Systemic Autoimmune and Autoinflammatory Diseases (B2)
February 8-11, 2024
| Beaver Run Conference Center, Breckenridge, CO, United States
Mariana J. Kaplan, Georg Schett and Carola G. Vinuesa
Scholarship Deadline: Nov. 1, 2023 | Abstract Deadline: Nov. 21, 2023 | Early Registration Deadline: Dec. 7, 2023
Thursday, February 8, 2024
| 4:00–8:00 PM |
Arrival and Registration |
Colorado Ballroom Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Colorado Ballroom Foyer |
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–9:00 AM |
Welcome and Keynote Address |
Peaks 4 & 5 |
| |
Kate A. Fitzgerald, University of Massachusetts Medical School
Nucleic Acid Sensors and Autoimmunity Development |
|
| 9:00–11:15 AM |
Autoinflammatory Diseases |
Peaks 4 & 5 |
| |
Seth L. Masters, Walter and Eliza Hall Institute
Remote Presentation: Disruptions of Organellar Homeostasis and Autoinflammation |
|
| |
Ivona Aksentijevich, NHGRI, National Institutes of Health
Disorders of Ubiquitination and Autoinflammation |
|
| |
Peter Grayson, NIAMS, National Institutes of Health
Somatic Mutations and Autoimmunity/Autoinflammation: VEXAS Syndrome |
|
| |
David Beck, NYU
Short Talk: Short Talk: UBA1-dependent Inflammation is Mediated by Proteotoxic Stress |
|
| 9:30–9:50 AM |
Coffee Break |
Colorado Ballroom Foyer |
| 11:15–1:00 PM |
Poster Setup |
Peaks 1-3 |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Peaks 1-3 |
| 3:00–4:30 PM |
Career Roundtable |
Peaks 4 & 5 |
| |
Aimee S. Payne, University of Pennsylvania
Irving Professor and Chair of Dermatology |
|
| |
Ivona Aksentijevich, NHGRI, National Institutes of Health
Associate Investigator, Medical Genetics Branch & Head, Inflammatory Disease Section |
|
| |
Jonathan Olsen, Bristol Myers Squibb
Senior Principal Scientist |
|
| 4:30–5:00 PM |
Coffee Available |
Colorado Ballroom Foyer |
| 5:00–7:00 PM |
Innate Immune Dysregulation and Autoimmunity |
Peaks 4 & 5 |
| |
Mariana J. Kaplan, NIAMS, National Institutes of Health
Neutrophils in the Initiation and Perpetuation of Systemic Autoimmunity |
|
| |
V. Michael Holers, University of Colorado Denver
Preclinical Pathogenesis and Prevention of Rheumatoid Arthritis |
|
| |
Chrysothemis Brown, Sloan Kettering Institute
Regulation of Immune Tolerance by RORgt+ Antigen-Presenting Cells |
|
| |
Carlos Donado, Harvard Medical School / Brigham and Women's Hospital
Short Talk: Short Talk: Granzyme K Activates a New Complement Pathway |
|
| |
Marcel F. Nold, Monash University
Short Talk: Short Talk: Monomeric IL-38 is a Checkpoint Inhibitor of the Pattern Recognition Receptor-interferon Axis |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Peaks 1-3 |
| 7:30–10:00 PM |
Poster Session 1 |
Peaks 1-3 |
Saturday, February 10, 2024
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–11:00 AM |
B Cells and Autoimmunity |
Peaks 4 & 5 |
| |
Nan Shen, Renji Hospital, Shanghai JiaoTong University School of Medicine
Transcriptional Regulation of ABCs and Autoimmunity |
|
| |
Ignacio Sanz, Emory University, School of Medicine
Autoantibody Responses in Autoimmunity and COVID-19 |
|
| |
Claudia Mauri, University College London
Deciphering the Metabolic Requirements of Regulatory Versus Effector B Cells |
|
| |
Carola G. Vinuesa, Francis Crick Institute
Genetic Determinants of B Cell-Mediated Autoimmunity |
|
| |
Nida Pellett, University of Rochester
Short Talk: Short Talk: Insights Into RA Synovial Autoimmunity via Combined Single-cell Profiling of B cell Repertoire and Gene Expression |
|
| |
Amalie Grenov, Francis Crick Institute
Short Talk: Short Talk: Exploring Autoantibody Formation and Longevity |
|
| 9:00–9:20 AM |
Coffee Break |
Colorado Ballroom Foyer |
| 11:00–1:00 PM |
Poster Setup |
