Biomolecular Condensates: Mechanisms and Therapeutic Opportunities (F1)
September 6-9, 2024
| Beaver Run Conference Center, Breckenridge, CO, United States
Mingjie Zhang and Jin Zhang
Scholarship Deadline: Jun. 6, 2024 | Abstract Deadline: Aug. 15, 2024 | Early Registration Deadline: Jul. 18, 2024
Friday, September 6, 2024
| 4:00–8:00 PM |
Registration |
Colorado Ballroom Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Colorado Ballroom Foyer |
Saturday, September 7, 2024
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–9:00 AM |
Welcome and Keynote Address |
Peaks 4 & 5 |
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* Jin Zhang, University of California, San Diego
Session Chair |
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Michael K. Rosen, University of Texas Southwestern Medical Center
Phase Separation in Biological Systems |
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| 9:00–11:15 AM |
Mechanisms of Phase Separation |
Peaks 4 & 5 |
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* Hao Wu, Harvard Medical School, Boston Children's Hospital
Session Chair |
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Jin Zhang, University of California, San Diego
Phase Separation in Protein Kinase Signaling |
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Tanja Mittag, St. Jude Children's Research Hospital
The Role of Emergent Condensate Properties in Transcription |
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Simon Alberti, Biotechnology Center of the TU Dresden
Phase Separation and Cell Stress Signaling |
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Anthony K. L. Leung, Johns Hopkins University/Leung Lab
Short Talk: Scope and Mechanism of Poly(ADP-ribose)-mediated Protein Condensation |
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| 9:30–9:50 AM |
Coffee Break |
Colorado Ballroom Foyer |
| 11:15–1:00 PM |
Poster Setup |
Peaks 1 - 3 |
| 11:15–2:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Foyer / Peaks 1 - 3 |
| 2:30–4:30 PM |
Symposia Spotlight 1: Hot off the Press: Talks Selected from Abstracts |
Peaks 4 & 5 |
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* Joshua Riback, Baylor College of Medicine
Session Chair |
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Saki Takayanagi, Johns Hopkins University
Development of a Molecular Tool iDoG to Explore the Physiological Roles of Biomolecular Condensates |
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Kevin Rhine, UC San Diego
Neuronal Aging Leads to Chronic Activation of the Stress Response |
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Daniel M Shapiro, Duke University
Synthetic Biomolecular Condensates Enhance Translation from a Target mRNA in Living Cells |
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Melanie Allram, University of Veterinary Medicine Vienna
The Role of lncRNAs in Biomolecular Condensation of Leukemia Fusion Oncoproteins |
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Benjamin R. Sabari, University of Texas Southwestern Medical Center
Gain-of-Function RNA Polymerase II Partitioning is a Shared Feature of Diverse Oncogenic Fusions |
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David Kuster, Max Planck Institute of Molecular Cell Biology
Biomolecular Condensates as Crucibles of Protein Aggregation |
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Huabin Zhou, University of Texas Southwestern Medical Center
Structures of Biomolecular Condensates by Cryo-ET |
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Huaiying Zhang, Carnegie Mellon University
TERRA-LSD1 Phase Separation Promotes R-Loop Formation for Telomere Maintenance in ALT Cancer Cells |
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| 4:30–5:00 PM |
Coffee Available |
Colorado Ballroom Foyer |
| 5:00–7:00 PM |
Biological Condensates in Genomic Organization and Transcriptional Regulation |
Peaks 4 & 5 |
| |
* Lindsay Case, Massachusetts Institute of Technology
Session Chair |
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Dirk Görlich, Max Planck Institute for Multidisciplinary Sciences
Passage of HIV Capsids through the FG Phase of Nuclear Pores |
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Pilong Li, Tsinghua University
Miscibility and Immiscibility of Condensates Control Chromatin Organization and Transcription |
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Marina Feric, Pennsylvania State University
Structure-Function Relationships in Mitochondrial Transcriptional Condensates |
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Kirstin Meyer, UCSF
Short Talk: YAP Signal Integration Through Transcriptional Condensates |
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Jonathan Henninger, Carnegie Mellon University
Short Talk: RNA in the Regulation of Transcriptional Condensates |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Peaks 1 - 3 |
| 7:30–10:00 PM |
Poster Session |
Peaks 1 - 3 |
Sunday, September 8, 2024
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–11:15 AM |
Biological Condensates in Cell Signaling |
Peaks 4 & 5 |
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* Mingjie Zhang, Southern University of Science and Technology
Phase Separation in Synapses |
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Sua Myong, Boston Children's Hospital
Size Regulation of FUS Condensates |
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Yi Lin, Tsinghua University
Phase Separation and Circadian Rhythm |
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Lindsay Case, Massachusetts Institute of Technology
Phase Separation in Integrin Signaling |
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Monica Sharma, Genentech
Short Talk: PD-1 Regulates the Formation of Protein Condensates in T-Cell Receptor Signaling |
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Maria F Ullo, Massachusetts Institute of Technology
Short Talk: Tuning Epidermal Growth Factor Receptor (EGFR) Condensate Properties Through Adaptor Protein Valency and Competition |
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Neus Sanfeliu Cerdán, ICFO - The Institute of Photonic Sciences
