Tumor Metabolism: Environmental Influences and Therapeutic Vulnerabilities (C3)
March 16-19, 2025
| Fairmont Hotel Vancouver, Vancouver, BC, Canada
Shannon Mumenthaler, Kathryn E. Wellen and Arkaitz Carracedo
Scholarship Deadline: Dec. 10, 2024 | Abstract Deadline: Feb. 21, 2025 | Early Registration Deadline: Jan. 29, 2025
| 4:00–8:00 PM |
Registration |
British/Columbia Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
British/Columbia Foyer |
| 7:00–8:00 AM |
Breakfast |
British Ballroom |
| 8:00–9:30 AM |
Welcome and Keynote Session |
Columbia Ballroom |
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* Shannon Mumenthaler, University of Southern California
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* Kathryn E. Wellen, University of Pennsylvania
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Joshua D. Rabinowitz, Princeton University
Metabolic Flux Analysis in Cancer |
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Tomi Akinyemiju, Duke University
Embodiment: The Influence of Social Stressors on Cancer Outcomes |
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| 9:30–9:50 AM |
Coffee Break |
British/Columbia Foyer |
| 9:50–12:00 PM |
Therapeutic Targeting of Metabolism |
Columbia Ballroom |
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* Christopher J Halbrook, University of California, Irvine
Session Chair |
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Issam Ben-Sahra, Northwestern University
Regulation of Nucleotide Metabolism in Cancer Cells |
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Marianne Koritzinsky, University Health Network
Dependency of Cancer Cells on Cysteamine Dioxygenase (ADO) |
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Jonathan D. Powell, Calico Life Sciences
Glutamine Antagonism and Immunotherapy |
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Ayelet Erez, Weizmann Institute of Science
Dissecting the tumor-host crosstalk to potentiate therapy |
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| 12:00–1:00 PM |
Poster Setup |
British Ballroom |
| 12:00–1:30 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
British Ballroom |
| 1:30–3:15 PM |
Symposia Spotlight 1: New Strategies for Therapeutic Targeting of Metabolism |
Columbia Ballroom |
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* Danielle Schmitt, University of California Los Angeles
Session Chair |
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Ruchika Pokhriyal, Dana-Farber Cancer Institute
Deciphering Resistance Mechanisms to DHODH Inhibition |
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Laurentz Schuhknecht, University of Basel
Annotating Drug Modes of Action by Large-scale Metabolic Fingerprinting |
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Yulseung Sung, Yonsei University
A Selective Allosteric Inhibition of Mitochondrial Glutamine Transporter, SLC1A5_Var, Induces Cancer Selective Metabolic Crisis and Creates Immune Vulnerabilities in the Tumor Microenvironment |
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Li Du, Beckman Research Institute City of Hope
Targeting mitochondria metabolism through SUMOylation inhibition Sensitizes Acute Myeloid Leukemia to Venetoclax treatment |
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Alejandro Gutierrez, St. Jude Children's Research Hospital
G6PD Loss Confers Sensitivity to Asparaginase Through Ammonia Toxicity |
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Roy Hajjar, Mayo Clinic
Dietary PPAR-Gamma Activators Modulate the Gut Microbiota and Prevent the Dissemination Of Colorectal Cancer Cells and the Growth of Extra-Intestinal Colorectal Tumors |
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Taryn Morningstar, University of California, Irvine
Overcoming Heterogeneity in Pancreatic Cancer by Targeting Ref-1 and Mitochondrial Metabolism |
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| 3:30–4:30 PM |
Advancing Understanding in Tumor Metabolism: Bridging Research and Patient Care |
Columbia Ballroom |
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Alejandro Gutierrez, St. Jude Children's Research Hospital
Panelist |
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Tomi Akinyemiju, Duke University
Panelist |
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Stacey D Finley, University of Southern California
Panelist |
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Sara Zanivan, MD Anderson Cancer Center
Panelist |
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| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–7:00 PM |
Signaling, Epigenetics and Tumor Metabolism |
Columbia Ballroom |
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* Isaac Harris, University of Rochester Medical Center
Session Chair |
