Epigenetic Mechanisms and Cancer Treatment (B1)
February 4-7, 2024
| Eldorado Hotel & Spa, Santa Fe, NM, United States
Tony Kouzarides, Rab K. Prinjha and Marisa S. Bartolomei
Scholarship Deadline: Oct. 31, 2023 | Abstract Deadline: Oct. 31, 2023 | Early Registration Deadline: Dec. 5, 2023
| 4:00–8:00 PM |
Arrival and Registration |
Concourse |
| 6:00–8:00 PM |
Welcome Mixer |
Cava Santa Fe |
| 7:00–8:00 AM |
Breakfast |
Anasazi Ballroom |
| 7:30–8:00 AM |
Poster Setup |
Anasazi Ballroom |
| 8:00–9:00 AM |
Welcome and Keynote Address |
Eldorado Ballroom |
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* Tony Kouzarides, University of Cambridge
Session Chair |
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Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School
Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Health and Disease |
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| 8:00–7:00 PM |
Poster Viewing |
Anasazi Ballroom |
| 9:00–11:15 AM |
Targeting Epigenetic Pathways in Cancer |
Eldorado Ballroom |
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* Ali Shilatifard, Northwestern University
Session Chair |
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Ali Shilatifard, Northwestern University
Principles of Epigenetics and Chromatin in Development and Human Disease |
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Mark A. Dawson, Peter MacCallum Cancer Centre
Targeting the Epigenome for Therapeutic Gain |
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Tony Kouzarides, University of Cambridge
Disruption of RNA Modification Pathways in Cancer |
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Andrew Muntean, University of Michigan
Short Talk: Short Talk: The YEATS Domain Impacts MLL-ENL Leukemic Stem Cell Frequency through Transcriptional Target Recognition |
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| 9:30–9:50 AM |
Coffee Break |
Concourse |
| 11:30–12:30 PM |
Lunch |
Anasazi Ballroom |
| 12:00–2:30 PM |
Poster Session 1 |
Anasazi Ballroom |
| 3:00–4:30 PM |
Career Roundtable |
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Kimberly Stegmaier, Dana-Farber Cancer Institute
Professor & Attending Physician |
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Musa M. Mhlanga, Radboud Institute for Molecular Life Sciences
Professor |
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Philippe Slos, Boehringer Ingelheim
Principal Scientist |
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| 4:30–5:00 PM |
Coffee Available |
Concourse |
| 5:00–7:00 PM |
Targeting Transcription in Cancer |
Eldorado Ballroom |
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* Karen Adelman, Harvard Medical School
Session Chair |
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Kristian Helin, The Institute of Cancer Research
Epigenetic Regulation of Transcription |
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Karen Adelman, Harvard Medical School
Rewiring of Transcriptional Enhancers in Cancer and in Response to Therapeutics |
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Musa M. Mhlanga, Radboud Institute for Molecular Life Sciences
Compartmentalisation and Gene Interplay in Transcription |
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Zuzana Tothova, Dana-Farber Cancer Institute
Short Talk: Short Talk: Cohesin Complex Regulates R-loop Resolution and Drives Development of Myeloid Malignancies |
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Nils Cordes, Helmholtz-Zentrum
Short Talk: Short Talk: Chromatin Architecture and Gene Expression are Critically Co-regulated by α7 Integrin in Head and Neck Cancer |
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| 7:00–8:00 PM |
On Own for Dinner |
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Tuesday, February 6, 2024
| 7:00–8:00 AM |
Breakfast |
Anasazi Ballroom |
| 8:00–11:00 AM |
Chromatin Structure and Regulation |
Eldorado Ballroom |
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* Robert E. Kingston, Massachusetts General Hospital
Session Chair |
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Robert E. Kingston, Massachusetts General Hospital
Nucleosome Compaction and Phase Transition in Repression |
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Shelley L. Berger, University of Pennsylvania
Epigenetic Enzymes and their Miss-Function in Disease |
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Anne C. Ferguson-Smith, University of Cambridge
The Genetics of Epigenetic Variation |
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Vincent van den Boom, University Medical Center Groningen
Short Talk: Short Talk: USP7 Inhibition Impacts on PRC1.1-mediated Gene Control through Increased Ubiquitination of PRC1.1 Subunits and Reduces Primary AML Cell Viability |
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Adrian P. Bracken, Trinity College Dublin
Short Talk: Short Talk: Specific cPRC1 Complexes are co-opted to Mediate Oncogenic Gene Repression in H3K27M-mutant Diffuse Midline Glioma |
|
| 9:00–9:20 AM |
Coffee Break |
Concourse |
| 11:00–1:00 PM |
Poster Setup |
Anasazi Ballroom |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Anasazi Ballroom |
| 2:30–4:30 PM |
Workshop 1 |
Eldorado A |
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* Yael David, Memorial Sloan Kettering Cancer Center
Session Chair |
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Giovanni Gambi, NYU Grossman School of Medicine
3D Chromatin Hubs as Regulatory Units of Identity and Survival in Human Acute Leukemia |
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Dorelle V Fawwal, Emory University
Characterizing the Oncogenic Impact of Novel H2B Variants |
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Akshay Sanghi, Stanford University
Chromatin Accessibility Associates with Protein-RNA Correlation in MAPK-driven Cancer |
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Zhen Sun, Memorial Sloan Kettering Cancer Center
Chromatin Regulation of Transcriptional Enhancers and Cell Fate by the Sotos Syndrome Gene NSD1 |
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Kishore R Akhouri, Dana-Farber Cancer Institute
