B Cells: Multifaceted Functions and Dysfunctions (B4)
February 23-26, 2025  | Fairmont Monte Carlo, Monte Carlo, Monaco
Rita Carsetti, Ali H. Ellebedy and Hedda Wardemann
Scholarship Deadline: Dec. 4, 2024 | Abstract Deadline: Jan. 31, 2025 | Early Registration Deadline: Jan. 8, 2025
* Session Chair † Invited but not yet accepted | Program current as of November 4, 2025 2 PM | For the most up-to-date details, visit https://www.keystonesymposia.org
Sunday, February 23, 2025
4:00–8:00 PM Registration Galerie Cristal
6:00–8:00 PM Welcome Mixer Galerie Cristal
Monday, February 24, 2025
7:30–8:30 AM Breakfast Individual Hotel
8:00–8:30 AM Poster Setup Salle d'Or 2
8:15–5:00 PM Poster Viewing Salle d'Or 2
8:30–9:30 AM Welcome and Keynote Address Salle d'Or 1
  * Rita Carsetti, Bambino Gesù Children Hospital
Session Chair		  
  Antonio Lanzavecchia, Vir Biotechnology, Inc.
Learning How to Design New Vaccines from Memory B Cells		  
9:30–11:45 AM Deploying B-Cell Responses to Protect Against Pathogens Salle d'Or 1
  * Hedda Wardemann, German Cancer Research Center
Session Chair		  
  * Jo Spencer, King's College London
Session Chair		  
  Ali H. Ellebedy, Washington University School of Medicine
Persistence of Germinal Center Reactions after mRNA Vaccination in Humans		  
  Carola G. Vinuesa, Francis Crick Institute
A B Cell Trilemma		  
  Paula M Cannon, University of Southern California, Keck School of Medicine
Genome Edited B Cells as Therapeutics Against Pathogens		  
  Robert Abbott, University of Texas Medical Branch
Short Talk: Antigen Avidity Drives the Durability of the Vaccine Immune Response.		  
10:00–10:20 AM Coffee Break Galerie Cristal
11:45–12:45 PM Lunch Galerie Cristal
11:50–12:50 PM Women in Science Networking Event Galerie Cristal
  * Hedda Wardemann, German Cancer Research Center
Session Chair		  
  * S. Rameeza Allie, Penn State College of Medicine
Session Chair		  
  * Kim Good-Jacobson, Monash University
Session Chair		  
  * Ali H. Ellebedy, Washington University School of Medicine
Session Chair		  
12:30–2:30 PM Poster Session 1 Salle d'Or 2
2:30–4:30 PM Symposia Spotlight 1: B Cell Function Salle d'Or 1
  * Pia Dosenovic, Karolinska Institutet
Session Chair		  
  * Jenna Guthmiller, University of Colorado SOM
Session Chair		  
  David R Glass, Fred Hutchinson Cancer Center
Bridging The Identity And Function Of Human Plasma Cells		  
  Katharina Lahl, University of Calgary
Maternal Immunity Protects Offspring from Enteric Viral Infection Without Negatively Affecting Humoral Immune Memory		  
  Michael Farzan, Boston Children's Hospital; Harvard Medical School
In Vivo Affinity Maturation of Mouse B Cells Engineered to Express Human Antibodies and Biologics		  
  Joshua F.E. Koenig, McMaster University
Type 2-Polarized Memory B Cells Hold Ige Memory Against Allergens and Helmiths Independently of Igg1 Expression		  
  Ragan Pitner, Seattle Children's Research Institute
Regulating Humoral And Cellular Immunity With Non-Differentiating Engineered Regulatory B Cells		  
  Roxane Biersteker, Leiden University Medical Center
Modulation Of Igg Oligomerization By Variable Domain Glycans: A Novel Mechanism To Regulate Complement Activation		  
  Jaime L Chao, University of Washington
B Cell Response Heterogeneity Is Spatially Encoded Across The Lymphatic Chain		  
  Mohammed Zghaebi, Medical University of Vienna
Aiming at Conserved Ige Lineages: A Novel Approach to Target Allergic Cascades in Birch Pollen Allergy. Submitter		  
4:30–5:00 PM Coffee Available Galerie Cristal
