Innate immunity: Molecular mechanisms, Diseases & Therapeutics (J1)
January 11-14, 2027  | Fairmont Banff Springs, Banff, AB, Canada
Lingyin Li, Carina Cristina de Oliveira Mann and Michael Crackower
* Session Chair † Invited but not yet accepted | Program current as of November 4, 2025 2 PM | For the most up-to-date details, visit https://www.keystonesymposia.org
Monday, January 11, 2027
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Tuesday, January 12, 2027
7:00–8:00 AM Breakfast
8:00–9:00 AM Welcome and Keynote Address (Joint)
  Catherine J Wu †, Dana-Farber Cancer Institute
Personalizing Medicine through Cancer Vaccines
 
9:00–11:15 AM T Cells and Innate Allies: Partners in Vaccination (Joint)
  Robert A. Seder, NIAID, National Institutes of Health
Vax-Innate
 
  Christopher Haqq †, Elicio Therapeutics
Lymph Node-Targeting Amphiphile Technology for Next-Generation Vaccines
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:15–1:00 PM Poster Setup
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
2:30–4:30 PM Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM dsDNA Sensing
  Zhijian James Chen †, University of Texas Southwestern Medical Center
cGAS-STING Signaling in Aging
 
  Daniel B. Stetson, University of Washington
How STING Activation Kill Cells
 
  Andrea Ablasser †, Ecole Polytechnique Fédérale de Lausanne
cGAS-STING Pathway in Innate Immunity: Molecular Mechanisms and Therapeutic Implications
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Wednesday, January 13, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Innate Signals in T Cells (Joint)
  Michael B. Brenner †, Harvard Medical School
The Role of GZMK+ T-Cells in Inflammatory Disease
 
  Hong-Bing Shu †, Wuhan University
Two Decades of STING Research
 
  Lingyin Li, Stanford University and Arc Institute
Extracellular cGAMP, the Immunotransmitter that Bridges Innate and Adaptive Immunity
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–12:00 PM Panel Discussion 1: Mouse Human Differences from Pathways to Molecules to Atomic Level Details
11:00–1:00 PM Poster Setup
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
1:30–2:45 PM Career Roundtable (Joint)
4:30–5:00 PM Coffee Available
5:00–7:00 PM ssDNA and RNA Sensing
  Hao Wu, Harvard Medical School, Boston Children's Hospital
Mitochondrial GSDMD
 
  Carina Cristina de Oliveira Mann, Technical University of Munich
Regulation of Nucleic Acid Receptors
 
  Russell E Vance, University of California, Berkeley
Effector-Triggered Immune Detection of Pathogens
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Thursday, January 14, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Innate Immunity in Cardiovascular/Metabolic/Autoimmune Diseases
  Min Ae Lee-Kirsch, Technische Universität Dresden
TLR Signaling in Interferonopathy
 
  Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital
Targeting Innate Immune Cell Death, PANoptosis, in Disease
 
  Garron Thomas Dodd, University of Melbourne
Pathogenic Hypothalamic Extracellular Matrix Promotes Metabolic Disease
 
  Michael Crackower, Ventus Therapeutics
The Development of Non-Canonical Inflammasome Inhibitors for the Treatment of Inflammatory Disease
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–12:00 PM Panel Discussion 2: Drug Development Challenges and VC Takes
12:00–5:00 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–6:45 PM Innate Immunity in Neuroinflammation
  Michael T. Heneka, University of Luxembourg
The Role of NLRP3 in Microglial Phagocytosis in Alzheimer's Disease
 
  Marina Romero-Ramos †, Aarhus University
The Role of the Immune System in Parkinson's Disease
 
  Li Gan, Weill Cornell Medicine
The Role of cGAS/STING in Neurodegeneration
 
  Short Talk(s) Chosen from Abstracts
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:00–8:00 PM Social Hour with Dinner
8:00–11:00 PM Entertainment
8:00–11:00 PM Cash Bar
Friday, January 15, 2027
12:00–11:59 PM Departure