Mechanisms of Microbiota-Immune Interactions-Towards the Next Decade (J4)
October 8-11, 2023
| Snowbird Resort, Snowbird, UT, United States
Jorge Henao-Mejia, Eran Elinav and Lora V. Hooper
Scholarship Deadline: Jul. 6, 2023 | Abstract Deadline: Jul. 6, 2023 | Early Registration Deadline: Aug. 8, 2023
| 4:00–8:00 PM |
Arrival and Registration |
Ballroom Lobby |
| 6:00–8:00 PM |
Welcome Mixer |
Ballroom Lobby |
| 7:00–8:00 AM |
Breakfast |
Golden Cliff / Eagles |
| 8:00–9:30 AM |
Welcome and Keynote Session (Joint) |
Ballroom 1-3 |
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* Sven Enerbäck, University of Gothenburg
Session Chair |
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* Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia
Session Chair |
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June L. Round, University of Utah
Microbes with Benefits: Microbe-immune Interactions that Promote Metabolic Health |
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Bruce M. Spiegelman, Dana-Farber Cancer Institute
Inputs and Outputs of Adipose |
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| 9:30–9:50 AM |
Coffee Break |
Ballroom Lobby |
| 9:50–11:15 AM |
Microbiota and Circulating Metabolites in Host Physiology and Immunity (Joint) |
Ballroom 1-3 |
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* Tim Hand, University of Pittsburgh
Session Chair |
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Kathryn E. Wellen, University of Pennsylvania
Understanding the Interplay Between Diet, Acetyl-CoA synthesis, and Hepatic Lipid Homeostasis |
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Michael A. Fischbach, Stanford University
Microbiota Derived Metabolites and Host Physiology |
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Nicole D. Sonnert, Yale University
Short Talk: Short Talk: A Host-Microbiota Interactome Reveals Extensive Transkingdom Connectivity |
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Erica Maissy, UCSD
Short Talk: Short Talk: Gut Microbial Bile Acid Modifications With Engineered Native Bacteria Ameliorate Metabolic Features In Polycystic Ovary Syndrome |
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| 11:15–1:00 PM |
Poster Setup |
Superior/Wasatch |
| 11:15–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Superior/Wasatch |
| 2:30–4:30 PM |
Workshop 1: Decoding the Mechanisms of Immune-host Commensals Interactions |
Ballroom 1 - 2 |
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* Michael A. Silverman, Children's Hospital of Philadelphia
Session Chair |
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Juan D. Matute, Harvard Medical School & Massachusetts General Brigham
Intelectin-1 Binds and Alters the Localization of the Mucus Barrier-modifying Bacterium Akkermansia Muciniphila |
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Mariia Taguer, Merck Research Labs
Spatial Recovery of the Gut Microbiome after Antibiotics Perturbation |
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Shaina Carroll, University of California, Berkeley
Identification and Characterization of Dendritic Cells Presenting Akkermansia Muciniphila Antigens in the Gut |
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Masaya Arai, Osaka University
Antigen-specific Stimulation Induced and Augmented Peripherally Derived Treg Cells which Establish Treg-specific Epigenome and Orchestrate Oral Tolerance |
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Emrah Altindis, Boston College
A Microbiota-derived Insulin Epitope Mimic and Type 1 Diabetes Onset |
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Djenet Bousbaine, Stanford University
Decoding and Engineering the B Cell Response to Skin Commensal Microbes |
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Gregory P. Donaldson, Rockefeller University
Immunoglobulin A Suppresses Tumorigenesis by Counteracting Epithelial Responses to Microbiota |
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Naama Geva-Zatorsky, Technion
Remote Presentation: Functional Plasticity in the Gut Microbiota and Phage-host Interactions |
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| 4:30–5:00 PM |
Coffee Available |
Ballroom Lobby |
| 5:00–7:00 PM |
Microbiota and Circulating Metabolites in Host Physiology and Immunity II |
Ballroom 1 - 2 |
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* Noah W. Palm, Yale University
Session Chair |
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Noah W. Palm, Yale University
Mapping Uncharted Landscapes of Host-Microbiota Communication |
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Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia
Regulation of Tumor-Associated Macrophage (TAM) Polarity by the Microbiota |
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Nicola Gagliani, University of Hamburg
The Effects of Short-term Dietary Interventions on Immunity and Tumor Therapies |
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Xiaofei Yu, Fudan University
Short Talk: Short Talk: Early Immune Activation Protects against Psychological Stress via Interleukin-22 |
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Siva Karthik Varanasi, The Salk Institute for Biological Studies
Short Talk: Short Talk: Microbial Derived Bile Acids Influence Liver Immunity during Viral Infection and Cancer |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Superior/Wasatch |
| 7:30–10:00 PM |
Poster Session 1 |
Superior/Wasatch |
Tuesday, October 10, 2023
| 7:00–8:00 AM |
Breakfast |
Golden Cliff / Eagles |
| 8:00–11:00 AM |
Microbiota, Inflammation and Host Metabolism |
Ballroom 1 - 2 |
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* Theresa Alenghat, Cincinnati Children’s Hospital
Session Chair |
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Lora V. Hooper, University of Texas Southwestern Medical Center
Immune-Microbiota Interactions and Nutrient Absorption |
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Theresa Alenghat, Cincinnati Children’s Hospital
Regulation of the Host-Microbiota Relationship |
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Dan R. Littman, HHMI/New York University School of Medicine
Instruction of T Cell Programs by the Commensal Microbiota |
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Sean Spencer, Stanford University
Short Talk: Short Talk: Fermented Food-derived Bacterial Metabolites Participate in a Transkingdom Metabolic Network to Regulate Intestinal Immunity and Diet Induced Obesity |
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Daniel Mucida, Rockefeller University
Remote Presentation: Microbiota and Neuro-Immune Interactions |
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| 9:00–9:20 AM |
Coffee Break |
Ballroom Lobby |
| 11:00–1:00 PM |
Poster Setup |
Superior/Wasatch |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Superior/Wasatch |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Ballroom 1-3 |
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Zoltan Arany, University of Pennsylvania
Professor |
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Rose L. Szabady, Ferring Pharmaceuticals, Inc.
