| 4:00–8:00 PM | Registration |
| 7:00–8:00 AM | Breakfast |
| 7:30–8:00 AM | Poster Setup |
| 7:45–5:00 PM | Poster Viewing |
| 8:00–8:10 AM | Welcome Remarks |
| 8:10–9:00 AM | Keynote Address |
| Serah Gitome, Kenya Medical Research Institute From Discovery to Delivery: Equity, Global Diversity, and the Social Determinants of Vaginal Microbiome Health |
| 9:00–11:15 AM | Global Diversity and Dynamics of the Vaginal Microbiome in Health and Disease |
| Jacques Ravel †, University of Maryland School of Medicine Global Structure of the Vaginal Microbiome: The Limits of CSTs and Clinical Correlates |
| Nicola Segata †, University of Trento Beyond CSTs: Strain-level and Functional Resolution of the VMB |
| Laura Symul †, Universite Catholique de Louvain Dynamics and Diversity across Populations: Do Current VMB Frameworks Hold up? |
| Hasmot Ali †, The JiVitA Project of Johns Hopkins University Short Talk: What do the Clinical Tools for BV Capture and Miss in Rural Bangladesh? |
| Lan Zhu †, Peking Union Medical College Hospital Short Talk: Geographic Diversification of Vaginal Microbiota Across China: Implications for Classification Frameworks and Regional Diagnostic Standards |
| Short Talk(s) Chosen from Abstracts |
| 9:30–9:50 AM | Coffee Break |
| 11:15–11:30 AM | Panel Discussion with Speakers: What Would a More Robust, Globally Applicable, Clinically Actionable Classification System for the Vaginal Microbiome Look Like and What Would it Take to Get There? |
| 11:30–12:30 PM | Health Equity Hot Seat |
| 12:30–1:30 PM | Lunch |
| 1:00–2:30 PM | Posters |
| 2:30–4:30 PM | Symposia Spotlight 1: Implementation-Focused/User-Centered Research |
| Short Talks Chosen from Abstracts |
| 4:30–5:00 PM | Coffee Available |
| 5:00–6:45 PM | Mechanistic Foundations of Host-Microbiome Interactions in the Vaginal Ecosystem |
| Douglas S Kwon †, Harvard Medical School Microbiome-Driven Mucosal Immune Activation: Innate and Adaptive Pathways Linking Vaginal Communities to Host Susceptibility |
| Amanda Lewis †, University of California, San Diego Metabolic Function of the Vaginal Microbiome: Biochemical Drivers of Community Stability, Transition, and Host Interaction |
| Adam Burgener †, Case Western Reserve University Proteomic Signatures of Host–Microbe Interactions: Defining Functional States of the Vaginal Ecosystem |
| Short Talk(s) Chosen from Abstracts |
| 6:45–7:00 PM | Panel Discussion with Speakers: What has VMT Taught us About the Host and Microbial Determinants of a Durable, Beneficial Vaginal Microbiome and Where Does that Point us for Intervention? |
| 7:00–8:00 PM | On Own for Dinner |
| 7:00–8:00 AM | Breakfast |
| 7:30–8:00 AM | Poster Setup |
| 7:45–5:00 PM | Poster Viewing |
| 8:00–11:00 AM | From Association to Prediction: Vaginal Microbiome Links to Pregnancy Outcomes |
| Bhabatosh Das †, Translational Health Science and Technology Institute Vaginal Microbiome Signatures of Preterm Birth in Indian Women: From Population-Level Association to Strain-Level Genomics and Point-of-Care Prediction |
| David MacIntyre †, Imperial College London Multi-Omic Integration and Predictive Modeling: Turning Microbiome Association into Clinical Prediction of Preterm Birth |
| Rachel Tribe †, King's College London From Association to Prediction: Biomarkers and Risk Stratification for Preterm Birth |
| Tobias Brummaier †, Mahidol University Short Talk: Vaginal Microbiota and Cytokine Signatures of Preterm Birth in Karen and Burman Women: A Multi-Omic Predictive Study from the Thai-Myanmar Border |
| Moses Obimbo Madadi †, University of Nairobi Short Talk: Multi-Omic Profiling of Vaginal Microbiome and Metabolites in Adverse Pregnancy Outcomes: Emerging Data from a Kenyan Prospective Cohort |
| Short Talk(s) Chosen from Abstracts |
| 9:00–9:20 AM | Coffee Break |
| 11:00–11:15 AM | Panel Discussion with Speakers: What would a Globally Applicable, Clinically Deployable Predictive Biomarker for VMB-Associated Preterm Birth Risk Look Like and are we Close? |
