Autophagy and Disease (J5)
December 3-6, 2023
| Keystone Resort, Keystone, CO, United States
Eric H. Baehrecke and Anastasia Henry
Scholarship Deadline: Aug. 30, 2023 | Abstract Deadline: Aug. 30, 2023 | Early Registration Deadline: Oct. 3, 2023
| 4:00–8:00 PM |
Arrival and Registration |
Shavano Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Shavano Foyer |
| 7:00–8:00 AM |
Breakfast |
Red Cloud/Crestone |
| 8:00–9:00 AM |
Welcome and Keynote Address (Joint) |
Torreys/Shavano Peak |
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* Ivan Dikic, Goethe University Medical School
Session Chair |
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Brenda A. Schulman, Max Planck Institute of Biochemistry
Twists and Turns in Ubiquitin Conjugation Cascades |
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| 9:00–11:30 AM |
Ubiquitin in Regulation of Autophagy and Disease (Joint) |
Torreys/Shavano Peak |
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* Kylie J. Walters, NCI, National Institutes of Health
Session Chair |
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* Achim Werner, National Institutes of Health
Session Chair |
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Michael Rape, University of California, Berkeley
Ubiquitin Ligases and Stress Responses |
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Tyler Franklin, Oregon Health and Science University
Short Talk: Short Talk: Bacterial Mimicry of Eukaryotic HECT Ubiquitin Ligation |
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Kylie J. Walters, NCI, National Institutes of Health
Proteasome Subunit Rpn13: Interactions, Activities and Therapeutic Opportunities |
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Sonja Lorenz, Max Planck Institute for Multidisciplinary Sciences
Short Talk: Short Talk: Structural Mechanism of the Ubiqutin Ligase HACE1 |
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Masaaki Komatsu, Juntendo University School of Medicine
p62-Ubiquitin Condensates: Formation, Physiology and Autophagic Degradation |
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| 9:30–9:50 AM |
Coffee Break |
Shavano Foyer |
| 11:30–1:00 PM |
Poster Setup |
Red Cloud/Crestone |
| 11:30–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Red Cloud/Crestone |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Shavano Peak |
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Carlos Castañeda, Syracuse University
Associate Professor |
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Mary Lilly, National Institutes of Health
Senior Investigator |
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Rupert Beale, The Francis Crick Institute
Clinical Group Leader |
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Judith A. Ronau, AbbVie, Inc.
Senior Scientist II |
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| 4:30–5:00 PM |
Coffee Available |
Shavano Foyer |
| 5:00–7:00 PM |
Biophysical and Novel Regulatory Mechanisms of Autophagy |
Shavano Peak |
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* Sharon A. Tooze, Francis Crick Institute
Session Chair |
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* Martin Graef, Cornell University
Session Chair |
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Hong Zhang, Chinese Academy of Sciences
Decoding of ER Ca2+ Transients to Trigger the Assembly of Autophagosome Formation Sites on the ER |
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Yang Wang, Chinese University of Hong Kong, Shenzhen
Short Talk: Short Talk: Structural Basis for Lipid Transfer by the ATG2A-ATG9A Complex |
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Mondira Kundu, St. Jude Children's Hospital
ULK/Atg1 and its Interacting Partners in the Regulation of Biomolecular Condensates: Relevance to Disease |
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Reuben J. Shaw, The Salk Institute for Biological Studies
Short Talk: Short Talk: AMPK and ULK1: Two Critical Kinases in Autophagy Initiation |
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James H. Hurley, University of California, Berkeley
The Molecular Acrobatics of Autophagy Initiation |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Red Cloud/Crestone |
| 7:30–10:00 PM |
Poster Session 1 |
Red Cloud/Crestone |
Tuesday, December 5, 2023
| 7:00–8:00 AM |
Breakfast |
Red Cloud/Crestone |
| 8:00–11:00 AM |
Lysosomal Biology and Damage in Autophagy and Disease |
Shavano Peak |
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* Chris Shoemaker, Dartmouth College
Session Chair |
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* Anne Simonsen, University of Oslo
Session Chair |
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Anastasia Henry, Denali Therapeutics
Rab12 Regulates LRRK2 Activity and Recruitment to Damaged Lysosomes |
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Sharon A. Tooze, Francis Crick Institute
Maintenance of Lysosome Integrity by ATG9A Effectors and PI4P |
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Dan Baird, Casma Tx
Targeting Autophagy Initiation |
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Mary Lilly, National Institutes of Health
Short Talk: Short Talk: The GATOR2 Complex Maintains Lysosomal-autophagic Function by Inhibiting MiT/TFEs Protein Degradation |
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Vojo Deretic, University of New Mexico Health Sciences Center
Membrane Atg8ylation During Infection |
|
| 9:10–9:30 AM |
Coffee Break |
Shavano Foyer |
| 11:00–1:00 PM |
Poster Setup |
Red Cloud/Crestone |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Red Cloud/Crestone |
| 2:30–4:30 PM |
Workshop |
Shavano Peak |
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* Mondira Kundu, St. Jude Children's Hospital
Session Chair |
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* Andreas Jenny, Albert Einstein College of Medicine
Session Chair |
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Louis R. Lapierre, Universite de Moncton