Associate Director, IBD Research |
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Elaine Y. Hsiao, University of California, Los Angeles
Associate Professor |
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Romina S. Goldszmid, NCI, National Institutes of Health
Earl Stadtman Investigator |
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Harry Sokol, INSERM
Professor |
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| 4:30–5:00 PM |
Coffee Available |
Ballroom Lobby |
| 5:00–7:00 PM |
Microbiota Immune Interactions in Early Life |
Ballroom 1 - 2 |
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* Meghan A. Koch, Fred Hutchinson Cancer Research
Session Chair |
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Tim Hand, University of Pittsburgh
Microbiota and Necrotizing Enterocolitis |
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Meghan A. Koch, Fred Hutchinson Cancer Research
Maternal Antibodies Regulate Host-Microbiota Mutualism in Early Life |
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Petter Brodin, Karolinska Institutet
Early Life Immune Development and Intestinal Tolerance |
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Michael A. Silverman, Children's Hospital of Philadelphia
Short Talk: Short Talk: Arresting Microbiome Development Limits Immune System Maturation And Resistance To Infection |
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Melody Zeng, Weill Cornell Medicine
Short Talk: Short Talk: Gut Bacteria-Derived Serotonin in Early-Life Immune Tolerance |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Superior/Wasatch |
| 7:30–10:00 PM |
Poster Session 2 |
Superior/Wasatch |
Wednesday, October 11, 2023
| 7:00–8:00 AM |
Breakfast |
Golden Cliff / Eagles |
| 8:00–11:00 AM |
Microbiota, Tumorigenesis, and Cancer Immunotherapy |
Ballroom 1 - 2 |
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* Romina S. Goldszmid, NCI, National Institutes of Health
Session Chair |
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Romina S. Goldszmid, NCI, National Institutes of Health
Regulation of the Tumor Microenvironment by the Diet and Microbiota |
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Thomas Gajewski, University of Chicago
Microbiota and Cancer Immunotherapy |
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Jens Puschhof, Deutsches Krebsforschungszentrum
Modelling Cancer-Microbe Interactions with Organoids and Organs-on-Chips |
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Liz Shepherd, Novome Biotechnologies
Microbial Cell Therapy: Engineering Gut Residents to Treat Disease |
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Yiyin (Erin) Erin Chen, Broad Institute of MIT and Harvard
Short Talk: Short Talk: Engineering Skin Commensal Bacteria for Tumor Immunotherapy |
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Joon Seok Park, Harvard Medical School
Short Talk: Short Talk: Targeting PD-L2–RGMb Overcomes Microbiome-related Immunotherapy Resistance |
|
| 9:00–9:20 AM |
Coffee Break |
Ballroom Lobby |
| 11:00–1:00 PM |
Poster Setup |
Superior/Wasatch |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Superior/Wasatch |
| 2:30–4:30 PM |
Workshop 2: Dietary Therapeutic Interventions in Autoimmunity and Cancer |
Ballroom 1 - 2 |
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* Nicola Gagliani, University of Hamburg
Session Chair |
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Margaret Alexander, University of California, San Francisco
A Diet-dependent Host Metabolite Shapes the Gut Microbiota to Protect from Autoimmunity |
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Asael Roichman, Princeton University
The Gut Microbiome Regulates the Anti-cancer Activity of PI3K Inhibitors |
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Abby E. Overacre, University of Pittsburgh
Too Sweet to be True: Sucralose Ablates Immunotherapy Response through Microbiome Disruption. |
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Khiem Lam, National Institutes of Health
Tumor-Intrinsic Factors Dictate the Beneficial Effect of Microbiota Intervention on Anti-Cancer Response |
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Annabell Bachem, The University of Melbourne
Improving CD8 T Cell-mediated Melanoma Control by Targeting Microbiota-derived Metabolites |
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Isabelle Bourdeau Julien, Université Laval
Metabolite Profile Response to Short-Term Dietary Interventions |
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Cate Ward, Stanford School of Medicine
Exploring the Interplay of Plant-Based Diets, Microbiota, and Metabolites: Implications for Cardiovascular Disease Prevention |
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Harry Sokol, INSERM
Role of the Gut Microbiota in Tryptophan Metabolism: A System Biology Approach |
|
| 4:30–5:00 PM |
Coffee Available |
Ballroom Lobby |
| 5:00–6:45 PM |
Microbiota, Inflammation and Protective Immunity |
Ballroom 1 - 2 |
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* Shruti Naik, New York University Langone Health
Session Chair |
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Eran Elinav, Weizmann Institute of Science
Remote Presentation: Nutrition, Microbiota and Innate Immunity in Epithelial Cells |
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Shruti Naik, New York University Langone Health
Skin Microbiota and Tissue Repair |
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Rose L. Szabady, Ferring Pharmaceuticals, Inc.
Development of Live Microbial Therapeutics for Treatment of Human IBD |
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Michael C Abt, University of Pennsylvania
Short Talk: Short Talk: Therapeutic Intervention Restores Host Responsiveness to Microbiota Transplant Treatment of C. Difficile Infection |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Ballroom 1 - 2 |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Superior/Wasatch |
| 7:30–10:00 PM |
Poster Session 3 |
Superior/Wasatch |
Thursday, October 12, 2023
