Fibrosis: Inflammation, Drivers, and Therapeutic Resolution (F4)
December 8-11, 2024
| Fairmont Chateau Whistler, Whistler, BC, Canada
Valerie Horsley, Michael T. Longaker and Thomas A Wynn
Scholarship Deadline: Sep. 11, 2024 | Abstract Deadline: Nov. 15, 2024 | Early Registration Deadline: Oct. 23, 2024
| 4:00–8:00 PM |
Registration |
Macdonald Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Macdonald Foyer |
| 7:00–8:00 AM |
Breakfast |
MacDonald CDEF |
| 8:00–9:00 AM |
Welcome and Keynote Address |
Macdonald AB |
| |
* Valerie Horsley, Yale University
Session Chair |
|
| |
Neil C. Henderson, Institute of Regeneration and Repair, University of Edinburgh
State of the Art Technologies to Study Organ Fibrosis |
|
| 9:00–11:30 AM |
Fibroblast Heterogeneity and Fibrosis |
Macdonald AB |
| |
* David Brenner, Sanford Burnham Prebys
Session Chair |
|
| |
* Jeff Biernaskie, University of Calgary
Session Chair |
|
| |
Darlene Dixon, NIEHS, National Institutes of Health
Mechanisms of Uterine Fibroids |
|
| |
Florian Rieder, Cleveland Clinic
Fibroblast-Driven Mechanisms in Intestinal Fibrosis |
|
| |
Rafael Kramann, RWTH Aachen University
Dissecting Mechanisms of Kidney and Heart Fibrosis Using Single Cell and Spatial Genomics |
|
| |
Tianhe Sun, Genentech, Inc.
Targeting TGF-beta 3 for Fibrotic Diseases |
|
| 9:30–9:50 AM |
Coffee Break |
Macdonald Foyer |
| 9:50–9:55 AM |
Jessica Langer, Helmsley Trust Introduction |
Macdonald AB |
| 11:30–1:00 PM |
Poster Setup |
MacDonald CDEF |
| 11:30–2:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
MacDonald CDEF |
| 2:30–4:30 PM |
Symposia Spotlight 1: Beyond the Multiome: Integrating -Omics and AI in Fibrosis Models |
Macdonald AB |
| |
* Shruti Naik, Icahn School of Medicine at Mount Sinai
Session Chair |
|
| |
* Rafael Kramann, RWTH Aachen University
Session Chair |
|
| |
Rico Chandra Ardy, Sloan Kettering Institute
Comprehensive Transcription Factor Perturbations Recapitulate Fibroblast Transcriptional States |
|
| |
Ross Fitzsimmons, University of Calgary
Multi-Omic Analysis of a Fibrosis-Prone Tendon in a Clinically Relevant Large Mammalian Model |
|
| |
Jingyi Xia, University of Michigan Ann Arbor
A 3D Image Atlas Chronicling Cellular and Structural Dynamics Following Lung Injury Identifies the Aberrant Expansion of Nonfunctional Endothelial Cells |
|
| |
Ari Glasner, Technion
Conserved Transcriptional Connectivity of Regulatory T Cells in the Tumor Microenvironment as Well as Injury Induced Lung Fibrosis Informs New Combination Therapy Strategies |
|
| |
Lesley A. Hill, University of British Columbia
Mechanisms Regulating Mesenchymal Stromal Cell Quiescence and Their Impact on Liver Regeneration, Fibrosis and Resolution |
|
| |
Michal Polonsky, Caltech
Fibroblasts Act as Key Spatial Determinants Following Acute Kidney Injury |
|
| |
Yvon Woappi, Columbia University
Delineating the Complexity of Mammalian Skin Wound Healing at Organ-Scale |
|
| 4:30–5:00 PM |
Coffee Available |
Macdonald Foyer |
| 5:00–7:00 PM |
Mechanobiology in Regulation of Fibrosis |
Macdonald AB |
| |
* Sabine Eming, University of Cologne
Session Chair |
|
| |
* Kara Spiller, Drexel University
Session Chair |
|
| |
Michael T. Longaker, Stanford School of Medicine
Mechanical Signaling in Skin Fibrosis and Repair |
|
| |
Daniel Tschumperlin, Mayo Clinic
Mechanical Regulation of Lung Fibrosis Development |
|
| |
Jennifer Elisseeff, Johns Hopkins University
T Cells and Senescence in Fibrosis |
|
| |
Rachel Biggs, MUSC
Short Talk: Evidence for Persistent Fibrosis in Heart Failure with a Reduced Ejection Fraction Linked to Phenotypic Differences in Human Cardiac Fibroblast Populations |
