Positive Strand RNA Viruses: Interdisciplinary Advances in Virology, Pathogenesis, Immunology, and Technology Development (F2)
October 21-24, 2024
| INEC Killarney Convention Centre, Killarney, KY, Ireland
Kizzmekia S. Corbett-Helaire, William B. Klimstra and Jolanda M. Smit
Scholarship Deadline: Jul. 24, 2024 | Abstract Deadline: Oct. 1, 2024 | Early Registration Deadline: Sep. 5, 2024
| 4:00–8:00 PM |
Registration |
INEC Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
INEC Foyer |
Tuesday, October 22, 2024
| 7:00–8:00 AM |
Breakfast |
Individual Hotel |
| 8:00–9:00 AM |
Welcome and Keynote Address |
INEC Main Auditorium |
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* William B. Klimstra, University of Pittsburgh
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* Jolanda M. Smit, University of Groningen
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Ted C. Pierson, NIAID, National Institutes of Health
Zika Virus Vaccine Development: Seeking a General Solution to Flavivirus Vaccine Design |
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| 9:00–11:15 AM |
On the Surface: Viral Attachment and Entry |
INEC Main Auditorium |
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* William B. Klimstra, University of Pittsburgh
Session Chair |
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* Jolanda M. Smit, University of Groningen
Early Events in Arbovirus Infection |
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Vidya Mangala Prasad, Indian Institute of Science
Structural Insights into Broadly Neutralizing Antibodies Against Dengue Virus |
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Jonathan Abraham, Harvard University
How Equine Encephalitic Alphaviruses Interact with Cellular Receptors |
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Shan-Lu Liu, Ohio State University
Short Talk: IFN-Inducible Phospholipid Scramblase 1 (PLSCR1) Differentially Modulates Viral Entry |
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| 9:30–9:50 AM |
Coffee Break |
INEC Foyer |
| 11:15–1:00 PM |
Poster Setup |
INEC Foyer |
| 11:15–2:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
INEC Foyer |
| 2:30–4:30 PM |
Symposia Spotlight 1: Novel Approaches to Virus Research |
INEC Main Auditorium |
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* Bogdan Dragnea, Indiana University
Session Chair |
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* James E. Crowe, Jr., Vanderbilt University Medical Center
Session Chair |
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Ramya Boddepalli, Indian Institute of Science Bengaluru
Integrative Mathematical Model to Elucidate the Role of Interferon-Stimulated-Genes (Isgs) in the Innate Immune Response During Positive-Sense RNA Virus Infection |
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Jonathan Burnie, Harvard T.H. Chan School of Public Health
Assessing Coronavirus Spike Epitope Accessibility on Native Virions Using Flow Virometry |
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Anastazia Jablunovsky, Penn State University
Investigating the Host Interactome and Intracellular Dynamics Of Zika Virus Genomic RNA Using a Fluorogenic Aptamer-Tag |
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Patrick T Dolan, NIH-NIAID
Linking Viral Genotype to Host Cell Phenotype Using Single-Cell RNA Sequencing |
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Anna K Overby, Umeå University
Whole Brain Imaging Reveals That Both the Type I IFN System and the Structural Proteins Shape Tropism of Tick-Borne Flavivirus Within the Brain. |
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Aarthi Narayanan, George Mason University
Optimizing a Machine Learning Strategy Towards the Development of an Artificial Intelligence Platform to Understand Host Drivers of Endothelial Damage in (Re)Emerging Viral Infections |
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Natasha Wyndham Hanners, University of Texas Southwestern Medical Center
Shiftless-Mediated Control of Zika Virus Neuropathogenesis |
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Frank van Kuppeveld, Utrecht University
Live Cell Single-Molecule Imaging to Study the Role of Enterovirus 2A Protease in the Early Phases of Viral RNA Translation and Replication |
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| 4:30–5:00 PM |
Coffee Available |
INEC Foyer |
| 5:00–7:00 PM |
Below the Surface: Mechanisms of Viral Replication, Assembly, and Pathogenesis |
INEC Main Auditorium |
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* Ana Fernandez-Sesma, Icahn School of Medicine at Mount Sinai
Session Chair |
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Stephanie Karst, University of Florida
Remote Presenter: Maternal Metabolism Determines Heightened Neonatal Susceptibility to Norovirus Disease |
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Margaret Kielian, Albert Einstein College of Medicine
Mechanisms of RNA Virus Entry and Transmission |
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Jan E. Carette, Stanford University
Genetic Screens Identify Host Proteins Required for Emerging Picornaviruses |
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Andrii Slonchak, University of Queensland
Short Talk: Zika Virus Noncoding RNA (Sfrna) Interacts With Viral Protein NS5 To Inhibit Antiviral Response and Promote Viral Replication and Pathogenesis |
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Chun-Chieh (Jack) Hsu, Rutgers University
Short Talk: SARS-Cov-2 NSP14 Induces N7-Methylguanosine Modifications in Host and Viral RNA |
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| 7:00–8:00 PM |
