DNA Replication Gaps, Cancer and Disease (D5)
April 27-30, 2025
| Daejeon Convention Center, Daejeon, Korea, Republic of
Sharon B. Cantor, Alberto Ciccia, Vincenzo Costanzo and Kyungjae Myung
Scholarship Deadline: Feb. 12, 2025 | Abstract Deadline: Apr. 4, 2025 | Early Registration Deadline: Mar. 12, 2025
| 4:00–8:00 PM |
Registration |
2nd Floor Lobby/Terrace |
| 6:00–8:00 PM |
Welcome Mixer |
2nd Floor Lobby/Terrace |
| 7:30–8:30 AM |
Breakfast |
Individual Hotel |
| 8:00–8:30 AM |
Poster Setup |
Room 202 |
| 8:00–5:00 PM |
Poster Viewing |
Room 202 |
| 8:30–9:30 AM |
Welcome and Keynote Address |
Room 201 |
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* Sharon B. Cantor, University of Massachusetts Chan Medical School
Session Chair |
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Helle D. Ulrich, Institute of Molecular Biology
Mind the Gap: How Ubiquitylation Controls Postreplicative Gap Formation and Repair in Response to DNA Replication Stress |
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| 9:30–12:00 PM |
DNA Replication Gaps: Causes and Consequences |
Room 201 |
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* Vanesa M. Gottifredi, Fundación Instituto Leloir
Session Chair |
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* Annabel Quinet, Francois Jacob Institute of Biology, CEA/INSERM
Session Chair |
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Vincenzo Costanzo, IFOM
Causes and Consequences of DNA Replication Gaps |
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Alessandro Vindigni, Washington University
Factors Modulating Gap Formation and Repair |
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Aura Carreira, Centro de Biologia Molecular Severo Ochoa (CBM)
Mediating Replication ssDNA Gap Prevention and Repair Through the Lenses of BRCA2 |
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Catherine H Freudenreich, Tufts University
Gap-Induced Fragility at DNA Structures Revealed in a Yeast Model |
|
| 10:00–10:20 AM |
Coffee Break |
Foyer |
| 12:00–1:00 PM |
Lunch |
Room 202 |
| 12:00–2:00 PM |
Poster Session 1 |
Room 202 |
| 2:30–4:30 PM |
Symposia Spotlight 1: Short Talks Chosen from Abstracts |
Room 201 |
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* Catherine H Freudenreich, Tufts University
Session Chair |
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* Aura Carreira, Centro de Biologia Molecular Severo Ochoa (CBM)
Session Chair |
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Gary Ying Wai Chan, The University of Hong Kong
FANCM Minimizes Single-Strand Gap Formation and Promotes PARP Inhibitor Resistance by Counteracting 53BP1 |
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So Young Joo, Seoul National University
BRCA2 at the Helm: Orchestrating Telomere G4 Dynamicity and its Impact in Ovarian Cancer |
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Ja Yil Lee, Ulsan National Institute of Science and Technology
Alteration of RPA Binding Modes on Single-Stranded DNA by NSMF Potentiates RPA Phosphorylation by ATR Kinase |
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Junko Murai, Ehime University
SLFN11 Enhances Chemotherapeutic Sensitivity by Binding to Multiple Types of Single-Stranded DNA Gaps |
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Yonghwan Kim, Sookmyung Women's University
RNF4 and USP7 Coordinate Spatial Regulation of SLX4 Stability within the PML Nuclear Bodies |
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Isabelle Seppa, Washington University in Saint Louis
Mechanisms of ssDNA Gap Resection in BRCA1-Proficient and -Deficient Cells |
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Helen E Grimsley, Memorial Sloan Kettering
The 9-1-1 Complex Protects ssDNA gaps in BRCA2-Deficient Cancer Cells To Preserve Cell Viability |
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Yohan An, KAIST
APOBEC3A, not APOBEC3B, Drives Deaminase-Associated Mutagenesis In Single-Stranded DNA Gaps in Human Gastric Epithelium |
|
| 4:30–5:00 PM |
Coffee Available |
Foyer |
| 5:00–7:00 PM |
Gaps, Cell Death and Immune Responses |
Room 201 |
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* Alessandro Vindigni, Washington University
Session Chair |
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* Katharina Schlacher, MD Anderson Cancer Center
Session Chair |
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Sharon B. Cantor, University of Massachusetts Chan Medical School
How the Gap Model Redefines Chemotherapy Response |
