Tuberculosis: Heterogeneity from Experimental Models to Human Disease (B1)
February 16-19, 2025
| Fairmont Copley Plaza, Boston, MA, United States
JoAnne L Flynn, Bryan D. Bryson and Henry C. Mwandumba
Scholarship Deadline: Nov. 13, 2024 | Abstract Deadline: Jan. 24, 2025 | Early Registration Deadline: Dec. 20, 2024
Sunday, February 16, 2025
| 4:00–8:00 PM |
Registration |
Lobby |
| 6:00–8:00 PM |
Welcome Mixer |
Venetian Room |
Monday, February 17, 2025
| 7:00–8:00 AM |
Breakfast |
Oval/Venetian Rooms |
| 7:30–8:00 AM |
Poster Setup |
Ballroom Foyer |
| 7:45–5:00 PM |
Poster Viewing |
Ballroom Foyer |
| 8:00–9:00 AM |
Welcome and Keynote Address |
Grand Ballroom |
| |
* JoAnne L Flynn, University of Pittsburgh School of Medicine
Session Chair |
|
| |
Sarah M. Fortune, Harvard TH Chan School of Public Health
The Intersection of Bacterial and Host Heterogeneity |
|
| 9:00–11:15 AM |
The Spectrum of Tuberculosis |
Grand Ballroom |
| |
Philana Ling Lin, UPMC Children's Hospital of Pittsburgh
SIV/HIV M. tuberculosis Coinfection |
|
| |
Reinout van Crevel, Radboud University Nijmegen Medical Centre
Paradoxical TB |
|
| |
* Gerhard Walzl, Stellenbosch University
Dynamics of Human TB |
|
| |
Dylan Kain, OHSU
Short Talk: Lung Resident MR1T Cells Across the Spectrum of Mycobacterium tuberculosis Infection |
|
| 9:30–9:50 AM |
Coffee Break |
Venetian Room |
| 11:15–12:15 PM |
Lunch |
Oval/Venetian Rooms |
| 11:20–12:20 PM |
Women in Science Networking Event |
Grand Ballroom |
| |
* Sarah M. Fortune, Harvard TH Chan School of Public Health
Session Chair |
|
| |
* JoAnne L Flynn, University of Pittsburgh School of Medicine
Session Chair |
|
| |
* Denise Kirschner, University of Michigan Medical School
Session Chair |
|
| |
* Sabine Ehrt, Weill Cornell Medical College
Session Chair |
|
| |
* Anne O'Garra, Francis Crick Institute
Session Chair |
|
| 12:30–2:30 PM |
Poster Session 1 |
Ballroom Foyer |
| 2:30–4:30 PM |
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions |
Grand Ballroom |
| |
* Riti Sharan, Texas Biomedical Research Institute
Session Chair |
|
| |
Jacques Augenstreich, University of Maryland College Park
Dynamic Interplay of Autophagy and Membrane Repair During Mycobacterium tuberculosis Infection |
|
| |
Stanzin Dawa, Emory University
M. Tuberculosis Regulates Early Lung Immunometabolism to Promote Tuberculosis Pathogenesis |
|
| |
Zoltan Maliga, Harvard Medical School
Single Cell Atlas of Fibrosis in Pulmonary Tuberculosis |
|
| |
Charlie J Pyle, Duke University
An EMP2-FAK Axis Regulates Mycobacterial Granuloma Structure and Stability |
|
| |
Rachel Kinsella, Emory University School of Medicine
ATG5 Suppresses Type I Interferon-Dependent Neutrophil Swarming and NET Release |
|
| |
Caleb Nwongbouwoh Muefong, University of Chicago
Expression of Ly6G and PD-L1 Drive Neutrophil-Mediated Mtb Susceptibility |
|
| |
Christian T Michael, Michigan Medicine
- Ideal Antibiotic Regimens for Tuberculosis Treatments Depend on the Definition of Treatment Success in Virtual Pre-Clinical Trials |
|
| 4:30–5:00 PM |
Coffee Available |
Venetian Room |
| 5:00–7:00 PM |
Spatial Heterogeneity in TB |
Grand Ballroom |
| |
Jake D Estes, Oregon Health and Science University
Early Granuloma Formation |
|
| |
Shumin Tan, Tufts University School of Medicine