Cocktail Hour Sponsored by Michelson Philanthropies |
INEC Foyer |
| 7:05–8:05 PM |
Dinner |
INEC Foyer |
| 7:10–8:10 PM |
Women in Science Networking Event |
INEC Foyer |
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* Margaret Kielian, Albert Einstein College of Medicine
Session Chair |
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* Aarthi Narayanan, George Mason University
Session Chair |
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* Jolanda M. Smit, University of Groningen
Session Chair |
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| 7:45–10:00 PM |
Poster Session 1 |
INEC Foyer |
Wednesday, October 23, 2024
| 7:00–8:00 AM |
Breakfast |
Individual Hotel |
| 8:00–11:00 AM |
Host Responses to RNA Virus Infection |
INEC Main Auditorium |
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* Stacey Lynne Schultz-Cherry, St. Jude Children's Research Hospital
Session Chair |
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* Julie M Fox, NIAID/NIH
Session Chair |
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Matthew D. Daugherty, University of California, San Diego
Tripping the Wire: Innate Immune Sensing of Viral Protease Activity Through Effector-Triggered Immunity |
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Suresh Mahalingam, Griffith University
Host Responses and Pathogenesis of Acute and Chronic Chikungunya Infection |
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Ana Fernandez-Sesma, Icahn School of Medicine at Mount Sinai
Innate Immune Modulation by Arboviruses |
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Katherine C Barnett, University of North Carolina at Chapel Hill
Short Talk: Cell Death, Damage, and Inflammation in SARS-Cov-2 Infection |
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Tulika Singh, University of California, Berkeley
Short Talk: Striking Differences in Pediatric Dengue Virus B Cell And Antibody Imprinting Based on Prior Flavivirus Infection |
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Megan M Dunagan, National Institutes of Health
Short Talk: Activating FcγRs on Monocytes are Necessary for Optimal Mayaro Virus Clearance and Disease Resolution |
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| 9:00–9:20 AM |
Coffee Break |
INEC Foyer |
| 11:00–1:00 PM |
Poster Setup |
INEC Foyer |
| 11:00–1:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
INEC Foyer |
| 1:30–3:00 PM |
Academia vs. Industry vs Government: Navigating Your Next Career Stage |
INEC Main Auditorium |
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Ted C. Pierson, NIAID, National Institutes of Health
Director, Vaccine Research Center |
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Crystal W Burke, US Army Medical Research Institute for Infectious Diseases
Branch Chief, Viral Pathogenesis |
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Chris Bahl, AI Proteins, Inc.
Co-Founder, CSO, and President |
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Zhiyun Wen, Merck Co., Inc.
Associate Principal Scientist |
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Michael Letko, Washington State University
Assistant Professor |
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Vidya Mangala Prasad, Indian Institute of Science
Assistant Professor |
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| 3:15–4:30 PM |
Views from Journal Editors: Tips and Tricks |
INEC Main Auditorium |
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Nonia Pariente, PLOS Biology
*Session Chair, Editor-in-Chief |
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Clare E. Thomas, Springer Nature
Senior Editor |
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Christiana Fogg, Science Immunology
Senior Editor |
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| 4:30–5:00 PM |
Coffee Available |
INEC Foyer |
| 5:00–7:00 PM |
The Structure/Function Relationship |
INEC Main Auditorium |
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* Richard J. Kuhn, Purdue University
Session Chair |
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* Jonathan Abraham, Harvard University
Session Chair |
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Dahai Luo, Nanyang Technological University
Molecular Architecture of the CHIKV Replication Complex |
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James E. Crowe, Jr., Vanderbilt University Medical Center
Human Monoclonal Antibodies for Prevention or Treatment of Positive Strand RNA Viruses |
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Shee Mei Lok, Duke-NUS Medical School
Tomography Studies of the Dengue Fusion Process |
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Paige D Hall, Washington University in St. Louis
Short Talk: Cryo-EM Structure Of Mature Human Astrovirus In Complex With Neonatal Fc Receptor |
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Matthew Sutton, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Short Talk: Potent Vaccine-Elicited Mabs: Structural Basis for Broad Protection Against Alphaviruses |
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| 7:00–8:00 PM |
Social Hour |
INEC Foyer |
| 7:05–8:05 PM |
Dinner Sponsored by Michelson Philanthropies |
INEC Foyer |
| 7:30–8:15 PM |
Michelson Philanthropies Award Ceremony |
INEC Foyer |
| 8:00–10:00 PM |
Poster Session 2 |
INEC Foyer |
Thursday, October 24, 2024
| 7:00–8:00 AM |
Breakfast |
Individual Hotel |
| 8:00–11:00 AM |
Zoonosis, Viral Evolution, and Epidemiology |
INEC Main Auditorium |
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* Michael Letko, Washington State University
Session Chair |
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Chris Bahl, AI Proteins, Inc.
