Neural Influence on Cancer, Tumor Microenvironment and Cancer Immunology (J2)
January 18-21, 2025
| Fairmont Banff Springs, Banff, AB, Canada
Brian M. Davis, Michelle Monje and Ihsan Ekin Demir
Scholarship Deadline: Oct. 23, 2024 | Abstract Deadline: Dec. 31, 2024 | Early Registration Deadline: Dec. 4, 2024
Saturday, January 18, 2025
| 4:00–8:00 PM |
Registration |
Riverview Lounge |
| 6:00–8:00 PM |
Welcome Mixer |
Riverview Lounge |
| 7:00–8:00 AM |
Breakfast |
Alberta/New Brunswick |
| 8:00–9:00 AM |
Welcome and Keynote Address |
Alhambra |
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* Brian M. Davis, University of Pittsburgh
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Michelle Monje, Stanford University
Neuronal Activity Drives Glioma Growth and Initiation through both Paracrine and Synaptic Signaling |
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| 9:00–11:15 AM |
Neuron-Cancer Electrochemical and Paracrine Signaling |
Alhambra |
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* Sonja Loges, German Cancer Research Center
Session Chair |
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Shawn Hervey-Jumper, University of California, San Francisco
Glioblastoma Remodels Functional Neural Circuits |
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Ihsan Ekin Demir, Technische Universität München
Neuronal Glutamate Signaling and Progression of Pancreatic Cancer |
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Yuan Pan, UT MD Anderson Cancer Center
Neuron-glial Crosstalk in NF1 Cancer Predisposition Syndrome |
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Matteo Bergami, University of Cologne
Short Talk: Functional Synapses Between Small Cell Lung Cancer and Glutamatergic Neurons |
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| 9:30–9:50 AM |
Coffee Break |
Riverview Lounge |
| 11:15–1:00 PM |
Poster Setup |
Alberta/New Brunswick |
| 11:15–2:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Alberta/New Brunswick |
| 2:30–4:30 PM |
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions |
Alhambra |
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* Jennifer Permuth, Moffitt Cancer Center
Session chair |
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Aeson Chang Chang, Monash Institute of Pharmaceutical Sciences
Triple Negative Breast Cancer Hijacks the Sympathetic Nervous System to Resist Anthracycline Chemotherapy |
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Tara Barron, Stanford University
GABAergic Neuron-To-Glioma Synapses in Diffuse Midline Glioma |
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Dominick Calvao, Brown University
A 3D Multi-Cellular Cortical Microtissue Model for the Study of Glioblastoma Multiforme Pathology and Therapeutic Screening |
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Rouzanna Istvánffy, Klinikum rechts der Isar, Technical University Munich
Adhesion of Cancer Cells to Schwann Cells Leads to Metabolic Adaptations with Increased Glutamine Synthetase Activity |
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David J Simon, Weill Cornell Medicine
Sympathetic Innervation as a Local Brake on Melanoma Growth in Mouse Models |
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Vera Thiel, Hi-Stem
Following the Nerve Trail: Unraveling How Cancer-Associated Neurons Shape the Tumor Microenvironment and Cancer’s Progression Via Trace-N-Seq |
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Heloise Leblanc, Boston University
Prefrontal Cortex High-Grade Glioma Alters Neuronal-Astrocyte Dynamics and Promotes Age-Dependent Dysregulation of Acute Stress Responses |
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Sofia Micheli, University of Zurich
Peripheral Glia Drive the Initiation of Cutaneous Squamous Cell Carcinoma |
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| 4:30–5:00 PM |
Coffee Available |
Riverview Lounge |
| 5:00–7:00 PM |
Neuronal Influence on Cancer Initiation and Growth |
Alhambra |
| |
* Nadine van Montfoort, Leiden University Medical Center
Session Chair |
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Moran Amit, University of Texas MD Anderson Cancer Center
Remote Presentation: Cancer Associated Neurogenesis and its Impact on Response to Therapy |
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Jeremy Borniger, Cold Spring Harbor Laboratory
A Central Mechanism Driving Aberrant HPA-Axis Function in Breast Cancer |
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Karen Dixon, University of Basel
Identifying and Disrupting Neuro-Immune Circuits in Cancer |
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Richard Drexler, Stanford University
