Immunity and Aging (F3)
October 1-4, 2023
| Whistler Conference Centre, Whistler, BC, Canada
Danica Chen, Sun Hur and Joan Mannick
Scholarship Deadline: Jun. 28, 2023 | Abstract Deadline: Jun. 28, 2023 | Early Registration Deadline: Aug. 1, 2023
| 10:00–2:00 PM |
Arrival and Registration |
Grand Foyer |
| 12:00–2:00 PM |
Welcome Mixer |
Valley Foyer |
| 1:00–2:00 AM |
Breakfast |
Garibaldi A/B |
| 2:00–3:00 AM |
Welcoming Remarks (Organizers) and Keynote Address |
Rainbow Theater |
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* Danica Chen, University of California, Berkeley
Session Chair |
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John Sedivy, Brown University
The Repeatome and Aging |
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| 3:00–5:15 AM |
Hallmarks of Aging |
Rainbow Theater |
| |
* Cynthia Kenyon, Calico Life Sciences
Session Chair |
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* Joan Mannick, Tornado Therapeutics
Session Chair |
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Danica Chen, University of California, Berkeley
Hematopoietic Stem Cell Aging |
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Ana Maria Cuervo, Albert Einstein College of Medicine
Proteostasis and Aging |
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Paul Robbins, University of Minnesota
Immune Dysfunction Drives Systemic Senescence and Aging |
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Peter James Mullen, University of Southern California
Short Talk: Short Talk: A Metabolic Atlas of Aging |
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| 3:30–3:50 AM |
Coffee Break |
Valley Foyer |
| 5:15–7:00 AM |
Poster Setup |
Garibaldi A/B |
| 5:15–11:00 AM |
On Own for Lunch |
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| 7:00–4:00 PM |
Poster Viewing |
Garibaldi A/B |
| 8:30–10:30 AM |
Workshop 1: Aging Immune System: From Hematopoietic Stem Cells to Innate and Adaptive Immunity |
Rainbow Theater |
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* Kenneth Walsh, University of Virginia School of Medicine
Session Chair |
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* Mary Mohrin, Genentech
Session Chair |
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Mary Mohrin, Genentech
Manf Regulates Age-Associated Changes In Hematopoietic Stem And Progenitor Cell Driven Repair Of Peripheral Fibrotic Tissue |
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Rong Lu, University of Southern California
Age-associated Imbalance of Adaptive and Innate immune Systems Originates from a Subset of Stem Cells |
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Chiraag Kapadia, Baylor College of Medicine
Murine Clonal Hematopoiesis is Common with Age and Accelerated Following Infection |
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Ines Fernandez Maestre, Memorial Sloan Kettering Center
Understanding Senescence in Clonal Hematopoiesis |
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Wenxiang Zhang, Boston Childrens Hospital/Harvard Medical School
Ladder-like Multimerization of FoxP3 Enables Microsatellite Recognition and DNA Bridging |
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Armin Aabish Gandhi, Sanford Burnham Prebys Medical Discovery Institute
Investigating the Effect of an Aged Liver Microenvironment on Immune Surveillance and Predisposition to Cancer |
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Annette Johanna Lis, Saarland University
Faster Cytotoxicity with Age: Increased Perforin and Granzyme Levels Shift CD8+ T Cells from Apoptotic to Necrotic Killers in the Elderly |
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Michelle Rice, University of Southern California
MOTS-c is a Mitochondrial-encoded Host Defense Peptide that Regulates Monocyte-to-Macrophage Differentiation in an Age-dependent Manner |
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| 10:30–11:00 AM |
Coffee Available |
Valley Foyer |
| 11:00–1:00 PM |
Immunity, Aging, and Diseases I |
Rainbow Theater |
| |
* Feng Shao, National Institute of Biological Sciences
Session Chair |
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* Sun Hur, Harvard Medical School
Session Chair |
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Feng Shao, National Institute of Biological Sciences
Inflammasomes |
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Kenneth Walsh, University of Virginia School of Medicine
Clonal Hematopoiesis: Consequences of Somatic Mutations in the Aging Immune System |
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Vishva M. Dixit, Genentech, Inc.
