Computational Design and Modeling of Biomolecules (C5)
March 29-April 1, 2027 | La Fonda on the Plaza, Santa Fe, NM, United States
Nicholas F. Polizzi, Torben Schiffner and Amy E. Keating
Scholarship Deadline: Dec. 4, 2026 | Abstract Deadline: Mar. 9, 2027 | Early Registration Deadline: Jan. 29, 2027
| 4:00–8:00 PM |
Registration |
Mezzanine |
| 6:00–8:00 PM |
Welcome Mixer |
La Terraza & Garden Terrace |
| 7:00–8:00 AM |
Breakfast |
La Terraza & Garden Terrace |
| 7:30–8:00 AM |
Poster Setup |
New Mexico & Portal |
| 7:45–5:00 PM |
Poster Viewing |
New Mexico & Portal |
| 8:00–8:10 AM |
Welcome Remarks |
Lumpkins Ballroom |
| 8:10–9:00 AM |
Keynote Address |
Lumpkins Ballroom |
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Tanja Kortemme, University of California, San Francisco
AI-Guided Design of Programmable Protein Dynamics and Cellular Behaviors |
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| 9:00–11:15 AM |
Binders, Boltz, and Beyond |
Lumpkins Ballroom |
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Amy E. Keating, Massachusetts Institute of Technology
Predicting and Designing Protein–Peptide Interaction Specificity with Computational Models |
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Antonia Mey †, University of Edinburgh
Talk Title to be Announced |
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Gabriele Corso, Boltz
Boltz: Towards Accurate Biomolecular Modeling and Design |
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Short Talk(s) Chosen from Abstracts
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| 9:30–9:50 AM |
Coffee Break |
Mezzanine |
| 11:25–12:25 PM |
Panel Discussion: How to Write Papers for Biology & Comp Sci Audiences |
Lumpkins Ballroom |
| 12:25–1:25 PM |
Lunch |
La Terraza & Garden Terrace |
| 12:30–2:30 PM |
Poster Session 1 |
New Mexico & Portal |
| 2:30–4:30 PM |
Symposia Spotlight 1: Methods and Applications for Design of Complex Function |
Lumpkins Ballroom |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
Mezzanine |
| 5:00–7:00 PM |
An Ensemble Cast: A Protein in Many Acts |
Lumpkins Ballroom |
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Frank DiMaio, University of Washington
Modeling Conformational Ensembles |
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Nicholas F. Polizzi, Dana-Farber Cancer Institute
De novo Design of a Single-Chain Small-Molecule Biosensor |
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Anum Glasgow, Columbia University
Rewiring Allosteric Signaling in Cellular Proteins Using Rational and ML-Driven Approaches |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
On Own for Dinner |
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Wednesday, March 31, 2027
| 7:00–8:00 AM |
Breakfast |
La Terraza & Garden Terrace |
| 7:30–8:00 AM |
Poster Setup |
New Mexico & Portal |
| 7:45–5:00 PM |
Poster Viewing |
New Mexico & Portal |
| 8:00–11:00 AM |
Data, Robots, and Models (O My) |
Lumpkins Ballroom |
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Philip Romero, Duke University
Closed-Loop Protein Engineering: Integrating Robotics, ML, and Massive Sequence–Function Maps |
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Huimin Zhao, University of Illinois at Urbana-Champaign
Scaling Up the Biofoundry: High-Throughput Genetic and Enzymatic Function Discovery with AI in the Loop |
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Polly Fordyce, Stanford University
Evolutionary-Scale Enzymology Enables Exploration of a Rugged Catalytic Landscape |
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Chris Bahl, AI Proteins, Inc.
de novo Design of Miniprotein Therapeutics |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
Mezzanine |
| 9:20–9:25 AM |
Award Recipient Acknowledgement |
Lumpkins Ballroom |
| 11:00–12:00 PM |
Lunch |
La Terraza & Garden Terrace |
| 12:30–2:30 PM |
Poster Session 2 |
New Mexico & Portal |
| 3:00–4:30 PM |
Career Roundtable |
Lumpkins Ballroom |
| 4:30–5:00 PM |
Coffee Available |
Mezzanine |
| 5:00–7:00 PM |
Active Sites and Ambitions: Designer Enzymes |
Lumpkins Ballroom |
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Brian Kuhlman, University of North Carolina at Chapel Hill
De novo Protein Design with Multi-Objective Fitness Functions |
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Alena Khmelinskaia, Ludwig-Maximilians-Universität München
Designed to Assemble—and to Know When |
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Ali Madani, Profluent Bio
Design of Functional Gene Editors using PLMs |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
On Own for Dinner |
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| 7:00–8:00 AM |
Breakfast |
La Terraza & Garden Terrace |
| 8:00–11:00 AM |
Into the Wild Type: Designed Proteins Meet Biology |
Lumpkins Ballroom |
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Neil P King, University of Washington
From Nanoparticles to Immunogens: Designing Functional Protein Assemblies for Biological Applications |
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Torben Schiffner, The Wistar Institute
Programmable Protein Scaffolds for Targeted Immune Modulation and Viral Neutralization |
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Glenna Foight, Baylor College of Medicine
Dynamic Transcription Factors and Designer Proteins for Controlling Immune Cell Fate |
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Dek Woolfson, University of Bristol, and Center for Protein Design, University of Copenhagen
Integrating Rational and Computational Protein Design for Applications in Cell Biology |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
Mezzanine |
| 11:10–12:10 PM |
Workshop: Hands-On Code Tutorial: Fine-Tuning Models / RL |
Lumpkins Ballroom |
| 12:10–1:10 PM |
Lunch |
La Terraza & Garden Terrace |
| 2:30–4:30 PM |
Symposia Spotlight 2 |
Lumpkins Ballroom |
| |
Short Talks Chosen from Abstracts
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|
| 4:30–5:00 PM |
Coffee Available |
Mezzanine |
| 5:00–6:45 PM |
Weight, Weight, Don't Tell Me: Emerging Methods in Machine Learning |
Lumpkins Ballroom |
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Olexandr Isayev, Carnegie Mellon University
AI Models for Chemistry at the Protein Interface: Learned Potentials for Reactivity and Binding |
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Jennifer Listgarten, University of California, Berkeley
ProteinGuide: On-the-Fly Property Guidance for Protein Sequence Generative Models |
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Emine Kucukbenli, Nvidia Corporation
Atomistic Modelling at the Speed of Light |
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Short Talk(s) Chosen from Abstracts
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions |
Lumpkins Ballroom |
| 7:00–8:00 PM |
On Own for Dinner |
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