Spatial Relationships of Intra-lesion Heterogeneity from the Bacterial Perspective |
|
| |
Denise Kirschner, University of Michigan Medical School
Temporal and Spatial Analysis of Granulomas at Both Tissue and Whole Host Scale |
|
| |
* Maximiliano Gutierrez, Francis Crick Institute
Imaging Mtb-Host Interaction Dynamics |
|
| 7:00–8:00 PM |
On Own for Dinner |
|
Tuesday, February 18, 2025
| 7:00–8:00 AM |
Breakfast |
Oval/Venetian Rooms |
| 7:30–8:00 AM |
Poster Setup |
Ballroom Foyer |
| 7:45–5:00 PM |
Poster Viewing |
Ballroom Foyer |
| 8:00–11:00 AM |
Bacterial Heterogeneity |
Grand Ballroom |
| |
* Bryan D. Bryson, Massachusetts Institute of Technology
Antigen Recognition in TB |
|
| |
Sabine Ehrt, Weill Cornell Medical College
Intersection of Bacterial Metabolism and Drug Susceptibility |
|
| |
Bree B Aldridge, Tufts University
Single Cell Microbiology |
|
| |
Anna-Lisa Lawrence, Tufts University School of Medicine
Short Talk: Elucidating Mycobacterium tuberculosis environmental and growth adaptation in spatiotemporal context during host colonization |
|
| |
Stephen M Carpenter, Case Western Reserve University
Short Talk: TCR Clonotype Analysis and Single-Cell Transcriptomics Distinguishes Human Memory CD4+ T Cells Linked to Recognition of Macrophages Infected with Mycobacterium Tuberculosis |
|
| |
Graham R Stewart, University of Surrey
Short Talk: Epigenetic Control of Replication, Gene Expression and Growth Phase By ADP-Ribosylation of DNA in Mycobacterium Tuberculosis |
|
| |
Margarida Saraiva, i3s
Short Talk: Genetically Diverse M. Tuberculosis Clinical Isolates Modulate IL-1β Responses with an Impact on the Outcome of Infection |
|
| 9:00–9:20 AM |
Coffee Break |
Venetian Room |
| 9:20–9:25 AM |
Award Recipient Acknowledgement |
Grand Ballroom |
| 11:00–12:00 PM |
Lunch |
Oval/Venetian Rooms |
| 12:30–2:30 PM |
Poster Session 2 |
Ballroom Foyer |
| 3:00–4:30 PM |
Career Roundtable |
Grand Ballroom |
| |
Gerhard Walzl, Stellenbosch University
Professor, Group Leader |
|
| |
Sagarika Haldar, PGIMER
Associate Professor |
|
| |
Khisimuzi E Mdluli, Bill & Melinda Gates Medical Research Institute
Discovery Project Leader |
|
| |
Monica Campo, University of Minnesota
Assistant Professor |
|
| 4:30–5:00 PM |
Coffee Available |
Venetian Room |
| 5:00–7:00 PM |
Functional Immune Heterogeneity I |
Grand Ballroom |
| |
Patricia S. Grace, University of Pittsburgh
Antibody Functions in TB |
|
| |
* JoAnne L Flynn, University of Pittsburgh School of Medicine
Compartment Heterogeneity and Protection |
|
| |
Munyaradzi Nyasha Musvosvi, University of Cape Town
Antigen Discovery for Vaccines |
|
| |
Chuangqi Wang, University of Colorado, Anschutz Medical Campus
Defining Humoral Immune Signatures for TB Progression and Preventive Treatment Failure |
|
| |
Michel Vierboom, Biomedical Primate Reserach Centre
Short Talk: Failure of Reactivation after Antimicrobial Treatment Reveals a Detrimental Effect of Therapeutic Mucosal BCG Vaccination in Rhesus Macaques. |
|
| |
Solomon Jauro, University of Pittsburgh
Short Talk: Protecting Simian Immunodeficiency Virus-Infected Macaques from Mycobacterium Tuberculosis by Intravenous Bacillus Calmette-Guérin Vaccination Requires Viral Control |
|
| 7:00–8:00 PM |
