Myeloid Targeting Strategies for Cancer Treatment (C7)
May 6-9, 2024  | INEC Killarney Convention Centre, Killarney, KY, Ireland
Miriam Merad and Matthew F. Krummel
Scholarship Deadline: Jan. 31, 2024 | Abstract Deadline: Jan. 31, 2024 | Early Registration Deadline: Mar. 6, 2024
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 8 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Monday, May 6, 2024
4:00–8:00 PM Arrival and Registration INEC Foyer
6:00–8:00 PM Welcome Mixer INEC Foyer
Tuesday, May 7, 2024
7:00–8:00 AM Breakfast Individual Hotel
8:00–9:00 AM Welcome and Keynote Address INEC Main Auditorium
  * Miriam Merad, Mount Sinai School of Medicine
Session Chair
 
  * Matthew F. Krummel, University of California, San Francisco
Session Chair
 
  Martin Guilliams, Ghent University - VIB
DC and Macrophage Diversity in Health and Diseases
 
9:00–11:15 AM Developmental Regulation of Myeloid Cells in Cancer and Beyond INEC Main Auditorium
  Miriam Merad, Mount Sinai School of Medicine
Enhancing DC Function in the TME
 
  * Christine Carine Moussion, Genentech, Inc.
Spatial Organization of Myeloid Programs in the TME
 
  Merav Cohen, Tel-Aviv University
Myeloid Cellular Cross-Talks During Cancer Development
 
  Robert Samstein, Icahn School of Medicine at Mount Sinai
Short Talk: Short Talk: HLA Class II Mediated Immune Surveillance of Lung Cancer
 
9:30–9:50 AM Coffee Break INEC Foyer
11:15–1:00 PM Poster Setup INEC Foyer
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing INEC Foyer
3:30–4:30 PM Career Roundtable INEC Main Auditorium
  Judith A. Varner, University of California, San Diego
Professor, Pathology
 
  Venkataraman Sriram, Foundery Innovations
Founder, Managing Member, & Chief Scientific Officer
 
  Matteo Iannacone, San Raffaele Scientific Institute & University
Group Leader
 
4:30–5:00 PM Coffee Available INEC Foyer
5:00–7:00 PM Enhancing DC Functionality in the TME INEC Main Auditorium
  * Matthew F. Krummel, University of California, San Francisco
Session Chair
 
  * Miriam Merad, Mount Sinai School of Medicine
Session Chair
 
  Rony Dahan, Weizmann Institute of Science
Antibody Targeting of Dendritic Cells in Cancer
 
  Ruth Lan, Asher Biotherapeutics
Cell-Specific Cytokine Delivery
 
  Livia Lacerda Mariano, Institute Curie
Short Talk: Short Talk: The TRPML1 Calcium Lysosomal Channel Controls Dendritic Cell Migration and Anti-tumor Immunity
 
  Raphael Mattiuz, Icahn School of Medicine at Mount Sinai
Short Talk: Short Talk: Dendritic Cells Form and Maintain Tertiary Lymphoid Structures (TLSs) in Cancer Contributing to Immunotherapeutic Responses
 
7:00–8:00 PM Social Hour with Lite Bites INEC Foyer
7:30–10:00 PM Poster Session 1 INEC Foyer
Wednesday, May 8, 2024
7:00–8:00 AM Breakfast Individual Hotel
8:00–11:00 AM Boosting Macrophage Tumorigenic Function INEC Main Auditorium
  * Julie Helft, Institut Cochin
FOLR2+ Macs and Antitumor Immunity
 
  Jennifer Guerriero, Brigham and Women's Hospital
Metabolic Targeting of Tumor Macrophages
 
  * Philippe Benaroch, INSERM Institut Curie
Myeloid Cell Engineering for Anti-Tumor Treatments
 
  Ido Amit, Weizmann Institute
Mapping Macrophages Inflammatory Programs
 
  Florent Ginhoux, Singapore Immunology Network
Regulation of Monocyte-Derived Cells Differentiation in Inflamed Tissues
 
  Meijun Wang, City University of Hong Kong (Shenzhen) Research Institute
Short Talk: Short Talk: Investigate the Role of IRF5 in Macrophages and Myeloid Cells in Anti-Tumor Immunity
 
  Lea Feldmann, Institut Pasteur
Short Talk: Short Talk: Understanding the Antitumoral Activity of CAR-Macrophages
 
9:00–9:20 AM Coffee Break INEC Foyer
11:00–1:00 PM Poster Setup INEC Foyer
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing INEC Foyer
2:30–4:30 PM Workshop INEC Main Auditorium
  Dalton Hermans, National Institutes of Health
ACT-VAX-INNATE: An Integrated Approach for Enhancing Tumor Control with Adoptive T Cell Therapy
 
