RNA Modifications: Bridging Biological Function and Therapeutic Potential (C2)
March 9-12, 2026
| Keystone Resort, Keystone, CO, United States
Michaela Frye, Schraga Schwartz, Yunsun Nam and Eckhard Jankowsky
Scholarship Deadline: Nov. 20, 2025 | Abstract Deadline: Feb. 17, 2026 | Early Registration Deadline: Jan. 8, 2026
| 4:00–8:00 PM |
Registration |
Longs Peak Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Longs Peak Foyer |
| 7:00–8:00 AM |
Breakfast |
Shavano/Torreys Peaks |
| 8:00–8:10 AM |
Welcome Remarks |
Grays Peak |
| 8:10–9:00 AM |
Keynote Address |
Grays Peak |
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Tsutomu Suzuki, University of Tokyo
Expanding Chemical Space of RNA Modifications |
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| 9:00–11:15 AM |
Molecular Mechanisms of RNA Modifications |
Grays Peak |
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Yunsun Nam, University of Texas Southwestern Medical Center
Structure and Function of RNA Modifying Protein |
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Olivier Duss, European Molecular Biology Laboratory
Dynamic RNA Biology at the Single-Molecule Level: Watching how Interconnected Processes Work in Real-Time |
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Sara H. Rouhanifard, Northeastern University
RNA Modifications on the Single Molecular Level and Spatial Transcriptomics |
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Julian König, Würzburg University
Short Talk: m6A Sites in the Coding Region Trigger Translation-dependent mRNA Decay |
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| 9:30–9:50 AM |
Coffee Break |
Longs Peak Foyer |
| 11:15–12:15 PM |
Meet the Editors |
Grays Peak |
| 12:15–1:00 PM |
Poster Setup |
Shavano/Torreys Peaks |
| 12:15–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Shavano/Torreys Peaks |
| 2:30–4:30 PM |
Symposia Spotlight 1 |
Grays Peak |
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W.S. Sho Goh, Shenzhen Bay Laboratory
I Read, therefore I m6Am: Deciphering m6Am’s functional impact through its Reader & Anti-Reader |
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Benedetta Ricci, Columbia University
The Dynamic Regulation of YTHDF-dependent m6A-mRNA Decay |
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hemendra singh panwar, Van Andel Institute
Structural Basis of Functional Asymmetry in Eukaryotic H/ACA snoRNPs |
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Keita Miyoshi, National Institute of Genetics
The Mammalian Rapid tRNA Decay Pathway Is Critical for N⁷‑Methylguanosine-Hypomodified tRNA Degradation under Physiological Conditions |
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Rui Su, City of Hope
Mitochondrial RNA Methylation Rewires Metabolism and Regulates Retrograde Mitochondrial-Nuclear Communication |
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Stacy M Horner, Duke University School of Medicine
m⁶A Remodeling During Zika Virus Infection by Isoform-Specific Targeting of METTL3 |
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Jeffrey Mugridge, University of Delaware
How Vitamin C Tunes the Activity and Selectivity of RNA Demethylases to Shape the Epitranscriptome |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Language Models Predicting RNA Modifications and Functions |
Grays Peak |
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Schraga Schwartz, Weizmann Institute of Science
Computational and Functional Analyses of Modifications |
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Prashant Mali, University of California, San Diego
Transcriptome Engineering Toolsets |
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Eduardo Eyras, EMBL Australia, Australian National University
Decoding the Temporal Landscape of mRNA Modifications at Single-molecule Resolution |
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Jonathan Goeke, Genome Institute of Singapore
Short Talk: Direct RNA-Seq for unbiased identification of RNA modifying enzymes in large-scale CRISPR screens |
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Ann E Ehrenhofer-Murray, Humboldt-Universität zu Berlin
Short Talk: The Functional tRNA Epitranscriptome: Queuosine, Cooperation with (ms2)i6A modification, and Nanopore Sequencing |
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| 7:00–8:00 PM |
Social Hour with Dinner |
Shavano/Torreys Peaks |
| 7:30–10:00 PM |
Poster Session 1 |
Shavano/Torreys Peaks |
Wednesday, March 11, 2026
| 7:00–8:00 AM |
Breakfast |
Shavano/Torreys Peaks |
| 8:00–11:00 AM |
RNA Therapeutics |
Grays Peak |
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Caroline Köhrer, Alltrna
tRNA Therapeutics |
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Peter C. Dedon, Massachusetts Institute of Technology
High Throughput Platforms for Epitranscriptomic Drug Discovery |
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Gudrun Stengel, Alida Biosciences
Short Talk: RNA Modifications in PBMCs Enable Disease Classification Where Transcript Abundance Lacks Discriminatory Power |
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Ivan Correa, New England Biolabs
Short Talk: Precision at the Ribosome: N2,7-Dimethylguanosine Formation by 16S rRNA Methyltransferase |
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Kohki Yamada, UT Southwestern Medical Center
Short Talk: Co-Transcriptional Modifications of 2’-Hydroxyls on Synthetic mRNA Enhance Ribonuclease Resistance and mRNA Lipid Nanoparticle Thermostability |
