Integrative Mitochondrial Medicine (C4)
March 21-24, 2027
| Fairmont Banff Springs, Banff, AB, Canada
Nils-Goran Larsson and Aleksandra Filipovska
Scholarship Deadline: Dec. 2, 2026 | Abstract Deadline: Mar. 2, 2027 | Early Registration Deadline: Jan. 20, 2027
| 4:00–8:00 PM |
Registration |
Van Horne Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Van Horne Foyer |
| 7:00–8:00 AM |
Breakfast |
Alberta/Cascade/Conservatory/New Brunswick |
| 8:00–8:10 AM |
Welcome Remarks |
Van Horne C |
| 8:10–9:00 AM |
Keynote Address |
Van Horne C |
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Vamsi K. Mootha, Massachusetts General Hospital
Treating Mitochondrial Dysfunction by Metabolic Interventions |
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| 9:00–11:15 AM |
Mitochondrial Genome Editing |
Van Horne C |
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Wendy Shoop, Precision BioSciences - Durham, NC
Using Designer Meganucleases to Correct Pathogenic Heteroplasmic mtDNA Mutations |
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Min Jiang, Westlake University
Mouse Models with Gene Edited mtDNA Mutations |
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Carlos T Moraes, University of Miami
Repairing Pathogenic mtDNA Mutations with Gene Editing |
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Short Talk(s) Chosen from Abstracts
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| 9:30–9:50 AM |
Coffee Break |
Van Horne Foyer |
| 11:25–12:25 PM |
Meet the Editors |
Van Horne C |
| 12:25–1:00 PM |
Poster Setup |
Alberta/Cascade/Conservatory/New Brunswick |
| 12:25–2:30 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Alberta/Cascade/Conservatory/New Brunswick |
| 2:30–4:30 PM |
Symposia Spotlight 1: Hot Topics |
Van Horne C |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Mitochondrial Synthetic Biology |
Van Horne C |
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Oliver Rackham, Curtin University
Synthetic Biology Tools to Manipulate Organelle Biogenesis |
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Martin Fussenegger, ETH Zürich
Synthetic Biology Approaches to Regulate Metabolism |
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Aleksandra Filipovska, University of Western Australia
Engineering Mitochondria for Improved Energy Conversion Efficiency |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
Alberta/Cascade/Conservatory/New Brunswick |
| 7:30–10:00 PM |
Poster Session 1 |
Alberta/Cascade/Conservatory/New Brunswick |
| 7:00–8:00 AM |
Breakfast |
Alberta/Cascade/Conservatory/New Brunswick |
| 8:00–11:00 AM |
Mitochondrial Imaging in Disease |
Van Horne C |
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Danielle Grotjahn, Scripps Research Institute
Regulation of Mitochondrial Dynamics and Disease |
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Antentor O Hinton Jr., Vanderbilt University School of Medicine
FIB-SEM Approaches to Image Mitochondria in the Cell in situ |
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Gulcin Pekkurnaz, University of California, San Diego
Mitochondrial Specialization in the Nervous System |
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Elisa Motori, University of Cologne
Neuronal Metabolism in Mitochondrial Disease |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:10–12:10 PM |
Panel Discussion: Shark Tank Pitch Session for Commercialization |
Van Horne C |
| 12:10–1:00 PM |
Poster Setup |
Alberta/Cascade/Conservatory/New Brunswick |
| 12:10–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Alberta/Cascade/Conservatory/New Brunswick |
| 3:00–4:30 PM |
Career Roundtable |
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| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Precision Medicine for Mitochondrial Dysfunction |
Van Horne C |
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Claes Gustafsson, University of Gothenburg
Mechanism-Guided Therapeutic Strategies for Mitochondrial mtDNA Depletion Disorders |
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Thomas Keating, Pretzel Therapeutics
Targeting Mitochondrial DNA Replication to Treat Diseases of mtDNA Depletion |
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Michio Hirano, Columbia University Medical Center
Therapeutic Correction of Unbalanced Mitochondrial dNTP Pools |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
Alberta/Cascade/Conservatory/New Brunswick |
| 7:30–10:00 PM |
Poster Session 2 |
Alberta/Cascade/Conservatory/New Brunswick |
Wednesday, March 24, 2027
| 7:00–8:00 AM |
Breakfast |
Alberta/Cascade/Conservatory/New Brunswick |
| 8:00–11:00 AM |
Metabolic Networks |
Van Horne C |
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Christian Frezza, University of Cologne
Metabolites Controlling Mitochondrial Function |
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Nils-Goran Larsson, Karolinska Institutet
The Link between mtDNA Gene Expression and Metabolic Disease |
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Natalie Niemi, Washington University in St. Louis
Regulation of Mitochondrial Metabolism |
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Jared Rutter, University of Utah
Mitochondria and Metabolic Signaling |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–2:30 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Symposia Spotlight 2: New Technologies |
Van Horne C |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Transplantation of Mitochondria |
Van Horne C |
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Robert McFarland, University of Newcastle
Use of Mitochondrial Donation to Prevent Transmission of Mitochondrial Disease |
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Janine Santos, NIEHS, National Institutes of Health
Antiretrovirals and the Postpartum Heart: Mitochondrial Drivers of Cardiac Reverse Remodeling |
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Heidi M. McBride, McGill University
Mitochondrial Signaling and Interorganellar Communication Pathways |
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Short Talk(s) Chosen from Abstracts
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Van Horne C |
| 7:00–8:00 PM |
Social Hour with Dinner |
Alberta/Cascade/Conservatory/New Brunswick |
| 8:00–11:00 PM |
Entertainment |
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