5:00–7:00 PM B Cell Responses to Global Pathogens Salle d'Or 1
  * Amy Chung, University of Melbourne
Session Chair		  
  Hedda Wardemann, German Cancer Research Center
Humoral Immune Responses to Malaria Vaccines		  
  Daniel Lingwood, Harvard Medical School
Expanding Exceptionally Broad Anti-flu Pathways from the Human B cell Repertoire		  
  Patrick Madden, La Jolla Institute for Immunology
Short Talk: Priming And Shepherding Rare B Cell Precursors With Germline-Targeting And Boosting Immunizations In Non-Human Primates		  
  Isabelle J Foo, The University of Melbourne
Short Talk: Historic 1994 Influenza Vaccine Cohorts Provide Key Insights into B Cell and Antibody Landscapes Toward Future Influenza Strains		  
7:00–8:00 PM On Own for Dinner
Tuesday, February 25, 2025
7:30–8:30 AM Breakfast Individual Hotel
8:00–8:30 AM Poster Setup Salle d'Or 2
8:15–5:00 PM Poster Viewing Salle d'Or 2
8:30–11:30 AM Longevity of B Cell Responses Salle d'Or 1
  * Marcus R Clark, University of Chicago
Session Chair		  
  * Michael Farzan, Boston Children's Hospital; Harvard Medical School
Session Chair		  
  Pavel Tolar, University College London
Regulation of Normal and Oncogenic BCR Signaling by Immunoglobulin Class-switching		  
  David M. Tarlinton, Monash University
Intrinsic and Extrinsic Regulators Setting Plasma Cell Lifespans		  
  Tomohiro Kurosaki, Osaka University
Making Sense of Memory B Cell Heterogeneity		  
  Adi Barzel, Tel Aviv University
In Vivo B Cell Engineering		  
  Andrew J MacLean, The Rockefeller University
Short Talk: Affinity Maturation of Antibody Responses is Mediated by Differential Plasma Cell Proliferation		  
  David R. Fooksman, Albert Einstein College of Medicine
Short Talk: Cd138 and April Regulate Pc Survival, Competition and Retention in the Bm Niche		  
9:30–9:50 AM Coffee Break Galerie Cristal
11:30–12:30 PM Lunch Galerie Cristal
12:00–2:00 PM Poster Session 2 Salle d'Or 2
2:15–3:45 PM Career Roundtable Salle d'Or 1
  F. Nina Papavasiliou, Deutsches Krebsforschungszentrum
Professor		  
  David R. Fooksman, Albert Einstein College of Medicine
Associate Professor		  
  Andre Limnander, Regeneron
Director, Immunology & Inflammation		  
  Martina Trokter, LifeArc
Senior Scientist		  
3:45–4:15 PM Coffee Available Galerie Cristal
4:15–6:15 PM B Cell Responses at Mucosa Sites Salle d'Or 1
  * Carla R. Nowosad, New York University
Session Chair		  
  * Lisa A. Chakrabarti, Institut Pasteur
Session Chair		  
  S. Rameeza Allie, Penn State College of Medicine
The Formation and Function of Lung-Resident Memory B Cells in Protection Against Viral Infections		  
  Davide Angeletti, University of Gothenburg
Dynamics of Mucosal B Cell Responses to Influenza Virus Infection		  
  Rita Carsetti, Bambino Gesù Children Hospital
Memory B Cells Turn Systemic Immunity into Local Protection		  
  Emily Siniscalco, Yale University
Short Talk: Antigen-Selected Gut Iga is Generated from Igg1 Germinal Center B Cells Submitter		  
  Anton Sholukh, Fred Hutch Cancer Center
Short Talk: Plasma Cells Establish Long-Term Residency and Secrete Virus-Specific Antibodies in Genital Skin Infected with Hsv-2		  
6:15–7:15 PM On Own for Dinner
Wednesday, February 26, 2025
7:00–8:00 AM Breakfast Individual Hotel
7:30–8:00 AM Poster Setup Salle d'Or 2
8:00–11:00 AM B Cells in Autoimmunity and Cancer Salle d'Or 1
  * Roberta Pelanda, University of Colorado Anschutz Medical Campus
Session Chair		  
  * Aaron J. Marshall, University of Manitoba
Session Chair		  
