Immunometabolism: From Mechanisms to Pathways to Therapies (C3)
March 18-21, 2024
| INEC Killarney Convention Centre, Killarney, KY, Ireland
Luke A. J. O'Neill, Evanna Mills and Erika L. Pearce
Scholarship Deadline: Dec. 7, 2023 | Abstract Deadline: Dec. 7, 2023 | Early Registration Deadline: Jan. 17, 2024
| 4:00–8:00 PM |
Arrival and Registration |
INEC Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
INEC Foyer |
| 7:00–8:00 AM |
Breakfast |
Individual Hotel |
| 8:00–9:00 AM |
Welcome and Keynote Address |
INEC Main Auditorium |
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Lydia Lynch, Harvard Medical School
Metabolism, Fat, and Cancer |
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| 9:00–11:15 AM |
New Approaches to Study Immunometabolism |
INEC Main Auditorium |
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Theodore Alexandrov, European Molecular Biology Laboratory
Spatial Single Cell Metabolomics |
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Rafael Jose Arguello, CIML
From Single Cell Metabolism, ER-Stress and Epigenetics to Prediction of Responses in Cancer Patients |
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Florent Ginhoux, Singapore Immunology Network
Macrophage-Mediated Tissue Metabolic Reprogramming During Development |
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David K. Finlay, Trinity Biomedical Sciences Institute
Short Talk: Short Talk: Using Biorthogonal (CLICK) Chemistry to Measure Nutrient Uptake Flux in Single Immune Cells |
|
| 9:30–9:50 AM |
Coffee Break |
INEC Foyer |
| 11:15–1:00 PM |
Poster Setup |
INEC Foyer |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
INEC Foyer |
| 3:30–4:30 PM |
Career Roundtable |
INEC Main Auditorium |
| |
Alice Prince, Columbia University
Physician Scientist/Professor |
|
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Frank Dorsey, Eli Lilly and Company
Associate Vice President |
|
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Theodore Alexandrov, European Molecular Biology Laboratory
Team Leader / Head of MCF / MMPU Faculty |
|
| 4:30–5:00 PM |
Coffee Available |
INEC Foyer |
| 5:00–7:00 PM |
Mito-Nuclear Communication by Mitochondrial Metabolites |
INEC Main Auditorium |
| |
Tiffany Horng, ShanghaiTech University
Mitochondrial Metabolism and Macrophage Function |
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Claudio J. Villanueva, University of California, Los Angeles
Transcriptional Mechanisms that Regulate Adipocyte Development and Biology |
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Murad R. Mamedov, UCSF / Gladstone
Short Talk: Short Talk: CRISPR Screens Reveal AMPK-Dependent Metabolic Regulation of Cancer Cell Killing by γδ T Cells |
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Luisa Maria Mateus Abreu, European Molecular Biology Laboratory
Short Talk: Short Talk: High-Throughput Single-Cell Metabolomics Reveals Distinct Metabolic States of Drug-Modulated Activated CD4+ T Cells |
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Dirk Brenner, Luxembourg Institute of Health
Short Talk: Short Talk: Beyond Ubiquitination: Ubc13 in the Core of Mitochondrial Regulation and Innate Immunity |
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Eloïse Marques, University of Cambridge, MRC Mitochondrial Biology Unit
Short Talk: Short Talk: Assessing the Impact of a Heteroplasmic mt-tRNA Mutation on Inflammatory Macrophage Function |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
INEC Foyer |
| 7:30–10:00 PM |
Poster Session 1 |
INEC Foyer |
Wednesday, March 20, 2024
| 7:00–8:00 AM |
Breakfast |
Individual Hotel |
| 8:00–11:00 AM |
Immunometabolism: A Microbe’s View |
INEC Main Auditorium |
| |
Janelle S. Ayres, The Salk Institute for Biological Studies
Iron Metabolism in Host/Pathogen Interactions |
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Alice Prince, Columbia University
Airway Metabolites Promote Persistent Infection |
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Kathrin Renner, University Hospital Regensburg
Metabolic Imbalance and COVID19 |
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Katherine L. Cook, Wake Forest University School of Medicine
Short Talk: Short Talk: Diet-Microbe Interactions Modulate Immune Checkpoint Blockade Response in Triple-Negative Breast Cancer |
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Johan Garaude, ImmunoConcEpT, INSERM ERL1303
Short Talk: Short Talk: Sensing of Microbial Viability Orchestrates the Metabolic Recycling of Engulfed Bacteria in Macrophages |
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Fran Prenen, Rega Institute for Medical Research
Short Talk: Short Talk: JAK/STAT Inhibition Restores Disease Tolerance in Malaria-Infected Glucocorticoid Receptor Knockout Mice by Preventing Lethal Hypoglycemia |