Location, Location, Location: Subcellular Protein Partitioning Modulates Proteostasis, Autophagy and Aging |
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Graham J Ray, MIT
The Substrates of Lysosomal RNA Degradation and the RNases that Degrade Them |
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Thabata L.A. Lopes Alberto Duque, University of New Mexico
Comparative Analysis of the Atg8ylation E3 Ligase ATG16L1 and a Candidate Alternative E3 Ligase ATG16L2 by Proximity Biotinylation Proteomics |
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Ta-Chiang Liu, Washington University School of Medicine
Macrophage LRRK2 Hyperactivity Impairs Autophagy and Induces Paneth Cell Dysfunction and Intestinal Inflammation |
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Guangyan Miao, UMASS Chan Medical School
Microglia are Key Executioners of Inflammation and Neuronal Cell Death Upon Mitochondrial Impairment in a Vps13D-deficient Mouse Model |
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Massiel C. Stolla, University of Washington
Atg4a Promotes Mitochondrial Clearance and Hemoglobin Production in vivo |
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Farzane Mirfakhar, Washington University in st louis
Cellular Cleanup Gone Awry: Tau Accumulates in Stem Cell Model of Tauopathy through Autophagy and Lysosomal Impairments |
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Rupert Beale, The Francis Crick Institute
Dissipation of Proton Gradients Leads to Recruitment of ATG16L1 |
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| 4:30–5:00 PM |
Coffee Available |
Shavano Foyer |
| 5:00–7:00 PM |
Autophagy, Organelle Contact and Disease |
Shavano Peak |
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* Herbert (Skip) W. Virgin, Washington University School of Medicine
Session Chair |
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Alexandra Stolz, Goethe University Frankfurt
Session Chair |
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Susan Ferro-Novick, University of California, San Diego
Autophagy Receptors Function at Distinct Endoplasmic Reticulum Domains |
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Mengying Cui, Osaka University
Short Talk: Short Talk: Identification of a Novel Target of TFEB Essential to Maintain Both Mitochondrial and Lysosomal Homeostasis, Preventing Cellular Senescence |
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Martin Graef, Cornell University
Autophagy Functions in Mitochondrial and Nuclear Genome Maintenance |
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Jose M Delgado, Dartmouth College
Short Talk: The ER Membrane Protein Complex Governs Lysosomal Turnover of a Mitochondrial Tail-anchored Protein, BNIP3, to Restrict Mitophagy |
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Eric H. Baehrecke, University of Massachusetts Medical School
Coordinated Selective Clearance of ER and Mitochondria |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Red Cloud/Crestone |
| 7:30–10:00 PM |
Poster Session 2 |
Red Cloud/Crestone |
Wednesday, December 6, 2023
| 7:00–8:00 AM |
Breakfast |
Red Cloud/Crestone |
| 8:00–8:45 AM |
Keynote Address (Joint) |
Torreys/Shavano Peak |
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* Eric H. Baehrecke, University of Massachusetts Medical School
Session Chair |
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J. Wade Harper, Harvard Medical School
Principles of Organelle Quality Control by Autophagy |
|
| 8:45–11:15 AM |
Autophagy, Ubiquitin, Organelle Clearance and Disease (Joint) |
Torreys/Shavano Peak |
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* Vojo Deretic, University of New Mexico Health Sciences Center
Session Chair |
|
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* Christina Towers, The Salk Institute for Biological Studies
Session Chair |
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Sylvie Urbé, University of Liverpool
E3 Ligase and DUB Imposed Restrictions on Mitophagy |
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Anne Simonsen, University of Oslo
Regulation of Mitophagy and Cellular Bioenergetics by Lipid-binding Proteins |
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Alexandra Stolz, Goethe University Frankfurt
Short Talk: The Function of ER-phagy Receptors is Regulated through Phosphorylation-dependent Ubiquitination Pathways |
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Philippa Rosewell, University of Dundee
Short Talk: Short Talk: Hexokinase II Catalytic Activity Regulates Mitophagy |
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Richard J. Youle, NINDS, National Institutes of Health
STING Activation of LC3 Lipidation and Linear (M1) Ubiquitination in Innate Immune Signaling |
|
| 9:15–9:35 AM |
Coffee Break |
Shavano Foyer |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 4:30–5:00 PM |
Coffee Available |
Shavano Foyer |
| 5:00–6:45 PM |
Autophagy in Cancer and Inflammatory Disease |
Shavano Peak |
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* Anastasia Henry, Denali Therapeutics
Session Chair |
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* Dan Baird, Casma Tx
Session Chair |
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Eileen P. White, Rutgers Cancer Institute of New Jersey
Autophagy and Cancer |
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Aditya Murthy, Gilead Sciences
Short Talk: Short Talk: Suppression of Anti-tumor Immunity in Colorectal Cancer by the Autophagy Gene ATG16L1 |
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Christina Towers, The Salk Institute for Biological Studies
Metabolic Adaptations to Autophagy Inhibition in Cancer |
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Herbert (Skip) W. Virgin, Washington University School of Medicine
Autophagy and Infection |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Shavano Peak |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Red Cloud/Crestone |
| 8:00–9:00 PM |
Trivia |
Shavano Peak |
| 8:00–9:00 PM |
Cash Bar |
Red Cloud/Crestone |
Thursday, December 7, 2023
