RNA Mediated Regulation of Immunity: Mechanism, Disease and Therapeutics (J5)
January 27-30, 2025
| Keystone Resort, Keystone, CO, United States
Uttiya Basu, Sun Hur and Noam Stern-Ginossar
Scholarship Deadline: Nov. 13, 2024 | Abstract Deadline: Jan. 7, 2025 | Early Registration Deadline: Dec. 11, 2024
| 4:00–8:00 PM |
Registration |
Longs Peak Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Longs Peak Foyer |
Tuesday, January 28, 2025
| 7:30–8:30 AM |
Breakfast |
Quandary Peak |
| 8:30–9:45 AM |
Welcome and Keynote Address (Joint) |
Longs/Grays Peaks |
| |
* Sebastian Kadener, Brandeis University
Session Chair |
|
| |
V. Narry Kim, Seoul National University Institute for Basic Science
Cellular Regulation of Exogenous Rnas: from Viral Rnas to Mrna Therapeutics |
|
| 9:45–10:05 AM |
Coffee Break |
Longs Peak Foyer |
| 10:05–12:05 PM |
RNA Biology and Immune System Diseases (Joint) |
Longs/Grays Peaks |
| |
* Sun Hur, Harvard Medical School
Session Chair |
|
| |
Noam Stern-Ginossar, Weizmann Institute of Science
Viral Pathogenesis and RNAs |
|
| |
Schraga Schwartz, Weizmann Institute of Science
Charting the Ribosomal Epitranscriptome |
|
| |
Judy Lieberman, Boston Children's Hospital; Harvard University
RNA Therapeutics to Modulate Tumor Immunity |
|
| |
Max Lauring, Columbia University Medical Center
Short Talk: An Anti-Retrotransposon Silencing Mechanism Promotes Antibody Diversification |
|
| |
Ignacio Ruiz Fernández, Spanish National Centre for Cardiovascular Research
Short Talk: T Cell-derived miR-721 as a Key Player in Inflammaging and Age-related Diseases |
|
| 10:20–10:25 AM |
Award Recipient Acknowledgement (Joint) |
Longs/Grays Peaks |
| 12:00–1:00 PM |
Poster Setup |
Quandary Peak |
| 12:00–2:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Quandary Peak |
| 3:00–4:30 PM |
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions |
Grays Peak |
| |
Valerie Griesche, German Cancer Research Center (DKFZ)
Impact of Adenosine mRNA Modifications on the Immune Function of Macrophages |
|
| |
Ksenia Skvortsova, Garvan Institute of Medical Research
Molecular Mechanisms of Transient Re-activation of the Inactive X Chromosome During Female Immune Cell Development |
|
| |
Daniel E Whisenant, Columbia University
RNA Processing Mechanisms in B Cell Development |
|
| |
* Claudia Ribeiro de Almeida, Babraham Institute
RNA Helicase Ddx1 Regulates Germinal Centre Selection and Affinity Maturation by Promoting Trna Ligase Activity |
|
| |
Alicia Gonzalez-Martin, Autonoma University of Madrid
Regulation of B Cell Tolerance and Autoimmunity by MicroRNAs |
|
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Gene Expression Control in Infection and Immunity |
Grays Peak |
| |
* Ram Savan, University of Washington
Session Chair |
|
| |
Kate A Fitzgerald, University of Massachusetts Medical School
lncRNA Mediated Regulation of Innate Immunity |
|
| |
Amy L Kenter, University of Illinois College of Medicine
Exuberant long noncoding RNA expression may regulate Igh locus function and V(D)J recombination on multiple levels |
|
| |
Eric M Poeschla, University of Colorado Denver School of Medicine
ADAR1 Haploinsufficiency and Viral RdRp dsRNA Synthesis Synergize to Dysregulate RNA Editing and Cause Multi-system Interferonopathy |
|
| |
Susan B Carpenter, University of California, Santa Cruz
High throughput and Targeted Approaches to Characterize lncRNAs in Macrophage Biology |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peak |
| 7:30–10:00 PM |
Poster Session 1 |
Quandary Peak |
Wednesday, January 29, 2025
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–11:00 AM |
Innate Immune Sensing of Foreign RNA |
Grays Peak |
| |
* Jayanta Chaudhuri, Memorial Sloan Kettering Cancer Center
Session Chair |
|
| |
Ram Savan, University of Washington
New Players in the RNA Sensing Pathway |
|
| |
Sun Hur, Harvard Medical School
Cytoplasmic dsRNA Sensors |
|
| |
Karlene A Cimprich, Stanford University
RNA/DNA Hybrids and Immune System Activators |
|
| |
Jacki Heraud-Farlow, Hudson Institute of Medical Research
Short Talk: GGNBP2 Regulates Self-sensing of Cellular Double-stranded RNA Following Loss of ADAR1 |
|
| |
Ramin M Hakami, George Mason University
Short Talk: Small Extracellular Vesicles (sEV) Released by Cells Infected with the Cytoplasmic RNA Virus Rift Valley Fever Virus Protect against Viral Infection by Inducing RIG-I-dependent IFN-B Activation that Leads to Activation of Autophagy |
|
| |
Michael Gantier, Hudson Institute of Medical Research
Short Talk: 2’-O-Methyl-Guanosine 3-Base RNA Fragments Mediate Essential Natural TLR7/8 Antagonism |
|
| |
Qin Li, University of Pennsylvania
Short Talk: MDA5-Mediated Immune Response to Endogenous dsRNAs as Driver of Type 1 Diabetes |
|
| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–1:00 PM |
Poster Setup |
Quandary Peak |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–2:30 PM |
Career Roundtable (Joint) |
Grays Peak |
| |
Damian Refojo, Max Planck Partner Institute - Buenos Aires
Principal Investigator |
|
| |
Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia
Professor |
|
| |
Emily M Anderson, Revvity, Inc.
