Cardiometabolism and Interorgan Crosstalk: Novel Mechanisms and Therapies (B2)
February 15-19, 2027  | Beaver Run Conference Center, Breckenridge, CO, United States
Saptarsi M. Haldar, Karol E. Watson and David A Kass
* Session Chair † Invited but not yet accepted | Program current as of October 8, 2025 6 PM | For the most up-to-date details, visit https://www.keystonesymposia.org
Saturday, January 6, 2007
Friday, January 1, 2027
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Saturday, January 2, 2027
4:00–5:00 PM Welcome and Keynote Address
  Daniel J. Drucker †, Lunenfeld-Tanenbaum Research Institute
Mechanisms of Incretin Therapy and their CV and Neurological Benefits
 
5:00–7:00 PM Nervous System Crosstalk in Cardiometabolic Disease
  Randy J. Seeley †, University of Michigan
The Central Nervous System in Cardiometabolic Disease Pathogenesis and Therapy
 
  Daniela Carnevale †, University La Sapienza in Rome
Heart-Brain-Splenic Axis and Control of Heart Failure and Hypertension
 
  Filip K. Swirski †, Icahn School of Medicine at Mount Sinai
Novel Immune/Neural Mechanisms in Cardiometabolic Disease
 
  Short Talk(s) Chosen from Abstracts
 
Sunday, January 3, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Skeletal Muscle, Renal, and Vascular Crosstalk and CV Disease
  Zoltan Arany †, University of Pennsylvania
Rerouting Metabolic Fuel Flux Utilization across Organs in Cardiometabolic Disease
 
  Flora Sam †, Eli Lilly
Skeletal Muscle Myokines and HFpEF
 
  Kristin I. Stanford †, Ohio State University
Exercise, Adipose & Metabolic Crosstalk
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–12:00 PM Panel Discussion: AI Tools in Cardiometabolic Research
12:00–1:00 PM Poster Setup
12:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
2:30–4:30 PM Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
  Short Talks Chosen from Abstracts
 
3:00–4:30 PM Career Roundtable
4:30–5:00 PM Coffee Available
5:00–7:00 PM Immune System Crosstalk in Cardiovascular and Metabolic Disease
  Kory J. Lavine †, Washington University School of Medicine
Single Cell Epigenomics to Reveal Cellular Crosstalk in CV Disease
 
  Diane Mathis †, Harvard Medical School
Immune Modulation of Skeletal Muscle Function and Exercise Adaptation
 
  Pradeep Natarajan †, Massachusetts General Hospital
Clonal Hematopoiesis in CVD
 
  Han Zhu †, Stanford University
T Lymphocyte Subsets in Cardiovascular Homeostasis and Response to Cancer Immunotherapy
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Monday, January 4, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Emerging Cardiometabolic Therapeutics
  William A. Chutkow †, Novartis Institute for Biomedical Research
Targeting Lean Muscle Mass in Cardiovascular and Metabolic Disease
 
  Ambarish Pandey †, UT Southwestern Medical Center
Who Responds Best to GLP-1R Agonists? -- an AI based Approach
 
  Speaker to be Announced
Novel Nucleic Acid-based Therapeutic Platforms in Cardiovascular and Metabolic Disease
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–5:00 PM On Own for Lunch
4:30–5:00 PM Coffee Available
5:00–6:45 PM Target Discovery and Patient Segmentation in Cardiometabolic Disease: AI and Human Genetics
  Luca Lotta †, Regeneron Pharmaceuticals Inc.
Human Genetics at the Intersection of Metabolism and CV Risk
 
  Rajat Gupta †, Massachusetts General Hospital
Functional Genomics and Perturbational Screening for Cardiometabolic Target Discovery
 
  Anna Helgadottir †, Decode genetics
Metabolic Drivers of CVD and Implications for Clinical Trial Enrichment
 
  Rohan Khera †, Yale University
AI-based Approaches for Precision Care and CV Outcomes Research
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
Tuesday, January 5, 2027
7:00–8:00 PM Breakfast
8:00–11:00 PM Adiposity, Diabetes and Clinical CV Disease
  David A. Kass, Johns Hopkins Hospital
Obesity + HFpEF = Bad Sarcomeres
 
  Karol E. Watson, University of California, Los Angeles
Novel Insights from the DPPOS Cohort
 
  Saptarsi M. Haldar, Amgen Inc.
Novel Approaches to Treating Obesity and Adiposity-Related Diseases
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 PM Coffee Break
11:00–5:00 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:30–6:45 PM Novel Mechanisms of Liver, Adipose and Cardiovascular Crosstalk
  Isha Jain †, Arc Institute and Gladstone/UCSF
Hypoxic Signaling and Interorgan Crosstalk in Physiology & Disease
 
  E. Dale Abel †, David Geffen School of Medicine and UCLA Health
Insulin Signaling, Mitochondria and Metabolic Heart Disease
 
  Katrin J. Svensson †, Stanford University
Novel Peptides as Obesity Therapeutic Targets
 
  Gabriele G Schiattarella †, Charité University Medical Center
Cardiometabolic-Hepatic Crosstalk
 
  Short Talk(s) Chosen from Abstracts
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
8:00–11:00 PM Cash Bar
8:00–11:00 PM Entertainment
12:00–11:59 PM Departure