Context-Dependent SOX9 Interactions with Components of BAF Complexes in Colon Neoplasia |
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Joanna Vuille, Cancer Center, Krantz Family Center for Cancer Research, Mass General Hospital
DNA Hypomethylation Silences Anti-tumor Immune Genes in Early Prostate Cancer and CTCs |
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Diana Chin, Case Western Reserve University
Epigenetic Drivers of Osteosarcoma Metastasis |
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| 4:30–5:00 PM |
Coffee Available |
Concourse |
| 5:00–7:15 PM |
Mechanisms of RNA and DNA Modulation in Cancer |
Eldorado Ballroom |
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* Marisa S. Bartolomei, University of Pennsylvania Perelman School of Medicine
Session Chair |
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Ramin Shiekhattar, University of Miami
RNA Processing by the Integrator-Complex and Its Role in Cancer |
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François Fuks, Université Libre de Bruxelles
Mapping and Function of RNA Modifications in Cancer |
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Marisa S. Bartolomei, University of Pennsylvania Perelman School of Medicine
DNA Methylation in Reprogramming |
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Andrea Piunti, University of Chicago
Short Talk: Short Talk: CATACOMB Prevents PRC2 Mediated Transcriptional Repression Upon DNA hypomethylation |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Anasazi Ballroom |
| 7:30–10:00 PM |
Poster Session 2 |
Anasazi Ballroom |
Wednesday, February 7, 2024
| 7:00–8:00 AM |
Breakfast |
Anasazi Ballroom |
| 8:00–11:00 AM |
Epigenetic Drug Discovery in Cancer |
Eldorado Ballroom |
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* Rab K. Prinjha, GlaxoSmithKline
Session Chair |
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Rab K. Prinjha, GlaxoSmithKline
Translating Novel Epigenetic Drugs into the Clinic |
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Helai P. Mohammad, SK Life Science Labs
Degradation of Epigenetic Machinery for the Treatment of Cancer |
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Tamara Maes, Oryzon Genomics
Identifying an Effective Team: Optimizing Combo Treatments With the LSD1 Inhibitor Iadademstat for Oncological Indications |
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Camiel Göbel, Netherlands Cancer Institute
Short Talk: Short Talk: Combined Epi-drugging as a Novel Treatment Modality for Diffuse Large B Cell Lymphoma |
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Brian C. Capell, University of Pennsylvania
Short Talk: Short Talk: Disruption of H3K36 Methylation Provokes Cellular Plasticity to Drive Aberrant Glandular Formation and Squamous Carcinogenesis |
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Adam D Durbin, St. Jude Children's Research Hospital
Short Talk: Short Talk: Group 3 Medulloblastoma Transcriptional Networks Collapse Under Domain-specific EP300/CBP Inhibition |
|
| 9:00–9:20 AM |
Coffee Break |
Concourse |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Workshop 2 |
Eldorado A |
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* Adrian P. Bracken, Trinity College Dublin
Session Chair |
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Isaac F. López-Moyado, La Jolla Institute for Immunology
Exacerbated Accumulation of R-loops Impairs the Proliferation of TET-deficient Cells |
|
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Samah W. Awwad, University of Cambridge
KLF5 Loss Sensitizes to ATR Inhibition and is Synthetic Lethal with ARID1A-Deficiency |
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Gregory Marshall, Rutgers University
Loss of KDM5C Promotes Immune Escape in Kidney Cancer |
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Darko Barisic, Weill Cornell Medicine
Mammalian SWI/SNF Chromatin Remodeling Complex Orchestrates Sequential Binding of Transcription Factors and Restricts Malignant Transformation |
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Rebecca Starble, Yale University
METTL7A Promotes Osimertinib Resistance by Regulating Chromatin Architecture and Driving Oncogene Amplification |
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Joseph Hsieh, University of Colorado Anschutz
Dependence of PAX3-FOXO1 Chromatin Occupancy on ETS1 Exposes New Targetable Vulnerability in Fusion-Positive Rhabdomyosarcoma |
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Qi Jiang, University of Pittsburgh
Synergistic Targeting of NuRD Complex and Proteostasis to Eradicate Quiescent Ovarian Cancer Cells |
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Ilaria Panzeri, Van Andel Institute
Developmental Priming of Cancer Risk |
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| 4:30–5:00 PM |
Coffee Available |
Concourse |
| 5:00–6:45 PM |
Epigenetics in Diagnosis and Treatment of Cancer |
Eldorado Ballroom |
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* Kimberly Stegmaier, Dana-Farber Cancer Institute
Session Chair |
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Kimberly Stegmaier, Dana-Farber Cancer Institute
Treatments in Pediatric Oncology |
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Yael David, Memorial Sloan Kettering Cancer Center
Short Talk: Short Talk: Thinking Outside the Chromosome: Interrogating Epigenetic Mechanisms in Non-Canonical Chromatin Species |
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Huijue Lyu, Northwestern University
Short Talk: Short Talk: GATA6 is a Novel Regulator of Gene Expression and 3D Genome in Colorectal Cancer |
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H. Courtney Hodges, Baylor College of Medicine
Short Talk: Short Talk: Reactivation of the G1 Enhancer Landscape Underlies Core Circuitry Addiction to SWI/SNF |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Eldorado Ballroom |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Anasazi Ballroom |
| 8:00–9:00 PM |
Trivia and Hosted Bar |
Eldorado Ballroom |
Thursday, February 8, 2024
