Replacement Therapies |
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Andrew F. Stewart, Mount Sinai School of Medicine
Novel Approaches for Pancreatic Beta Cell Regeneration |
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Kevan C. Herold, Yale University
Clinical Trial Advances to Decode Beta Cell Resilience in Type 1 Diabetes: Cellular Pathways that Prevent Immune Destruction |
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Lucy S. K. Walker, University College London
T Cell Dysregulation Type 1 Diabetes |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:10–12:10 PM |
Panel Discussion 1: What are Current Issues in Trial Design Diabetes-Obesity Clinical Trials |
Grays Peak |
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* Manu Chakravarthy, Roche
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| 12:10–1:00 PM |
Poster Setup |
Longs Peak |
| 12:10–2:30 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Longs Peak |
| 2:30–4:30 PM |
Symposia Spotlight 1: Basic Aspects of Diabetes Pathophysiology |
Grays Peak |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
New Mechanisms with Clinical Results |
Grays Peak |
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David Moller, Third Rock Ventures
Overview of Emerging Clinical Trial Results - Impact and Implications |
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David Kendall, Zealand Pharma
Amylin Biology-Rationale and Clinical Results |
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Scott Harris, Altimmune Inc.
Harnessing Glucagon Agonism to Amplify Efficacy |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
Longs Peak |
| 7:30–10:00 PM |
Poster Session 1 |
Longs Peak |
Wednesday, February 3, 2027
| 7:00–8:00 AM |
Breakfast |
Longs Peak |
| 8:00–11:00 AM |
Addressing Shortcomings and Expanding Use of Incretin-Based Therapies |
Grays Peak |
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Philip Larsen, Sixpeaks Bio AG
Residual Challenges: Weight Regain, Sarcopenia, Long-Term Weight Maintenance |
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Brian Finan, Eli Lilly
Incretin based Tri Agonists |
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Lotte B Knudsen
GLP-1 and Beyond: Clinical Drug-Specific Mechanisms in Diabetes, Obesity, Cardiovascular, Kidney, Liver and Brain Diseases |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 9:20–9:25 PM |
Award Recipient Acknowledgement |
Grays Peak |
| 11:10–12:10 PM |
Meet the Editors |
Grays Peak |
| 12:10–1:00 PM |
Poster Setup |
Longs Peak |
| 12:10–2:15 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Longs Peak |
| 2:15–3:15 PM |
Career Roundtable |
Grays Peak |
| 3:30–4:30 PM |
Panel: Health Equity |
Grays Peak |
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Disease Biology and Novel Therapeutic Targets |
Grays Peak |
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Anna Krook, Karolinska Institutet
Skeletal Muscle as a Player in Pathobiology and a Therapeutic Target Organ |
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Philipp E. Scherer, University of Texas Southwestern Medical Center
Novel Adipose Biology and Targets |
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Judith A. Simcox, University of Wisconsin - Madison
Molecular and Cellular Regulation of Thermogenesis |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
Longs Peak |
| 7:30–10:00 PM |
Poster Session 2 |
Longs Peak |
Thursday, February 4, 2027
| 7:00–8:00 AM |
Breakfast |
Longs Peak |
| 8:00–11:00 AM |
New Approaches Aimed at Modulating Energy Balance |
Grays Peak |
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Randy J. Seeley, University of Michigan
Neural Pathways Regulating Food Intake and Energy Balance |
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Katrin J. Svensson, Stanford University
Novel Peptides that Regulate Feeding and Obesity |
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Eleftheria Maratos-Flier, Harvard Medical School and Alnylam
FGF21: What have we Learned from Mice and Human Trials? |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–2:30 PM |
On Own for Lunch |
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| 2:00–4:00 PM |
Symposia Spotlight 2: Novel Therapeutic Opportunities |
Grays Peak |
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Short Talks Chosen from Abstracts
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| 4:00–4:30 PM |
Coffee Available |
Longs Peak Foyer |
| 4:30–6:15 PM |
Clinical Technology Innovations & Devices |
Grays Peak |
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Jose C. Florez, Massachusetts General Hospital
Use of Big Data to Advance Precision Medicine in the Clinic |
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Emmanuel Opara, Wake Forest Institute for Regenerative Medicine
Re-Engineering the Bioartificial Pancreas |
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Aaron Kowalski, Juvenile Diabetes Research Foundation International
Technology Advances for Optimizing Care in Insulin-Requiring Patients |
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Short Talk(s) Chosen from Abstracts
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| 6:25–6:55 PM |
Panel Discussion 2: What Does the Future Hold for Strategies to Predict, Prevent, and Treat Diabetes Mellitus |
Grays Peak |
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* Jennifer Green, Duke University
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| 6:55–7:10 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Grays Peak |
| 7:10–8:10 PM |
Social Hour with Dinner |
Longs Peak |
| 8:00–9:00 PM |
Entertainment |
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