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Katherine Aird, University of Pittsburgh School of Medicine
CDKN2A-Low Cancer Cells Outcompete Macrophages for Microenvironmental Zinc to Drive Immunotherapy Resistance |
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Brendan D Manning, Harvard School of Public Health
mTOR Signaling and Metabolic Control in the Tumor Microenvironment |
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Sara Sdelci, Centre for Genomic Regulation
Chromatome Profiling Uncovers Extensive Nuclear Localization of Metabolic Enzymes |
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Kathryn E. Wellen, University of Pennsylvania
Metabolism-epigenetics Crosstalk in Cancer |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
British Ballroom |
| 7:30–10:00 PM |
Poster Session |
British Ballroom |
| 7:00–8:00 AM |
Breakfast |
British Ballroom |
| 7:30–8:00 AM |
Poster Setup |
British Ballroom |
| 7:45–5:00 PM |
Poster Viewing |
British Ballroom |
| 8:00–11:00 AM |
Metabolic Crosstalk Between Tumor Cells and their Microenvironment |
Columbia Ballroom |
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* Sam McBrayer, UT Southwestern Medical Center
Session Chair |
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Shannon Mumenthaler, University of Southern California
Biomimetic Models to Study Tumor Metabolism in Context |
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M. Celeste Simon, University of Pennsylvania
Effects of Hypoxia on Cancer Metabolism |
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Sara Zanivan, MD Anderson Cancer Center
Cell Metabolism in the TME: Sculpting Antitumor Immunity |
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Pankaj Singh, University of Oklahoma Health Science Center, Stephenson Cancer Center
Short Talk: Lipophagy-Dependent Fatty Acid Oxidation is a Metabolic Vulnerability for KRAS Signaling Inhibition in Pancreatic Cancer |
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Paolo Ceppi, University of Southern Denmark
Short Talk: Contact-Dependent Thymidylate Transfer as a Mechanism of Collective Tumor Growth |
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Swagata Goswami, Massachusetts Institute of Technology
Short Talk: Ceramides Drive Colorectal Cancer Metastasis Through a Revival Stemness Program |
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Manas Kohli, Institute of Cancer Research
Short Talk: A Pan-Cancer Atlas of Tumour Metabolism Through Flux Balance Analysis |
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| 9:00–9:20 AM |
Coffee Break |
British/Columbia Foyer |
| 9:20–9:25 AM |
Award Recipient Acknowledgement |
Columbia Ballroom |
| 11:00–12:00 PM |
Lunch |
British Ballroom |
| 12:00–2:30 PM |
Poster Session |
British Ballroom |
| 3:00–4:30 PM |
Career Roundtable |
Columbia Ballroom |
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Katherine Aird, University of Pittsburgh School of Medicine
Associate Professor |
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Alejandro Gutierrez, St. Jude Children's Research Hospital
Principal Investigator, Member |
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Jintan Liu, Merck
Associate Principal Scientist |
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Alfredo Gimenez-Cassina, Nature Metabolism
Senior Editor |
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| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–7:00 PM |
Immune Microenvironment and Metabolism |
Columbia Ballroom |
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* Julie-Aurore Losman, Dana-Farber Cancer Institute
Session Chair |
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Costas A. Lyssiotis, University of Michigan
Targeting Lipid Metabolism in Pancreatic Cancer |
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Stacey D Finley, University of Southern California
Systems Biology Modeling of Metabolic Interactions in the Tumor Microenvironment |
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Deanna N. Edwards, Vanderbilt University Medical Center
Short Talk: Transendothelial Delivery of Long Chain Fatty Acids during Metastatic Outgrowth Suppresses Anti-tumor Immunity |
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Michael S Dahabieh, Van Andel Institute
Short Talk: Unveiling NRF2-Mediated Crosstalk in Tumor Metabolism and Immunotherapy Resistance |
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| 7:00–8:00 PM |
On Own for Dinner |
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Wednesday, March 19, 2025
| 7:00–8:00 AM |
Breakfast |
British Ballroom |
| 8:00–11:00 AM |
Systemic Influences on Tumor Metabolism |
Columbia Ballroom |
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* Kathryn Lemberg, Johns Hopkins School of Medicine