NF-KB and Inflammation |
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Myong-Hee Mia Sung, NIH
Short Talk: Short Talk: Double Knock-in Reporter Mice Reveal NF-κB Trajectories in Signaling, Immune Cell Development, and Aging |
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Nan-ping Weng, NIA, National Institutes of Health
Short Talk: Short Talk: Transcriptome and Mutation Changes of Human CD8+ T Cells Across Nine dDecades of Life |
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| 1:00–2:00 PM |
Social Hour with Lite Bites |
Garibaldi A/B |
| 1:30–4:00 PM |
Poster Session 1 |
Garibaldi A/B |
| 1:00–2:00 AM |
Breakfast |
Garibaldi A/B |
| 2:00–5:00 AM |
Inflammaging |
Rainbow Theater |
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* Andrew Brack, University of California San Francisco
Session Chair |
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* John Sedivy, Brown University
Chair Person |
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Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne
Remote Presentation: cGAS Signaling and Senescence |
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David Furman, Buck Institute for Research on Aging
Inflammatory Age Connects Non-communicable Multimorbidity and Immunosenescence |
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Cornelia M. Weyand, Stanford University
Mechanisms Underlying T Cell Aging |
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Anthony J. Covarrubias, UCLA
Short Talk: Short Talk: The Role of Macrophage Senescence in Inflammaging and Metabolic Disease: Aging at the Cross Roads of Inflammation and Metabolism |
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Anissa A. Widjaja, DUKE-NUS Medical School
Short Talk: Short Talk: Inhibition of an Immunometabolic Axis of IL11-mTORC1 Activation Extends Mammalian Healthspan |
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Ana M. Basso, Abbvie
Short Talk: Short Talk: Targeting Immunosenescence for Age-associated Immune Dysfunction and Diseases |
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Francesca Castoldi, Karolinska Institutet
Short Talk: Short Talk: Anti-senescence Immunotherapy: Targeting Senescence Associated Immune Checkpoints in Tissue Injury |
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| 3:00–3:20 AM |
Coffee Break |
Valley Foyer |
| 5:00–7:00 AM |
Poster Setup |
Garibaldi A/B |
| 5:00–11:00 AM |
On Own for Lunch |
|
| 7:00–4:00 PM |
Poster Viewing |
Garibaldi A/B |
| 9:00–10:30 AM |
Career Roundtable |
Sea to Sky B |
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Tyler J. Curiel, Dartmouth College
Professor of Medicine |
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Hong I. Wan, Tallac Therapeutics
President, Chief Executive Officer and Co-Founder |
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Dinis Pedro Calado, Francis Crick Institute
Senior Group Leader |
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Myong-Hee Mia Sung, NIH
Earl Stadtman Investigator & Chief, Transcription Systems Dynamics and Biology Unit |
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| 10:30–11:00 AM |
Coffee Available |
Valley Foyer |
| 11:00–1:00 PM |
Immunity, Aging, and Diseases II |
Rainbow Theater |
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* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital
Session Chair |
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* Gerald S. Shadel, The Salk Institute for Biological Studies
Session Chair |
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Anjana Rao, La Jolla Institute for Immunology
Potential Role of DNA Methylation/Demethylation Pathways in Cellular Senescence and Aging |
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Jenny P.Y. Ting, University of North Carolina at Chapel Hill
Importance of Innate Immune Receptors in Adaptive Lymphocytes |
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Gerald S. Shadel, The Salk Institute for Biological Studies
Nucleic Acid-Mediated Mitonuclear Signaling |
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Sun Hur, Harvard Medical School
Self Assemblies in Transcriptional Regulation of T Cell Development –– AIRE |
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| 1:00–2:00 PM |
Social Hour with Lite Bites |
Garibaldi A/B |
| 1:30–4:00 PM |
Poster Session 2 |
Garibaldi A/B |
| 8:30–10:30 AM |
Workshop 2: Aging, Vaccination, COVID-19 |
Rainbow Theater |
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* Stanley Perlman, University of Iowa
Session Chair |
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* Albert C Shaw, Yale School of Medicine
