| 7:00–8:00 PM | Registration | Foyer |
| 7:00–8:30 AM | Registration Continues | Foyer |
| 7:30–8:30 AM | Breakfast | Independence Salons EFGH |
| 8:00–8:30 AM | Poster Setup | Independence Salons EFGH |
| 8:00–5:00 PM | Poster Viewing | Independence Salons EFGH |
| 8:30–9:30 AM | Welcome and Keynote Address | Independence Salons ABCD |
| * Rino Rappuoli, Fondazione Biotecnopolo di Siena Session Chair |
| Peter J. Hotez, Baylor College of Medicine Vaccines and Immunizations in a Time of Global Boiling, Megacities, and Antiscience |
| 9:30–9:40 AM | Why Should I Trust You? Podcast Introduction | Independence Salons ABCD |
| 9:40–11:45 AM | Learning the Molecular Immunology of mRNA Vaccines | Independence Salons ABCD |
| * Bali Pulendran, Stanford University School of Medicine Comparative Responses to mRNA and Adjuvanted Vaccines |
| Ali H Ellebedy, Washington University School of Medicine B Cell Responses to mRNA Vaccination/Induction of New Epitopes |
| * Rita Carsetti, Bambino Gesù Children Hospital Early Immune Responses to Vaccination |
| Michela Locci, University of Pennsylvania Short Talk: Distinct Components of Nucleoside-modified Messenger RNA Vaccines Cooperate to Instruct Efficient T Follicular Helper Cell Responses |
| 10:10–10:30 AM | Coffee Break | Foyer |
| 11:45–12:45 PM | Lunch | Independence Salons EFGH |
| 12:15–2:30 PM | Poster Session 1 | Independence Salons EFGH |
| 2:30–4:30 PM | Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions | Independence Salons ABCD |
| * Wolfgang W Leitner, National Institute of Allergy and Infectious Diseases, NIH, DHHS Session Chair |
| * Catherine J Wu, Dana-Farber Cancer Institute Session Chair |
| Artem Ashurov, University Hospital of Cologne Remote Presentation: Structural Characterization of Antibodies for Synergistic HCMV Neutralization |
| Namit Chaudhary, Scripps Research Alumina-coated Microparticles Enable Extended Antigen Delivery of HIV Immunogens in a Single Shot |
| Grace Freeman, National Institutes of Health Isolation of Monoclonal Antibodies against H5Nx Influenza Viruses from Individuals Immunized with a Monovalent H5N1 Vaccine |
| Grace Hendricks, University of Washington Computationally Designed mRNA-launched Protein Nanoparticle Immunogens as an Integrated Vaccine Platform |
| Fnu Alakesh, Stanford University Understanding the Immune Landscape behind TLR-based Hydrogel Vaccines |
| Sacha Zinn, Garvan Institute of Medical Research Tailoring SARS-CoV-2 Humoral Responses using mRNA-encoded mAbs |
| Giovanna de Brito Carneiro, Instituto Butantan CyaA Vector Carrying Fragments of the Pneumococcal Surface Protein A as a Vaccine Candidate against Streptococcus Pneumoniae |
| Hervé Besançon, University of California, San Diego A STING-Adjuvanted Outer Membrane Vesicle Nanoparticle Vaccine Against Klebsiella pneumoniae |
| 4:30–5:00 PM | Coffee Available | Foyer |
| 5:00–7:00 PM | Vaccines, Emerging Reality in Cancer Therapy | Independence Salons ABCD |
| * Laurence Zitvogel, Institut Gustave Roussy Session Chair |
| Catherine J Wu, Dana-Farber Cancer Institute Personalized Cancer Vaccines: Updates and Encouraging Results |
| * Ira Mellman, Parker Institute for Cancer Immunotherapy Combining Checkpoints Inhibitor Immunotherapy and Personalized Vaccines |
| Pirooz Zareie, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne Defining TRM Cell Fate: The Combined Influence of TCR Signaling and Tissue Instruction |
| Shuang Chen, UT Southwestern Medical Center Short Talk: Systemic STING Nanovaccine for HPV-Induced Cancer Therapy |