Session Chair |
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* Shuang Liang, UT Southwestern Medical Center
Session Chair |
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Matthew G Vander Heiden, Massachusetts Institute of Technology
Diet and Tumor Metabolism |
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Sarah-Maria Fendt, VIB-KU Leuven
Metabolic Vulnerabilities of Metastatic Cancer Cells |
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Marcus D. Goncalves, NYU Langone
Cancer Cachexia |
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George Poulogiannis, Institute of Cancer Research
Short Talk: Dietary Omega-6/3 Fats and Aspirin Govern PI3Kα-Induced Oncogenicity |
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Sarah Cherkaoui, University Children's Hospital Zurich
Short Talk: Reprogramming Neuroblastoma by Diet-Enhanced Polyamine Depletion |
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Christian F Ruiz, Yale University
Short Talk: Dietary Fats Dictate Pancreatic Cancer Fate Via Phospholipid Saturation |
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Evan C Lien, Van Andel Institute
Short Talk: Lipid Availability Influences Ferroptosis Sensitivity in Cancer Cells by Regulating Polyunsaturated Fatty Acid Trafficking |
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| 9:00–9:20 AM |
Coffee Break |
British/Columbia Foyer |
| 11:00–1:30 PM |
On Own for Lunch |
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| 1:30–3:15 PM |
Symposia Spotlight 2: Understanding how Environment (Local and Systemic) Impacts Tumorigenesis |
Columbia Ballroom |
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* Brandon Faubert, University of Chicago
Session Chair |
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Genevieve Deblois, University of Montreal
Mitochondrial Stress-Induced Metabolic Signaling Modulates Chromatin Accessibility to Support Adaptation in Breast Cancer |
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Milan R. Savani, University of Texas Southwestern Medical Center
Nitrogen Metabolism Profiling Reveals Mechanisms of Pyrimidine Synthesis Pathway Choice |
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Sonia Boscenco, Memorial Sloan Kettering Cancer Center
Mitochondrial Ribosomal RNA is the Target Of Functionally Dominant Hotspot Mutations in Cancer |
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Alphonse N Dimeck, Roswell Park Comprehensive Caner Center
Mitochondrial Metabolic Enzymes in Prostate Tumors Regulate the Immunosuppressive Tumor Microenvironment |
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Julien Guillard, University of Chicago
From Waste to Nutrient: Ammonia's Recycling by Fibroblasts to Sustain Collagen Production |
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Toshitha Kannan, University of Würzburg
Uncoupling of Tumor and Host Metabolism Induces Immune-Dependent Remission of PDAC |
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Won-Suk Song, University of California, Irvine
Polyunsaturated Fatty Acid Elongation as a Mechanism of Ferroptosis Evasion in Liver Cancer |
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| 3:30–4:30 PM |
Panel Discussion: Innovative Clinical Trial Strategies |
Columbia Ballroom |
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* Jonathan D. Powell, Calico Life Sciences
Panel Moderator |
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Chi V Dang, Ludwig Institute for Cancer Research
Panelist |
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Marianne Koritzinsky, University Health Network
Panelist |
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Marcus D. Goncalves, NYU Langone
Panelist |
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| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–6:15 PM |
Challenges in Targeting Cancer Metabolism: Lessons Learned |
Columbia Ballroom |
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* Jiyoung Lee, George Washington University
Session Chair |
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Chi V Dang, Ludwig Institute for Cancer Research
MYC and The Complexity of Targeting Cell Metabolism |
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Andrew M. Intlekofer, Memorial Sloan Kettering Cancer Center
Acquired resistance to IDH inhibition |
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Asael Roichman, Princeton University
Short Talk: Microbiome Metabolism of Dietary Phytochemicals Controls the Anticancer Activity of PI3K Inhibitors |
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| 6:15–6:30 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Columbia Ballroom |
| 6:30–7:30 PM |
Social Hour with Lite Bites |
British Ballroom |
| 7:30–8:30 PM |
Entertainment |
Columbia Ballroom |
