| 4:00–8:00 PM | Registration | Foyer International |
| 6:00–8:00 PM | Welcome Mixer | Foyer International |
| 7:00–8:00 AM | Breakfast | Individual Hotel |
| 7:30–8:00 AM | Poster Setup | Zurich Ballroom |
| 7:45–5:00 PM | Poster Viewing | Zurich Ballroom |
| 8:00–8:10 AM | Welcome Remarks | New York Ballroom |
| 8:10–9:00 AM | Keynote Address | New York Ballroom |
| * Karim-Jean Armache, New York University Grossman School of Medicine Session Chair |
| Joanna Wysocka, Stanford University Epigenetic Regulators in Development and Disease |
| 9:00–11:30 AM | Chromatin Regulatory Mechanisms Governing Cell Fate in Health and Disease | New York Ballroom |
| * Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School Session Chair |
| Robert J. Klose, University of Oxford Understanding how CpG Island regulate Gene Expression |
| Anja Groth, University of Copenhagen Maintaining Cell Fate through Replication |
| Karim-Jean Armache, New York University Grossman School of Medicine Structure and Function of Epigenetic Complexes: Basic and Disease Mechanisms |
| Scott A. Armstrong, Dana-Farber Cancer Institute Mechanisms of Menin Inhibitor Sensitivity and Resistance |
| Beat Fierz, EPFL Short Talk: Choreography of Epigenetic Control Captured on the Molecular Level |
| 9:30–9:50 AM | Coffee Break | Foyer International |
| 11:30–12:30 PM | Lunch | Europe Ballroom |
| 12:00–2:00 PM | Poster Session 1 | Zurich Ballroom |
| 2:00–4:00 PM | Symposia Spotlight 1 | New York Ballroom |
| * Anja Groth, University of Copenhagen Session Chair |
| James K. Nuñez, University of California, Berkeley Short Talk: DNA Methylation Interplays With RNA M6a Factors To Establish Heritable Epigenetic Silencing In Human Cells |
| Jean-Paul Armache, Penn State University Short Talk: Structure-function and Chromatin Biology |
| Diego Pasini, European Institute of Oncology Short Talk: Control of Transcriptional Identity by the Polycomb Repressive Machinery |
| Robert L Yauch, Genentech, Inc. Short Talk: Antibody-Mediated Delivery of SMARCA2/A4 Protein Degraders Affords Strong Anti-Tumor Efficacy in SMARCA4-Mutant NSCLC and Prostate Cancer Models |
| Aliaksandra (Alex) Radzisheuskaya, The Institute of Cancer Research Short Talk: Uncovering Critical Lysines in Mammalian Histone H3 with High-Throughput CRISPR Prime Editing |
| Mo Chen, Tsinghua University Short Talk: Spatiotemporal Control of SMARCA5 by a MAPK-RUNX1 Axis Distinguishes Mutant KRAS-Driven Pancreatic Malignancy From Tissue Regeneration |
| Serena Sanulli, Stanford University Short Talk: Allosteric Regulation Of The Nucleosome Core Biases Cell State |
| Adrian P Bracken, Trinity College Dublin Short Talk: The Abundant AEBP2 Long Isoform Restrains PRC2 to Direct H3K27me2 in Development and Cancer |
| 4:00–4:30 PM | Coffee Available | Foyer International |
| 4:30–6:30 PM | Therapeutic Opportunities Informed by Genetic Disruption of Chromatin Factors | New York Ballroom |
| * Aliaksandra (Alex) Radzisheuskaya, The Institute of Cancer Research Session Chair |
| Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School Structure and Function of Chromatin Remodeling Complexes in Human Disease: From Basic Mechanisms to Therapeutic Opportunities |
| Nicolas H Thomä, EPFL Lausanne Structural Basis of Transcription Factors and Protein Degradation |
| Isaac A. Klein, Dewpoint Therapeutics Condensate Modulating Drugs: Targeting Gene Regulation Via Condensate Disruption |
| François Fuks, University of Brussels RNA Modifications in Health and Disease |
