Circulating Metabolic Intermediates as Fuels and Signals (J3)
October 8-11, 2023
| Snowbird Resort, Snowbird, UT, United States
Sven Enerbäck, Joshua D. Rabinowitz and Sarah-Maria Fendt
Scholarship Deadline: Jul. 6, 2023 | Abstract Deadline: Jul. 6, 2023 | Early Registration Deadline: Aug. 8, 2023
| 10:00–2:00 PM |
Arrival and Registration |
Ballroom Lobby |
| 12:00–2:00 PM |
Welcome Mixer |
Ballroom Lobby |
| 1:00–2:00 AM |
Breakfast |
Golden Cliff / Eagles |
| 2:00–3:30 AM |
Welcome and Keynote Session (Joint) |
Ballroom 1-3 |
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* Sven Enerbäck, University of Gothenburg
Session Chair |
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* Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia
Session Chair |
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June L. Round, University of Utah
Microbes with Benefits: Microbe-immune Interactions that Promote Metabolic Health |
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Bruce M. Spiegelman, Dana-Farber Cancer Institute
Inputs and Outputs of Adipose |
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| 3:30–3:50 AM |
Coffee Break |
Ballroom Lobby |
| 3:50–5:15 AM |
Microbiota and Circulating Metabolites in Host Physiology and Immunity (Joint) |
Ballroom 1-3 |
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* Tim Hand, University of Pittsburgh
Session Chair |
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Kathryn E. Wellen, University of Pennsylvania
Understanding the Interplay Between Diet, Acetyl-CoA synthesis, and Hepatic Lipid Homeostasis |
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Michael A. Fischbach, Stanford University
Microbiota Derived Metabolites and Host Physiology |
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Nicole D. Sonnert, Yale University
Short Talk: Short Talk: A Host-Microbiota Interactome Reveals Extensive Transkingdom Connectivity |
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Erica Maissy, UCSD
Short Talk: Short Talk: Gut Microbial Bile Acid Modifications With Engineered Native Bacteria Ameliorate Metabolic Features In Polycystic Ovary Syndrome |
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| 5:15–7:00 AM |
Poster Setup |
Superior/Wasatch |
| 5:15–11:00 AM |
On Own for Lunch |
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| 7:00–4:00 PM |
Poster Viewing |
Superior/Wasatch |
| 9:00–10:30 AM |
Workshop 1 |
Ballroom 3 Lobby |
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* Karthikeyani Chellappa, Brown University
Session Chair |
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Haopeng Xiao, Dana-Farber Cancer Institute/ Harvard Medical School
A Multiomic Systems Approach to Mechanistically Characterize Novel Regulators of Metabolic Pathways |
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Rachel K. Meyer, University of Arizona
Impact of Postprandial Butyrate Production on Hepatic Glucose Production via Colonic and Hepatic Signaling Pathways |
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Joseph R. Visker, University of Utah
Targeting the Mitochondrial Pyruvate Carrier (MPC1) Ameliorates Myocardial Ischemic Reperfusion Injury in Mice |
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Karthikeyani Chellappa, Brown University
Microbial NAD Metabolism: Missing Link in Organismal NAD Biology |
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Adam J. Rauckhorst, University of Iowa
Pathways of Hepatic De Novo Lipogenesis |
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Samuel M. Lancaster, Stanford University
Deep Metabolic Phenotyping of Newborn Cord Blood Reveals Maternal-fetal Interactions and Disease Risk |
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| 10:30–11:00 AM |
Coffee Available |
Ballroom Lobby |
| 11:00–1:00 PM |
Intermediary Metabolites as Fuels |
Ballroom 3 |
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* Sarah-Maria Fendt, VIB-KU Leuven
Session Chair |
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* Joshua D. Rabinowitz, Princeton University
Session Chair |
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Joshua D. Rabinowitz, Princeton University
Lactate as Waste and Fuel |
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Marc K. Hellerstein, University of California, Berkeley
Flux in Humans.Very Useful. |
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Maria Dolores Moya-Garzon, Stanford
Short Talk: Short Talk: A Family of Orphan Ketone Metabolites that Regulates Energy Homeostasis |
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Eric S. Goetzman, University of Pittsburgh
Short Talk: Short Talk: Dodecanedioic Acid as an Alternative Metabolic Fuel |
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Elaine Y. Hsiao, University of California, Los Angeles
Microbiome-diet Interactions for Regulating Neuronal Activity |
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| 1:00–2:00 PM |
Social Hour with Lite Bites |
Superior/Wasatch |
| 1:30–4:00 PM |
Poster Session 1 |
Superior/Wasatch |
Tuesday, October 10, 2023
| 1:00–2:00 AM |
Breakfast |
Golden Cliff / Eagles |
| 2:00–5:00 AM |
Muscle and Exercise |
Ballroom 3 |
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* Katrien De Bock, Swiss Federal Institute of Technology
Session Chair |
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George A. Brooks, University of California, Berkeley
Muscle and Whole Body Lactate Kinetics: Organ-Organ, Cell-Cell, Intracellular, and Postprandial Lactate Shuttles |
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Katrien De Bock, Swiss Federal Institute of Technology
Glutamine Metabolism and Muscle Stem Cell Fate Decisions |
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Zoltan Arany, University of Pennsylvania
Metabolic Flux in Exercise |
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Charlotte Mann, ETHZ
Short Talk: Short Talk: Sulfur Amino Acid Restriction Enhances Exercise Capacity in Mice by Reprogramming Glycolytic Muscle Metabolism |
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Arthur Kaser, University of Cambridge
Short Talk: Short Talk: A Purine Nucleotide Cycle Interlocking Energy Metabolism is Widespread across the Organism |
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| 3:00–3:20 AM |
Coffee Break |
Ballroom Lobby |
| 5:00–7:00 AM |
Poster Setup |
Superior/Wasatch |
| 5:00–11:00 AM |
On Own for Lunch |
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| 7:00–4:00 PM |
Poster Viewing |
Superior/Wasatch |
| 9:00–10:30 AM |
Career Roundtable (Joint) |
Ballroom 1-3 |
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Zoltan Arany, University of Pennsylvania
Professor |
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Rose L. Szabady, Ferring Pharmaceuticals, Inc.
