Drug Delivery to the Brain (B3)
February 15-18, 2027
| Rimrock Banff, Emblems Collection, Banff, AB, Canada
Joy Yu Zuchero and Peter Tessier
Scholarship Deadline: Oct. 21, 2026 | Abstract Deadline: Jan. 23, 2027 | Early Registration Deadline: Dec. 16, 2026
Monday, February 15, 2027
| 4:00–8:00 PM |
Registration |
Solstice Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Solstice Foyer |
Tuesday, February 16, 2027
| 7:00–8:00 AM |
Breakfast |
Solstice Salon B/C |
| 8:00–8:10 AM |
Welcome Remarks |
Solstice Salon A |
| 8:10–9:00 AM |
Keynote Address |
Solstice Salon A |
| |
Stacie Weninger, F Prime Capital
Progress in CNS Therapeutic Development: Perspectives from a Neuroscientist and Investor |
|
| 9:00–11:15 AM |
Mechanisms of BBB Delivery |
Solstice Salon A |
| |
Roberto Villaseñor, Roche Innovation Center Basel
In Vitro Shuttle Trafficking |
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Martin Lauritzen, University of Copenhagen
In Vivo Trafficking using Live Imaging |
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Joy Yu Zuchero, Denali Therapeutics Inc
TfR and CD98hc-Mediated vs. Traditional IgG Delivery |
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Short Talk(s) Chosen from Abstracts
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|
| 9:30–9:50 AM |
Coffee Break |
Solstice Foyer |
| 11:15–1:00 PM |
Poster Setup |
Solstice Salon C |
| 11:15–2:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Solstice Salon C |
| 2:30–4:30 PM |
Symposia Spotlight 1: Emerging Principles of CNS Delivery Platform Engineering |
Solstice Salon A |
| |
Short Talks Chosen from Abstracts
|
|
| 4:30–5:00 PM |
Coffee Available |
Solstice Foyer |
| 5:00–7:00 PM |
Engineering for Additional Properties of BBB Platforms |
Solstice Salon A |
| |
Peter Tessier, University of Michigan
Next-Generation Shuttles for Improved CNS Delivery |
|
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Jasi Atwal, Genentech, Inc.
Leveraging FcRn to Enhance Antibody Transport Across the BBB |
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Viviana Gradinaru, California Institute of Technology
Engineering AAVs |
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Matthew Tiffany, Sangamo Therapeutics
Engineering BBB-Penetrant AAV Capsids for Brain-Wide Epigenetic Regulation in Neurological Disorders |
|
| 7:00–8:00 PM |
Social Hour with Dinner |
Solstice Salon B/C |
| 7:30–10:00 PM |
Poster Session 1 |
Solstice Salon C |
Wednesday, February 17, 2027
| 7:00–8:00 AM |
Breakfast |
Solstice Salon B/C |
| 8:00–11:00 AM |
Additional Modes of Delivery |
Solstice Salon A |
| |
Isabelle Aubert, University of Toronto
Focused Ultrasound Drug Delivery for Alzheimer's Disease |
|
| |
Eric E. Swayze, Ionis Pharmaceuticals, Inc.
Delivery with Bicycles and Camelids - Targeted Delivery of Oligonucleotide Drugs to the Central Nervous System via the Transferrin Receptor |
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Benjamin E. Deverman, Broad Institute of MIT and Harvard
AAV Delivery, New RMT Target |
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| |
Yizhou Dong, Icahn School of Medicine at Mount Sinai
mRNA/LNP Delivery to CNS/gamma Secretase Targeted BBB Crossing, Delivery of ASOs |
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| |
Short Talk(s) Chosen from Abstracts
|
|
| 9:00–9:20 AM |
Coffee Break |
Solstice Foyer |
| 11:00–1:00 PM |
Poster Setup |
Solstice Salon C |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Solstice Salon C |
| 3:00–4:30 PM |
Career Roundtable |
Solstice Salon A |
| 4:30–5:00 PM |
Coffee Available |
Solstice Foyer |
| 5:00–7:00 PM |
Novel and Emerging BBB Targets |
Solstice Salon A |
| |
Karen Duffy, Manifold Bio
Discovering Brain Shuttles and Targets through Multiplexed In Vivo Screening |
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Sang Hoon Lee, ABL Bio
Igf1R Binding GrabodyB Platform for Brain Delivery |
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Sophia M. Shi, Harvard University
BBB Glycocalyx in Drug Delivery |
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Short Talk(s) Chosen from Abstracts
|
|
| 7:00–8:00 PM |
Social Hour with Dinner |
Solstice Salon B/C |
| 7:30–10:00 PM |
Poster Session 2 |
Solstice Salon C |
Thursday, February 18, 2027
| 7:00–8:00 AM |
Breakfast |
Solstice Salon B/C |
| 8:00–11:00 AM |
Therapeutic Applications Enabled by BBB Platforms |
Solstice Salon A |
| |
Per-Ola Freskgard, BioArctic AB
BrainTransporter to Facilitate Brain Delivery of Drug Modalities |
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Nina Leksa, Sanofi
Learning the Rules of Engagement for Brain Delivery across Different Shuttles and Payload Modalities |
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Katherine Cygnar, Regeneron Pharmaceuticals
In vivo Biofactories allow Multiple Routes to Reach the Brain for Lysosomal Diseases |
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| |
Short Talk(s) Chosen from Abstracts
|
|
| 9:00–9:20 AM |
Coffee Break |
Solstice Foyer |
| 11:00–2:30 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Symposia Spotlight 2: Emerging Modalities and Future Opportunities in Targeted Brain Delivery |
Solstice Salon A |
| |
Short Talks Chosen from Abstracts
|
|
| 4:30–5:00 PM |
Coffee Available |
Solstice Foyer |
| 5:00–6:45 PM |
Preclinical to Clinical Translation |
Solstice Salon A |
| |
Stuart Cobb, University of Edinburgh
Talk Title to be Announced |
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Jens Niewoehner, Roche Pharma Research and Early Development
Optimizing Oligonucleotide Delivery to the Brain |
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Peter Chin, Denali Therapeutics
Clinical Validation of TfR-mediated Brain Delivery: Lessons from Tividenofusp alfa and Beyond |
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Short Talk(s) Chosen from Abstracts
|
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions |
Solstice Salon A |
| 7:00–8:00 PM |
Social Hour with Dinner |
Solstice Salon B/C |
| 8:00–11:00 PM |
Entertainment |
|
Friday, February 19, 2027