| Tomasz Cierpicki, University of Michigan Short Talk: Discovery of PRC1 Inhibitors with In Vivo Efficacy |
| 6:30–7:30 PM | On Own for Dinner |
| 7:00–8:00 AM | Breakfast | Individual Hotel |
| 7:30–8:00 AM | Poster Setup | Zurich Ballroom |
| 7:45–5:00 PM | Poster Viewing | Zurich Ballroom |
| 8:00–11:00 AM | Novel Target Identification and Chemical Approaches | New York Ballroom |
| * François Fuks, University of Brussels Session Chair |
| Tom W. Muir, Princeton University New Chemical Approaches to Reveal and Understand Chromatin Mechanisms |
| Jelena Urosevic, AstraZeneca Epigenetic Targeting in Oncology: Translating Mechanisms to Practice with MTAP-Selective PRMT5 Inhibition—The AZD3470 Story |
| Scott B Rothbart, Van Andel Institute Revealing Novel Cancer Therapeutic Strategies Through Molecular Studies Of Chromatin Modification Crosstalk |
| Steven F Bellon, Foghorn Therapeutics Identification of First-In-Class Selective ARID1B Degraders |
| Bryan Venters, EpiCypher, Inc. Short Talk: Unraveling Chromatin Regulation With Fiber-seq: a Single-Molecule, Long-Read Assay That Simultaneously Measures Chromatin Architecture and DNA Methylation |
| Alejandro Correa Sáez, University of Dundee Short Talk: Dual E3 Ligase Recruitment by Monovalent Degraders Enables Redundant and Tunable Degradation of SMARCA2/4b |
| 9:00–9:20 AM | Coffee Break | Foyer International |
| 9:20–9:25 AM | Award Recipient Acknowledgement | New York Ballroom |
| 11:00–12:00 PM | Lunch | Europe Ballroom |
| 11:30–1:45 PM | Poster Session 2 | Zurich Ballroom |
| 2:00–2:45 PM | Career Roundtable | New York Ballroom |
| Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School *Session Moderator |
| Karim-Jean Armache, New York University Grossman School of Medicine *Session Moderator |
| Emily Bernstein, Mount Sinai School of Medicine Professor |
| Nicolas H Thomä, EPFL Lausanne Senior Group Leader |
| Robert L Yauch, Genentech, Inc. Executive Director |
| Jelena Urosevic, AstraZeneca Associate Principal Scientist |
| 2:45–3:30 PM | Panel Discussion: From Mechanisms to Drugs: Therapeutic Challenges and Opportunities Unique to Our Field | New York Ballroom |
| Karim-Jean Armache, New York University Grossman School of Medicine *Session Moderator |
| Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School *Session Moderator |
| Scott A. Armstrong, Dana-Farber Cancer Institute Panelist |
| Nada Jabado, McGill University Health Centre Panelist |
| Isaac A. Klein, Dewpoint Therapeutics Panelist |
| Steven F Bellon, Foghorn Therapeutics Panelist |
| 3:30–4:00 PM | Coffee Available | Foyer International |
| 4:00–6:00 PM | Mechanisms and Vulnerabilities Conferred by DNA Methylation | New York Ballroom |
| * Scott B Rothbart, Van Andel Institute Session Chair |
| Yael David, Memorial Sloan Kettering Cancer Center Targeting a New Metabolism-Epigenetic Axis Towards Improved CAR T Therapy |
| Chao Lu, Columbia University Lineage-Specific Metabolic Regulation of Chromatin Contributes to Tumor Plasticity |
| Alla Sigova, CAMP4 Therapeutics RNA Amplifier Therapeutics Targeting Regulatory RNAs to Upregulate Disease-Associated genes |
| Emily Hodges, Vanderbilt University Short Talk: Predicting Past, Present and Future Cell States with DNA Methylation |
| Eneda Toska, Johns Hopkins University Short Talk: Epigenetic Mechanisms of Therapy Resistance in Hormone Receptor–Positive Breast Cancer |
| 6:00–7:00 PM | On Own for Dinner |
| 7:00–8:00 AM | Breakfast | Individual Hotel |
| 7:30–8:00 AM | Poster Setup | Zurich Ballroom |
