Lipids in Cellular Function and Disease (D1)
April 6-9, 2025  | Beaver Run Conference Center, Breckenridge, CO, United States
Valerie B. O'Donnell, Junken Aoki and Vytas A. Bankaitis
Scholarship Deadline: Jan. 29, 2025 | Abstract Deadline: Mar. 21, 2025 | Early Registration Deadline: Feb. 26, 2025
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 4 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Sunday, April 6, 2025
4:00–6:00 PM Workshop on Networking & Communication Skills for Early-Career Scientists Peaks 4-5
4:00–8:00 PM Registration Colorado Ballroom Foyer
6:00–8:00 PM Welcome Mixer Colorado Ballroom Foyer
Monday, April 7, 2025
7:00–8:00 AM Breakfast Summit Gallery
8:00–9:00 AM Welcome and Keynote Address Peaks 4 - 5
  * Valerie B. O'Donnell, Cardiff University
 
  * Junken Aoki, University of Tokyo
 
  Marcus Conrad, Helmholtz Zentrum München
Role of Lipids in Driving Ferroptosis in Mitochondria
 
9:00–11:15 AM Organelle Stress and Ferroptosis in Health and Diseases Peaks 4 - 5
  * L. A Cowart, Virginia Commonwealth University
Session Chair
 
  Karen Reue, University of California, Los Angeles
Identification of Genes that Control Lipid Metabolism
 
  Guillaume Thibault, Nanyang Technological University
Lipid Bilayer Stress-Induced Unfolded Protein Response in Aging
 
  James A Olzmann, University of California, Berkeley
At The Intersection of Lipid Droplets and Ferroptosis
 
  Cyrus Nikain, Memorial Sloan Kettering Cancer Center, New York
Short Talk: IFITM3 Regulates Ferroptosis Through Membrane Remodeling
 
9:30–9:50 AM Coffee Break Colorado Ballroom Foyer
11:15–1:00 PM Poster Setup Peaks 1 - 3
11:15–2:30 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Peaks 1 - 3
2:30–4:30 PM LIPID MAPS/ILS Workshop Peaks 4 - 5
  Kim Ekroos, Lipidomics Consulting Ltd.
 
  Gerhard Liebisch, University of Regensburg
 
  Matthew Conroy, Cardiff University
 
  Dominik Kopczynski, University of Vienna
 
4:30–5:00 PM Coffee Available Colorado Ballroom Foyer
5:00–7:00 PM Lipids in Metabolic Disease Peaks 4 - 5
  * Valerie B. O'Donnell, Cardiff University
Session Chair
 
  * Michael H. Gelb, University of Washington
Session Chair
 
  Judith A. Simcox, University of Wisconsin - Madison
Regulation of Energy Expenditure by Plasma Lipid Signaling
 
  Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center
Cholesterol Metabolism
 
  L. A Cowart, Virginia Commonwealth University
Diversity of Structures and Roles of Atypical Sphingolipids
 
  Mehdi Damaghi, Stony Brook University
Short Talk: Sphingolipids Metabolic Plasticity Defines Cancer Cell Fitness in Adaptation to Acidic Tumor Microenvironments
 
  Robert Ahrends, University of Vienna
Short Talk: Critical Shifts In Lipid Metabolism Promote Megakaryocyte Differentiation And Proplatelet Formation
 
7:00–8:00 PM Social Hour with Lite Bites Peaks 1 - 3
7:30–10:00 PM Poster Session 1 Peaks 1 - 3
Tuesday, April 8, 2025
7:00–8:00 AM Breakfast Summit Gallery
8:00–11:00 AM Role of Lipids in Organisms and Metabolic Disease Peaks 4 - 5
  * Karen Reue, University of California, Los Angeles
Session Chair
 
  * Judith A. Simcox, University of Wisconsin - Madison
Session Chair
 
  Dominic Campopiano, University of Edinburgh
Remote Presentation: Novel Sphingolipids Generated by Bacteria
 
  Michael H. Gelb, University of Washington
Mass Spectrometry-Based Expansion of Newborn Screening
 
