Tumor Microenvironment: Metastasis and the Host (J1)
January 18-21, 2025
| Fairmont Banff Springs, Banff, AB, Canada
Mikala Egeblad, Julio Aguirre-Ghiso and Manuel Valiente
Scholarship Deadline: Oct. 23, 2024 | Abstract Deadline: Dec. 31, 2024 | Early Registration Deadline: Dec. 4, 2024
Saturday, January 18, 2025
| 4:00–8:00 PM |
Registration |
Riverview Lounge |
| 6:00–8:00 PM |
Welcome Mixer |
Riverview Lounge |
| 7:00–8:00 AM |
Breakfast |
Alberta/New Brunswick |
| 8:00–9:00 AM |
Welcome and Keynote Address |
Cascade Ballroom |
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* Manuel Valiente, Spanish National Cancer Research Centre
Session Chair |
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Eduard Batlle, Institute for Research in Biomedicine
Plasticity, Therapy Resistance and Immune Evasion in Metastatic Colorectal Cancer |
|
| 9:00–11:15 AM |
The Disseminated Cell in the Metastatic Niche |
Cascade Ballroom |
| |
* Don Nguyen, Yale School of Medicine
Session Chair |
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Julio Aguirre-Ghiso, Montefiore Einstein Cancer Center
Plasticity of Cancer Cells and Dormancy Programs |
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Leah Cook, NCI, National Institutes of Health
Delineating the Role of Neutrophils in the Prostate Cancer-Bone Microenvironment |
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Eric S. Lightcap, HiberCell
Perk Inhibition by Hc-5404 Alters the Tumor Microenvironment: Preclinical and Clinical Exploration |
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Elena Guido Vinzoni, ETH
Short Talk: In Vivo Crispra Screen of Ligands and Receptors in Liver Endothelial Cells Highlights the Impact of Early Interactions During Colorectal Cancer Metastatic Seeding |
|
| 9:30–9:50 AM |
Coffee Break |
Riverview Lounge |
| 11:15–1:00 PM |
Poster Setup |
Alberta/New Brunswick |
| 11:15–2:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Alberta/New Brunswick |
| 2:30–4:30 PM |
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions |
Cascade Ballroom |
| |
* Leah Cook, NCI, National Institutes of Health
Session Chair |
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Jelani C. Zarif, Johns Hopkins University School of Medicine
Glutamine Antagonist Prodrug JHU083 Reprograms Immunosuppressive Tumor-Associated Macrophages (TAMS) To Drive Tumor Immunity In Urologic Cancers |
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| |
Don Nguyen, Yale School of Medicine
Epigenetic Regulation of Tumor Cell Clustering and Metastasis in Lung Adenocarcinoma |
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| |
Christoph A Reichel, Department of Otorhinolaryngology, LMU Munich/Germany
Granulopoiesis and Thrombopoiesis Aberrantly Synergize in Cancer to Promote Tumor Progression |
|
| |
Yuto Hamazaki, The University of Tokyo
Deciphering the Diversity of Cells and Exosome in Metastatic Mechanisms |
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| |
Matthew Eason, University of Maryland School of Medicine
Pleckstrin Homology Domains Regulate PI3K/Akt to Quiet the Invasive Matrix Metalloproteinase Milieu and Block Breast Cancer Dissemination |
|
| 4:30–5:00 PM |
Coffee Available |
Riverview Lounge |
| 5:00–7:00 PM |
Microenvironmental Regulation of Metastasis |
Cascade Ballroom |
| |
* Mikala Egeblad, Johns Hopkins University
Session Chair |
|
| |
Daniela F Quail, McGill University
Obesity as a Driver of Pro-Metastatic Niche Formation |
|
| |
Anwesha Dey, Genentech, Inc.