Associate Director, IBD Research |
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Elaine Y. Hsiao, University of California, Los Angeles
Associate Professor |
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Romina S. Goldszmid, NCI, National Institutes of Health
Earl Stadtman Investigator |
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Harry Sokol, INSERM
Professor |
|
| 10:30–11:00 AM |
Coffee Available |
Ballroom Lobby |
| 11:00–1:00 PM |
Metabolite Drivers of Health and Disease |
Ballroom 3 |
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* Sven Enerbäck, University of Gothenburg
Session Chair |
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* Sarah-Maria Fendt, VIB-KU Leuven
Session Chair |
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Sarah-Maria Fendt, VIB-KU Leuven
Metabolic Rewiring Driving Metastasis Formation |
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Lora K. Heisler, Rowett Institute, University of Aberdeen
Metabolites Influencing Obesity and Type 2 Diabetes |
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Gregory S. Ducker, University of Utah
Flexibility of Carbohydrate Metabolism in the Normal and Failing Heart |
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Kyle N Dunlap, University of Utah
Short Talk: Short Talk: A Functional Genomics Screen Reveals an Essential Citrulline Transporter |
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| 1:00–2:00 PM |
Social Hour with Lite Bites |
Superior/Wasatch |
| 1:30–4:00 PM |
Poster Session 2 |
Superior/Wasatch |
Wednesday, October 11, 2023
| 1:00–2:00 AM |
Breakfast |
Golden Cliff / Eagles |
| 2:00–5:00 AM |
Metabolites as Signaling Molecules |
Ballroom 3 |
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* Joshua D. Rabinowitz, Princeton University
Session Chair |
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* Sven Enerbäck, University of Gothenburg
Session Chair |
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Sven Enerbäck, University of Gothenburg
How Foxk1 and Foxk2 Regulate Aerobic Glycolysis – Implications for Systemic Energy Homeostasis and Type 2 Diabetes |
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Mariia Yuneva, Francis Crick Institute
Identifying Metabolic Requirements of Tumours in vivo |
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Edward T. Chouchani, Dana-Farber Cancer Institute
Mechanisms of Protein Regulation by Lactate |
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Christine Vohwinkel, University of Colorado, School of Medicine
Lactate Mediated Metabolic Cross-talk Between Alveolar Macrophages and Epithelium in Acute Lung Injury Attenuates Excessive inflammation via histone lactylation |
|
| 3:00–3:20 AM |
Coffee Break |
Ballroom Lobby |
| 5:00–7:00 AM |
Poster Setup |
Superior/Wasatch |
| 5:00–11:00 AM |
On Own for Lunch |
|
| 7:00–4:00 PM |
Poster Viewing |
Superior/Wasatch |
| 9:00–10:30 AM |
Workshop 2 |
Ballroom 3/Lobby |
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* Andrea Galmozzi, UW Madison SMPH
Session Chair |
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Andrea Galmozzi, UW Madison SMPH
Adipose Heme Biosynthesis Regulates Metabolic Homeostasis and Energy Expenditure |
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Anthony Verkerke, BIDMC
BCAA Flux in Brown Fat Regulates Insulin Sensitivity Independent of Thermogenesis |
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Tong Wang, Brigham and Women’s Hospital; Harvard Medical School
Machine Learning for Precision Nutrition |
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Jaclyn A Rivas, University of New Mexico Health Sciences
Metabolomic and Transcriptomic Alterations in the Colon of Mice with Metabolic Syndrome in the Absence of Inflammation |
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Hadar Israeli, Hadassa Medical School, Hebrew University
Unraveling Weight Loss-Independent Mechanisms following Sleeve Gastrectomy for Alleviating Non-Alcoholic Fatty Liver Disease |
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Genki Ichihara, Keio University School of Medicine
MRP1-dependent Extracellular Release of Glutathione Induces Cardiomyocyte Ferroptosis After Ischemia-Reperfusion |
|
| 10:30–11:00 AM |
Coffee Available |
Ballroom Lobby |
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* Joanna Kalucka, Aarhus University
Session Chair |
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Michelle F. Clasquin, Pfizer, Inc.
Expanding the Chemical Space of Synthetic Metabolites to Study a Protein of Unknown Function with Therapeutic Potential in NASH |
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Joanna Kalucka, Aarhus University
Heterogeneity of Vascular Endothelial Cells in Human Adipose Tissue: Implications for Health and Disease |
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Bowen Tan, Rockefeller University
Short Talk: Short Talk: Cellular and Molecular Basis of Leptin Resistance |
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Rémi Montané, Restore Institute
Short Talk: Short Talk: Regulation of Systemic Lactate Fluxes by Brown and Beige Adipose Tissues |
|
| 12:45–1:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Ballroom 3 |
| 1:00–2:00 PM |
Social Hour with Lite Bites |
Superior/Wasatch |
| 1:30–4:00 PM |
Poster Session 3 |
Superior/Wasatch |
| 5:00–6:45 PM |
Obesity and Metabolic Syndrome |
Ballroom 3 |
Thursday, October 12, 2023