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 9:20–9:25 AM |
Award Recipient Acknowledgement |
Grays Peak |
| 11:00–1:00 PM |
Poster Setup |
Shavano/Torreys Peaks |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Shavano/Torreys Peaks |
| 2:15–3:15 PM |
Career Roundtable |
Grays Peak |
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Gudrun Stengel, Alida Biosciences
CEO & Co-Founder |
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| 3:30–4:30 PM |
Panel Discussion: Science Meets Industry |
Grays Peak |
| 4:30–5:00 PM |
Coffee Available |
Shavano/Torreys Peaks |
| 5:00–7:00 PM |
RNA Modifications in Diseases I |
Grays Peak |
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Samie Jaffrey, Weill Medical College of Cornell University
Cap Modifications in Healthy Cells and Disease |
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Jordan L Meier, National Cancer Institute
Cytidine Acetylation across the Tree of Life |
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Michaela Frye, Deutsches Krebsforschungszentrum
tRNA Modifications in Cancer |
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Moritz Cornelius Pauli, University hospital heidelberg
Short Talk: A Ribosomal RNA 2ʹ-O-Methylation Signature Drives a Pro-metastatic Phenotype in Lung Adenocarcinoma |
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Natalia Pinello, Insitut Pasteur de Montevideo
Short Talk: Loss of NLRP3 m6A Methylation via Single Nucleotide Variant is Associated with Autoinflammatory Disease |
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| 7:00–8:00 PM |
Social Hour with Dinner |
Shavano/Torreys Peaks |
| 7:30–10:00 PM |
Poster Session 2 |
Shavano/Torreys Peaks |
| 7:00–8:00 AM |
Breakfast |
Shavano/Torreys Peaks |
| 8:00–11:00 AM |
RNA Engineering and Editing Approaches |
Grays Peak |
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Namita Bisaria, AIRNA
Therapeutics based on ADAR -Base Editing |
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Nicole Martinez, Stanford University
Regulatory Features Driving Pseudouridine Synthase Activity |
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Kate Meyer, Duke University
Genetically Encoded Tools for Studying mRNA Methylation |
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Jin Billy Li, Stanford University
RNA Editing and Sensing as a Common Mechanism Underlying the Genetic Risk of Inflammation |
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Qi Chen, University of Utah School of Medicine
Short Talk: Complete Decoding of tsRNA Modifications Reveals a Single-Site Switch for RNA Structure and Function |
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Eric S Martin, Storm Therapeutics Ltd
Short Talk: Inhibition of METTL3 Induces RNA Misprocessing that Results in dsRNA Formation, Activation of Innate Immunity and an Enhanced Anti-tumor Response |
|
| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 12:00–5:00 PM |
On Own for Lunch |
|
| 2:30–4:00 PM |
Symposia Spotlight 2 |
Grays Peak |
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Thomas J Santangelo, Colorado State University
Targeted, Efficient, Site-specific Modification of Selected RNAs in vivo |
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Matthias Soller, University of Manchester
Decoding of TOP Messenger RNA 2`-O-methylation Status for mRNA Stability and Localization to Synapses |
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Hong Li, Van Andel Institute
Making Ribosomes: Critical Roles of Chemical Modifications in rRNA |
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Homa Ghalei, Emory University
Ribosomal RNA Modification Heterogeneity in Biology and Cancer |
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Aurora Esquela Kerscher, Virginia Health Sciences at Old Dominion University
Glycosylated RNA as a Molecular Indicator of Reduced Tumor Aggressiveness in Prostate Cancer |
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Eleni Liapi, Aarhus University
Dynamic RNA Acetylation during Oxidative Stress in Mammalian Cells |
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| 4:00–4:30 PM |
Coffee Available |
Longs Peak Foyer |
| 4:30–6:15 PM |
RNA Modifications Diseases II |
Grays Peak |
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Zoya Ignatova, University of Hamburg
tRNA Engineering to Suppress Nonsense Mutations in Disease |
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Victoria H. Cowling, Cancer Research UK Scotland Institute
RNA Cap Regulation in Neurons |
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Chuan He, University of Chicago
RNA Modifications in Physiology and Immune-Related Disease |
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Zhangli Su, University of Alabama at Birmingham
Short Talk: Friend or Foe: TRMT6/61A in Cellular Stress and Human Disease |
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| 6:15–7:00 PM |
Closing Keynote Address |
Grays Peak |
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Muthiah Manoharan, Alnylam Pharmaceuticals, Inc.
siRNA Therapeutics |
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| 7:00–7:15 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Grays Peak |
| 7:15–8:15 PM |
Social Hour with Dinner |
Shavano/Torreys Peaks |
| 8:00–9:00 PM |
Entertainment |
Shavano/Torreys Peaks |
| 8:15–9:00 PM |
Cash Bar |
Shavano/Torreys Peaks |