| 11:15–12:15 PM | Lunch |
| 1:00–2:30 PM | Posters |
| 3:00–4:30 PM | Career Roundtable |
| 4:30–5:00 PM | Coffee Available |
| 5:00–6:45 PM | Vaginal Microbiome, HIV, and HPV: From Population Risk to Mechanism in the PrEP and HPV vaccine Era |
| Joshua Kimani †, University of Nairobi- KACP Vaginal Microbiome, HIV, and HPV in High-Risk Populations: Cohort Evidence from East Africa |
| Kristina M. Broliden †, Karolinska Institute Cervicovaginal Mucosal Immunity and HPV: How VMB States Shape Viral Persistence, Immune Evasion, and Progression to Dysplasia |
| Sujatha Srinivasan †, Fred Hutchinson Cancer Research Center Microbiome-Driven Inflammation and Mucosal Susceptibility to HIV: From Bacterial Taxa to Reproducible Immune Signatures Across Diverse Populations |
| Jeanne M. Marrazzo, Infectious Disease Society of America Does the Vaginal Microbiome Still Matter? Rethinking Infection Risk in the PrEP and HPV vaccine Era |
| Ieera Madan Aggarwal †, KK Women’s and Children’s Hospital Short Talk: Predominance and High-Risk HPV Infection: Clinical Data from a Singapore Tertiary Colposcopy Centre |
| Short Talk(s) Chosen from Abstracts |
| 6:45–7:00 PM | Panel Discussion with Speakers: In the Era of Cabotegravir PrEP and the HPV Vaccine, for Whom and in What Settings does the Vaginal Microbiome Remain a Clinically Actionable Target for HIV and HPV Prevention and What Would it Take to Act on That? |
| 7:00–8:00 PM | On Own for Dinner |
| 7:00–8:00 AM | Breakfast |
| 8:00–11:00 AM | Engineering the Vaginal Microbiome: Progress, Limits, and the Path to Durable Engraftment |
| Kelly Arnold †, University of Michigan From Proof-of-Concept to Population Impact: Modeling the Requirements for Durable Vaginal Microbiome Interventions |
| Johan van Hylckama Vlieg †, Freya Biosciences Beyond Single Strains: Multi-Strain Consortia and Rational Design for Vaginal Microbiome Restoration |
| Samuel Alizon †, Collège de France Resource Competition and Ecological Stability: Why Vaginal Microbiome States Persist—and How They Might Be Shifted |
| Short Talk(s) Chosen from Abstracts |
| 9:00–9:20 AM | Coffee Break |
| 11:00–11:15 AM | Panel Discussion with Speakers: What is the Single Biological or Ecological Barrier that, if not Solved, Will Prevent any LBP from Achieving Durable Engraftment Regardless of How Well it is Designed? |
| 11:15–12:15 PM | Workshop: Emerging Models and Methods |
| 12:15–1:15 PM | Lunch |
| 2:30–4:30 PM | Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions |
| Short Talks Chosen from Abstracts |
| 4:30–5:00 PM | Coffee Available |
| 5:00–6:00 PM | Emerging Frontiers: Beyond Live Biotherapeutics—Host and Molecular Strategies to Enable Durable |
| Sharon Achilles, Bill & Melinda Gates Foundation The Limits of Lactobacillus: A Funder's Case for Augmenting LBPs to Drive Real-World Impact |
| Meilin Zhu †, Ragon Institute of MGH, MIT, and Harvard Host Lipid Landscapes as a Lever for Microbiome Control: Clinical Evidence and Translational Potential |
| Katharina Ribbeck †, Massachusetts Institute of Technology Mucus as a Gatekeeper: Structural Control of Microbial Colonization and Ecosystem Stability |
| Matthew J. Cummings †, Precisio Biotix Therapeutics Precision Engineered Lysins Against BV Pathobionts with Multi-Target Design |
| Short Talk(s) Chosen from Abstracts |
| 6:00–6:15 PM | Panel Discussion with Speakers: What is the Most Important Unanswered Question Standing between the Science Presented Today and a Combination Intervention that could move into a Phase 2 Efficacy Trial in an LMIC Setting? |
| 6:15–7:00 PM | Closing Keynote Address |
| Caroline M. Mitchell †, Massachusetts General Hospital From Microbiome to Medicine: What It Will Take to Translate Vaginal Microbiome Science into Women's Health Impact |
| 7:00–8:00 PM | On Own for Dinner |
| 12:00–11:59 PM | Departure |