Targeting the Hippo Pathway in Cancers |
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| |
Clare M Isacke, Institute of Cancer Research
Microenvironmental Changes Driving Breast Cancer Metastatic Relapse |
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Laura Alvaro, CNIO
Short Talk: Targeting a Disease-Associated Subpopulation of Macrophages/ Microglia Uncovers a Novel Vulnerability of Brain Metastasis |
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Meera Murgai, National Cancer Institute, National Institutes of Health
Short Talk: Pericyte-Tumor Crosstalk Promotes Metastatic Tumor Dormancy Through Calcium Activated Phospholipid Transfer. |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Alberta/New Brunswick |
| 7:30–10:00 PM |
Poster Session 1 |
Alberta/New Brunswick |
| 7:00–8:00 AM |
Breakfast |
Alberta/New Brunswick |
| 8:00–11:00 AM |
Defining and Shaping the Metastatic Microenvironment (Joint) |
Cascade Ballroom |
| |
* Maria S Sosa, Albert Einstein College of Medicine
Session Chair |
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* Lyse A. Norian, University of Alabama, Birmingham
Session Chair |
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Devon A. Lawson, University of California, Irvine
Conserved Microenvironmental Interactions Mediating Multi-Organ Metastasis |
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David Lyden, Weill Cornell Medical College
Tumor Induced Liver Metabolic Dysfunction Drives Metastasis |
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Sergei Grivennikov, Cedars-Sinai Medical Center
Microbiota Induced Cytokines Control Anti-Tumor Immunity and Colorectal Cancer Metastasis. |
|
| |
Mikala Egeblad, Johns Hopkins University
Immune Control and Escape at the Metastatic Site |
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Alexandra Newman, New York University
Short Talk: Myocardial Infarction Increases Metastatic Cancer in The Lung |
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Morgan Fox, University of Colorado
Short Talk: Non-Canonical Activation of FGFR1 Drives ER+ Breast Cancer Brain Metastasis in the Aged and E2-Depleted TME |
|
| 9:00–9:20 AM |
Coffee Break |
Riverview Lounge |
| 9:20–9:25 AM |
Award Recipient Acknowledgement |
Cascade Ballroom |
| 11:00–1:00 PM |
Poster Setup |
Alberta/New Brunswick |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Alberta/New Brunswick |
| 2:30–4:00 PM |
Career Roundtable (Joint) |
Alhambra |
| |
Frank Winkler, University Hospital Heidelberg
Professor, Physician, and Group Leader |
|
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Eric S. Lightcap, HiberCell
Vice President of Translational Sciences |
|
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Meera Murgai, National Cancer Institute, National Institutes of Health
Stadtman Investigator |
|
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Mario Flores, University of Texas at San Antonio
Assistant Professor |
|
| 4:00–5:00 PM |
Coffee Break with Hot Chocolate, Firepits & Mountain Views |
Conservatory Terrace |
| 5:00–7:00 PM |
The Brain-Body Axis in Metastasis (Joint) |
Cascade Ballroom |
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* Michelle Monje, Stanford University
Session Chair |
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* Donna L Senger, Lady Davis Institute for Medical Research/ McGill University
Session Chair |
|
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Humsa Venkatesh, Brigham and Women's Hospital
Neuronal-Activity Dependent Mechanisms of Small Cell Lung Cancer Progression |
|
| |
Manuel Valiente, Spanish National Cancer Research Centre
Strategies to Challenge Brain Metastasis Lethality in Mice and Human/The Effects of Brain Metastasis on Neural Circuits |
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Erica K Sloan, Monash University
Blocking Stress Signaling to Control Metastatic Breast Cancer |
|
| |
Golnaz Morad, MD Anderson Cancer Center
Short Talk: Metastatic Brain Tumors Harbor Intracellular Bacterial Signals Associated with the Oral Microbiota |
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Kylynda C Bauer, National Institutes of Health - National Cancer Institute
