Epigenetics in Health and Disease (D4)
April 12-15, 2027  | Rimrock Banff, Emblems Collection, Banff, AB, Canada
Liling Wan and Bradley E. Bernstein
Scholarship Deadline: Dec. 18, 2026 | Abstract Deadline: Mar. 24, 2027 | Early Registration Deadline: Feb. 12, 2027
* Session Chair † Invited but not yet accepted | Program current as of August 26, 2026 3 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Monday, April 12, 2027
4:00–8:00 PM Registration Solstice Foyer
6:00–8:00 PM Welcome Mixer Solstice Foyer
Tuesday, April 13, 2027
7:00–8:00 AM Breakfast Solstice Salon B/C
8:00–8:10 AM Welcome Remarks Solstice Salon A
8:10–9:00 AM Keynote Address Solstice Salon A
  Michael K. Rosen, University of Texas Southwestern Medical Center
Phase Separation in Chromatin Organization		  
9:00–11:15 AM Genome Architecture in Development and Disease Solstice Salon A
  Eileen E.M. Furlong, European Molecular Biology Laboratory
Enhancer-Promoter Interactions in Development		  
  Liling Wan, University of Pennsylvania
Condensate-Mediated Chromatin Looping in Cancer		  
  Short Talk(s) Chosen from Abstracts
  
9:30–9:50 AM Coffee Break Solstice Foyer
11:15–1:00 PM Poster Setup Solstice Salon C
11:15–2:30 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Solstice Salon C
2:30–4:30 PM Symposia Spotlight 1: Epigenetic Mechanisms Governing Cell Fate in Health and Disease Solstice Salon A
  Short Talks Chosen from Abstracts
  
4:30–5:00 PM Coffee Available Solstice Foyer
5:00–7:00 PM Epigenetic Dysregulation in Cancer: Mechanisms and Therapeutic Targets Solstice Salon A
  Margaret A Goodell, Baylor College of Medicine
DNA Methylation in Hematological Malignancies		  
  Ali Shilatifard, Northwestern University
Transcriptional Elongation in Health and Disease		  
  Christopher Vakoc, Cold Spring Harbor Laboratory
Transcriptional Dependencies in Cancer		  
  Short Talk(s) Chosen from Abstracts
  
7:00–8:00 PM Social Hour with Dinner Solstice Salon B/C
7:30–10:00 PM Poster Session 1 Solstice Salon C
Wednesday, April 14, 2027
7:00–8:00 AM Breakfast Solstice Salon B/C
8:00–11:00 AM Epigenetic Mechanisms of Transcriptional Control Solstice Salon A
  Karen Adelman, Harvard Medical School
Transcriptional Elongation and Enhancer-Promoter Communication		  
  Kathrin Plath, University of California, Los Angeles
RNA-Mediated Regulation of Gene Expression		  
  Geneviève Almouzni, Centre National de la Recherche Scientifique
Histone Variants in Chromatin Assembly and Genome Stability		  
  Bradley E. Bernstein, Dana-Farber Cancer Institute
Functional Epigenomics and Cancer Mechanisms		  
  Short Talk(s) Chosen from Abstracts
  
9:00–9:20 AM Coffee Break Solstice Foyer
11:00–1:00 PM Poster Setup Solstice Salon C
11:00–2:30 PM On Own for Lunch
1:00–2:30 PM Career Roundtable Solstice Salon A
1:00–10:00 PM Poster Viewing Solstice Salon C
2:30–4:30 PM Symposia Spotlight 2: Environmental Inputs and Chromatin Dynamics in Physiology and Disease Solstice Salon A
  Short Talks Chosen from Abstracts
  
4:30–5:00 PM Coffee Available Solstice Foyer
5:00–7:00 PM Mapping and Perturbing the Epigenome Solstice Salon A
  Bing Ren, New York Genome Center and Columbia University
3D Genome and Epigenomic Architecture		  
  Charles Gersbach, Duke University
CRISPR-Based Epigenome Editing		  
  Alla Sigova, CAMP4 Therapeutics
Targeting Regulatory RNAs With Antisense Oligonucleotides Enables Potentially Therapeutically Relevant Upregulation of Gene Expression		  
  Short Talk(s) Chosen from Abstracts
  
7:00–8:00 PM Social Hour with Dinner Solstice Salon B/C
7:30–10:00 PM Poster Session 2 Solstice Salon C
Thursday, April 15, 2027
7:00–8:00 AM Breakfast Solstice Salon B/C
8:00–11:00 AM Epigenetic Modification Dynamics and Function in Development and Disease Solstice Salon A
  Shelley L Berger, University of Pennsylvania
Histone Modifications in Gene Regulation		  
  Wei Xie, Tsinghua University
Transcription Regulation in Early Mammalian Development		  
  Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics
Dosage Compensation in Development		  
  Kristian Helin, The Institute of Cancer Research
Roles of Histone Methylation in Transcription and Development		  
  Short Talk(s) Chosen from Abstracts
  
9:00–9:20 AM Coffee Break Solstice Foyer
11:00–2:30 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 3: Emerging Tools, Technologies, and Therapeutics Solstice Salon A
  Short Talks Chosen from Abstracts
  
4:30–5:00 PM Coffee Available Solstice Foyer
5:00–5:50 PM Closing Keynote Address Solstice Salon A
  Mark A. Dawson, Peter MacCallum Cancer Centre
Understanding Chromatin Regulation using Unbiased Functional Genomics		  
5:50–7:35 PM Epigenetic Plasticity in Physiology and Tissue Homeostasis Solstice Salon A
  Diana Hargreaves, The Salk Institute for Biological Studies
SWI-SNF Complexes in Immunity		  
  Justin Brumbaugh, University of Colorado
Epigenetic Regulation in Cell Plasticity and Regeneration in the Intestinal Epithelium		  
  Jan Zylicz, University of Copenhagen
Epigenetic and Metabolic Regulation of Early Development		  
  Short Talk(s) Chosen from Abstracts
  
7:35–7:45 PM Meeting Wrap-Up: Outcomes and Future Directions Solstice Salon A
7:45–8:45 PM Social Hour with Dinner Solstice Salon B/C
8:00–11:00 PM Entertainment
8:00–11:00 PM Cash Bar
Friday, April 16, 2027
12:00–11:59 PM Departure