Hematopoiesis (B4)
February 25-28, 2024
| Keystone Resort, Keystone, CO, United States
Trista E. North, Michael G. Kharas and Nina Cabezas-Wallscheid
Scholarship Deadline: Nov. 29, 2023 | Abstract Deadline: Nov. 29, 2023 | Early Registration Deadline: Dec. 19, 2023
Sunday, February 25, 2024
| 4:00–8:00 PM |
Arrival and Registration |
Longs Peak Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Longs Peak Foyer |
Monday, February 26, 2024
| 7:00–8:00 AM |
Breakfast |
Longs Peak |
| 8:00–9:00 AM |
Welcome and Keynote Address |
Grays Peak |
| |
* Trista E. North, Boston Children’s Hospital
Session Chair |
|
| |
* Nina Cabezas-Wallscheid, Max Planck Institute of Immunobiology and Epigenetics
Session Chair |
|
| |
* Michael G. Kharas, Memorial Sloan Kettering Cancer Center
Session Chair |
|
| |
Hanna K.A. Mikkola, University of California, Los Angeles
Dissecting Human Hematopoietic Stem Cell Specification and Self-Renewal at Single Cell Level |
|
| 9:00–11:15 AM |
Developmental Hematopoiesis |
Grays Peak |
| |
* Trista E. North, Boston Children’s Hospital
Session Chair |
|
| |
* Andrew G Elefanty, Murdoch Children's Research Institute
Session Chair |
|
| |
Elisa Laurenti, University of Cambridge
Remote Presentation: Why do Human Haematopoietic Stem Cells Lose Function Ex Vivo? |
|
| |
Trista E. North, Boston Children’s Hospital
Extrinsic Regulation of Hematopoietic Stem Cell Specification in the Vertebrate Embryo |
|
| |
Anna E. Beaudin, University of Utah School of Medicine
Metabolic Regulation of Hematopoietic Development and Function |
|
| |
Mo Ebrahimkhani, University of Pittsburgh School of Medicine
Short Talk: Short Talk: Modelling Human Post-Implantation Embryogenesis to Multilineage Yolk Sac Haematopoiesis Ex-Utero |
|
| 9:30–9:50 AM |
Coffee Break |
Longs Peak Foyer |
| 11:15–1:00 PM |
Poster Setup |
Longs Peak |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Longs Peak |
| 2:30–4:30 PM |
Workshop 1: Biological Basis of Blood Development and Disease |
Grays Peak |
| |
* Hanzhi Luo, Memorial Sloan Kettering Cancer center
Session Chair |
|
| |
* Simona Colla, University of Texas MD Anderson Cancer Center
Session Chair |
|
| |
Alissa J Trzeciak, Memorial Sloan Kettering Cancer Center
Macropinocytosis Enforces Macrophage Lineage Fidelity |
|
| |
Ondrej Svoboda, Institute of Molecular Genetics
Origins of Primitive Erythropoiesis in Zebrafish |
|
| |
Franco Izzo, Weill Cornell Medicine
Mapping Genotypes to Chromatin Accessibility Profiles In Single Cells |
|
| |
Nicole Woodhead, UW-Madison
Loss of integrin α4 Function During Development Leads to Premature Aging of Hematopoietic Stem and Progenitor Cells in Adulthood |
|
| |
Aaron D. Viny, Columbia University Irving Medical Center
Cohesin Mutations Prevent HSC Chromatin Silencing of Fli1 Targets to Exit Stemness |
|
| |
Stephanie Z Xie, University Health Network
CD83 Marks an Effector State of Human Inflammatory Memory Hematopoietic Stem Cells |
|
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Hematopoietic Stem Cell Biology |
Grays Peak |
| |
* Keisuke Ito, Albert Einstein College of Medicine
Session Chair |
|
| |
* Vanessa M Scanlon, UConn Health
Session Chair |
|
| |
Nina Cabezas-Wallscheid, Max Planck Institute of Immunobiology and Epigenetics
Epigenetic and Metabolic Regulation of Hematopoietic Stem Cell Dormancy |
|
| |
Toshio Suda, Cancer Science Institute of Singapore
