Obesity Therapeutics: Unlocking Benefits and Minimizing Side Effects (J5)
January 26-29, 2026  | Keystone Resort, Keystone, CO, United States
Lora K. Heisler, James Trevaskis, Michael A Cowley and Matthias H. Tschöp
Scholarship Deadline: Sep. 25, 2025 | Abstract Deadline: Jan. 6, 2026 | Early Registration Deadline: Nov. 25, 2025
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 8 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Monday, January 26, 2026
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Tuesday, January 27, 2026
7:00–8:00 AM Breakfast
8:00–9:00 AM Welcome and Keynote Address (Joint)
  Richard D DiMarchi, Indiana University
The Chemical Evolution of Peptides To Transform Human Health
 
9:00–11:15 AM Beyond Weight Loss: New Directions for Obesity Therapeutics (Joint)
  Rachel J. Roth Flach, Valo Health
Targeting Metabolism for HFpEF
 
  Susan Quaggin, Northwestern University
A United Vision for Kidney and Cardiovascular Disease Treatment
 
  James Trevaskis, Eli Lilly
Incretins for MASH Treatment
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:15–12:15 PM Meet the Editors (Joint)
  * Rong Tian, University of Washington
 
11:15–1:00 PM Poster Setup
11:15–2:30 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
2:30–4:30 PM Symposia Spotlight 1: Emerging Therapies, Lifestyle Interventions and AI Approaches (Joint)
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM Late Breaking Research on Obesity Development
  Ana Paula Arruda, University of California, Berkeley
Metabolic Adaptations to Nutritional Fluctuations
 
  Jason Gill, University of Glasgow
Ethnic Differences in the Development and Management of Obesity
 
  Randy J. Seeley, University of Michigan
Body Weight Set Point
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Poster Session 1
Wednesday, January 28, 2026
7:00–8:00 AM Breakfast
8:00–11:00 AM CNS Mechanisms of Action of Weight Loss
  Michael A Cowley, Monash University
Hypothalamic Neurocircuits that Mediate Drug Actions
 
  Lora K. Heisler, Rowett Institute, University of Aberdeen
Brain GPCR Targets and Circuits Controlling Food Intake
 
  Bei B. Zhang, Novo Nordisk
Modulation of GLP-1 and Amylin Receptors for Weight Management
 
  Giuseppe D'Agostino, University of Manchester
Appetite and Body Weight Control via Caudal Brainstem Circuits
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–1:00 PM Poster Setup
11:00–1:30 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
1:30–2:45 PM Career Roundtable (Joint)
4:30–5:00 PM Coffee Available
5:00–7:00 PM Leveraging Enteroendocrine Cell Secretion
  Shirly Pinto, Kallyope
Unlocking GLP-1 Expressing Cells for Novel Therapeutics
 
  Fiona M. Gribble, University of Cambridge
Mechanisms Underlying Nutrient Sensing in Human Intestinal-Secreting Cells
 
  Kevin G. Murphy, Imperial College London
Dietary Drivers of Gut Hormone Release
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Poster Session 2
Thursday, January 29, 2026
7:00–8:00 AM Breakfast
8:00–11:00 AM Emerging Therapies for Obesity and Cardiometabolic Diseases (Joint)
  Matthias H. Tschöp, Helmholtz Munich
Dual and Triple Co-Agonists: From Discovery to Best-in-Class
 
  Kirsten Raun, Novo Nordisk A/S
Amylin: The All-Inclusive Obesity Therapeutic
 
  Thomas Alexander Lutz, University of Zürich
Amylin Physiology and its Therapeutic Potential to Treat Metabolic Diseases
 
  Murielle M Véniant-Ellison, Amgen Inc.
Unlocking the Power of GIPR and GLP-1R Targeting for Effective Weight Loss and Metabolic Improvement
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–2:30 PM On Own for Lunch
1:00–2:00 PM Panel: Perspectives: Personalized Medicine & Patient-Centered Strategies (Joint)
2:30–4:30 PM Symposia Spotlight 2: Leveraging Genetics
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–6:45 PM Preservation of Muscle Mass and Function during Weight Loss
  Mark W. Sleeman, Regeneron Pharmaceuticals
Strategies to Prevent Muscle Loss
 
  Philip Larsen, Sixpeaks Bio AG
Preservation of Skeletal Muscle is a Key to Healthy Weight Loss
 
  Ffolliott M Fisher, Keros Therapeutics
Targeting the TGF-β super Family for the Preservation of Muscle Mass and Weight Loss
 
  Short Talk(s) Chosen from Abstracts
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:00–8:00 PM Social Hour with Dinner
8:00–11:00 PM Cash Bar
8:00–11:00 PM Entertainment
Friday, January 30, 2026
12:00–11:59 PM Departure