Session Chair |
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Albert C Shaw, Yale School of Medicine
Effects of Age and Influenza Vaccination on Human Platelet Response |
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Duygu Ucar, The Jackson Laboratory
Distinct Baseline Immune Characteristics Associated with Responses to Conjugated and Unconjugated Pneumococcal Polysaccharide Vaccines in Older Adults |
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Marine Barthez, University of California Berkeley
SIRT2 Suppresses Aging-associated Inflammation and Vulnerability to COVID-19 |
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Ines Sturmlechner, Mayo Clinic
Age-related Mis-differentiation of Antigen-specific Memory T Cells to Regulatory T Cell Phenotypes After Vaccination |
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Debbie Van Baarle, National Institute of Public Health and Environment
Baseline Immunotypes Identify Individuals at Risk of Low Vaccine Responsiveness |
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Anne-Marie Buisman, The Institute of Public Health and the Environment, The Netherlands
A Large Heterogeneity in Health Characteristics and Frailty of the Ageing Population Influences the COVID-19 Vaccine Responsiveness |
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Liam B. Healy, Harvard University/Boston Children's Hospital
ROS-dependent Palmitoylation is an Obligate Licensing Modification for GSDMD Pore Formation |
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Pingze Zhang, Max Planck Institute for Biology of Ageing
S6K Regulates Inflammageing, Immunosenescence and Lifespan through the Endolysosomal System |
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Wednesday, October 4, 2023
| 1:00–2:00 AM |
Breakfast |
Garibaldi A/B |
| 2:00–5:00 AM |
Harnessing Big Data Sets to Understand Immunity and Aging |
Rainbow Theater |
| |
* Rong Lu, University of Southern California
Session Chair |
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* Anthony J. Covarrubias, UCLA
Session Chair |
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Mihai G. Netea, Radboud University
Impact of Aging on Trained Immunity |
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Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital
Molecular Mechanisms of Innate Immunity and Inflammation in Health and Disease |
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Isabel Beerman, National Institute on Aging
Epigenetic Alterations of Aged HSCs |
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Ryan Englander, Jackson Laboratory for Genomic Medicine
Short Talk: Short Talk: Age-related Intron Retention in STAT2 Modulates Antiviral and Antitumor Immunity |
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Charlotte Moss, University of Sheffield
Short Talk: Short Talk: Transcription Factors MYC and USF1 Drive Chronic Macrophage Dysfunction in Ageing |
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Nicole L. La Gruta, University of Melbourne
Short Talk: Short Talk: Epigenetic Changes Associated with Distinct Signatures of Aging-related CD8 T Cell Dysfunction |
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Sophia Liu, Ragon Institute
Short Talk: Short Talk: Spatiotemporal Dynamics of the Thymus Reveal Changes Underlying Immune Decline and Regeneration |
|
| 3:00–3:20 AM |
Coffee Break |
Valley Foyer |
| 5:00–11:00 AM |
On Own for Lunch |
|
| 10:30–11:00 AM |
Coffee Available |
Valley Foyer |
| 11:00–12:45 PM |
Clinical Applications |
Rainbow Theater |
| |
* Joan Mannick, Tornado Therapeutics
Session Chair |
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* Tyler J. Curiel, Dartmouth College
Session Chair |
|
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Joan Mannick, Tornado Therapeutics
Targeting Immunosenescence with mTOR Inhibitors in Older Adults |
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Tyler J. Curiel, Dartmouth College
Age Effects on Immune Checkpoint Expression and ICB Efficacy |
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Stanley Perlman, University of Iowa
COVID-19 and Aging |
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Yin Huang, Lyell Immunopharma
Short Talk: Short Talk: Rejuvenation of Aged T Cells: Enhancing Function and Therapeutic Potential in Solid Tumor |
|
| 12:45–1:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Rainbow Theater |
| 1:00–2:00 PM |
Social Hour with Lite Bites |
Garibaldi A/B |
| 2:00–3:00 PM |
Cash Bar |
Garibaldi A/B |
Thursday, October 5, 2023
