Tumor Metabolism (B3)
February 12-15, 2024  | Fairmont Banff Springs, Banff, AB, Canada
Gina DeNicola, Rushika M. Perera and David B. Shackelford
Scholarship Deadline: Nov. 7, 2023 | Abstract Deadline: Nov. 7, 2023 | Early Registration Deadline: Dec. 12, 2023
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 4 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Monday, February 12, 2024
4:00–8:00 PM Arrival and Registration Van Horne Foyer
6:00–8:00 PM Welcome Mixer Van Horne Foyer
Tuesday, February 13, 2024
7:00–8:00 AM Breakfast Mezzanine 2
8:00–9:00 AM Welcome and Keynote Address Van Horne A
  * Gina DeNicola, Moffitt Cancer Center
Session Chair		  
  Jared Rutter, University of Utah
Mitochondrial Bioenergetics		  
9:00–11:15 AM Organelles Van Horne A
  * Gina DeNicola, Moffitt Cancer Center
Session Chair		  
  Rushika M. Perera, University of California, San Francisco
Lysosome Mediated Regulation of Metabolism		  
  Gerta Hoxhaj, UT Southwestern Medical Center
Regulation and Function of NADPH Metabolism		  
  Wilhelm Palm, German Cancer Reserach Center
Metabolic Stress Adaptations in Cancer		  
  Aakriti Jain, UC Berkeley
Short Talk: Short Talk: Identifying and Targeting Novel Lysosomal Enzymes in Pancreatic Cancer		  
9:30–9:50 AM Coffee Break Van Horne Foyer
11:15–1:00 PM Poster Setup Mezzanine 2
11:15–5:00 PM On Own for Lunch
1:00–2:00 PM Career Roundtable (Joint) Van Horne C
  Leon O. Murphy, Casma Therapeutics
Senior Vice President Biology		  
  Ana J. García-Sáez, University of Cologne
Professor and Director of the Max Planck Institute of Biophysics		  
  Tamas Balla, NICHD, National Institutes of Health
Senior Investigator		  
  Dustin Hancks, University of Texas Southwestern Medical Center
Assistant Professor		  
1:00–10:00 PM Poster Viewing Mezzanine 2
2:30–4:30 PM Workshop 1: Mitochondrial Regulation and Organelle Communication Van Horne A
  * Rushika M. Perera, University of California, San Francisco
Session Chair		  
  Srimayee Vaidyanathan, Peter MacCallum Cancer Centre
Cholesterol-dependent Remodeling of the Endoplasmic Reticulum Regulates CAF Function		  
  Eduardo Cararo Lopes, Rutgers Cancer Institute of New Jersey
Tumor Respiration Defects Limit Serine Synthesis Required To Suppress Oxidative Stress		  
  Celia de la Calle Arregui, University of Texas Southwestern medical center
Understanding the Role of mtDNA Alterations and Electron Transport Chain Function in Thyroid Cancer		  
  Emily N. Arner, Vanderbilt University Medical Center
NDUFA4L2 Drives Metastasis in RCC by Inhibiting Oxidative Phosphorylation to Facilitate EMT		  
  Lucia Minarrieta, University of Ottawa
Loss of Mitochondrial Fission Impairs Breast Cancer Metastasis		  
  Karina Geurtzen, KU Leuven
Breast Cancer Cells Rely on Mitochondrial Respiration to Form Bone Metastases		  
  Gilles Rademaker, UCSF
Differential Acquisition of Extracellular Lipid Correlates with Pancreatic Cancer Subtype and Metastatic Tropism		  
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–7:00 PM Stress Van Horne A
  * Daniel A. Tennant, University of Birmingham
Session Chair		  
  Elda Grabocka, Thomas Jefferson University
Stress Granules at the Crossroads of Cellular Stress and Pancreatic Cancer		  
  Gina DeNicola, Moffitt Cancer Center
Cellular Adaptation to Cysteine Starvation		  
  Russell G. Jones, Van Andel Research Institute