|
| |
Aya Nassereddine, Yale University
Short Talk: A Mechanosensitive Pathway Drives Epigenetic and Transcriptional Fibrotic Responses |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
MacDonald CDEF |
| 7:05–8:05 PM |
Women in Science Networking Event |
MacDonald CDEF |
| |
* Shruti Naik, Icahn School of Medicine at Mount Sinai
Session Chair |
|
| |
* Carla V. Rothlin, Yale University
Session Chair |
|
| |
* Valerie Horsley, Yale University
Session Chair |
|
| 7:30–10:00 PM |
Poster Session #1 |
MacDonald CDEF |
Tuesday, December 10, 2024
| 7:00–8:00 AM |
Breakfast |
MacDonald CDEF |
| 8:00–11:00 AM |
Inflammatory Drivers of Fibrosis |
Macdonald AB |
| |
* Jennifer Elisseeff, Johns Hopkins University
Session Chair |
|
| |
* Florian Rieder, Cleveland Clinic
Session Chair |
|
| |
Thomas A Wynn, Pfizer
Type 2 Immunity and Macrophages in the Pathogenesis of Fibrosis |
|
| |
Shruti Naik, Icahn School of Medicine at Mount Sinai
Inflammatory Memory in Skin Regeneration |
|
| |
Jeff Biernaskie, University of Calgary
Fibroblast Dynamics during Regenerative versus Fibrotic Skin Repair |
|
| |
Vinicio de Jesus Perez, Stanford University
Targeting Hyaluronan in Pulmonary Hypertension Associated with Lung Fibrosis: Insights from the SATURN Study |
|
| |
Anthony Chang, UCSF
Short Talk: Defining a Stromal Niche for Type 2-Like Regulatory T Cells |
|
| |
Asma Farhat, Medical University of Vienna/CeMM
Short Talk: An Ageing Bone Marrow Exacerbates Lung Fibrosis Via a Dysregulated Regulatory T Cell Axis, Fueling Profibrotic Macrophage Persistence. |
|
| 9:00–9:20 AM |
Coffee Break |
Macdonald Foyer |
| 11:00–1:00 PM |
Poster Setup |
MacDonald CDEF |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
MacDonald CDEF |
| 3:00–4:30 PM |
Career Roundtable |
Macdonald AB |
| |
Darlene Dixon, NIEHS, National Institutes of Health
Senior Investigator |
|
| |
Yvon Woappi, Columbia University
Assistant Professor |
|
| |
Min Lu, Morphic Therapeutic, a wholly owned subsidiary of Eli Lilly and Company
Executive Director, Head of Fibrosis |
|
| |
Audrey Sambeat, Boehringer-Ingelheim
Principal Scientist |
|
| |
Andreas Ramming, University of Erlangen-Nuremberg
Senior Physician & Professor |
|
| 4:30–5:00 PM |
Coffee Available |
Macdonald Foyer |
| 5:00–7:00 PM |
Macrophage-Fibroblast Interactions |
Macdonald AB |
| |
* Michael T. Longaker, Stanford School of Medicine
Session Chair |
|
| |
* M. Carrie Miceli, University of California, Los Angeles
Session Chair |
|
| |
Charlotte L. Scott, University of Ghent & VIB
Remote Presenter: Investigating Macrophage Functional Heterogeneity in the Fibrotic Liver |
|
| |
Carla V. Rothlin, Yale University
Cell Death Mechanisms During Tissue Repair |
|
| |
Sabine Eming, University of Cologne
Metabolic Regulation of Macrophages in Skin Fibrosis |
|
| |
Shin-Huey Lin, National Tsing Hua University
Short Talk: Foxm1 Regulates Macrophage Polarization and Cytokine Secretion to Drive Renal Fibrosis After Acute Kidney Injury |
|
| |
Preethy Parthiban, University of Minnesota- Twin Cities
Short Talk: Macrophage-Derived CCL24 Promotes Fibrosis and Worsens Cardiac Dysfunction During Heart Failure |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
MacDonald CDEF |
| 7:30–10:00 PM |
Poster Session #2 |
MacDonald CDEF |
Wednesday, December 11, 2024
| 7:00–8:00 AM |
Breakfast |
MacDonald CDEF |
| 8:00–11:00 AM |
New Horizons: Resolving Fibrosis |
Macdonald AB |
| |
* Jeff Biernaskie, University of Calgary
Session Chair |
|
| |
Valerie Horsley, Yale University
Cellular and Molecular Crosstalk During Fibrosis Resolution |
|
| |
Tatiana Kisseleva, University of California, San Diego