| Xinbo Gao, Tianjin Medical University Short Talk: Enhancing Pancreatic Cancer Vaccines with OX40 Agonist and PD-1 Inhibitor to Synergize Antitumor Immunity and Reshape the Immune Microenvironment |
| 7:00–8:00 PM | On Own for Dinner |
| 7:30–8:30 AM | Breakfast | Independence Salons EFGH |
| 8:30–11:30 AM | Preparing for New Pandemics and Emerging Infections | Independence Salons ABCD |
| * Galit Alter, Ragon Institute of MGH, MIT, and Harvard Session Chair |
| Penny L Moore, University of the Witwatersrand and National Institute for Communicable Diseases Remote Presentation: Views from the African Continent |
| * Kanta Subbarao, Université Laval WHO Strategy, One Health Considerations, Equity |
| Cristina Cassetti, Independent Expert, Retired Division Deputy Director at NIAID Prototype Vaccines |
| Rino Rappuoli, Fondazione Biotecnopolo di Siena An Institute for Pandemic Preparedness |
| Masaru Kanekiyo, NIAID, NIH Short Talk: A Mosaic Nanoparticle Displaying Stabilized Stem Trimers of Multiple Hemagglutinin Subtypes Elicits Broadly Cross-Reactive and Protective Immunity in Nonhuman Primates |
| Nitesh Mishra, The Scripps Research Institute Short Talk: Machine Learning Enabled Conformational Mapping Optimizes Lassa Virus Vaccine Candidates |
| 9:30–9:50 AM | Coffee Break | Foyer |
| 9:50–9:55 AM | Award Recipient Acknowledgement | Independence Salons ABCD |
| 11:30–1:00 PM | Poster Setup | Independence Salons EFGH |
| 11:30–2:45 PM | On Own for Lunch |
| 1:00–10:00 PM | Poster Viewing | Independence Salons EFGH |
| 2:00–3:30 PM | Career Roundtable | Independence Salons ABCD |
| Rita Carsetti, Bambino Gesù Children Hospital Head, B cell Lab |
| Mihai L Azoitei, Duke University Associate Professor |
| Meron Mengistu, Gilead Sciences Principal Scientist |
| Swapnika Ramu, Cell Press Senior Scientific Editor |
| 3:45–4:30 PM | Panel Discussion: Transforming Early-Stage Vaccine Development | Independence Salons ABCD |
| * Rino Rappuoli, Fondazione Biotecnopolo di Siena Panel Moderator |
| John Tsang, Yale University School of Medicine Panelist |
| Neil P King, University of Washington Panelist |
| Nicole Lurie, Coalition for Epidemic Preparedness Innovations - CEPI Panelist |
| 4:30–5:00 PM | Coffee Available | Foyer |
| 5:00–6:30 PM | Understanding Mechanistic Immunology to Drive Vaccine Design | Independence Salons ABCD |
| * Michel C. Nussenzweig, HHMI/Rockefeller University Germinal Center Selection |
| * Emanuele Andreano, Fondazione Biotecnopolo di Siena B Cell Responses |
| Matthew J Wiest, University of Michigan Short Talk: Heterologous Prime-pull Immunization Strategies for SARS-CoV-2 Drives Enhanced, Long-lived Mucosal and Systemic Cellular and Antibody Responses |
| Vishal N Rao, Icahn School of Medicine at Mount Sinai Short Talk: Convergent and Clonotype-enriched Mutations Drive Affinity Maturation of a Public Antibody |
| 6:30–7:30 PM | Social Hour with Lite Bites | Independence Salons EFGH |
| 7:30–10:00 PM | Poster Session 2 | Independence Salons EFGH |
| 7:30–8:30 AM | Breakfast | Independence Salons EFGH |
| 8:30–11:30 AM | Designing and Evaluating New Vaccines | Independence Salons ABCD |
| Jason S McLellan, The University of Texas at Austin Structure Based Design |
| Wolfgang W Leitner, National Institute of Allergy and Infectious Diseases, NIH, DHHS NIAID Vaccine Adjuvant Program and New Trends in Adjuvant Research |
| Galit Alter, Ragon Institute of MGH, MIT, and Harvard Mechanistic and Non Mechanistic Correlates of Protection |
| * Florian Krammer, Icahn School of Medicine at Mount Sinai Development of Broadly Protective Vaccines to Antigenically Variable Viruses |