The Prostacyclin Receptor is an Nrf2-regulated Immune Checkpoint for CD8 T Cell Function		  
  Dohoon Kim, University of Massachusetts Medical School
Short Talk: Short Talk: Uncovering and Exploiting Toxic Metabolite Pathways in Cancer Cells		  
  Kenji Fujihara, New York University School of Medicine
Short Talk: Short Talk: Linking Cystine Deprivation to Selenium Insufficiency: A Novel Explanation for Cystine Deprivation-induced Ferroptosis		  
7:00–8:00 PM Social Hour with Lite Bites Mezzanine 2
7:30–10:00 PM Poster Session 1 Mezzanine 2
Wednesday, February 14, 2024
7:00–8:00 AM Breakfast Mezzanine 2
8:00–11:00 AM Metabolic/Bioenergetic Heterogeneity Van Horne A
  * Christopher J. Halbrook, University of California, Irvine
Session Chair		  
  Shawn M. Davidson, Northwestern
Spatiotemporal Analysis of Metabolism		  
  David B. Shackelford, University of California, Los Angeles
Three Dimesional Imaging of Cancer Mitochondria		  
  Mariia Yuneva, Francis Crick Institute
Dissecting Metabolic Tumour Heterogeneity in vivo		  
  David F. Kashatus, University of Virginia
Control of Tumor Cell Metabolism by Mitochondrial Dynamics		  
  Thomas P Mathews, UT Southwestern Medical Center
Short Talk: Short Talk: Comprehensive Isotope Tracing of Fatty Acids in vivo Reveals Differences Between Primary Tumors and Metastatic Sites		  
  Deepak Nagrath, University of Michigan
Short Talk: Short Talk: Machine Learning-based Method to Analyze Metabolic Fluxes of Patient Tumors		  
9:00–9:20 AM Coffee Break Van Horne Foyer
11:00–1:00 PM Poster Setup Mezzanine 2
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Mezzanine 2
2:30–4:30 PM Workshop 2: Metabolic Targets and Vulnerabilities Van Horne A
  * David B. Shackelford, University of California, Los Angeles
Session Chair		  
  Aki Ogawa-Iio, University of Cincinnati
Fueling the Way—The Role of Localized GTP Synthesis in Renal Cell Carcinoma Metastasis		  
  Megan Radyk, University of Michigan
Loss of NADPH-producing Enzymes Accelerates Precancerous Lesions in the Pancreas		  
  Rebekah Crake, University of Liege
Identifying Targetable Metabolic Adaptations in Drug Tolerant BRAFV600E Mutant Non-small Cell Lung Cancer		  
  Remya Nair, Emory University
Heme Increases Purine Metabolism in Multiple Myeloma to Promote Resistance to Apoptosis		  
  Amanda M Sherwood, Moffitt Cancer Center
Investigating the Roles of GSH and TXN Antioxidant Systems in NSCLC Tumor Progression		  
  Krystle Kalafut, Harvard University
The Oncoprotein Grb7 is a Novel Physiological Target of mTORC1: Implications for Breast Cancer and Hepatic Insulin Resistance		  
  Sheila K Singh, Centre for Discovery in Cancer Research, McMaster University
A Phenotypic Drug Discovery Screen Reveals de novo GTP Synthesis as a Targetable Metabolic Vulnerability in Brain Metastases		  
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–7:00 PM Targeting Metabolism Van Horne A
  * Raul Mostoslavsky, Mass General Hospital- Harvard Medical School
Session Chair		  
  Sarah-Maria Fendt, VIB-KU Leuven
Metabolic Vulnerabilities of Metastasis		  
  Leon O. Murphy, Casma Therapeutics
Targeting Autophagy		  
  Isaac Spencer Harris, University of Rochester
Understanding the Roles of Antioxidants in Cancer		  
  Heather Christofk, University of California, Los Angeles
Metabolic Targeting for Rare Cancers		  