  Edward A Dennis, University of California, San Diego
Specificity of Lipid Enzymes in Cellular Function and Metabolic Disease
 
  Yarden Ariav, Weizmann Institute of Science
Short Talk: Elevating cGMP Levels Through PDE5A Inhibition Restricts Cancer Metastasis By Impeding NPC1-Mediated Cholesterol Trafficking
 
  Eugene Koo, University of Texas Southwestern Medical Center
Short Talk: Bacterial Lipopolysaccharide Stimulates Long Chain Fatty Acid Uptake in The Small Intestine
 
  Josie Daldegan Rezende, University of Maryland, Baltimore
Short Talk: Correlation Of Hepatoxicity Markers And Sphingolipid Enzymatic Activity To Sphingolipid Structure And Abundance
 
  Xiaoman Liu, The Broad Institute of MIT and Harvard
Short Talk: Abnormal Lipid Metabolism and Altered Neuronal Support by Astrocytes Lacking Akap11, a Risk Gene for Schizophrenia and Bipolar Disorder
 
9:00–9:20 AM Coffee Break Colorado Ballroom Foyer
9:20–9:25 AM Award Recipient Acknowledgement Peaks 4 - 5
11:00–1:00 PM Poster Setup Peaks 1 - 3
11:00–3:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Peaks 1 - 3
1:30–2:30 PM Career Roundtable Peaks 4 - 5
  Judith A. Simcox, University of Wisconsin - Madison
Assistant Professor
 
  Robert Ahrends, University of Vienna
Professor
 
  Camille M Konopnicki, Korro Bio
Principal Scientist
 
3:00–4:30 PM Intersections between Lipid Metabolism and Ferroptosis Peaks 4 - 5
  * Ginger L. Milne, Vanderbilt University Medical Center
Session Chair
 
  * Marcus Conrad, Helmholtz Zentrum München
Session Chair
 
  Daniela Costa, Cardiff University
Platelet-Derived Enzymatically Oxidized Phospholipids Link Coagulopathies To Systemic Inflammation In Thromboembolic Disease
 
  Javier Garcia-Bermudez, University of Texas Southwestern Medical Center
Dissecting The Roles Of Lipid Uptake In Tumors
 
  Justine Mucinski, AdventHealth
Effects of 24 months of calorie restriction on circulating ceramides and associated sphingolipids in healthy adults
 
  Michele R Plewes, University of Nebraska Medical Center
Dysregulated Lipid Metabolism and SREBP1/2 Signaling Contribute to Granulosa Cell Dysfunction and Impaired Ovarian Response
 
  Sri Ramya Donepudi, University of Pittsburgh
Investigating The Role Of Epoxyeicosatrienoic Acids In Allergic Asthma: Sex Differences And The Effect Of Seh Inhibitor On Lung Function In Females And Males
 
  Ke Shan, Duke Univeristy
TMEM16F as a Regulator of Ferroptosis in Astrocytes and Trophoblasts: Implications for Neurodegeneration and Placental Biology
 
4:30–5:00 PM Coffee Available Colorado Ballroom Foyer
5:00–7:00 PM Phospholipid Metabolism in Physiology and Disease Peaks 4 - 5
  * Alan R Brash, Vanderbilt University School of Medicine
Session Chair
 
  * Guillaume Thibault, Nanyang Technological University
Session Chair
 
  Timothy T Hla, Boston Children's Hospital/Harvard Medical School
Endothelial Protective Property of S1P as a Therapeutic Strategy in Diseases of Multiple Organ Systems
 
  Junken Aoki, University of Tokyo
An Emerging Role of PAQR Family Members as Phospholipid Remodeling PLA2
 
  William L. Holland, University of Utah
Genetics of Hyperceramidemia
 
  Gerhard Liebisch, University of Regensburg
Lipidomics Reveals Novel Insights into Platelet Activation in Patients with Antiphospholipid Syndrome
 
7:00–8:00 PM Social Hour with Lite Bites Peaks 1 - 3
7:30–10:00 PM Poster Session 2 Peaks 1 - 3
Wednesday, April 9, 2025
7:00–8:00 AM Breakfast Summit Gallery
8:00–11:00 AM Lipids and Regulation of Cellular Homeostasis Peaks 4 - 5
  * Junken Aoki, University of Tokyo
Session Chair
 