Peaks 1-3 |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Peaks 1-3 |
| 2:30–4:30 PM |
Workshop |
Peaks 4 & 5 |
| |
Mariasilvia Colantuoni, Boston Children's Hospital
Immune-Mediated IL-1RA Gene Therapy: A Breakthrough Treatment For A Spectrum Of Inflammatory Diseases |
|
| |
Jessica A. Hamerman, Benaroya Research Institute
Lupus IgA1 Autoantibodies Synergize with IgG to Enhance pDC Responses to RNA-Containing Immune Complexes |
|
| |
Danni Zhu, Harvard Medical School
Lupus-Associated Innate Receptors Drive Extrafollicular Evolution of Autoreactive B Cells |
|
| |
Evaristus Mbanefo, NIH/NEI
Interleukin-35-Producing Regulatory B-Cells Secrete IL-35-Containing Exosomes and Suppress Autoinflammation and GVHD by Upregulating Inhibitory Receptors |
|
| |
Jun Inamo, University of Colorado
Deciphering Pathogenic Phenotypes by Deep Single-Cell Blood Immunophenotyping in Individuals At-Risk for Rheumatoid Arthritis |
|
| |
Eduardo Patino Martinez, NIH
Aconitate Decarboxylase 1 Modulates Murine Lupus and Associates with Markers of Cardiometabolic Function in Systemic Lupus Erythematosus |
|
| |
Atika Dhar, NIH
Blau Syndrome NOD2 Mutations Result in Loss of NOD2 Cross-Regulatory Function |
|
| |
Anna Helena Jonsson, University of Colorado
Cell-Type Abundance Phenotypes (CTAPs) Classify Rheumatoid Arthritis Synovial Tissue into Clinically Relevant Inflammatory Subtypes |
|
| 4:30–5:00 PM |
Coffee Available |
Colorado Ballroom Foyer |
| 5:00–7:00 PM |
Infections and Autoimmunity |
Peaks 4 & 5 |
| |
Jose Scher, NYU Langone Health
The Microbiome in Chronic Inflammatory Arthritides |
|
| |
William H. Robinson, Stanford University School of Medicine
EBV and Systemic Autoimmunity |
|
| |
Maureen McGargill, St Jude Children's Research Hospital
The Intersection of Viral Immunity and Autoimmunity |
|
| |
Stefan Uderhardt, University of Erlangen
Short Talk: Short Talk: Tissue Homeostats Determine Inflammation Thresholds In Vivo Through Dynamic Network Communication |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Peaks 1-3 |
| 7:30–10:00 PM |
Poster Session 2 |
Peaks 1-3 |
Sunday, February 11, 2024
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–11:00 AM |
T Cells and Systemic Autoimmunity |
Peaks 4 & 5 |
| |
Avery August, Cornell University
Tec Kinases and Autoimmunity |
|
| |
Cornelia M. Weyand, Stanford University
T Cell Senescence and Autoimmunity |
|
| |
Diane Mathis, Harvard Medical School
Thymic Mimetics and Systemic Autoimmunity |
|
| |
Hussein Al-Mossawi, Immunocore
Soluble-TCR Therapies in Autoimmunity and Cancer |
|
| |
Kenji Ichiyama, Osaka University
Short Talk: Short Talk: Ikzf1 Association With Foxp3 for Foxp3-Dependent Gene Repression in Treg Cells: Induction of Autoimmunity by Disrupting the Association |
|
| |
Catherine Lu, New York University
Short Talk: Short Talk: Immune-Mesenchymal TNFa-CXCL13 Feedback Initiates the Formation of the Tertiary Lymphoid Structures in Human Skin Autoimmune Pathogenesis |
|
| 9:00–9:20 AM |
Coffee Break |
Colorado Ballroom Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 4:30–5:00 PM |
Coffee Available |
Colorado Ballroom Foyer |
| 5:00–6:45 PM |
Novel Therapies in Autoimmunity and Autoinflammation |
Peaks 4 & 5 |
| |
Frank Oliver Nestle, Sanofi
Novel Therapeutics Approaches for Chronic Inflammatory Disease |
|
| |
Georg Schett, Universitätsklinikum Erlangen
CART Cells and the Treatment of Systemic Autoimmunity |
|
| |
Aimee S. Payne, University of Pennsylvania
Chimeric Autoantibody Receptor T Cells: A Precision Cellular Immunotherapy for Antigen-Specific B Cell Depletion |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Peaks 4 & 5 |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Peaks 1-3 |
| 8:00–9:00 PM |
Cash Bar |
Peaks 1-3 |
Monday, February 12, 2024
