Drug Delivery to the Brain (B3)
February 15-18, 2027
| Rimrock Banff, Emblems Collection, Banff, AB, Canada
Joy Yu Zuchero and Peter Tessier
Monday, February 15, 2027
| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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Tuesday, February 16, 2027
| 8:00–9:00 AM |
Welcome and Keynote Address |
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| 9:00–11:15 AM |
Mechanisms of BBB Delivery |
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Roberto Villaseñor, Roche Innovation Center Basel
in vitro Shuttle Trafficking |
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Martin Lauritzen, University of Copenhagen
in vivo Trafficking using Live Imaging |
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Joy Yu Zuchero, Denali Therapeutics Inc
TfR and CD98hc-Mediated vs. Traditional IgG Delivery |
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Short Talk(s) Chosen from Abstracts
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| 9:30–9:50 AM |
Coffee Break |
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| 11:15–1:00 PM |
Poster Setup |
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| 11:15–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 2:30–4:30 PM |
Symposia Spotlight 1: Emerging Principles of CNS Delivery Platform Engineering |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Engineering for Additional Properties of BBB Platforms |
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Peter Tessier, University of Michigan
Next-Generation Shuttles for Improved CNS Delivery |
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Jasi Atwal, Genentech, Inc.
Leveraging FcRn to Enhance Antibody Transport Across the BBB |
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Viviana Gradinaru, California Institute of Technology
Engineering AAVs |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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Wednesday, February 17, 2027
| 8:00–11:00 AM |
Additional Modes of Delivery |
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Isabelle Aubert, University of Toronto
Focused Ultrasound Drug Delivery for Alzheimer's Disease |
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Haiyan Peng †, Alnylam Pharmaceuticals
Intrathecal ASO Delivery |
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Benjamin E. Deverman, Broad Institute of MIT and Harvard
AAV Delivery, New RMT Target |
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Yizhou Dong, Icahn School of Medicine at Mount Sinai
mRNA/LNP Delivery to CNS/gamma Secretase Targeted BBB Crossing, Delivery of ASOs |
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Short Talk(s) Chosen from Abstracts
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|
| 9:00–9:20 AM |
Coffee Break |
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| 11:00–1:00 PM |
Poster Setup |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 3:00–4:30 PM |
Career Roundtable |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
New RMT Target Biology and Novel Target Screening Strategies |
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Karen Duffy, Manifold Bio
Discovering Brain Shuttles and Targets through Multiplexed In Vivo Screening |
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Sang Hoon Lee, ABL Bio
Igf1R Binding GrabodyB Platform for Brain Delivery |
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Sophia M. Shi, Harvard University
BBB Glycocalyx in Drug Delivery |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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Thursday, February 18, 2027
| 8:00–11:00 AM |
Therapeutics Enabled by BBB Platforms using Preclinical Models |
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Per-Ola Freskgard †, BioArctic AB
Antibody Delivery |
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David Ojala †, Sangamo Therapeutics, Inc.
AAV Delivery of Zinc Finger Repressor for PrP |
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Nina Leksa, Sanofi
Learning the Rules of Engagement for Brain Delivery across Different Shuttles and Payload Modalities |
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Katherine Cygnar, Regeneron Pharmaceuticals
In vivo Biofactories allow Multiple Routes to Reach the Brain for Lysosomal Diseases |
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Short Talk(s) Chosen from Abstracts
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|
| 9:00–9:20 AM |
Coffee Break |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Symposia Spotlight 2: Emerging Modalities and Future Opportunities in Targeted Brain Delivery |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:45 PM |
Preclinical to Clinical Translation |
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Jens Niewoehner, Roche Pharma Research and Early Development
Optimizing Oligonucleotide Delivery to the Brain |
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Peter Chin †, Denali Therapeutics
Talk Title to be Announced |
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Stacie Weninger, F Prime Capital
Progress in CNS Therapeutic Development: Perspectives from a Neuroscientist and Investor |
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Short Talk(s) Chosen from Abstracts
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 PM |
Entertainment |
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Friday, February 19, 2027
