DNA Replication: Pathway Crosstalk Shaping Physiology and Disease (D2)
April 5-8, 2027  | Mercure London Earls Court, London, United Kingdom
Karlene A Cimprich, Alessandro Vindigni and Massimo Lopes
Scholarship Deadline: Dec. 10, 2026 | Abstract Deadline: Mar. 17, 2027 | Early Registration Deadline: Feb. 5, 2027
* Session Chair † Invited but not yet accepted | Program current as of December 25, 2025 1 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Monday, April 5, 2027
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Tuesday, April 6, 2027
7:30–8:30 AM Breakfast
8:00–8:30 AM Poster Setup
8:15–5:00 PM Poster Viewing
8:30–8:40 AM Welcome Remarks
8:40–9:30 AM Keynote Address
  John F.X. Diffley, Francis Crick Institute
40 Years of DNA Replication
 
9:30–11:45 AM DNA Replication and Repair
  Jo R. Morris, University of Birmingham
New Recombination/Replication Interface
 
  Roger Greenberg, University of Pennsylvania
Break-Induced Replication
 
  Vincenzo Costanzo, IFOM
Replication-Coupled Repair
 
  Short Talk(s) Chosen from Abstracts
 
10:00–10:20 AM Coffee Break
11:45–12:45 PM Lunch
12:30–2:30 PM Posters
2:30–4:30 PM Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM DNA Replication and Transcription
  Stephan Hamperl †, Helmholtz-Zentrum Munich
Resolving Transcription-Replication Conflicts
 
  Martijn Luijsterburg †, Leiden University Medical Center
Transcription-Coupled Repair Mechanisms
 
  Karlene A Cimprich, Stanford University
DNA:RNA Hybrids: Processing and Signaling
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM On Own for Dinner
Wednesday, April 7, 2027
7:30–8:30 AM Breakfast
8:00–8:30 AM Poster Setup
8:15–5:00 PM Poster Viewing
8:30–11:30 AM DNA Replication across DNA Damage
  Priyanka Verma †, Washington University
Replication of DNA Adducts
 
  Kasper Fugger, University College London
Nucleotide Metabolism and Replication Stress
 
  Puck Knipscheer †, Hubrecht Institute
Replication across DNA Crosslinks
 
  Alessandro Vindigni, Washington University
Mechanisms of Replication Fork Restart Upon Cancer Therapies
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:30–12:30 PM Lunch
12:30–2:30 PM Posters
3:00–4:30 PM Career Roundtable
4:30–5:00 PM Coffee Available
5:00–7:00 PM DNA Replication, Metabolism and Inflammation
  Philippe Pasero, Institute of Human Genetics
Fork Resection and Inflammatory Signaling
 
  Agnel Sfeir, Memorial Sloan Kettering Cancer Center
Polθ Channels Replication-Induced DNA Breaks into Microhomology-Mediated Repair
 
  Lorenza Penengo, University of Zurich
Interferon Responses and DNA Replication Stress
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM On Own for Dinner
Thursday, April 8, 2027
7:30–8:30 AM Breakfast
8:30–11:30 AM DNA Replication, Chromatin and Nuclear Dynamics
  Jiazhi Hu, Peking University
The Impact of Chromatin Structure on DNA Replication
 
  Nynke H. Dekker †, University of Oxford
Nucleosomes and Condensability of Nascent DNA
 
  Peter Ly, University of Texas Southwestern Medical Center
Replication of Cytoplasmic Chromosomes in Micronuclei
 
  Nitika Taneja, Erasmus Medical Center
Chromatin Organization in the Replication Stress Response
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:30–12:30 PM Meet the Editors
12:30–1:30 PM Lunch
2:30–4:30 PM Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–6:15 PM DNA Replication Plasticity in Physiology and Disease
  Agata Smogorzewska, Rockefeller University
Living with DNA Damage: Consequences of Replication-Associated Defects for Human Health
 
  Massimo Lopes, University of Zürich
Tissue-Specific Replication Fork Plasticity
 
  Short Talk(s) Chosen from Abstracts
 
6:15–7:00 PM Closing Keynote Address
  Johannes C. Walter, Harvard Medical School
Coordination of Replication and Repair by Disease-Related Factors
 
7:00–7:15 PM Meeting Wrap-Up: Outcomes and Future Directions
7:15–8:15 PM On Own for Dinner
Friday, April 9, 2027
12:00–11:59 PM Departure