Neurobiology of Ingestive Behavior (D4)
April 22-25, 2025
| Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Daniela Cota, Timo D. Müller and Dana M. Small
Scholarship Deadline: Jan. 24, 2025 | Abstract Deadline: Apr. 1, 2025 | Early Registration Deadline: Mar. 5, 2025
| 4:00–8:00 PM |
Registration |
Chapel |
| 6:00–7:00 PM |
Dinner |
Crocker Dining Room |
| 7:00–8:00 PM |
Welcome Mixer and Social Hour |
Chapel |
Wednesday, April 23, 2025
| 7:30–8:30 AM |
Breakfast |
Crocker Dining Room |
| 8:30–9:30 AM |
Welcome and Keynote Address |
Chapel |
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* Daniela Cota, INSERM U1215 Neurocentre Magendie
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* Timo D. Müller, Institute for Diabetes and Obesity, Helmholtz Munich
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* Dana M. Small, McGill University and the Research Institute of the McGill University Health Center (RI-MUHC)
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Matthias H. Tschöp, Helmholtz Munich
Multi-Receptor Drugs for Obesity: Discovery, Mechanism & Clinical Impact |
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| 9:30–12:00 PM |
CNS Mechanisms of Novel Therapies Against Obesity and Beyond |
Chapel |
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* Daniela Cota, INSERM U1215 Neurocentre Magendie
Session Chair |
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Timo D. Müller, Institute for Diabetes and Obesity, Helmholtz Munich
A Novel Incretin-based Quintuple Agonist for the Treatment of Obesity and Diabetes |
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Julie Moyers, Eli Lilly and Company
Novel Drugs Targeting CNS Mechanisms of Body Weight Loss: The Oral GLP-1R Agonist, Orforglipron |
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Karin Conde-Knape, Novo Nordisk A/S
CNS Mechanisms of Cagrilintide-Semaglutide Combinatorial Therapy to Treat Obesity |
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Mafalda M.A. Pereira, Boehringer Ingelheim
Deciphering the Mechanisms of Survodutide as an Anti-Obesity Therapy |
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| 10:00–10:20 AM |
Coffee Break |
Chapel |
| 12:00–1:00 PM |
Poster Setup |
Chapel |
| 12:00–1:00 PM |
Lunch |
Crocker Dining Room |
| 12:30–1:30 PM |
Poster Viewing |
Chapel |
| 1:30–3:30 PM |
Symposia Spotlight 1: Research presentations selected from abstract submissions |
Chapel |
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* Robyn M. Brown, University of Melbourne
Session Chair |
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Tim Gruber, Van Andel Institute
Binge-Eating Disorder Vulnerability Is Determined By Tet1 Dosage In Midbrain Dopamine Neurons |
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Giulia Mazzini, University of Zurich
From Metabolism To Memory: Exploring Amylin's Physiological Role In The Hippocampus |
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Leontine Sandforth, Institute for Diabetes Research and Metabolic Diseases, Tübingen, Germany
Hippocampal Response To Central Insulin Is Reduced With Age In Females With Unhealthy Fat Distribution |
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Emily McGrath, UCSF
Apolipoprotein E Regulates Microglial Remodeling Of Hypothalamic Myelin In Obesity |
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Xinyu Yue, University of California, San Francisco
Molecular Representation Of Peripheral Energy Levels By Neuronal Cilia |
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Moonsun Sa, Seoul national university
Role Of Hypothalamic Gabra5 Neurons And Astrocytic Gaba In Fat Regulation And Obesity |
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Hallie Wachsmuth, University of Arizona
Mediobasal Hypothalamic Aryl Hydrocarbon Receptor Is Critical For Metabolic Homeostasis Via Regulation Of Hypothalamic Inflammation |
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Madina Sokolov, University of Michigan
Defining The Gut-Pancreas Neuronal Circuit That Controls Insulin Secretion |
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| 3:30–4:00 PM |
Coffee Available |
Chapel |
| 4:00–6:00 PM |
Gut-Brain Axis and Feeding Behavior |
Chapel |
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* Dana M. Small, McGill University and the Research Institute of the McGill University Health Center (RI-MUHC)
Session Chair |
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Zachary A. Knight, University of California, San Francisco
Learning from Post-Ingestive Rewards |
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Ivan E. de Araujo, Max Planck Institute for Biological Cybernetics
The Gut-Brain Axis in Feeding Behavior |
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Martin G. Myers, Jr., University of Michigan
Hindbrain Circuits in the Control of Eating Behavior and Energy Balance |