Short Talk: Brainstem Neuromodulatory Neurons Promote Glioma Growth Locally and Via Long-Range Projections to Midline and Cortical Structures |
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Hanan Bloomer, Tufts University
Short Talk: Triple-Negative Breast Cancer Cells Activate Sensory Neurons via TRPV1 to Drive Neurite Outgrowth and Tumor Progression |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Alberta/New Brunswick |
| 7:30–10:00 PM |
Poster Session 1 |
Alberta/New Brunswick |
| 7:00–8:00 AM |
Breakfast |
Alberta/New Brunswick |
| 8:00–11:00 AM |
Defining and Shaping the Metastatic Microenvironment (Joint) |
Cascade Ballroom |
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* Maria S Sosa, Albert Einstein College of Medicine
Session Chair |
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* Lyse A. Norian, University of Alabama, Birmingham
Session Chair |
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Devon A. Lawson, University of California, Irvine
Conserved Microenvironmental Interactions Mediating Multi-Organ Metastasis |
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David Lyden, Weill Cornell Medical College
Tumor Induced Liver Metabolic Dysfunction Drives Metastasis |
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Sergei Grivennikov, Cedars-Sinai Medical Center
Microbiota Induced Cytokines Control Anti-Tumor Immunity and Colorectal Cancer Metastasis |
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Mikala Egeblad, Johns Hopkins University
Immune Control and Escape at the Metastatic Site |
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Alexandra Newman, New York University
Short Talk: Myocardial Infarction Increases Metastatic Cancer in The Lung |
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Morgan Fox, University of Colorado
Short Talk: Non-Canonical Activation of FGFR1 Drives ER+ Breast Cancer Brain Metastasis in the Aged and E2-Depleted TME |
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| 9:00–9:20 AM |
Coffee Break |
Riverview Lounge |
| 9:20–9:25 AM |
Award Recipient Acknowledgement |
Cascade Ballroom |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 11:00–10:00 PM |
Poster Setup |
Alberta/New Brunswick |
| 1:00–10:00 PM |
Poster Viewing |
Alberta/New Brunswick |
| 2:30–4:00 PM |
Career Roundtable (Joint) |
Alhambra |
| |
Frank Winkler, University Hospital Heidelberg
Professor, Physician, and Group Leader |
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Eric S. Lightcap, HiberCell
Vice President of Translational Sciences |
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Meera Murgai, National Cancer Institute, National Institutes of Health
Stadtman Investigator |
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Mario Flores, University of Texas at San Antonio
Assistant Professor |
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| 4:00–5:00 PM |
Coffee Break with Hot Chocolate, Firepits & Mountain Views |
Conservatory Terrace |
| 5:00–7:00 PM |
The Brain-Body Axis in Metastasis (Joint) |
Cascade Ballroom |
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* Donna L Senger, Lady Davis Institute for Medical Research/ McGill University
Session Chair |
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* Michelle Monje, Stanford University
Session Chair |
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Humsa Venkatesh, Brigham and Women's Hospital
Neuronal-Activity Dependent Mechanisms of Small Cell Lung Cancer Progression |
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Manuel Valiente, Spanish National Cancer Research Centre
Strategies to Challenge Brain Metastasis Lethality in Mice and Human/The Effects of Brain Metastasis on Neural Circuits |
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Erica K Sloan, Monash University
Blocking Stress Signaling to Control Metastatic Breast Cancer |
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Golnaz Morad, MD Anderson Cancer Center
Short Talk: Metastatic Brain Tumors Harbor Intracellular Bacterial Signals Associated with the Oral Microbiota |
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Kylynda C Bauer, National Institutes of Health - National Cancer Institute
Short Talk: Gut Microbiome Modulates Liver Cancer Via Neuroimmune Crosstalk |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Alberta/New Brunswick |
| 7:05–8:05 PM |
Women in Science Networking Event |
Alberta/New Brunswick |
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* Maria S Sosa, Albert Einstein College of Medicine
Session Chair |
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* Deisy L Segura-Villalobos, Albert Einstein College of Medicine
Session Chair |
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* Anna Adam Artigues, Albert Einstein College of Medicine
