Long COVID and Post Acute Sequalae of SARS CoV 2 (PASC): Pathogenesis and Treatment (F1)
August 27-30, 2023
| Eldorado Hotel & Spa, Santa Fe, NM, United States
Steven G Deeks, Michael J. Holtzman, Resia Pretorius and Catherine A. Blish
Scholarship Deadline: May. 25, 2023 | Abstract Deadline: May. 25, 2023 | Early Registration Deadline: Jun. 28, 2023
| 10:00–2:00 PM |
Registration |
Cava Santa Fe |
| 12:00–2:00 PM |
Welcome Mixer |
Cava Santa Fe |
| 1:00–2:00 AM |
Breakfast |
Anasazi Ballroom |
| 1:30–2:00 AM |
Poster Setup |
Anasazi Ballroom |
| 2:00–3:00 AM |
Welcome and Keynote Address |
Eldorado Ballroom |
| |
* Michael J. Holtzman, Washington University in St. Louis / NuPeak Therapeutics
Sesion Chair |
|
| |
* Steven G. Deeks, University of California, San Francisco
Session Chair |
|
| |
Gary H. Gibbons, NHLBI, National Institutes of Health
Addressing the Public Health Threat of PASC—NIH RECOVER Initiative |
|
| 2:00–1:00 PM |
Poster Viewing |
Anasazi Ballroom |
| 3:00–5:30 AM |
Acute to Chronic |
Eldorado Ballroom |
| |
* Avindra Nath, NINDS, National Institutes of Health
Session Chair |
|
| |
* Michael J. Peluso, University of California, San Francisco
Session Chair |
|
| |
Michael J. Holtzman, Washington University in St. Louis / NuPeak Therapeutics
Defining and Fixing Viral Reprogramming |
|
| |
Andrea Lynn Cox, Johns Hopkins University
Sex, Obesity, Immunometabolism, and Viral Persistence in Post-acute Sequelae of SARS-CoV-2 Infection |
|
| |
Akiko Iwasaki, Yale University/HHMI
Distinguishing Features of Long COVID Identified through Immune Profiling |
|
| |
Michael J. Peluso, University of California, San Francisco
Short Talk: Short Talk: Multimodal Assessment of Antigen Persistence in the Post-Acute Phase of SARS-CoV-2 Infection |
|
| |
Ella Borberg, Harvard Medical School
Short Talk: Short Talk: Uncovering the Link between SARS-CoV-2 Antigen Persistence and Post-Acute Sequelae of COVID-19 |
|
| 3:30–3:50 AM |
Coffee Break |
Concourse |
| 5:30–6:30 AM |
Lunch |
Anasazi Ballroom |
| 6:00–8:30 AM |
Poster Session 1 |
Anasazi Ballroom |
| 8:30–10:30 AM |
Workshop 1: Pathogenesis |
Eldorado Ballroom |
| |
* Harlan Krumholz, Yale University School of Medicine
Session Chair |
|
| |
Julio Silva, Yale School of Medicine
Session Chair |
|
| |
Michael J. Patton, Hugh Kaul Precision Medicine Institute
Determinants of Pulmonary Post-acute Sequelae of SARS-COV-2 (PASC): A Single-Center Retrospective Study |
|
| |
Ling Li, University of Minnesota
Capturing the Impact of Age, Sex, and APOE Genotype on the Progression of SARS-CoV-2 Infection and Subsequent Neuroinflammation in Mouse Models |
|
| |
Seynt Jiro Sahagun, University of New England College of Osteopathic Medicine
Endotrophin and PASC Symptoms at 12 Months After Acute COVID-19 Infection |
|
| |
John Michael Powers, University of North Carolina at Chapel Hill
Omicron Lineage Variants Display Acute and Chronic Fibrotic Pathologic Lung Disease in BALB/c Mice |
|
| |
Amber Wolabaugh, Columbia University
A Novel Human Immune System Mouse Model for COVID-19 |
|
| |
Julio Silva, Yale School of Medicine
Testosterone is a Key Differentiator of Sex-specific Immune Profiles and Symptomology in Long COVID |
|
| |
Alexandra Tabachnikova, Yale University
Identification of Elevated and Altered Humoral Responses to Epstein-Barr Virus in Long COVID |
|
| 10:30–11:00 AM |
Coffee Available |
Concourse |
| 11:00–1:30 PM |
Immunopathology of Long COVID/PASC |
Eldorado Ballroom |
| |
* Janko Z. Nikolich, University of Arizona College of Medicine
Session Chair |
|
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* Sara Morón-López, AIDS Research Institute - IrsiCaixa