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Nicholas V DiPatrizio, University of California Riverside School of Medicine, Center for Cannabinoid Research
Short Talk: The Ups And Downs Of Brain-Gut-Brain Endocannabinoid Signaling In Food Intake And Reward |
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Nikolai Pirmin P Jaschke, Yale School of Medicine
Short Talk: Gut-To-Brain Communication Protects Against Dietary Protein Toxicity During Recovery From Catabolic States |
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| 6:00–7:00 PM |
Dinner |
Crocker Dining Room |
| 7:00–9:00 PM |
Poster Session 1 |
Chapel |
| 7:30–8:30 AM |
Breakfast |
Crocker Dining Room |
| 8:30–11:30 AM |
Neuronal Circuits Integrating Hunger and Other Competing States |
Chapel |
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* Matthew R. Hayes, University of Pennsylvania
Session Chair |
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Marc Tittgemeyer, Max Planck Institute for Metabolism Research
Need State Regulation of Motivational Drive |
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Hyung Jin Choi, Seoul National University College of Medicine
Neural Circuits Integrating Hunger and Food Choices |
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Robyn M. Brown, University of Melbourne
Neural Circuits Underlying Stress-Related Eating |
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Heidi H Pak, UT Southwestern
Short Talk: Habitual Feeding Schedule Enhances The Metabolic And Physiological Effects Of Calorie Restriction |
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Tanya Pattnaik, University of Illinois, Urbana-Champaign
Short Talk: Dopamine Signaling Regulates Feeding Behavior During Lactation In Mice |
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Elijah D Lowenstein, Beth Israel Deaconess Medical Center
Short Talk: A Hypothalamic Circuit For Anticipating Future Changes In Energy Balance |
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Yael Kuperman, Weizmann Institute
Short Talk: Disruption Of The Developmental Factor Otp In The Adult Forebrain Reveals Its Diverse Physiological Functions |
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| 9:30–9:50 AM |
Coffee Break |
Chapel |
| 9:50–9:55 AM |
Award Recipient Acknowledgement |
Chapel |
| 12:00–1:00 PM |
Lunch |
Crocker Dining Room |
| 12:00–1:00 PM |
Poster Setup |
Chapel |
| 1:00–2:00 PM |
Career Roundtable |
Chapel |
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Karin Conde-Knape, Novo Nordisk A/S
Senior Vice President, Global Drug Discovery |
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Laura Huckins, Yale School of Medicine
Associate Professor |
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Marc Tittgemeyer, Max Planck Institute for Metabolism Research
Professor, Research Group Leader |
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Jonathan D Douros, Indiana Biosciences Research Institute
Senior Scientific Director |
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| 1:00–2:30 PM |
Poster Viewing |
Chapel |
| 2:00–3:45 PM |
Panel Discussion: How to Fill the Gap between Academic Research and Clinical Implementation? Addressing Reproducibility, Research Standards and Translation Towards the Clinic |
Chapel |
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* Daniela Cota, INSERM U1215 Neurocentre Magendie
Session Chair |
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* Timo D. Müller, Institute for Diabetes and Obesity, Helmholtz Munich
Session Chair |
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Matthias H. Tschöp, Helmholtz Munich
Panelist |
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Dana M. Small, McGill University and the Research Institute of the McGill University Health Center (RI-MUHC)
Panelist |
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Brian Finan, Eli Lilly
Panelist |
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Monika Murphy, Kallyope
Panelist |
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Martin G. Myers, Jr., University of Michigan
Panelist |
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Stephen O'Rahilly, University of Cambridge
Panelist |
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| 3:45–4:00 PM |
Coffee Available |
Chapel |
| 4:00–6:00 PM |
Aversive and Non-Aversive Circuits of Appetite Suppression |
Chapel |
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* Thomas Alexander Lutz, University of Zürich
Session Chair |
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Matthew R. Hayes, University of Pennsylvania
GIP and GLP-1 Signaling in Satiety and Nausea |
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Stephen O'Rahilly, University of Cambridge
GDF15 in Nausea and Beyond |
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Laura Huckins, Yale School of Medicine