Session Chair |
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* Michelle Monje, Stanford University
Session Chair |
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* Elizabeth A. Repasky, Roswell Park Cancer Institute
Session Chair |
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| 7:30–10:00 PM |
Poster Session 2 |
Alberta/New Brunswick |
Tuesday, January 21, 2025
| 7:00–8:00 AM |
Breakfast |
Alberta/New Brunswick |
| 8:00–11:00 AM |
Nervous System Effects on the Immune System and Immuno-Oncology |
Alhambra |
| |
* Ramiro Garzon, University of Utah/Huntsman Cancer Institute
Session Chair |
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Sébastien Talbot, Queen’s University
Tumor-Infiltrating B Cells tune Nociceptor Neurons Immunomodulation |
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Nicole N Scheff, University of Pittsburgh
Sympathetic and Sensory Nerve Coupling Modulates Cancer Immunosurveillance and Growth |
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Elizabeth A. Repasky, Roswell Park Cancer Institute
Beta Adrenergic Receptors as a Targetable Checkpoint for Reducing Immune Suppression in the Tumor Microenvironment |
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Alexander Birbrair, University of Wisconsin - Madison
Short Talk: Sensory Neurons Interact Directly with Melanoma Malignant Cells and Pericytes Via CGRP-RAMP1 Signaling to Promote Melanoma Metastatic Outgrowth |
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Ania Bogoslowski, UBC
Short Talk: TRPV1+ Nociceptors Control Tumour Growth and The Neuroimmune Landscape in Breast Cancer |
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Yuri Bunimovich, University of Pittsburgh
Short Talk: Tumor-Draining Lymph Node Innervation Regulates Anti-Tumor Immunity |
|
| 9:00–9:20 AM |
Coffee Break |
Riverview Lounge |
| 11:00–2:30 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions |
Alhambra |
| |
* Masahiro Kawashima, Kyoto University
Session Chair |
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Jami Saloman, University of Pittsburgh School of Medicine
PDAC Tumor Induced Hyperinnervation in Pancreatic Draining Lymph Nodes |
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Javier Marco Sanz, FIMA
Modulating Conventional Type 1 Dendritic Cells to Limit Neurocognitive Sequelae After Pediatric Brain Tumor Radiotherapy |
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Phillip Gärtner, Technische Universität München
Monocyte-Derived Proteases Mediate Pancreatic Pain in Pancreatic Cancer |
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Michela Perego, Wistar Institute
Neuromedin U Activates Neutrophils to Create And Immunosuppressive Environment In Early Prostate Cancer |
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Yusha Sun, University of Pennsylvania
A Brain-Wide Connectome Reveals Cholinergic Synapses with Human Glioblastoma |
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Carmen Mota Reyes, Klinikum rechts der isar
Integrative Spatial Multiomics and Cross-Platform Analysis To Decipher Neural Invasion In Pancreatic Cancer |
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Anastasia Maria Zavitsanou, Columbia University
Investigating How Lung Cancer Alters Behavior Via Regulating The Internal Sensory System |
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Lily Yang, Emory University School of Medicine
Tumor And Stroma-Targeted Nanotherapeutics Enhance Therapeutic Efficacy In Pancreatic Cancer By Inhibiting Tumor Cell Growth, Neural Invasion, And Activating Immune Response |
|
| 4:30–5:00 PM |
Coffee Available |
Riverview Lounge |
| 5:00–6:45 PM |
Nervous System Effects on Cancer Invasion and Metastasis |
Alhambra |
| |
* Chris Bakal, Institute of Cancer Research
Session Chair |
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Frank Winkler, University Hospital Heidelberg
Neuronal Influence on Glioma Invasion and Brain Metastasis |
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Richard J. Wong, Memorial Sloan Kettering Cancer Center
Mechanisms of Perineural Invasion |
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Nisha J. D'Silva, University of Michigan School of Dentistry
Neural Phenotypes in Cancer Progression |
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Anabel Eckerling, Tel Aviv University
Short Talk: Sympathetic Regulation of Tumor Secretome and Anti-Tumor Immunity: Perioperative Blockade of Β-Adrenergic and Prostaglandin Signaling Limits Metastatic Progression |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Alhambra |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Alberta/New Brunswick |
| 8:00–9:00 PM |
Trivia |
Cascade Ballroom |
Wednesday, January 22, 2025