Session Chair |
|
| |
Catherine A. Blish, Stanford University School of Medicine
Adipose Tissue Inflammation as a Potential Driver of Long COVID |
|
| |
Anna Aschenbrenner, Systems Medicine, DZNE
Immunologic Correlates of Long COVID Following Mild Disease |
|
| |
Anthony Dominic Kelleher, University of New South Wales
Resolution of Immune Dysregulation and Improvement in Health-related Quality of Life in Individuals with Long COVID at 2-years Following SARS-CoV-2 Infection |
|
| |
Timothy J. Henrich, University of California, San Francisco
Imaging |
|
| |
Jennifer A Liu, John’s Hopkins Bloomberg School of Public Health
Short Talk: Short Talk: Sex Differences in SARS-CoV-2 during Acute and Post-acute Infection in a Mouse Model of COVID-19 |
|
| |
Brent Appelman, Amsterdam UMC
Short Talk: Short Talk: Muscle Abnormalities Contribute to Post-Exertional Malaise in Long COVID |
|
| 1:30–2:30 PM |
On Own for Dinner |
|
| 1:00–2:00 AM |
Breakfast |
Anasazi Ballroom |
| 2:00–5:00 AM |
Vascular Disease |
Eldorado Ballroom |
| |
* Karl Morten, University of Oxford
Session Chair |
|
| |
* Jane Mitchell, Imperial College
Session Chair |
|
| |
Resia Pretorius, Stellenbosch University
Microclots and Platelet Hyperactivation as Key Pathologies in Long COVID |
|
| |
Jane A. Mitchell, Imperial College London
COVID19 Brings Endothelitits and Systemic Vascular Manifestations of Infection into the Spotlight |
|
| |
Avindra Nath, NINDS, National Institutes of Health
Neuroinflammatory Syndromes and Microvascular Disease with COVID-19 |
|
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Massimo Nunes, Stellenbosch University
Short Talk: Short Talk: Long COVID and ME/CFS: Shared Dysregulation of Coagulation, Complement Machinery, and the Endothelium Revealed by DIA LC-MS/MS Analysis of Plasma |
|
| |
Kailin Yin, Gladstone Institutes
Short Talk: Short Talk: Long COVID Manifests with T Cell Dysregulation, Inflammation, and an Uncoordinated Adaptive Immune Response to SARS-CoV-2 |
|
| |
Lavanya Visvabharathy, Northwestern University
Short Talk: Short Talk: Mild SARS-CoV-2 Infection Promotes Autoantibody Production in Long COVID Patients Despite Vaccination |
|
| |
Jon Izquierdo Pujol, IrsiCaixa AIDS Research Institute
Short Talk: Short Talk: PBMC Immunophenotyping, Plasma Inflammatory Profile and Antibody Levels of Children with Long COVID |
|
| 3:00–3:20 AM |
Coffee Break |
Concourse |
| 5:00–7:00 AM |
Poster Setup |
Anasazi Ballroom |
| 5:00–11:00 AM |
On Own for Lunch |
|
| 7:00–4:00 PM |
Poster Viewing |
Anasazi Ballroom |
| 9:00–10:30 AM |
Career Roundtable |
Eldorado Ballroom |
| |
Lisa E. Gralinski, University of North Carolina
Assistant Professor |
|
| |
Rosie D Lyles, AbbVie
Medical Director of Infectious Diseases |
|
| 10:30–11:00 AM |
Coffee Available |
Concourse |
| 11:00–1:00 PM |
Organ-Specific Syndromes |
Eldorado Ballroom |
| |
* Braeden Charlton, Vrije Universiteit
Session Chair |
|
| |
* Mitchell Miglis, Stanford University
Session Chair |
|
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Mitchell Miglis, Stanford University
Dysautonomia and POTS |
|
| |
John Wood, University of Southern California
Brain Fog in Children |
|
| |
Clifford J. Rosen, Maine Medical Center
Metabolic Aspects of PASC: The Impact of HDL and Lipid Peroxides |
|
| |
Matthew S Durstenfeld, University of California, San Francisco
Short Talk: Short Talk: Cardiopulmonary Exercise Testing and Heads up Tilt Table Testing in Cardiopulmonary PASC |
|
| |
Kristin Sauter, Oregon National Primate Research Center, OHSU
