Tuberculosis: The Host-Pathogen Interface (C4)
March 24-27, 2024
| Keystone Resort, Keystone, CO, United States
Marcel A. Behr, Lalita Ramakrishnan and Kevin B. Urdahl
Scholarship Deadline: Dec. 19, 2023 | Abstract Deadline: Dec. 19, 2023 | Early Registration Deadline: Jan. 24, 2024
| 4:00–8:00 PM |
Arrival and Registration |
Longs Peak Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Longs Peak Foyer |
| 7:00–8:00 AM |
Breakfast |
Colorado Rockies Ballroom |
| 8:00–9:00 AM |
Welcome and Keynote Address |
Longs/Grays Peak |
| |
Lluis Quintana-Murci, Institut Pasteur, CNRS UMR2000 and Collège de France
Lessons from the Human Genome about Past and Present Epidemics |
|
| 9:00–12:15 PM |
Early Interactions I |
Longs/Grays Peak |
| |
Russell E. Vance, University of California, Berkeley
The Innate Immune Response to Mycobacterium Tuberculosis |
|
| |
Abiola F Ogunsola, University of Massachusetts Chan Medical School
Short Talk: Short Talk: A T-cell Independent Mechanism of BCG-mediated Protection to Tuberculosis in a Collaborative Cross Strain |
|
| |
Yogita Kapoor, CSIR-Centre for Cellular and Molecular Biology
Short Talk: Short Talk: Wag31, A Membrane Tether, is Crucial for Lipid Homeostasis in Mycobacteria |
|
| |
Rania Bouzeyen, UCSF
Short Talk: Short Talk: Antibody-mediated Immunity to Early M. Tuberculosis Infection in Mice Depends on NLRP3 Inflammasome Formation |
|
| |
Galit Alter, Moderna, Inc.
Antibodies and TB: Over-Looked but Under-Rated |
|
| |
Elisa Nemes, University of Cape Town
Host Blood Biomarkers for the Diagnosis, Prognosis and Treatment Response of Childhood Tuberculosis |
|
| |
Chetan Seshadri, University of Washington
Short Talk: Short Talk: T Cell Phenotypes in M. Tuberculosis ‘Resisters’ Correlate with Bacterial Control |
|
| |
Megan Proulx, University of Massachusetts Chan Medical School
Short Talk: Short Talk: Characterizing Non-canonical Immune Mechanisms in Genetically Diverse Mice |
|
| 10:15–10:35 AM |
Coffee Break |
Longs Peak Foyer |
| 12:15–1:00 PM |
Poster Setup |
Colorado Rockies Ballroom |
| 12:15–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Colorado Rockies Ballroom |
| 3:00–4:30 PM |
Career Roundtable |
Longs/Grays Peak |
| |
Gloria Marcela Rodriguez, Rutgers University
Associate Professor |
|
| |
Daniel L. Barber, NIAID, National Institutes of Health
Chief, T-Lymphocyte Biology Section |
|
| |
Elisa Nemes, University of Cape Town
Associate Professor/Principal Investigator |
|
| |
Alison Kraigsley, Bill and Melinda Gates Foundation
Program Officer, TB Vaccines |
|
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:15 PM |
Early Interactions II |
Longs/Grays Peak |
| |
Alissa C. Rothchild, University of Massachusetts Amherst
Alveolar Macrophages and the Initiation of Immunity |
|
| |
Kevin B. Urdahl, Seattle Children's Research Institute
Distinct Protective Roles for CD4 and CD8 T Cells in Vaccine-mediated Immunity against Tuberculosis |
|
| |
Chrissy M. Leopold Wager, Texas Biomedical Research Institute
Short Talk: Short Talk: Mycobacterium Tuberculosis Evades Host Defense by Activating Transcription Factor CREB in Human Macrophages |
|
| |
Prashant Bajpai, Emory University
Short Talk: Short Talk: Single Cell Transcriptomics of Lung Responses to Mycobacterium Tuberculosis in People Living with HIV Reveal Impaired TNF Signaling Networks |
|
| |
Todia Pediatama Setiabudiawan, Radboudumc
Short Talk: Short Talk: Immune Correlates of Early Clearance of Mycobacterium Tuberculosis among Tuberculosis Household Contacts in Indonesia |
