Positive-Strand RNA Viruses: Mechanisms of Viral Pathogenesis, Host Immunity, and Countermeasures (F1)
September 20-24, 2027  | Location to be Determined
David R. Martinez, Eng Eong Ooi and Yoke Fun Chan
* Session Chair † Invited but not yet accepted | Program current as of September 3, 2026 12 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Monday, September 20, 2027
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Tuesday, September 21, 2027
7:00–8:00 AM Breakfast
8:00–8:10 AM Welcome Remarks (Joint)
8:10–9:00 AM Keynote Address (Joint)
  Raul Andino †, University of California, San Francisco
Virus Evolution and Live-Attenuated Viral Vaccines
 
9:00–11:15 AM Spillover Risk, Surveillance, and Potential from Animals to Humans (Joint)
  Le Van Tan †, Oxford University Clinical Research Unit
Viral Surveillance: What Probing Nature Teaches Us About Pandemic Preparedness
 
  Michael S. Diamond †, Washington University School of Medicine
Zoonotic Reservoirs, Spillover Mechanisms, and Surveillance of Emerging Positive-Strand RNA Viruses
 
  Cleo Bertelsmeier †, University of Lausanne
Wildlife Trade Drives Animal-to-Human Pathogen Transmission
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:15–1:00 PM Poster Setup
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
2:30–4:30 PM Symposia Spotlight 1: Viral Surveillance to Inform Pandemic Preparedness
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM The Replication Machinery: Insights from RNA and Protein Synthesis into Viral Co-Opting of Host Processes
  Montserrat Barcena †, Leiden University Medical Center
Host Cell Membrane Remodeling and Cellular Organelle Hijacking
 
  Shin-Ru Shih †, Chang Gung University
Host Translation Shutoff and Cellular Metabolic Reprogramming
 
  Yue Wan †, Genome Institute of Singapore
Mapping Long-Range Viral RNA-RNA Interactions
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Wednesday, September 22, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM AI in Infectious Disease Research (Joint)
  Ethan Jackson †, Microsoft
Project Premonition: Reimagining Pathogen Surveillance with AI, Robotics, and Genomics
 
  Aude Bernheim †, Institut Pasteur
Evolution of Immunity Across Domains of Life
 
  David Baker †, University of Washington
Design of New Antibodies Using Deep Learning
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–1:00 PM Poster Setup
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
3:00–4:30 PM Career Roundtable
4:30–5:00 PM Coffee Available
5:00–7:00 PM Viral Pathogenesis Determinants in Mammalian and Mosquito Hosts
  Craig B. Wilen †, Yale University
Norovirus infection and Pathogenesis
 
  Gisa Gerold †, Medical University of Innsbruck-Institute of Virology
Alphavirus Pathogenesis Mechanisms in Mammals and Mosquitoes
 
  Gong Cheng †, Tsinghua University
Mosquito Host-Viral Interactions in Orthoflavivirus Infection
 
  Yoke Fun Chan, University Malaya
Mechanisms of Pathogenesis of Picornaviruses
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Thursday, September 23, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Countermeasures: Recent Advances in Vaccines to Positive-Stranded RNA Viruses
  David R. Martinez, Yale University School of Medicine
Vaccination Strategies Against RNA Viruses
 
  Long Ping Victor Tse †, Saint Louis University
Using Directed Evolution to Inform Live-Attenuated Dengue Vaccines that Bypass Antibody-Dependent Enhancement
 
  Eng Eong Ooi, Duke-NUS Medical School
Dengue Virus Vaccines
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:10–12:10 PM Panel Discussion: Bridging Basic Virology to Clinical Post-Acute Care
12:10–5:00 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2: Countermeasure Development in a Post-Pandemic World
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–6:45 PM Targeting the Virus: Small Molecules and Biologics to Counter Viral Disease
  Priscilla L. Yang †, Stanford University School of Medicine
Orthoflavivirus Antivirals: Current Landscape and Future Targets
 
  Sara R. Cherry †, University of Pennsylvania
Clinical Development of Antivirals Against Emerging and Re-Emerging RNA Viruses
 
  Camila H Coelho †, Icahn School of Medicine at Mount Sinai
Broadly Cross-Reactive Immunity Against Emerging Coronaviruses and Flaviviruses
 
  Tomas Cihlar †, Gilead Sciences, Inc.
Preclinical and Clinical Development of Antivirals
 
  Short Talk(s) Chosen from Abstracts
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions
7:00–8:00 PM Social Hour with Dinner
8:00–11:00 PM Cash Bar
8:00–11:00 PM Entertainment
Friday, September 24, 2027
12:00–11:59 PM Departure