Principal Scientist |
|
| |
Xiaoyi Yuan, UTHealth Houston
Assistant Professor |
|
| 1:00–10:00 PM |
Poster Viewing |
Quandary Peak |
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
RNA Structure, Modifications and Processing in the Immune System |
Grays Peak |
| |
* Karlene A Cimprich, Stanford University
Session Chair |
|
| |
Uttiya Basu, Columbia University
Pathogenic Noncoding RNA Processing in Immune and Neural Diseases |
|
| |
Rhiju Das, Stanford University
Use of Artificial Intelligence in Designing Immunogenic RNAs |
|
| |
Chuan He, University of Chicago
m6A RNA Modification in Immune Cells |
|
| |
Jayanta Chaudhuri, Memorial Sloan Kettering Cancer Center
G4 RNAs in B Cells |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peak |
| 7:30–10:00 PM |
Poster Session 2 |
Quandary Peak |
Thursday, January 30, 2025
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–11:00 AM |
Retrotransposition and RNA Viruses |
Grays Peak |
| |
* Trey Westbrook, Baylor College of Medicine
Session Chair |
|
| |
Kathleen H Burns, Dana Farber Cancer Institute | Harvard Medical School
The Immune Impact of L1 Retrotransposons |
|
| |
Paul J. Lehner, Cambridge Institute of Therapeutic Immunology and Infectious Disease
How HUSH Directs RNA-Mediated Epigenetic Silencing |
|
| |
Helen Rowe, Queen Mary University of London
HUSH Complexes in L1 Silencing in Immune Cells |
|
| |
Yorgo Modis, University of Cambridge
Structures of HUSH Domains | MDA5 Variants Trade Antiviral Activity for Autoimmune Protection |
|
| |
Tiffany Hsu, Brigham and Women's Hospital
Short Talk: Extracellular Functions of Viral RNA Sensor MDA5 in Complex with Disease-associated Autoantibody |
|
| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–12:00 PM |
Meet the Editors (Joint) |
Longs Peak |
| |
Mishtu Dey, Cell Chemical Biology, Cell Press
*Session Chair, Editor-in-Chief |
|
| |
Gail Teitzel, Cell Press
Deputy Editor |
|
| |
Iris Marchal, Springer Nature AG & Co. KG
Associate Editor, Reviews |
|
| |
Yehu Moran, Hebrew University of Jerusalem
Academic Editor, EMBO Press |
|
| 11:00–2:30 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions |
Grays Peak |
| |
* Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia
Session Chair |
|
| |
Scott Alper, National Jewish Health
Myelodysplastic Syndrome-Associated Spliceosome Mutations Weaken Host Defense by compromising myeloid cell function |
|
| |
David Dulin, VU Amsterdam
Short Talk: MDA5 Employs ATP Hydrolysis to Condense Long Dsrna into a Stable Nucleoprotein Complex |
|
| |
Ruxiao Tian, Columbia University
A Long Noncoding RNA Genetic Risk Factor of Systemic Lupus Erythematosus |
|
| |
Ira Fleming, University of Colorado, Anschutz
Complementary Transcriptomic Methods Provide Alternative Views of Messenger RNA Vaccine Distribution in the Murine Lymph Node |
|
| |
Morgane Gourvest, NYU Langone Medical Center - NYU Grossman School of Medicine
Long Noncoding RNA Regulation of Inflammation in Atherosclerosis |
|
| |
Pooja Mukherjee, UC Berkeley
miRNA-Mediated Translational Activation and Repression During Early T Cell Activation in Jurkat Cells |
|
| |
Ainara Castellanos-Rubio, University of Basque Country
Epitranscriptomic Regulation of Immune Response: The Role of MAPKAPK5AS1 lncRNA in IFN-γ Secretion and Autoimmune Disease Modulation |
|
| |
Kristin Patrick, Vanderbilt University School of Medicine
Neat1 and the Nuclear Paraspeckle Orchestrate the Early Innate Immune Response in Macrophages |
|
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–6:45 PM |
RNA and Therapeutics (Joint) |
Longs/Grays Peaks |
| |
* Uttiya Basu, Columbia University
Session Chair |
|
| |
Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia
RNA Regulation of Tumor Associated Macrophages |
|
| |
Trey Westbrook, Baylor College of Medicine
Targeting RNA Splicing in Cancer: From Synthetic Lethality to Immuno-Oncology |
|
| |
Michael G Kharas, Memorial Sloan Kettering Cancer Center
RNA Methylation and Control of Cellular Fate in the Blood |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Longs/Grays Peaks |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peak |
| 8:00–9:00 PM |
Entertainment |
Longs Peak |
| 8:00–9:00 PM |
Cash Bar |
Quandary Peak |