|
| |
Sarah Schmidiger, Swiss Tropical and Public Health Institute
Short Talk: Short Talk: A Battlefield in the Spotlight: CyTOF Immune Profiling of Ex Vivo-Induced TB Granulomas |
|
| |
Alexander C. Schmidt, Gates Medical Research Institute
Short Talk: Short Talk: Safety and Efficacy of BCG Revaccination for the Prevention of Sustained Mycobacterium tuberculosis Infection |
|
| 7:15–8:15 PM |
Social Hour with Lite Bites |
Colorado Rockies Ballroom |
| 7:30–10:00 PM |
Poster Session 1 |
Colorado Rockies Ballroom |
| 7:00–8:00 AM |
Breakfast |
Colorado Rockies Ballroom |
| 8:00–10:15 AM |
Within-Granuloma Battle I |
Longs/Grays Peak |
| |
Gloria Marcela Rodriguez, Rutgers University
Nutritional Immunity of M. tuberculosis Infection |
|
| |
Michael Y. Gerner, University of Washington
Dissecting the Mechanisms Leading to Granuloma Formation and Structure |
|
| |
Clare M. Smith, Duke University
Host-Pathogen Interactions Underlie Distinct Infection Microenvironments |
|
| |
Edward A. Miao, Duke University
Short Talk: Short Talk: CCR2 is Essential to Assemble an Innate Granuloma that Eradicates Infection |
|
| |
Carl Feng, University of Sydney
Short Talk: Short Talk: Organization of Human Tuberculosis Granuloma at Single-cell Resolution |
|
| |
Sarah Monard, Institute of Pharmacology and Structural Biology
Short Talk: Short Talk: Identification of a Novel Nerve Cell Population in Lung Granulomas during Tuberculosis |
|
| 10:15–10:35 AM |
Coffee Break |
Longs Peak Foyer |
| 10:35–12:20 PM |
Autophagy Workshop |
Longs/Grays Peak |
| |
Antonio J. Pagan, University of Cambridge / Stanford University
Non-canonical Roles of Autophagy-related Proteins in Tuberculosis |
|
| |
Pooja Uchil, Ragon Institute of MGH, MIT and Harvard
Host Factors Engaged in the Repair of the Mtb Containing Phagosome Membrane |
|
| |
Ekansh Mittal, School of Medicine Washington University in St. Louis
Phthiocerol Dimycocerosate (PDIM) Promotes Growth of Mycobacterium Tuberculosis in vivo by Counteracting Autophagy |
|
| |
Yating Wang, Tsinghua University
Redefine the Role of Autophagy in Mycobacterium tuberculosis Infection |
|
| |
Bennett H. Penn, University of California, Davis
Ubiquitin Signaling Regulates the Macrophage Response to M. Tuberculosis |
|
| |
Weihao Zheng, UCSF
Mycobacterium Tuberculosis Resides in Lysosome-poor Monocyte-derived Lung Cells during Chronic Infection |
|
| 12:20–1:00 PM |
Poster Setup |
Colorado Rockies Ballroom |
| 12:20–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Colorado Rockies Ballroom |
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Within-Granuloma Battle II |
Longs/Grays Peak |
| |
Daniel L. Barber, NIAID, National Institutes of Health
Role of IFN? in the Structure and Function of Rhesus Macaque Tuberculomas |
|
| |
Igor B. Kramnik, Boston University
Short Talk: Short Talk: Macrophage Redox Reprogramming by Myc Fuels Iron-mediated Lipid Peroxidation, Type I Interferon Hyperactivity and Pulmonary TB Progression |
|
| |
Vivek V. Thacker, University of Heidelberg
Short Talk: Short Talk: Mechanopathology of Biofilm-like Mycobacterium Tuberculosis Cords |
|
| |
Lalita Ramakrishnan, University of Cambridge
Mechanisms of Granuloma Necrosis |
|
| |
Marta Lisete Santos da Silva, I3S
Short Talk: Short Talk: Timely Activation of the LXR Pathway is a Promising Host-Directed Therapy for Tuberculosis |
|
| |
Gowri Vishal Gupta Kolluru, IISc Bangalore
Short Talk: Short Talk: Three-dimensional (3D) Hydrogel Culture Systems to Study Host-pathogen Interaction and Drug Efficacy in Tuberculosis |