Short Talk: Short Talk: Effect of Obesity on Long-term Response to SARS-CoV-2 Infection in Rhesus Macaques |
|
| 1:00–2:00 PM |
Social Hour with Lite Bites |
Anasazi Ballroom |
| 1:30–4:00 PM |
Poster Session 2 |
Anasazi Ballroom |
Wednesday, August 30, 2023
| 1:00–2:00 AM |
Breakfast |
Anasazi Ballroom |
| 2:00–5:00 AM |
Lessons Learned from other Post-Infections Complications |
Eldorado Ballroom |
| |
* Leonard H Calabrese, Cleveland Clinic
Session Chair |
|
| |
* Adriana Marques, NIAID, National Institutes of Health
Session Chair |
|
| |
Lisa McCorkell, Patient-Led Research Collaborative
Patient Insights into Long COVID and Associated Conditions |
|
| |
Karl Morten, University of Oxford
Developing a Blood Cell-Based Diagnostic Test for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Peripheral Blood Mononuclear Cells |
|
| |
William H. Robinson, Stanford University School of Medicine
EBV as a Driver of Chronic Disease |
|
| |
Adriana Marques, NIAID, National Institutes of Health
Post-Lyme Complications |
|
| |
Sarah R. Leist, University of North Carolina at Chapel Hill
Short Talk: Short Talk: A Model of Persistent Post SARS-CoV-2 Induced Lung Disease in Mice for Target Identification and Evaluation of Therapeutic Strategies |
|
| |
Braeden Charlton, Vrije Universiteit
Short Talk: Short Talk: Skeletal Muscle Structure and Function Contribute to Exercise Intolerance in Long COVID Patients |
|
| 3:00–3:20 AM |
Coffee Break |
Concourse |
| 5:00–11:00 AM |
On Own for Lunch |
|
| 8:30–10:30 AM |
Workshop 2: Disease Management |
Eldorado Ballroom |
| |
* Rasika Karnik, University of Chicago
Session Chair |
|
| |
* Rebecca Hamlin, Stanford University
Session Chair |
|
| |
Vashi Negi, Purdue University
A BSL-2 Chimeric System Designed to Screen SARS-CoV-2 E Protein Ion Channel Inhibitors |
|
| |
James N. Baraniuk, Georgetown University
Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in NK Cells From Post COVID-19 Condition Patients |
|
| |
Rebecca L. Skalsky, Oregon Health & Sciences University
Virus-encoded MicroRNAs as Biomarkers of SARS-CoV2 Infection States |
|
| |
Rebecca Hamlin, Stanford University
Investigating the Immunobiological Basis of Long COVID in a Prospective Clinical Cohort |
|
| |
Tongcui Ma, Academia (University, Research Institute etc.)
Post-acute Immunological and Behavioral Sequelae in Mice after Omicron Infection |
|
| |
Brian Walitt, NIH/NINDS
Premorbid Conditions Predict Onset of New Neurological Manifestations and Long-term Disability Following SARS-CoV-2 Infection |
|
| |
Monika Haack, Beth Israel Deaconess Medical Center & Harvard Medical School
Pain in PASC – The Role of Sleep Disturbances |
|
| |
Sindhu Mohandas, Children's Hospital Los Angeles
Exploring the Clinical Spectrum of Pediatric Long COVID and the Impact of COVID-19 Vaccines on Disease Course |
|
| 10:30–11:00 AM |
Coffee Available |
|
| 11:00–12:45 PM |
Diagnostics, Management, and Therapy |
Eldorado Ballroom |
| |
* Matthew S Durstenfeld, University of California, San Francisco
Session Chair |
|
| |
* Lisa E. Gralinski, University of North Carolina
Session Chair |
|
| |
Lisa E. Gralinski, University of North Carolina
Complement Signaling Mediates Both Acute and Chronic Coronavirus-induced Lung Injury |
|
| |
Harlan Krumholz, Yale University School of Medicine
Novel, Digital, Participant-Centric Approaches to Long-COVID Research |
|
| |
David M. Systrom, Harvard Medical/Brigham & Women's Hospital
Neurovascular Dysregulation During Exercise |
|
| 11:45–12:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Eldorado Ballroom |
| 1:00–2:00 PM |
Social Hour with Lite Bites |
Anasazi Ballroom |
Thursday, August 31, 2023