  Virginia Pascual, Cornell University
The B Helper T Cell Compartment in Human SLE		  
  Georg A Schett, Uniklinikum Erlangen
Control of Autoimmune Diseases via CD19-Targeted CAR T Cells		  
  F. Nina Papavasiliou, Deutsches Krebsforschungszentrum
ADAR1-Mediated Editing Promotes B Cell Lymphoma		  
  Ziv Shulman, Weizmann Institute
Generation and Function of Tumor Reactive Antibodies		  
  Nataliya Yeremenko, University of Nantes
Short Talk: Targeting Bob1: A Novel Strategy For Gc-Derived B Cell Diseases From Autoimmunity To Cancer		  
  Naiara Juan-Larrea, Centro Nacional de Investigaciones Oncológicas (CNIO)
Short Talk: The B-Side Of Melanoma: Midkine Rewires B Cells to Support Tumor Growth and Immune Evasion		  
8:15–5:00 PM Poster Viewing Salle d'Or 2
9:00–9:20 AM Coffee Break Galerie Cristal
11:00–12:15 PM Panel Discussion: Data Sharing and Preprint Publication, Discussion Involving Journals Editors Salle d'Or 1
  Hedda Wardemann, German Cancer Research Center
*Session Chair		  
  Facundo D. Batista, Massachusetts Institute of Technology and Harvard University
Chief Editor, The EMBO Journal		  
  Ursula Weiss, Nature
Senior Editor		  
  Courtney Malo, Science Translational Medicine
Associate Editor		  
  Kirsty Minton, Nature Publishing Group
Senior Editor		  
12:15–1:15 PM Lunch Galerie Cristal
12:45–2:30 PM Poster Session 3 Salle d'Or 2
2:30–4:30 PM Symposia Spotlight 2: Single Cell Technologies Salle d'Or 1
  * Gunilla B. Karlsson Hedestam, Karolinska Institutet
Session Chair		  
  * Arash Grakoui, Emory University
Session Chair		  
  Chiara Dionisi, King's College London
Analysis of Paired B Cell Epigenetic and Transcriptomic Features Reveals Aspects of Human B Cell Subset Development		  
  Lisan H Kuijper, Sanquin Research
Clonal Relatedness Between B Cell Phenotypic Subsets: Using Multimodal Single-Cell Analysis of Antigen-Specific B Cells to Delineate Ef Vs Gc Response Evolution		  
  Davide G. Franchina, Stanford University
Integration of Single Cell Mass Cytometry Imaging and Glyco-Imaging to Characterize B Cell Follicle Dynamics		  
  Vitor R. C. Aguiar, Boston Children's Hospital
A Multiomics Resource of B Cell Activation Helps Decipher Disease Pathogenesis		  
  Yiming Zhang, Massachusetts Institute of Technology
Investigating The Impact Of Vaccine Formulations On Humoral Immunity Via Integrated Single-Cell Multi-Omic Analysis		  
  Gabriela Maciel da Silva, Universidade Federal do Rio de Janeiro
A Single-Cell Culture-Based Method For Comprehensive Analysis Of Memory B Cell Repertoire		  
4:30–4:45 PM Coffee Available Galerie Cristal
4:45–6:30 PM Regulation of B Cell Responses Salle d'Or 1
  * Zia Rahman, Thomas Jefferson University
Session Chair		  
  * Steven Kerfoot, University of Western Ontario
Session Chair		  
  Facundo D. Batista, Massachusetts Institute of Technology and Harvard University
Antibody-Feedback Regulates B Cell Responses		  
  Kim Good-Jacobson, Monash University
Molecular Control of Memory B Cell Differentiation		  
  Almudena R. Ramiro, Centro Nacional de Investigaciones Cardiovasculares
The Antibody Immune Response in Atherosclerosis		  
  Virginia G de Yébenes Mena, Universidad Complutense de Madrid
Short Talk: miR-28 Shapes Germinal Center Duration and Antibody Affinity in Viral Infection		  
6:30–6:45 PM Meeting Wrap-Up: Outcomes and Future Directions Salle d'Or 1
  * Ali H. Ellebedy, Washington University School of Medicine
  
6:45–7:45 PM On Own for Dinner
Thursday, February 27, 2025
12:00–11:59 PM Departure