Cancer Epigenetics: Emerging Concepts to Therapeutic Innovation (C6)
March 27-30, 2028
| Examination Schools, University of Oxford, Oxford, United Kingdom
Yang Shi, Mark A. Dawson and Yael David
| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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| 8:00–8:30 AM |
Poster Setup |
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| 8:15–5:00 PM |
Poster Viewing |
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| 8:30–8:40 AM |
Welcome Remarks |
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| 8:40–9:30 AM |
Keynote Address |
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Aviv Regev †, Genentech
AI-Driven Models of Cellular and Epigenetic States |
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| 9:30–11:45 AM |
Epigenetic Therapeutics and Drug Discovery |
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Mark A. Dawson, Roche
Targeting Chromatin Regulators in Cancer |
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François Fuks †, University of Brussels
DNA/RNA Modification Crosstalk and Impacts on Gene Expression |
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Hugh Y. Rienhoff †, Aluco BioSciences
Treatment of Essential Thrombocythemia by Targeting the Histone Demethylase LSD1 |
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Short Talk(s) Chosen from Abstracts
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| 10:00–10:20 AM |
Coffee Break |
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| 2:30–4:30 PM |
Symposia Spotlight 1 |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Epigenetic Drivers of Cancer Evolution |
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Richard White †, Ludwig Institute for Cancer Research, Oxford
Mechanisms of Location-Specific Tumors |
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Johanna A. Joyce †, University of Lausanne
Tumor Microenvironment and Epigenetic Plasticity |
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Scott W. Lowe †, Memorial Sloan Kettering Cancer Center
Cell-State Transitions and Cancer Evolution Driven by Epigenetic Changes |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
On Own for Dinner |
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Wednesday, March 29, 2028
| 8:00–8:30 AM |
Poster Setup |
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| 8:15–5:00 PM |
Poster Viewing |
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| 8:30–11:30 AM |
Mechanisms of Chromatin Regulation |
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Karen Adelman †, Harvard Medical School
Transcriptional Regulation and RNA Polymerase Control |
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Shelley L Berger †, University of Pennsylvania
Chromatin Dynamics, Metabolism, and Cancer |
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Ali Shilatifard †, Northwestern University
Histone Modifications and Transcriptional Control |
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Short Talk(s) Chosen from Abstracts
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| 9:30–9:50 AM |
Coffee Break |
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| 3:00–4:30 PM |
Career Roundtable |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Chromatin Chemistry and New Frontiers in Therapeutics |
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Yael David, Memorial Sloan Kettering Cancer Center
Chromatin Chemistry and Metabolic Regulation of Epigenetics |
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Cigall Kadoch †, Dana-Farber Cancer Institute, Harvard Medical School
Chromatin Remodeling Complexes as Therapeutic Targets |
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Robert J. Sims †, Flare Therapeutics
Txn Factor Targeting |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
On Own for Dinner |
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| 8:30–11:30 AM |
Genome Organization and Cell State Control |
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Yang Shi, Ludwig Institute for Cancer Research, Oxford Branch
Epigenetic Regulation of Cell Fate and Identity |
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Effie Apostolou †, Weill Cornell Medical College
Epigenetic Inheritance and Mitotic Bookmarking of Cell Identity |
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Lori Friedman †, ORIC Pharmaceuticals
Targeting Epigenetic Plasticity in Cancer |
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Short Talk(s) Chosen from Abstracts
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| 9:30–9:50 AM |
Coffee Break |
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| 11:40–12:40 PM |
Panel Discussion: AI and the Future of Cancer Epigenetics |
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| 2:30–4:30 PM |
Symposia Spotlight 2 |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:45 PM |
AI, Predictive Epigenomics, and Functional Modeling |
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Trey Ideker †, University of California, San Diego and University of Oxford
Predictive Network Modeling and Computational Epigenomics |
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Benjamin F. Cravatt III †, The Scripps Research Institute
Chemical Proteomics for Chromatin and Signaling Pathways |
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Ronald A. DePinho †, University of Texas MD Anderson Cancer Center
Epigenetic Mechanisms of Tumor Progression and Aging |
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Short Talk(s) Chosen from Abstracts
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| 6:30–7:15 PM |
Closing Keynote Address |
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Dana Pe'er †, Memorial Sloan Kettering Cancer Center
AI-Enabled Single-Cell Analysis for Cancer Biology and Precision Therapeutics |
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| 7:15–7:30 PM |
Meeting Wrap-Up: Outcomes and Future Directions |
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| 7:30–8:30 PM |
On Own for Dinner |
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