| * Alessandro Sette, La Jolla Institute for Immunology Short Talk: The Identification and Validation of Conserved T Cell Epitope Regions in Viral Pathogen Families with Pandemic Potential |
| Mihai L Azoitei, Duke University Short Talk: Development and Validation of Pan-Betacoronavirus Vaccine Candidates that Target the S2 Domain of Spike |
| 9:30–9:50 AM | Coffee Break | Foyer |
| 11:30–12:45 PM | Innovations in Vaccine Science: Advancing Precision Medicine | Independence Salons ABCD |
| * Rino Rappuoli, Fondazione Biotecnopolo di Siena Session Chair |
| * Cristina Cassetti, Independent Expert, Retired Division Deputy Director at NIAID Session Chair |
| Courtney L Page, Wake Forest University School of Medicine An Influenza HA-expressing mRNA-LNP vaccine induces potent and protective responses in newborn NHP |
| Florian W Gegenfurtner, Karolinska Institutet Antibody Responses to Pneumoviruses Fluctuate During Life – Implications for RSV Vaccination |
| Murilo Sena Amaral, Instituto Butantan Protection in Rhesus Macaques Against Schistosoma Mansoni Induced by a Multi-Epitope Vaccine Candidate |
| Elizabeth M Villasis, Universidad Peruana Cayetano Heredia Assessment of the Functional Role of Purified Antibodies from Asymptomatic P. vivax-infected Individuals from the Peruvian Amazon using P. Knowlesi in vitro Culture Model |
| Kobporn Boonnak, Siriraj Hospital, Mahidol University Characterization of Neutralizing Versus Binding Antibody and T Cell Responses to Varicellar-zoster Virus in the Elderly |
| 12:45–3:00 PM | On Own for Lunch |
| 3:00–4:30 PM | Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions | Independence Salons ABCD |
| * Marie Pancera, Fred Hutchinson Cancer Center Structural Basis for Antibody Cross-neutralization of Dengue and Zika Viruses |
| Natacha Madelon, University of Geneva Reactogenicity to mRNA Vaccines is Linked to Heightened Inflammatory Responses Driven by Vaccine-specific Antibody Responses and Host-intrinsic Factors |
| Maya Sangesland, National Institutes of Health Functional, Immunogenetic, and Structural Convergence in Influenza Immunity between Humans and Macaques |
| Bo Zhang, Fred Hutchinson Cancer Center CD4+ T Cell Responses to Vaccination in People with HIV Correlate with Risk of COVID-19 in the CoVPN 3008 Clinical Trial |
| Nicholas Cheang, National University of Singapore Intranasal Dendritic Cell-targeting Vaccine Booster Elicits Cross-clade, Durable and Protective Systemic and Mucosal Immunity against Sarbecoviruses. |
| * Sylvain Baize, Institut Pasteur Immunogenicity and Efficacy of Vaccines against Crimean-Congo Hemorrhagic Fever Virus Based on Mopevac, a New Live-Attenuated Virus Vaccine Platform |
| 4:30–5:00 PM | Coffee Available | Foyer |
| 5:00–6:45 PM | Exploiting Tissue Specific Protection to Prevention and Cure | Independence Salons ABCD |
| Yasmine Belkaid, Institut Pasteur Immune Control of Host Physiology |
| * Laurence Zitvogel, Institut Gustave Roussy Gut Microbiota Impacts the Immunogenicity of Vaccines |
| Christopher Chiu, Imperial College London Clinical Trials for Intranasal and Aerosol SARS-CoV-2 Vaccine Development |
| Kerrie Sandgren, Westmead Institute for Medical Research Short Talk: Adjuvant As01 Activates an Innate Immune Cascade in Human Lymph Node Explants, Initiated by Subcapsular Sinus-Lining Macrophages, in an Age-Independent Manner |
| 6:45–7:00 PM | Meeting Wrap-Up: Outcomes and Future Directions (Organizers) | Independence Salons ABCD |
| 7:00–8:00 PM | Social Hour with Lite Bites | Independence Salons EFGH |
| 8:00–9:00 PM | Trivia | Independence Salons ABCD |
| 12:00–11:59 PM | Departure |