Short Talk: Gut Microbiome Modulates Liver Cancer Via Neuroimmune Crosstalk |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Alberta/New Brunswick |
| 7:05–8:05 PM |
Women in Science Networking Session |
Alberta/New Brunswick |
| |
* Maria S Sosa, Albert Einstein College of Medicine
Session Chair |
|
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* Michelle Monje, Stanford University
Session Chair |
|
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* Deisy L Segura-Villalobos, Albert Einstein College of Medicine
Session Chair |
|
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* Anna Adam Artigues, Albert Einstein College of Medicine
Session Chair |
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* Elizabeth A. Repasky, Roswell Park Cancer Institute
Session Chair |
|
| 7:30–10:00 PM |
Poster Session 2 |
Alberta/New Brunswick |
Tuesday, January 21, 2025
| 7:00–8:00 AM |
Breakfast |
Alberta/New Brunswick |
| 8:00–11:00 AM |
Cancer Cell Plasticity and Evolution During Metastasis |
Cascade Ballroom |
| |
* Devon A. Lawson, University of California, Irvine
Session Chair |
|
| |
Gelareh Zadeh, University Health Network
Remote Presenter: Methylation and Proteomic Signatures of Lung Cancer as Predictive Biomarkers of Brain Metastasis |
|
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Samra Turajlic, Francis Crick Institute
Genetic and Transcriptional Determinants of Metastatic Competence |
|
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Jean-Christophe W Marine, Vlaams Interuniversitair Instituut, Katholieke Universiteit Leuven
Influence of the Niche on Cancer Cell Hierarchy |
|
| |
Ashley M Laughney, Weill Cornell Medicine
Tackling the Genotype-to-Phenotype Problem in Cancer Evolution |
|
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Myriam Labelle, St. Jude Children's Research Hospital
Short Talk: ZBTB18 Limits Tumor Cell Pliancy and Tumor Cell-Immune Cell Crosstalk to Inhibit Metastasis |
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Maria S Sosa, Albert Einstein College of Medicine
Short Talk: Contributions of Evolutionarily Distinct Types of Disseminated Cancer Cells to the Metastatic Disease |
|
| 9:00–9:20 AM |
Coffee Break |
Riverview Lounge |
| 11:00–2:30 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions |
Cascade Ballroom |
| |
* Julio Aguirre-Ghiso, Montefiore Einstein Cancer Center
Session Chair |
|
| |
Yunfan Sun, Zhongshan Hospital, Fudan University
Spatiotemporal Multi-Omics Uncover Tumor Ecosystem Dynamics Driving Metastatic Colonization |
|
| |
Rebecca Dodd, University of Iowa
Epigenetic Plasticity Drives Sarcoma Metastasis through PRC2-Dependent Stromal Remodeling and IL-17D Signaling |
|
| |
Anna Adam Artigues, Albert Einstein College of Medicine
Peripheral Sympathetic Nerve Damage Induces a Loss of Brain Niche Homeostasis Stimulating Metastatic Outgrowth of Disseminated Cancer Cells. |
|
| |
Jonathan Rennhack, Loyola University Chicago
Transcription Factor Dynamics Induced by Cytokine Interaction in Metastatic Sites of Colorectal Cancer |
|
| |
Mary Clare Beytagh, UCSF
Dissecting Mechanisms of Medulloblastoma Metastasis in Vivo |
|
| 4:30–5:00 PM |
Coffee Available |
Riverview Lounge |
| 5:00–6:45 PM |
Engineering and Targeting of Host Mechanisms of Metastasis |
Cascade Ballroom |
| |
* Sergei Grivennikov, Cedars-Sinai Medical Center
Session Chair |
|
| |
Edgar G. Engleman, Stanford University School of Medicine
Remote Presenter: Harnessing Innate Immune Response to Reduce Metastatic Seeding |
|
| |
Ronit Satchi-Fainaro, Tel Aviv University
3D Bioprinted Cancer Models: From Basic Biology to Drug Development |
|
| |
Daniel A. Heller, Memorial Sloan Kettering Cancer Center
Nanotherapeutic Targeting of Metastatic Cancer to the Brain |
|
| |
Pierina Barturen-Larrea, California Institute of Technology
Short Talk: Acoustic Reporter Genes for In Situ Monitoring of Metastasis Dynamics |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Cascade Ballroom |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Alberta/New Brunswick |
| 8:00–9:00 PM |
Trivia |
Cascade Ballroom |
Wednesday, January 22, 2025