| 7:45–5:00 PM | Poster Viewing | Zurich Ballroom |
| 8:00–11:00 AM | Interplay between Chromatin Regulation and Transcription Dynamics in Human Disease | New York Ballroom |
| * Eneda Toska, Johns Hopkins University Session Chair |
| Emily Bernstein, Mount Sinai School of Medicine Mechanisms of Chromatin Remodeling Mutations in Cancer |
| Ali Shilatifard, Northwestern University The Long Road of Transcription: Elongation Control in Aging, Disease and Cancer |
| Danny F Reinberg, University of Miami Opportunities in Cancer |
| Stefan Niekamp, Massachusetts General Hospital Short Talk: Mutual Antagonism between PRC1 Condensates and SWI/SNF in Chromatin Regulation |
| Amanda Engstrom, Baylor College of Medicine Short Talk: Dose-Dependent Molecular Consequences of MeCP2 Dysregulation in Neurological Disorders |
| Chul-Hwan Lee, Seoul National University Short Talk: EZH1 Orchestrates 3D Chromatin Architecture To Establish De Novo Heterochromatin And Safeguard Lineage Commitment |
| Jane A. Skok, New York University School of Medicine Short Talk: Replication-Coupled Cohesin Remodeling Reorganizes Nucleosome Phasing And Insulation |
| Joseph C Sudar, New York University Grossman School of Medicine Short Talk: Epigenetics in Parasite Survival and Host Immune Evasion |
| 9:00–9:20 AM | Coffee Break | Foyer International |
| 11:00–12:15 PM | Lunch | Europe Ballroom |
| 12:00–2:30 PM | Poster Session 3 | Zurich Ballroom |
| 2:30–4:30 PM | Symposia Spotlight 2 | New York Ballroom |
| * Chul-Hwan Lee, Seoul National University Session Chair |
| Lu Wang, Northwestern University Short Talk: Molecular Dissection of Gene Essentiality and Transcriptional Reprogramming in Cancer |
| Oliver Bell, Keck School of Medicine of USC Short Talk: ZNF462 Haploinsufficiency Disrupts G9A/GLP-Mediated Gene Silencing To Drive Neurogenic Priming in Weiss-Kruszka Syndrome |
| Alejandra Laguillo-Diego, Weill Cornell Medicine Short Talk: KAT7 and KAT6A/B Dictate Cell Identity Decisions During M-to-G1 |
| Caroline Clarke, AstraZeneca Short Talk: Distinct Specialisations of Cohesin-STAG1 and Cohesin-STAG2 Reshape 3D Genome Architecture and Gene–Protein Networks in Cancer |
| Yumeng Zhan, Max Planck Institute for Multidisciplinary Sciences Short Talk: The +1 Nucleosome Functions in the Initiation-Elongation Transition of Pol II Transcription |
| Eric M Conway, University College Dublin Short Talk: Divergent Pathogenic PR-DUB Complex Variants Converge Functionally Via PRC2 Displacement From Chromatin |
| Melanie Eckersley-Maslin, Peter MacCallum Cancer Centre Short Talk: Hijacking Chromatin Regulators of Developmental Plasticity in Cancer |
| 4:30–5:00 PM | Coffee Available | Foyer International |
| 5:00–6:20 PM | Chromatin Regulatory Machinery in Human Health and Disease | New York Ballroom |
| * Chao Lu, Columbia University Session Chair |
| Effie Apostolou, Weill Cornell Medical College Epigenetic Mechanisms of Post-Mitotic Transcriptional Activation |
| Nada Jabado, McGill University Health Centre Epigenetics of Pediatric Brain Cancers |
| Lluis Morey, University of Miami Miller School of Medicine Short Talk: Decoding the Role of PRC1 Missense Mutations in Neurodevelopmental Disorders |
| Siddhant Jain, Dana-Farber Cancer Institute, Boston , Massachusetts, US Short Talk: A SWI/SNF-Specific Ig-Like Domain, SWIFT, is a Transcription Factor Binding Platform |
| 6:20–6:35 PM | Meeting Wrap-Up: Outcomes and Future Directions (Organizers) | New York Ballroom |
| 6:35–7:35 PM | On Own for Dinner |
| 12:00–11:59 PM | Departure |