Tuberculosis: Understanding the Disease Across Scales (C4)
March 23-26, 2026  | Southern Sun Cape Sun, Cape Town, WC, South Africa
Maximiliano Gutierrez, Digby F. Warner, Bree B Aldridge and Margarida Saraiva
Scholarship Deadline: Nov. 25, 2025 | Abstract Deadline: Mar. 3, 2026 | Early Registration Deadline: Jan. 23, 2026
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 4 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Monday, March 23, 2026
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Tuesday, March 24, 2026
7:30–8:30 AM Breakfast
8:00–8:30 AM Poster Setup
8:00–5:00 PM Poster Viewing
8:30–9:30 AM Welcome and Keynote Address
  Valerie Mizrahi, University of Cape Town
Physiology of Mtb and Drug Discovery
 
9:30–11:45 AM Tuberculosis Genetics Across Scales
  Jeremy Rock, Rockefeller University
Mtb Genetics and Biology
 
  Stephanie Boisson-Dupuis, The Rockefeller University
Human Genetic and Immunologic Determinants of Tuberculosis
 
  Maha Farhat, Massachusetts General Hospital
Genotypes and Phenotypes in TB
 
  Short Talk(s) Chosen from Abstracts
 
10:00–10:20 AM Coffee Break
11:45–12:45 PM Lunch
12:30–2:30 PM Poster Session 1
2:30–4:30 PM Symposia Spotlight 1: Human In vitro Models
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM Mtb Infection of Host Cells
  Maximiliano Gutierrez, Francis Crick Institute
Mtb Infection of Human Macrophages in Time and Space
 
  Trude Helen Flo, Norwegian University of Science and Technology
Host Cell Defense Against Mtb Infection
 
  Volker Briken, University of Maryland
Molecular Mechanisms of Mtb-Host Cell Interactions
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM On Own for Dinner
Wednesday, March 25, 2026
7:30–8:30 AM Breakfast
8:00–8:30 AM Poster Setup
8:00–5:00 PM Poster Viewing
8:30–11:30 AM Tuberculosis Disease Across Populations
  Digby F. Warner, University of Cape Town
Tuberculosis Aerobiology
 
  Hanif Esmail, University College London
Tuberculosis Across the Disease Spectrum
 
  Adrie J Steyn, Africa Health Research Institute & UAB
Tuberculosis Infection in Tissues
 
  Jayne S Sutherland, MRC Unit The Gambia at LSHTM
Identification of Protective Immunity in Mtb-Exposed Household Contacts from The Gambia
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:30–12:30 PM Lunch
12:30–2:30 PM Poster Session 2
1:45–2:45 PM Career Roundtable
3:00–4:30 PM Panel Discussion: TB Community, Engagement and Adherence
4:30–5:00 PM Coffee Available
5:00–7:00 PM Tuberculosis Models Across Scales
  Carl Feng, University of Sydney
Spatial Mapping of Granulomas
 
  Vivek V. Thacker, University of Heidelberg
Organ on Chip Models of Tuberculosis
 
  Alissa C Rothchild, University of Massachusetts Amherst
Innate Immune Responses to Mtb in the Lung
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM On Own for Dinner
Thursday, March 26, 2026
7:30–8:30 AM Breakfast
8:30–11:30 AM Imaging Mtb Physiology
  Bree B Aldridge, Tufts University
Single-Cell Growth Behaviors of Mtb
 
  Giulia Manina, Institut Pasteur
Microbial Individuality during Infection
 
  Amit Singh, Indian Institute of Science
Mycobacterial Persistence and Drug Tolerance
 
  Mireille Kamariza, University of California, Los Angeles
Visualising the Mtb Cell Wall
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:30–12:30 PM Lunch
2:30–4:30 PM Symposia Spotlight 2: Imaging
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–6:45 PM Tuberculosis Immunology
  Margarida Saraiva, i3s
Regulation of the Immune Response by Diverse M. tuberculosis Isolates
 
  Katrin D Mayer-Barber, NIAID, National Institutes of Health
Cellular Mechanisms of Immunity in Tuberculosis
 
  Christina L Stallings, Washington University School of Medicine
Immunological Control of Mtb
 
  Short Talk(s) Chosen from Abstracts
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:00–8:00 PM On Own for Dinner
Friday, March 27, 2026
12:00–11:59 PM Departure