Using AI to Predict SARS-CoV-2 Variant Evolution |
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Eva Harris, University of Califonia, Berkeley
Lessons from a Longitudinal Flavivirus Infection Cohort in Nicaragua: Immunological Underpinnngs of the Complex Interplay between Dengue and Zika Viruses |
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Michael Letko, Washington State University
Functional Viromics of Beta-Coronavirus Entry |
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Dixitkumar Nanubhai Tandel, CSIR-Centre for Cellular and Molecular Biology
Short Talk: Evolutionary Tale of SARS-Cov-2 Variants from The Perspective of Host Innate Immune Response |
|
| 9:00–9:20 AM |
Coffee Break |
INEC Foyer |
| 11:00–1:00 PM |
Poster Setup |
INEC Foyer |
| 11:00–2:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
INEC Foyer |
| 2:30–4:30 PM |
Symposia Spotlight 2: Detecting and Preparing for Emerging Viral Threats |
INEC Main Auditorium |
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* Shan-Lu Liu, Ohio State University
Session Chair |
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Raul Y Sanchez-David, Blizard Institut, Queen Mary University London
Novel Strategy to Enhance Self-Amplifying mRNA's Technologies Activity in Mammalian Cells by Spatial Redistribution of the Vectors Double Stranded RNA |
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Nicole Stark, Indiana University
The Interactive Effects of Wolbachia And Nop60B on Sindbis Virus Replication |
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Nicholas J Catanzaro, University of North Carolina at Chapel Hill
Species-Specific ACE2 Receptor Usage by The Merbecovirus HKU5: Divergence from MERS-Cov and Implications for Antiviral Strategies. |
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Paula Bueno Fernández, Spanish National Center for Biotechnology
Discovery of a Novel Coronaviral Molecular Target Through Characterization of Molecules with Pan-Coronavirus Antiviral Activity |
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Ségolène Gracias, Institut Pasteur
Investigating the Entry Mechanisms and Innate Immune Response of Bat Cells to BANAL-236 and Related Viruses |
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M. Alejandra Tortorici, University of Washington
Structural and Functional Characterization of the Emerging FCoV-23 Coronavirus |
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Ji Min Lee, University of Washington
A Broadly Generalizable Stabilization Strategy for Sarbecovirus Fusion Machinery Vaccines |
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| 4:30–5:00 PM |
Coffee Available |
INEC Foyer |
| 5:00–6:45 PM |
The Future of Vaccines, Antibodies, and Antivirals |
INEC Main Auditorium |
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* Mario Roederer, NIH
Session Chair |
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* Andres Merits, University of Tartu
Session Chair |
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Timothy P. Sheahan, University of North Carolina
Preparing for Tomorrow’s Pandemics Today Through the Development of Broadly Active Antivirals |
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William B. Klimstra, University of Pittsburgh
Informed Design of Live-Attenuated Alphavirus Vaccines |
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James Brett Case, Washington University School of Medicine
A Trivalent Mucosal Vaccine Encoding Phylogenetically Inferred Ancestral RBD Sequences Confers Pan-Sarbecovirus Protection in Mice |
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Christian K.O Dzuvor, Harvard University
Short Talk: Multivalent Endemic Immunodominant Domain (IDD) Nanoparticle Immunogens Induce Broadly Cross-reactive Anti-Coronavirus Responses |
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
INEC Main Auditorium |
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* William B. Klimstra, University of Pittsburgh
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* Jolanda M. Smit, University of Groningen
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| 7:00–8:00 PM |
Dinner and Surveys |
INEC Foyer |
| 7:30–10:00 PM |
Poster Session 3 |
INEC Foyer |