|
| |
Mark Hatherill, University of Cape Town
Short Talk: Short Talk: Efficacy of H56:IC31 Vaccine for Prevention of Recurrent Tuberculosis: A Randomized, Double-blind, Placebo-controlled Trial |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Colorado Rockies Ballroom |
| 7:30–10:00 PM |
Poster Session 2 |
Colorado Rockies Ballroom |
Wednesday, March 27, 2024
| 7:00–8:00 AM |
Breakfast |
Colorado Rockies Ballroom |
| 8:00–10:15 AM |
Onward Spread: Transmissible Pathology |
Longs/Grays Peak |
| |
Marcel A. Behr, McGill University
Lineage Specific Virulence Factors and the Outcome of Infection |
|
| |
Emily B. Wong, Africa Health Research Institute
Subclinical TB and its Potential Role in Mtb Transmission in Rural KwaZulu-Natal |
|
| |
Michael Shiloh, University of Texas Southwestern Medical Center
Closing the Loop: Experimental Transmission of M. tuberculosis |
|
| |
Nicole Howard, Harvard T.H. Chan School of Public Health
Short Talk: Short Talk: Leveraging a Paired Analysis of Host and Pathogen Genomes to Identify Determinants of Human Tuberculosis |
|
| |
Vaishnavi Satish Kaipilyawar, Rutgers New Jersey Medical School
Short Talk: Short Talk: Immune Mechanisms Regulating Distinct Immunopathologies in High- and Low-Transmission Mycobacterium Tuberculosis Infections |
|
| |
William Bishai, Johns Hopkins School of Medicine
Short Talk: Short Talk: Female Protection from TB Disease Progression is Strongly Associated with Improved T Cell Immunity and Maturation of B Cell Follicles |
|
| 10:15–10:35 AM |
Coffee Break |
Longs Peak Foyer |
| 10:35–12:20 PM |
Workshop: Deadly Detour: TB Meningitis |
Longs/Grays Peak |
| |
Xavier S. Nassif, Institut Necker Enfants-Malades and Université Paris Cité
The Blood Brain Barrier and Bacterial Infections |
|
| |
Cressida Madigan, University of California, San Diego
How Mycboacteria Cross the Blood Brain Barrier |
|
| |
Guy Edward Thwaites, Oxford University Clinical Research Unit
New Insights into TBM Pathogenesis from Clinical Cohorts |
|
| |
Arjan van Laarhoven, Radboud University Medical Centre
Short Talk: Short Talk: Cerebrospinal Fluid Fatty Acid Metabolism and Tuberculous Meningitis Mortality |
|
| 12:20–5:00 PM |
On Own for Lunch |
|
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–6:00 PM |
Inflammation and Neutrophils: TB and Beyond |
Longs/Grays Peak |
| |
Andrew R. DiNardo, Baylor College of Medicine
Short Talk: Short Talk: Metabolic and Epigenetic Drivers of Persistent Inflammation Despite Successful Anti-Tuberculosis Therapy |
|
| |
Ananda Rankin, Washington University in St. Louis
Short Talk: Short Talk: Investigating How Mycobacterium Tuberculosis Promotes its Survival in Neutrophils |
|
| |
Krishna C. Chinta, The University of Alabama at Birmingham
Short Talk: Short Talk: Nutrient Availability and HO-1 Alter Neutrophil Bioenergetics and Immunometabolism During Mycobacterium Tuberculosis Infection |
|
| |
Elizabeth Gold, Seattle Children's Research Institute
Short Talk: Short Talk: APOE Protects Against Severe Infection with Mycobacterium Tuberculosis by Restraining Production of Neutrophil Extracellular Traps |
|
| 6:00–6:45 PM |
Closing Keynote Address |
Longs/Grays Peak |
| |
Paul Kubes, University of Calgary
Intravital Imaging of Pulmonary Infections |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Longs/Grays Peak |
| 7:00–8:30 PM |
Social Hour with Lite Bites |
Colorado Rockies Ballroom |
| 7:15–10:00 PM |
Poster Session 3 |
Colorado Rockies Ballroom |