  * Alexander B. Sigalov, SignaBlok, Inc.
Ligand-Independent TREM-1 Blockade in Cancer Treatment
 
  Thomas Jaquin, IOmx Therapeutics AG
IOMX-0675 , a LILRB1 and LILRB2 Cross-Specific Antibody, Effectively Repolarizes Immunosuppressive Myeloid Cells and Activates T Cells Leading to Potent Tumor Cell Killing
 
  Martina Molgora, Washington University School of Medicine
Lack of TREM2 During anti-PD1 Therapy Reprograms Intestinal Macrophages and Microbiota to Enhance Tumor Rejection
 
  Daniela C Cerezo-Wallis, Yale University
Cancer Enables Auxiliary Pathways of Granulopoiesis to Potentiate Tumorassociated Neutrophils
 
  * Damya Laoui, Vrije Universiteit Brussel-VIB
Intratumoral Delivery of Lipid Nanoparticle-Formulated mRNA Encoding IL-21, IL-7, and 4-1BBL Induces Anti-Tumor Immunity
 
  Cristina Contreras Burrola, National Cancer Institute
Going the Distance: Uncovering a Global Myeloid Reprogramming in Human Metastatic and Adjacent Microenvironments
 
  Garett Dunsmore, University of Paris Saclay
Timing and Location Dictate Monocyte Fate and Their Transition to Tumor-Associated Macrophages
 
4:30–5:00 PM Coffee Available INEC Foyer
5:00–7:00 PM Dampening Myeloid Regulatory Programs INEC Main Auditorium
  * Martin Guilliams, Ghent University - VIB
Session Chair
 
  Venkataraman Sriram, Foundery Innovations
Targeting Trem2 in Cancer Patients
 
  * Judith A. Varner, University of California, San Diego
Targeting Immunosupressive Macrophages
 
  Megan Clark, UPenn
Short Talk: Short Talk: Mitochondrial NDUFA4 is a Functional Switch Controlling TAM Function and Tumor Immunity
 
  Nicoletta Caronni, Ospedale San Raffaele
Short Talk: Short Talk: IL-1β+ Macrophages Fuel Pathogenic Inflammation in Pancreatic Cancer
 
  Matthew Arvedson, UCSF
Short Talk: Short Talk: Aire-Expressing Tumor-Associated Macrophages Promote Cancer Immune Evasion
 
  Samarth Hegde, Icahn School of Medicine at Mount Sinai
Short Talk: Short Talk: Epigenetic Dysregulation of Myeloid Progenitors Fuel Immunosuppressive Macrophages in Tumor Microenvironment
 
7:00–8:00 PM Social Hour with Lite Bites INEC Foyer
7:30–10:00 PM Poster Session 2 INEC Foyer
Thursday, May 9, 2024
7:00–8:00 AM Breakfast Individual Hotel
8:00–11:00 AM Myeloid Cell Control of the Tissue Ecosystem INEC Main Auditorium
  * Matthew F. Krummel, University of California, San Francisco
Space-Time 'Movements' in Tissues
 
  * Laurence Zitvogel, Institut Gustave Roussy
Bile Acids Module the Gut Immune Rheostat Tuning Cancer Immunosurveillance
 
  Luke A. J. O'Neill, Trinity Biomedical Sciences Institute
A Break in Mitochondrial Endosymbiosis as a Basis for Inflammatory Diseases
 
  Jo A. Van Ginderachter, Vrije Universiteit Brussel
Short Talk: Short Talk: Kupffer Cell-Derived MIF as Regulator of Liver Metastasis
 
  Ayumi Kuratani, Osaka University
Short Talk: Short Talk: Identification of a Tumor-Specific Macrophage Subset and its Functional Analysis by Labeling and Depletion Using the Novel VeDTR Mouse System
 
9:00–9:20 AM Coffee Break INEC Foyer
11:00–5:00 PM On Own for Lunch
4:30–5:00 PM Coffee Available INEC Foyer
5:00–6:45 PM Myeloid Cells in Viral and Inflammatory Diseases INEC Main Auditorium
  * Matteo Iannacone, San Raffaele Scientific Institute & University
Targeting Myeloid Cells in Viral Diseases
 
  * Carla V. Rothlin, Yale University
Myeloid and Stromal Crosstalk in Non-Resolving Inflammation
 
  Duale A Ahmed, Carleton University
Short Talk: Short Talk: Vaccinia-Induced Early Anti-Tumour Immune Responses Are Dependent on Differential Reprogramming of Myeloid Cell Populations in Highly Versus Weakly Immunogenic Murine Cancer Models
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) INEC Main Auditorium
7:00–8:00 PM Social Hour with Lite Bites INEC Foyer
8:00–9:00 PM Cash Bar INEC Foyer
Friday, May 10, 2024
7:00–11:59 PM Departure