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Slater Clay, Harvard T.H. Chan School of Public Health
Short Talk: Short Talk:Acetoacetate Regulates Anti-Tumor Immunity |
|
| 9:00–9:20 AM |
Coffee Break |
INEC Foyer |
| 11:00–1:00 PM |
Poster Setup |
INEC Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
INEC Foyer |
| 3:00–4:30 PM |
Workshop |
INEC Main Auditorium |
| |
Laura Atehortua, CCHMC
Apolipoprotein E-Containing HDL Enhances Survival of Memory Regulatory T Lymphocytes by Regulating Lipid Metabolism and Mitochondrial Fitness |
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Laura R Dwyer, UCSF
Decoding the Role of CD38 and Metabolic Pathways on the Heightened Treg Potential of Human Neonatal CD4+ T Cells |
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Amy Lorraine Seufert, Portland State University
Palmitic Acid Mediates Innate Immune Memory via Ceramide Metabolism in Vitro and in Vivo |
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Alva Casey, University of Cambridge
Elucidating the Mechanism of Mitochondrial Superoxide Production in Pro-Inflammatory Macrophages |
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Beatrice Angi, University of Padova
Cell-Specific Deletion of Kv1.3 Potassium Channel Modulates Regulatory T Cell-Dependent Pro-Tumor Activity in Vivo |
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Jackie Bader, Vanderbilt University Medical Center
PD-1 Directly Suppresses Macrophage Metabolism in an Obesity-Cancer Connection to Restrain Anti-Tumor Immunity |
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Alaa Madi, German Cancer Research Center, DKFZ
Triacylglycerol Synthesis Camouflages Sexual Dimorphism in Antitumor Immunity |
|
| 4:30–5:00 PM |
Coffee Available |
INEC Foyer |
| 5:00–7:00 PM |
Macrophage Metabolism: Emerging Metabolites |
INEC Main Auditorium |
| |
Karsten Hiller, Technische Universität Braunschweig
Mesaconate and Itaconate in Macrophage Function |
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Dan Ye, Shanghai Medical College, Fudan University
Itaconate in Host Defense and inflammation |
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Luke A. J. O'Neill, Trinity Biomedical Sciences Institute
Anti-Inflammatory Potential of Targeting Immunometabolism in Inflammation and Coagulopathies |
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Evanna Mills, Dana-Farber Cancer Institute
Metabolite Signaling in Macrophages as a Regulator of Thermogenesis |
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Jean-Philippe Auger, University Hospital Erlangen & University of Erlangen-Nuremberg
Short Talk: Short Talk: Mitochondrial Rewiring Essentially Contributes to the Anti-Inflammatory Effects of Glucocorticoids |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
INEC Foyer |
| 7:30–10:00 PM |
Poster Session 2 |
INEC Foyer |
| 7:00–8:00 AM |
Breakfast |
Individual Hotel |
| 8:00–11:00 AM |
Metabolite Signaling in the Tumor Microenvironment: Friend and Foe |
INEC Main Auditorium |
| |
Erika L. Pearce, Johns Hopkins University
Macrophage Tissue Residency |
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Speaker to be to be Announced
Talk Title to be Announced |
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Mark A. Febbraio, Monash Institute of Pharmaceutical Sciences
Exercise Mediated Extracellular Vesicles Influence Tumor Progression |
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Frank Dorsey, Eli Lilly and Company
Immunometabolism: Targeting Metabolic Nodes that Regulate Immunity |
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Roddy O'Connor, University of Pennsylvania
Short Talk: Short Talk: Arginine Links 1-Carbon Metabolism to Histone Methylation in CAR T Cells with Enhanced Metabolic Fitness |
|
| 9:00–9:20 AM |
Coffee Break |
INEC Foyer |
| 11:00–1:00 PM |
Poster Setup |
INEC Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
INEC Foyer |
| 4:30–5:00 PM |
Coffee Available |
INEC Foyer |
| 5:00–6:45 PM |
Immunometabolism: Translational Potential |
INEC Main Auditorium |
| |
Jonathan D. Powell, Calico Life Sciences
Targeting Metabolism in Aging |
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Mariana J. Kaplan, NIAMS, National Institutes of Health
Metabolism and Autoimmunity |
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Edward Driggers, General Metabolics
Metabolic Control of Autoimmunity and Inflammatory Disease |
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Chutao Chen, TWINCORE, Centre for Experimental and Clinical Infection Research
Short Talk: Short Talk: Development of Citraconate Derivatives as Novel ACOD1 Inhibitors |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
INEC Main Auditorium |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
INEC Foyer |
| 7:30–10:00 PM |
Poster Session 3 |
INEC Foyer |