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Roger Greenberg, University of Pennsylvania
Tolerance to Stress vs. Immune Induction |
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Vanesa M. Gottifredi, Fundación Instituto Leloir
Causes and Consequences of the Choice between Template Switching, Traslesion DNA Synthesis and Repriming |
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Hervé Técher, Université Côte d'Azur
Short Talk: MRE11 Nuclease Activity Controls Senescence by Coordinating Replication Stress And Interferon Signaling |
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Dmitry Ivanov, Institute for Basic Science
Short Talk: The Role of Translesion Synthesis (TLS) Polymerases in Temozolomide Resistance |
|
| 7:00–8:00 PM |
On Own for Dinner |
|
| 7:30–8:30 AM |
Breakfast |
Individual Hotel |
| 8:00–8:30 AM |
Poster Setup |
Room 202 |
| 8:00–5:00 PM |
Poster Viewing |
Room 202 |
| 8:30–11:30 AM |
Visualizing and Defining the Gap Architecture |
Room 201 |
| |
* Dale A. Ramsden, University of North Carolina
Session Chair |
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Maria Spies, University of Iowa
Structure of the RAD52 double-ring at stalled replication forks, restriction of fork reversal and prevention of replication gaps |
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Katharina Schlacher, MD Anderson Cancer Center
A BRCA Replication Fork Protecteome in Inflammation and Disease |
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Nitika Taneja, Erasmus Medical Center
Local & Spatial Chromatin Reorganization under Replication Stress |
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Annabel Quinet, Francois Jacob Institute of Biology, CEA/INSERM
Central Role of Repriming by PRIMPOL in the Response To Replication Stress Induced By Low Doses of Genotoxic Agents |
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Maximilian Donsbach, Ludwig Maximilians University Munich
Short Talk: A Non-Proteolytic Release Mechanism for HMCES-DNA-Protein Crosslinks |
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Jinho Park, Stanford University
Short Talk: Dissecting the Mechanism of Repriming during DNA Damage Response Using Single-Molecule Imaging |
|
| 9:30–9:50 AM |
Coffee Break |
Foyer |
| 9:50–9:55 AM |
Award Recipient Acknowledgement |
Room 201 |
| 11:30–12:30 PM |
Lunch |
Room 202 |
| 12:00–2:00 PM |
Poster Session 2 |
Room 202 |
| 2:15–3:15 PM |
Panel Discussion: Brainstorming Gap Detection Tools |
Room 201 |
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Alessandro Vindigni, Washington University
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Nitika Taneja, Erasmus Medical Center
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David Szuts, HUN-REN Research Centre for Natural Sciences
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Joanna Loizou, The Institute of Cancer Research
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| 3:30–4:30 PM |
Career Roundtable |
Room 201 |
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Karlene A Cimprich, Stanford University
Professor |
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Kei-ichi Takata, Institute for Basic Science
Section Head |
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Nele Hug, Nature Communications
Senior Editor |
|
| 4:30–5:00 PM |
Coffee Available |
Foyer |
| 5:00–7:00 PM |
Gap Suppression and Avoidance Pathways in Cancer |
Room 201 |
| |
* Karlene A Cimprich, Stanford University
Session Chair |
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* Fumiko Esashi, University of Oxford
Session Chair |
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Alberto Ciccia, Columbia University
Dependency of ALT-Positive Cancer Cells on the SMARCAL1 DNA Translocase |
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Dale A. Ramsden, University of North Carolina
Pol Theta and the Response to Replication Stress |
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David Szuts, HUN-REN Research Centre for Natural Sciences
A Genetic Delineation of Template Switching Bypass and its Role in Spontaneous Mutagenesis |
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Diego Dibitetto, Istituto di Ricerche Farmacologiche Mario Negri
Short Talk: DNA-PK Counteracts Toxic Single-Strand Breaks Accumulation and Promotes PARP Inhibitor Resistance |
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Kei-ichi Takata, Institute for Basic Science