On Own for Dinner |
|
Wednesday, February 19, 2025
| 7:00–8:00 AM |
Breakfast |
Oval/Venetian Rooms |
| 7:30–8:00 AM |
Poster Setup |
Ballroom Foyer |
| 7:45–5:00 PM |
Poster Viewing |
Ballroom Foyer |
| 8:00–11:00 AM |
Functional Immune Heterogeneity II |
Grand Ballroom |
| |
David G. Russell, Cornell University
Why Heterogeneity will Always Favor the Pathogen |
|
| |
* Henry C. Mwandumba, Liverpool School of Tropical Medicine
Human Lung Immunity |
|
| |
Anne O'Garra, Francis Crick Institute
Correlates and Mechanisms of M. Tuberculosis Infection Outcome |
|
| |
Molly Kanagy, Seattle Childrens Research Institute
Short Talk: CXCR2 as a Promising Target to Reshape Mtb Lesions and Reduce Neutrophil-driven Lung Pathology |
|
| |
Alex Mohapatra, UCSF Division of Experimental Medicine
Short Talk: A Novel Approach to Determine the Protective Value of ESAT-6-Specific T Cells in Tuberculosis |
|
| |
Manish Gupta, Johns Hopkins University
Short Talk: Female Protection from TB is Attributable to Superior T Cell Immunity and Maturation of B Cell Follicles |
|
| |
Monica Campo, University of Minnesota
Short Talk: Early Immune Activation of Human Alveolar Macrophages in Response to BCG |
|
| 9:00–9:20 AM |
Coffee Break |
Venetian Room |
| 12:00–1:00 PM |
Lunch |
Oval/Venetian Rooms |
| 12:30–2:30 PM |
Poster Session 3 |
Ballroom Foyer |
| 2:30–4:30 PM |
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions |
Grand Ballroom |
| |
* Chuangqi Wang, University of Colorado, Anschutz Medical Campus
Session Chair |
|
| |
Rocky Lai, University of Massachusetts Medial School
Investigating Sexual Dimorphism in TB Disease Using Collaborative Cross Mice |
|
| |
Neha Jain, Ragon Insititute/MGH
Deciphering the Role of the ER Stress Response in Early Host Response Against Mtb Infection |
|
| |
Miriam Herbert, Max Planck Institute for Infection Biology
Deciphering the Complex Role of IL-4/IL-13 Signaling in Tuberculous Granuloma Formation |
|
| |
Xin Wang, Harvard University School of Public Health
Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model |
|
| |
Saradee Warit, TB Team, IMBG, BIOTEC, NSTDA
Heterogeneity of Mycobacterium Tuberculosis Infection and Pathogenesis in Naturally Mtb-Infected Cynomolgus Macaques |
|
| |
Benjamin Koleske, Johns Hopkins University School of Medicine
Loss of the PPE71-esxX-esxY-PPE38 Locus Drives Adaptive Transcriptional Responses and Hypervirulence of Mycobacterium Tuberculosis Lineage 2 |
|
| |
Fikadu G. Tafesse, Oregon Health Sciences University, OHSU
Nanobodies as Probes to Study M. Tuberculosis Cellular Pathways and Granuloma Development |
|
| 4:30–5:00 PM |
Coffee Available |
Venetian Room |
| 5:00–6:45 PM |
Translational TB Research |
Grand Ballroom |
| |
Rada Savic, University of California, San Francisco
Shortening Treatment |
|
| |
Alexander C. Schmidt, Gates Medical Research Institute
TB Vaccine Development – Challenges and Opportunities |
|
| |
* Galit Alter, Ragon Institute of MGH, MIT, and Harvard
Correlate Inspired mRNA Vaccine Design |
|
| |
Yating Wang, Tsinghua University
Short Talk: IV-BCG Reprograms Monocytes to Induce Tissue Resident CD4 T Cells in Mice |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Grand Ballroom |
| 7:00–8:00 PM |
On Own for Dinner |
|
Thursday, February 20, 2025