Metabolic Control of Hematopoietic Stem Cell Regeneration and Lineage Potential |
|
| |
Eirini D. Trompouki, IRCAN-Institute for research on Cancer and Aging
Institute for Research on Cancer and Aging |
|
| |
Ashley N. Kamimae-Lanning, MRC Weatherall Institute of Molecular Medicine - University of Oxford
Short Talk: Short Talk: Hematopoietic Stem Cell Extinction & Clonal Dominance Driven by Endogenous Formaldehyde |
|
| |
Alanna Van Huizen, St. Jude Children's Research Hospital
Short Talk: Short Talk: Gprasp2 Expression Identifies a Deeply Quiescent HSC Subset with Superior Stemness and Self-Renewal |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Longs Peak |
| 7:30–10:00 PM |
Poster Session 1 |
Longs Peak |
Tuesday, February 27, 2024
| 7:00–8:00 AM |
Breakfast |
Longs Peak |
| 8:00–11:00 AM |
Hematopoietic Microenvironment |
Grays Peak |
| |
* Owen J. Tamplin, University of Wisconsin-Madison
Session Chair |
|
| |
* Marta Derecka, St. Jude Children's Research Hospital
Session Chair |
|
| |
Claudia Waskow, Friedrich Schiller University Jena
Defining Cellular Interplay in the Hematopoietic Bone Marrow Niche |
|
| |
Elizabeth S. Ng, Murdoch Children's Research Institute
Long-term Engrafting Haematopoietic Cells Differentiated from Human Pluripotent Stem Cells |
|
| |
César Nombela-Arrieta, University Hospital Zurich
Remodeling and Regeneration of the Bone Marrow Microenvironment Post-Inflammatory Stress |
|
| |
David T. Scadden, Massachusetts General Hospital and Harvard University
Microenvironmental Regulation of the Bone Marrow Niche in Hematologic Disease States |
|
| |
Chloe Baron, Boston Children's Hospital
Short Talk: Short Talk: Apelin-Mediated Clonal Expansion of Niche Endothelial Cells Drives Selection of Leukemic and Normal HSC Clones |
|
| |
Kira Gritsman, Albert Einstein College of Medicine
Short Talk: Short Talk: Hematopoietic Stem Cell Numbers are Not Solely Determined by Niche Availability |
|
| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–1:00 PM |
Poster Setup |
Longs Peak |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Longs Peak |
| 3:00–4:30 PM |
Career Roundtable |
Grays Peak |
| |
Ravi Majeti, Stanford University
Professor |
|
| |
Eirini D. Trompouki, IRCAN-Institute for research on Cancer and Aging
Research Director |
|
| |
Anna E. Beaudin, University of Utah School of Medicine
Associate Professor |
|
| |
Yahyah Aman, Springer Nature
Associate Editor |
|
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–6:45 PM |
Aging and Stress Hematopoiesis |
Grays Peak |
| |
* Stephanie Z Xie, University Health Network
Session Chair |
|
| |
* Franco Izzo, Weill Cornell Medicine
Session Chair |
|
| |
Emmanuelle Passegué, Columbia University
Inflammatory Regulation of Hematopoietic Homeostasis Drives Aging Phenotypes |
|
| |
Fernando D. Camargo, Boston Children's Hospital
Tracing Contributions of Hematopoietic Stem and Progenitor Population to Life-Long Hematopoiesis |
|
| |
Matthew Porteus, Stanford University School of Medicine
Engineering Hematopoiesis by Homology Directed Repair Genome Editing |
|
| |
Hitoshi Takizawa, Kumamoto University
Short Talk: Short Talk: Mitochondrial Translation Regulates Fetal Erythropoiesis Through Regulation of Iron Homeostasis |
|
| |
Rebecca Austin, NYU Langone
Short Talk: Short Talk: Inflammation Drives Aberrant Hematopoiesis in the Spleens of Patients with Advanced Myelofibrosis |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Longs Peak |