Short Talk: DNA Helicase HELQ Facilitates Fork Reversal in Response to Leading Strand Gaps |
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| 7:00–8:00 PM |
On Own for Dinner |
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Wednesday, April 30, 2025
| 7:30–8:30 AM |
Breakfast |
Individual Hotel |
| 8:30–11:30 AM |
Gaps, R-Loops and Replication Stress |
Room 201 |
| |
* Maria Spies, University of Iowa
Session Chair |
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* Roger Greenberg, University of Pennsylvania
Session Chair |
|
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Kristijan Ramadan, Nanyang Technical University
The Role of Nucleophagy in DNA Repair and Genome Stability |
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Fumiko Esashi, University of Oxford
Untangling DNA Breakage at Centromeres |
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Joanna Loizou, The Institute of Cancer Research
POLtheta Processes ssDNA Gaps and Promotes Replication Fork Progression in BRCA1-Deficient Cells |
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Karlene A Cimprich, Stanford University
Mechanisms for Rna-Mediated Genome Instability |
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Marie Sebald, The Francis Crick Insitute
Short Talk: SLX complex Promotes Okazaki Fragment Maturation in FEN1 Deficient Cells |
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Larissa Milano, University of Sussex
Short Talk: BRCA1 and BRCA2-Mediated Maturation of Nascent DNA Strands During DNA Replication |
|
| 9:30–9:50 AM |
Coffee Break |
Foyer |
| 11:30–2:30 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Symposia Spotlight 2: Short Talks Chosen from Abstracts |
Room 201 |
| |
* David Szuts, HUN-REN Research Centre for Natural Sciences
Session Chair |
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* Orlando D Schärer, University of Pittsbrugh
Session Chair |
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Kyunghwan Kim, IBS
Enhanced Precision Targeting of Cancer Cells Using the CRISPR/Cas9 System and Lipid Nanoparticles |
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Seung Woo Cho, UNIST
Efficient and precise targeting of cancer cells using multiplexed CRISPR/Cas9-nickase |
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Jieya Shao, Washington University in St. Louis
Moonlighting Nuclear Function of The Actin-Binding Factor Profilin-1 In ssDNA Gap Formation |
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Hyunje Kang, Stanford university
Fork Reversal Prevents TRAIP-Mediated POLE1 Degradation Under Conditions of ROS |
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Néstor García-Rodríguez, CABIMER/University of Sevilla
The Role of ssDNA Gap Expansion in ATR Checkpoint Activation and Synthetic Lethality in BRCA1-defcient Cells |
|
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John J Turchi, Indiana University School of Medicine
Chemical Inhibition of RPA Gap Protection Sensitizes BRCA1-deficient Cancers to PARP Inhibition |
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Pauline Luise Pfuderer, University of Cambridge
Artificial Intelligence-based High-resolution Analysis of DNA Replication Dynamics on Extrachromosomal DNA |
|
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Ronnie Low, The Francis Crick Institute
MEN1 Loss Confers Resistance to Replication Stress-Inducing Drugs |
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| 4:30–5:00 PM |
Coffee Available |
Foyer |
| 5:00–6:30 PM |
Drugs Modulating and Capitalizing on a Cancer Gap Vulnerability |
Room 201 |
| |
* Joanna Loizou, The Institute of Cancer Research
Session Chair |
|
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* Isabelle Seppa, Washington University in Saint Louis
Session Chair |
|
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Orlando D Schärer, University of Pittsbrugh
Trabectedin - Targeting Tumors through Transcription-Coupled Nucleotide Excision Repair Induced DNA Gaps |
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Jill Bargonetti, Hunter College, City University of New York
p53 Gain of Function working together with PARP1 for Cancer Persistent Repair at Gaps |
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Kyungjae Myung, Institute for Basic Science and UNIST
Translation of DNA Damage Including Gap for Cancer Therapy |
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| 6:30–6:45 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Room 201 |
| 6:45–7:45 PM |
Social Hour with Lite Bites |
Room 202 |