Portal Fibroblasts in Liver Fibrosis Resolution |
|
| |
Michelle Griffin, Stanford University
Piezo Inhibition Prevents and Rescues Scarring by Targeting the Adipocyte To Fibroblast Transition |
|
| |
Konrad Hoeft, RWTH Aachen University
Short Talk: ADAMTS12 Promotes Fibrosis by Restructuring Extracellular Matrix to Enable Activation and Migration of Injury-Responsive Fibroblasts |
|
| |
Resat Cinar, NIAAA, National Institutes of Health
Short Talk: Targeting Fibrometabolism Via Glutamate Mediated Metabotropic Glutamate Receptor 5 (Mglur5) Signaling in Pulmonary Fibroblasts to Reverse Pulmonary Fibrosis: Prospective of Repositioning Basimglurant, a Negative Allosteric Modulator of Mglur5 |
|
| |
Hyun Young Kim, University of California San Diego
Short Talk: LARP6 Binding Modulates Mrna Translation in Human Liver Fibrosis |
|
| 9:00–9:20 AM |
Coffee Break |
Macdonald Foyer |
| 11:00–2:30 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Symposia Spotlight 2: Common Fibrosis Mechanisms: Lessons Across Tissues |
Macdonald AB |
| |
* Mehdi Maneshi, abbvie
Session Chair |
|
| |
* Lisa Ahne, Martin-Luther-University Halle-Wittenberg
Silencing Neat1 Alleviates Fibrosis in an in Vivo Model Of Metabolic Dysfunction-Associated Steatohepatitis (MASH) |
|
| |
Kara Spiller, Drexel University
Biomaterials-Based Engineering of Macrophages for Regenerative Medicine |
|
| |
Sritejasvinithi Karimikonda, Medical College of Wisconsin
Exploring the Role of Fibroblast Reg3 Proteins In Response to Intestinal Inflammation |
|
| |
M. Carrie Miceli, University of California, Los Angeles
Transcriptomics Reveals DMD Driven Cell Dynamics and Mechanisms of Fibroblast Inflammatory Tissue Priming in Human Dystrophic Muscle |
|
| |
Sruthi Purushothaman, University of British Columbia
The Nail Bed Orchestrates a Multicellular Response To Promote Mammalian Fingertip (Digit Tip) Regeneration Versus Fibrosis |
|
| |
Ryan M Friedman, University of Pennsylvania & Children's Hospital of Philadelphia
Inhibition of the MRTF-A/SRF Axis Alleviates Vocal Fold Scarring |
|
| |
Anne-Katrine Z. Johansen, Cincinnati Children’s Hospital Medical Center
Down-Regulation of the Basic Helix-Loop-Helix Transcription Factor TCF21 is Necessary for the Development of Cardiac Fibrosis |
|
| |
Astrid Hofman, University Hospital Zürich
Integrating Liver and Cardiac Microtissues in a Multi-Organ-on-a-Chip Model Reveales Liver-Mediated Modulation of Cardiac Fibrosis |
|
| 4:30–5:00 PM |
Coffee Available |
Macdonald Foyer |
| 5:00–6:45 PM |
Clinical Innovations in Fibrosis |
Macdonald AB |
| |
* Thomas A Wynn, Pfizer
Session Chair |
|
| |
* Michael Underhill, University of British Columbia
Session Chair |
|
| |
Martin L. Decaris, Pliant Therapeutics
Translational Approaches used in the Development of Bexotegrast, a Dual αvβ6/αvβ1 Integrin Inhibitor, for IPF |
|
| |
Haig Aghajanian, Capstan Therapeutics
In vivo Generated CAR T Cells Targeting Pathogenic Fibroblasts for the Treatment of Cardiac Fibrosis |
|
| |
Steve Ho, Pliant Therapeutics
Short Talk: Multi-Omic Approach Toward Identifying Pharmacodynamic Biomarkers in Fibrotic Human Liver Explants |
|
| |
Mehdi Maneshi, abbvie
Short Talk: Leveraging Recent Advances in Human Precision-Cut Tissue Slices: Improved Translational Models to Pursue a Cure for Fibrotic Diseases |
|
| |
Paul J. Yaworsky, Mediar Therapeutics
Short Talk: Anti-WISP1 (MTX-463) as a Novel Potential Therapy for Idiopathic Pulmonary Fibrosis |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Macdonald AB |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
MacDonald CDEF |
| 8:00–9:00 PM |
Trivia |
Macdonald AB |
Thursday, December 12, 2024