| 7:30–10:00 PM |
Poster Session 2 |
Longs Peak |
Wednesday, February 28, 2024
| 7:00–8:00 AM |
Breakfast |
Longs Peak |
| 8:00–11:00 AM |
Hematologic Malignancies |
Grays Peak |
| |
* Aaron D. Viny, Columbia University Irving Medical Center
Session Chair |
|
| |
Michael G. Kharas, Memorial Sloan Kettering Cancer Center
RNA Regulators and Control of Leukemic Cell Fate |
|
| |
Andreas Trumpp, German Cancer Research Center
The Role of AML Stem Cells in Patients Treated with Venetoclax |
|
| |
John E. Dick, Princess Margaret Cancer Centre
What Makes a Stem Cell a Stem Cell and How Does it Go Bad? |
|
| |
Eirini P. Papapetrou, Icahn School of Medicine at Mount Sinai
Insights into Disease Mechanisms and Discovery of New Therapeutic Targets for Myeloid Malignancies from Human iPSC Models |
|
| |
Fatemeh Alikarami, Children's Hospital of Philadelphia
Short Talk: Short Talk: GATA2 Promotes Drug Resistance in KMT2A-rearranged Acute Myeloid Leukemia by Enhancing the Protein Stability of MDM2 |
|
| |
Daisuke Nakada, Baylor College of Medicine
Short Talk: Short Talk: Selenocysteine Recoding is a Vulnerability of FLT3-Mutant Leukemias |
|
| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Workshop 2: Novel Technologies and Therapeutics Discovery in Hematology |
Grays Peak |
| |
* David A. Alagpulinsa, Yale University School of Medicine
Session Chair |
|
| |
* Chloe Baron, Boston Children's Hospital
Session Chair |
|
| |
Makayla Pardo, Brown University
10x Spatial Transcriptomics of Human AML Core Bone Marrow Biopsies Reveals the Complex Remodeling of the Non-Hematopoietic Stromal Microenvironment Post-Treatment |
|
| |
Marta Derecka, St. Jude Children's Research Hospital
EBF1: A New Regulator of Onco-Niche in Myelofibrosis |
|
| |
Stéphane J. C. Mancini, INSERM
Bone Marrow B Cell Niche Signals Shape the Pre-Leukemic Cell Fate of B Cell Acute Lymphoblastic leukemia |
|
| |
Kasidy Dobish, University of Utah
p85⍺ Ubiquitination as a Target in Hematopoietic Malignancies |
|
| |
Juan Jose Rodriguez-Sevilla, MD Anderson Cancer Center
Myelodysplastic Syndrome HSCs’ Plasticity Drives Venetoclax Therapy Escape |
|
| |
Caroline Kubaczka, Boston Children's Hospital
Engineered hiPSC Derived CAR T Cells with Enhanced Safety Profile |
|
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Directed Differentiation and Therapeutics |
Grays Peak |
| |
* Stéphane J. C. Mancini, INSERM
Session Chair |
|
| |
* Adrienne Dorrance, Huntsman Cancer Institute
Session Chair |
|
| |
Ross L. Levine, Memorial Sloan Kettering Cancer Center
Single-Cell Profiling of Clonal Evolution in Myeloid Malignancies |
|
| |
Pablo Menendez, Josep Carreras Leukaemia Institute
Cell-of-Origin, Pathobiology and Therapeutics of MLL-rearranged Pediatric B-cell ALL |
|
| |
Ravi Majeti, Stanford University
Stem Cells in Human AML |
|
| |
Stefan Radtke, Fred Hutchinson Cancer Center
Short Talk: Short Talk: Long-term Persisting HSCs Contribute During Early Neutrophil Recovery and Form Clonal Pools: Implications for Ex Vivo and In Vivo HSC Gene Therapy Applications |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Grays Peak |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Longs Peak |
| 8:00–9:00 PM |
Trivia |
Grays Peak |
| 8:00–9:00 PM |
Cash Bar |
Longs Peak |
Thursday, February 29, 2024