7:00–8:00 PM Social Hour with Lite Bites Mezzanine 2
7:30–10:00 PM Poster Session 2 Mezzanine 2
Thursday, February 15, 2024
7:00–8:00 AM Breakfast Mezzanine 2
8:00–11:00 AM Nutrient Acquisition and Utilization Van Horne A
  * Roberto Zoncu, University of California, Berkeley
Session Chair		  
  Kathryn E. Wellen, University of Pennsylvania
Branched chain amino acid metabolism and pancreatic tumorigenesis		  
  Cosimo Commisso, Sanford Burnham Prebys Medical Discovery Institute
Metabolic Adaptations to Glutamine Mimetics: From Discovery to Therapeutics		  
  Donita C. Brady, University of Pennsylvania
Harnessing Chemical Interactions to Explore Tumor Cell Biological Responses to Fluctuations in Metal and Micronutrient Availability		  
  Jason R. Cantor, Morgridge Institute for Research, University of Wisconsin-Madison
Short Talk: Short Talk: Conditional Lethality Profiling in Human Cancer Cells		  
  Hao Fan, The University of Chicago
Short Talk: Short Talk: Trans-vaccenic Acid Reprograms CD8+ T Cells and Anti-tumour Immunity		  
  Kamiya Mehla, University of Oklahoma Health Science Center
Short Talk: Short Talk: Nutrient Constrain-induced Metabolic Rewiring Impacts NK Cell Function in Pancreatic Cancer		  
  Inna Smalley, H. Lee Moffitt Cancer Center & Research Institute, Inc.
Short Talk: Short Talk: Branched-chain Keto Acids Promote an Immune-suppressive and Neurodegenerative Microenvironment in Leptomeningeal Disease		  
9:00–9:20 AM Coffee Break Van Horne Foyer
11:00–1:00 PM Poster Setup Mezzanine 2
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Mezzanine 2
2:30–4:30 PM Workshop 3: Nutrient Requirements and Toxicities Van Horne A
  * Yanxiang (Jessie) Guo, Rutgers University
Session Chair		  
  Yetis Gultekin, MIT
Altered Exocrine Function Promotes Pancreatic Cancer-associated Autophagic Proteolysis in the Muscle		  
  Chesta Jain, University of Michigan
Assessing the Mechanism of Iron Mediated Cell Toxicity in Colon Cancer		  
  Tashbib Khan, BIDMC - Harvard Medical School
The Oncogenic Roles of Glycogen in PI3K/AKT/mTOR Signaling		  
  Pankaj Singh, OUHSC
Selective Dependence on Stromal Acetate-induced Polyamine Metabolism Provides Unique Therapeutic Opportunities in Pancreatic Cancer		  
  Hila Tishler, Weizmann Institute of Science
Modulating JAK-STAT Signaling in the Tumor Microenvironment by Regulating Arginine Cross-Talks		  
  Alex C. Sternisha, UT Southwestern Medical Center
A Forward Genetic Approach Reveals Mechanisms of Alpha-Ketoglutarate Regulation in the Nucleus		  
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–6:45 PM Tumor-Host Interactions Van Horne A
  * Kristin K Brown, Peter MacCallum Cancer Centre
Session Chair		  
  Ana P. Gomes, Lee Moffitt Cancer Center & Research Institute
Metabolic Reprogramming: A Bridge Between Aging and Cancer		  
  Ralph J. DeBerardinis, University of Texas Southwestern Medical Center
Metabolism in situ		  
  Peter James Mullen, University of Southern California
A Metabolic Atlas of Aging		  
  Asael Roichman, Princeton University
Short Talk: Short Talk: The Gut Microbiome Regulates the Anti-cancer Activity of PI3K Inhibitors		  
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Van Horne A
7:00–8:00 PM Social Hour with Lite Bites Mezzanine 2
7:30–10:00 PM Poster Session 3 Mezzanine 2
Friday, February 16, 2024
7:00–11:59 PM Departure