  Takeshi Harayama, Institute of Molecular and Cellular Pharmacology
Manipulating Cellular Lipidome to Discover Novel Regulatory Mechanisms of Lipid Composition
 
  Meng C. Wang, HHMI/Janelia Research Campus
Lysosome Lipid Signaling in Neurons Regulates Longevity
 
  Stacy L Gelhaus, University of Pittsburgh
Electrophilic Fatty Acid Regulation of Cellular Metabolism Mediates Inflammation Resolution
 
  Kasparas Petkevicius, University of Cambridge
CLN8 is an acyltransferase catalyzing a key step in bis(monoacylglycero)phosphate biosynthesis
 
  Maia Kinnebrew, Stanford University
Short Talk: ACC1 Links Lipid Droplet Metabolism to Cellular Cholesterol Homeostasis
 
  Johannes Morstein, UCSF
Short Talk: Direct Targeting of Protein-Membrane Interactions
 
  Gregory Wyant, MGH/HMS
Short Talk: Plasmalogen Control of Peroxisome Degradation Confers Ischemic Protection
 
9:00–9:20 AM Coffee Break Colorado Ballroom Foyer
11:00–11:10 AM People's Choice Poster Award Announcement Peaks 4 - 5
11:10–2:30 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight: Research Presentations Selected from Abstract Submissions Peaks 4 - 5
  * Stacy L Gelhaus, University of Pittsburgh
Session Chair
 
  * William L. Holland, University of Utah
Session Chair
 
  Alan R Brash, Vanderbilt University School of Medicine
Structural Basis Of Covalent Binding Of Acylceramides In Formation Of The Skin Permeability Barrier
 
  Alessandra Ferrari, University of California, Berkeley
Nonvesicular Trafficking In Enterocytes Facilitates The Uptake Of Diet-Derived Cholesterol
 
  Anna Hains, University of Manchester
Ceramides Mediate the Resolution of Psoriasis-Like Skin Inflammation
 
  Takese T McKenzie, MD Anderson Cancer Center
Loss Of Lipocalin Prostaglandin D2 Synthase Impairs Myelin Debris Clearance And Microglial Activation During Demyelination
 
  Ginger L. Milne, Vanderbilt University Medical Center
Metabolism Of Oxidized Lipid Mediators By UDP-Glucuronosyltransferases (Ugts): Implications For In Vivo Quantification
 
  Brendan Prideaux, University of Texas Medical Branch
Spatial Lipidomic Analysis of Inflammatory Pathways in Pulmonary Tuberculosis
 
  Bin Zheng, Cedars-Sinai Medical Center
DHODH Modulates Immune Evasion of Cancer Cells Via CDP-Choline Dependent Regulation of Phospholipid Metabolism
 
4:30–5:00 PM Coffee Available Colorado Ballroom Foyer
5:00–6:30 PM Bioactive Lipids in Inflammatory Disease Peaks 4 - 5
  * James A Olzmann, University of California, Berkeley
Session Chair
 
  Valerie B. O'Donnell, Cardiff University
The SARS-CoV2 Envelope Responds to Host Lipid Metabolism through Changing its Coat
 
  Scott A. Summers, University of Utah
Remodeling the Ceramide Backbone to Treat Cardiorenal Metabolic Disease
 
  Mei Yee Koh, University of Utah
Short Talk: HAF Promotes Lipid Dysregulation and Progression from MASH to MASH-HCC
 
  Marta Overchuk, University of North Carolina at Chapel Hill
Short Talk: Concurrent Induction of Ferroptosis- and Apoptosis-like Lipid Signatures in Ovarian Cancer Cells with Photodynamic Therapy
 
6:30–6:45 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Peaks 4 - 5
6:45–8:00 PM Social Hour with Lite Bites Peaks 1 - 3
7:30–9:00 PM Entertainment Peaks 4 - 5
8:00–9:00 PM Cash Bar Peaks 1 - 3
Thursday, April 10, 2025
12:00–11:59 PM Departure