Genetic and Biological Determinants of Anorexia Nervosa |
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Stephan Herzig, Helmholtz Zentrum München
Cancer Cachexia: Bridging the CNS with Peripheral Wasting |
|
| 6:00–7:00 PM |
Dinner |
Crocker Dining Room |
| 7:00–9:00 PM |
Poster Session 2 |
Chapel |
| 7:30–8:30 AM |
Breakfast |
Crocker Dining Room |
| 8:30–11:30 AM |
Neuroendocrine Control of Food Intake, Body Weight and Metabolism |
Chapel |
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* Martin G. Myers, Jr., University of Michigan
Session Chair |
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Karine Clément, INSERM / Sorbonne Universite
REMOTE PRESENTER: Precision Medicine Approach in Patients with Melanocortin Pathway Disorders |
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Daniela Cota, INSERM U1215 Neurocentre Magendie
Hypothalamic Responses to Energy Surfeit in the Regulation of Energy Balance |
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Thomas Alexander Lutz, University of Zürich
Brain Circuits for Amylin Action |
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Elizabeth Godschall, University of Virginia
Short Talk: A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs |
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Shuke Xiao, Stanford University
Short Talk: A Postprandial Python Metabolite Mediates A Gut-Liver-Brain Feeding Axis |
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Mireia Montaner, University of Cambridge
Short Talk: Interactions Between Olfactory Bulb Glp-1, Sensory Perception Of Food And Feeding Behaviour |
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Zhenggang Zhu, UC San Diego
Short Talk: Hedonic Eating Is Controlled By Dopamine Neurons That Oppose Glp-1r Satiety |
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| 9:30–9:50 AM |
Coffee Break |
Chapel |
| 12:00–1:00 PM |
Lunch |
Crocker Dining Room |
| 12:00–1:00 PM |
Poster Setup |
Chapel |
| 12:30–1:30 PM |
Poster Viewing |
Chapel |
| 1:30–3:30 PM |
Symposia Spotlight 2: Research presentations selected from abstract submissions |
Chapel |
| |
* Laura Huckins, Yale School of Medicine
Session Chair |
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Robert M Gutgesell, Helmholtz Center Munich
Gipr Agonism and Antagonism Decrease Body Weight and Food Intake Via Different Mechanisms of Action |
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Caitlin M Baumer Harrison, University of Pennsylvania
Biased Agonism Of The Glp-1r Maintains Glycemic Control Without Producing Nausea Or Emesis In Preclinical Models |
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Antje Körner, Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) at Helmholtz Munich and Leipzig University
A Novel Monogenic Agouti-Like Obesity Trait: New Insights From Mice And Men |
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Mette Ludwig, Novo Nordisk
Cross-Species Atlas Of The Dorsal Vagal Complex Reveals Neural Mediators Of Cagrilintide’s Effects On Energy Balance |
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Jo E Lewis, University of Cambridge
Glucose-Dependent Insulinotrophic Polypeptide Regulates Food Intake And Body Weight Via The Area Postrema In Mice |
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Samantha Fortin, University of Pennsylvania
Regulation Of Food Intake By The Locus Coeruleus |
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Han Tan, Rockefeller University
The Cellular And Molecular Basis For Leptin Regulation Of Energy Balance |
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Abbey Blake, UCSF
A New Crispri Approach To Investigate The Pathogenic Mechanism Of Obesity-Associated Genes |
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| 3:30–4:00 PM |
Coffee Available |
Chapel |
| 4:00–5:45 PM |
Neural Substrates of Hedonic Eating and Decision Making |
Chapel |
| |
* Ivan E. de Araujo, Max Planck Institute for Biological Cybernetics
Session Chair |
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Christian Lüscher, University of Geneva
Circuits of Hedonic Feeding in Health and Disease |
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Dana M. Small, McGill University and the Research Institute of the McGill University Health Center (RI-MUHC)
Sugar and Fat: Distinct Reinforcement Mechanisms and Adaptations in Obesity |
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Soyoung Q. Park, German Institute of Human Nutrition Potsdam-Rehbruecke
Neural Determinants of Decision Making in Feeding Behavior |
|
| 5:45–6:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Chapel |
| 6:00–7:00 PM |
Dinner |
Crocker Dining Room |
| 7:00–9:00 PM |
Poster Session 3 |
Chapel |
| 7:30–9:00 AM |
Breakfast |
Crocker Dining Room |
| 12:00–1:00 PM |
Lunch |
Crocker Dining Room |