Short Talk: Liquid-to-Solid Phase Transition of MEC-2 Condensates is Required for Mechanotransduction During Touch |
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| 9:30–9:50 AM |
Coffee Break |
Colorado Ballroom Foyer |
| 11:30–12:30 PM |
Lunch |
Peaks 1 - 3 |
| 11:30–12:30 PM |
Women in Science Networking Event |
Peaks 1 - 3 |
| 11:30–6:00 PM |
Poster Viewing |
Peaks 1 - 3 |
| 12:45–2:15 PM |
Panel Discussion: Challenges and Opportunities of Phase Separation in Biology |
Peaks 4 & 5 |
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* Jin Zhang, University of California, San Diego
Panelist |
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Mingjie Zhang, Southern University of Science and Technology
Panelist |
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Michael K. Rosen, University of Texas Southwestern Medical Center
Panelist |
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Tanja Mittag, St. Jude Children's Research Hospital
Panelist |
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Lindsay Case, Massachusetts Institute of Technology
Panelist |
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| 2:30–4:00 PM |
Career Roundtable |
Peaks 4 & 5 |
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Benjamin Wolozin, Aquinnah Pharmaceuticals and Boston University
Co-Founder & Chief Scientific Officer, Professor |
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Kandice Levental, University of Virginia
Associate Professor |
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Paul Lang, Sanofi
US Head In Vitro Biology, Integrated Drug Discovery |
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Yi Lin, Tsinghua University
Associate Professor |
|
| 4:00–4:30 PM |
Coffee Available |
Colorado Ballroom Foyer |
| 4:30–6:15 PM |
Interface Between Membraneless and Membrane Organelles |
Peaks 4 & 5 |
| |
* Bo Huang, University of California, San Francisco
Session Chair |
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Sarah L. Veatch, University of Michigan
Phase Separation in Cell Signaling |
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Hong Zhang, Chinese Academy of Sciences
Phase Separation in Autophagy |
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Kandice Levental, University of Virginia
Phase Separation and Cell Signaling at Membrane Interface |
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Joo-Yeon Yoo, Postech
Short Talk: Membrane-Associated SCOTIN Condensates in the Regulation of Organelle Stress Response and Dynamics |
|
| 6:15–7:00 PM |
On Own for Dinner |
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Monday, September 9, 2024
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–11:00 AM |
Biomolecular Condensates: Disease Implications and Therapeutic Opportunities |
Peaks 4 & 5 |
| |
* Pilong Li, Tsinghua University
Session Chair |
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Jidong Zhu, Etern Therapeutics
Harnessing Phase Separation for Drug Development |
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Diego A Vargas, Dewpoint Therapeutics
Discovery of Condensate Modifying Drugs Through AI-Powered Experimental Platform |
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Benjamin Wolozin, Aquinnah Pharmaceuticals and Boston University
Applying RNA Binding Proteins and Biological Condensates to Develop Therapeutic Pipelines for Amyotrophic Lateral Sclerosis and Alzheimer’s Disease |
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Dorothee Dormann, Johannes Gutenberg University Mainz
TDP-43 Phase Transitions in Neurodegenerative Diseases |
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Shannon Moreno, Whitehead Institute
Short Talk: Condensate Proteolethargy is a Pathogenic Mechanism in Chronic Disease |
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Eman Elshalia, University of Denver
Short Talk: G-Quadruplexes Modulate TDP-43 Aggregation In Vitro And In Vivo |
|
| 9:00–9:20 AM |
Coffee Break |
Colorado Ballroom Foyer |
| 11:00–3:30 PM |
On Own for Lunch |
|
| 3:30–4:30 PM |
Symposia Spotlight 2: Young Investigator Forum |
Peaks 4 & 5 |
| |
* Yi Lin, Tsinghua University
Session Chair |
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Zheng Shi, Rutgers University
Alpha-Synuclein Regulates the Material Properties of Synapsin Condensates in Live Cells |
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Runwen Yao, UT Southwestern Medical Center
Size-Dependent Functional Transitions in Actin Signaling Protein Condensates |
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Barak Raveh, The Hebrew University of Jerusalem
Combining Molecular and Whole-Cell Models to Reveal Design Features Underlying Nucleocytoplasmic Transport |
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Salman Banani, University of Chicago
Active RNA Synthesis Patterns Nuclear Condensates |
|
| 4:30–5:00 PM |
Coffee Available |
Colorado Ballroom Foyer |
| 5:00–6:45 PM |
Methodologies for Phase Separation Research |
Peaks 4 & 5 |
| |
* Jin Zhang, University of California, San Diego
Session Chair |
|
| |
Hao Wu, Harvard Medical School, Boston Children's Hospital
Inflammasomes: Condensates and Ordered Supramolecular Assemblies |
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Felipe Quiroz, Emory University and Georgia Institute of Technology
High-Fidelity Probing of Intracellular Phase Separation Dynamics |
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Xiaokun Shu, University of California, San Francisco
Oncoprotein Transcription Factor MYC Undergoes Phase Separation that Differentially Modulates the Transcriptome |
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Joshua Riback, Baylor College of Medicine
Short Talk: Physical-Chemical Probing Reveals a Networked Nucleolar Structure Funneling Ribosome Biogenesis |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Peaks 4 & 5 |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Peaks 1 - 3 |
| 8:00–9:00 PM |
Entertainment |
Peaks 4 & 5 |
| 8:00–9:30 PM |
Cash Bar |
Peaks 1 - 3 |
Tuesday, September 10, 2024
