Ubiquitin Biology and Disease (J6)
December 3-6, 2023
| Keystone Resort, Keystone, CO, United States
Ivan Dikic and Cynthia Wolberger
Scholarship Deadline: Aug. 30, 2023 | Abstract Deadline: Aug. 30, 2023 | Early Registration Deadline: Oct. 3, 2023
| 4:00–8:00 PM |
Arrival and Registration |
Shavano Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Shavano Foyer |
| 7:00–8:00 AM |
Breakfast |
Red Cloud/Crestone |
| 8:00–9:00 AM |
Welcome and Keynote Address (Joint) |
Torreys/Shavano Peak |
| |
* Ivan Dikic, Goethe University Medical School
Session Chair |
|
| |
Brenda A. Schulman, Max Planck Institute of Biochemistry
Twists and Turns in Ubiquitin Conjugation Cascades |
|
| 9:00–11:30 AM |
Ubiquitin in Regulation of Autophagy and Disease (Joint) |
Torreys/Shavano Peak |
| |
* Kylie J. Walters, NCI, National Institutes of Health
Session Chair |
|
| |
* Achim Werner, National Institutes of Health
Session Chair |
|
| |
Michael Rape, University of California, Berkeley
Ubiquitin Ligases and Stress Responses |
|
| |
Tyler Franklin, Oregon Health and Science University
Short Talk: Short Talk: Bacterial Mimicry of Eukaryotic HECT Ubiquitin Ligation |
|
| |
Kylie J. Walters, NCI, National Institutes of Health
Proteasome Subunit Rpn13: Interactions, Activities and Therapeutic Opportunities |
|
| |
Sonja Lorenz, Max Planck Institute for Multidisciplinary Sciences
Short Talk: Short Talk: Structural Mechanism of the Ubiqutin Ligase HACE1 |
|
| |
Masaaki Komatsu, Juntendo University School of Medicine
p62-Ubiquitin Condensates: Formation, Physiology and Autophagic Degradation |
|
| 9:30–9:50 AM |
Coffee Break |
Shavano Foyer |
| 11:30–1:00 PM |
Poster Setup |
Red Cloud/Crestone |
| 11:30–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Red Cloud/Crestone |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Shavano Peak |
| |
Carlos Castañeda, Syracuse University
Associate Professor |
|
| |
Mary Lilly, National Institutes of Health
Senior Investigator |
|
| |
Rupert Beale, The Francis Crick Institute
Clinical Group Leader |
|
| |
Judith A. Ronau, AbbVie, Inc.
Senior Scientist II |
|
| 4:30–5:00 PM |
Coffee Available |
Shavano Foyer |
| 5:00–7:00 PM |
Expanding Mechanisms of Ub Conjugation and Deconjugation |
Torreys Peak |
| |
* Fumiyo Ikeda, Osaka University
Session Chair |
|
| |
* Yogesh Kulathu, University of Dundee
Session Chair |
|
| |
Rachel Klevit, University of Washington
Is that RING Mutant Really Ligase-dead? |
|
| |
Ian J. Fucci, National Cancer Institute
Short Talk: Short Talk: Exploring the Transitions Between Open and Closed States in E2~Ub Conjugates |
|
| |
Yogesh Kulathu, University of Dundee
Ribosome UFMylation in ER Homeostasis |
|
| |
Cynthia Wolberger, Johns Hopkins University School of Medicine
Histone H2B Ubiquitination in Transcription Regulation |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Red Cloud/Crestone |
| 7:30–10:00 PM |
Poster Session 1 |
Red Cloud/Crestone |
Tuesday, December 5, 2023
| 7:00–8:00 AM |
Breakfast |
Red Cloud/Crestone |
| 8:00–11:00 AM |
Dynamics and Specificity of the Ubiquitin System |
Torreys Peak |
| |
* Sonja Lorenz, Max Planck Institute for Multidisciplinary Sciences
Session Chair |
|
| |
* Claudio A. P. Joazeiro, University of Heidelberg
Session Chair |
|
| |
Christopher D. Lima, Memorial Sloan Kettering Cancer Center
Capturing Conformational Transitions in the Ubiquitin Conjugation Cascade |
|
| |
Fumiyo Ikeda, Osaka University
Linear Ubiquitination in Regulation of Innate Immunity |
|
| |
Gabriela Prus, University of Copenhagen
Short Talk: Short Talk: A Global, Integrated View of the Ubiquitylation Site Occupancy and Dynamics |
|
| |
Claudio A. P. Joazeiro, University of Heidelberg
Mechanism and Evolutionary Origins of Alanine-tail C-degron Recognition by E3 Ligases Pirh2 and CRL2-KLHDC10 |
|
| |
Ivan Dikic, Goethe University Medical School
Ubiquitination and ER Remodeling |
|
| |
Jacob E. Corn, ETH Zürich
Short Talk: Short Talk: C-terminal Amides Mark Proteins for Degradation via SCF-FBXO31 |
|
| 9:00–9:20 AM |
Coffee Break |
Shavano Foyer |
| 11:00–1:00 PM |
Poster Setup |
Red Cloud/Crestone |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Red Cloud/Crestone |
| 4:30–5:00 PM |
Coffee Available |
Shavano Foyer |
| 5:00–7:00 PM |
Ubiquitin in Disease Mechanisms |
Torreys Peak |
| |
* Carlos Castañeda, Syracuse University
Session Chair |
|
| |
Daniel J. Finley, Harvard University
Global Remodeling of the Proteome in Terminal Differentiation |
|
| |
Xin Gu, Harvard Medical School
Short Talk: Short Talk: The Midnolin-proteasome Pathway Catches Proteins for Ubiquitination-independent Degradation |
|
| |
Achim Werner, National Institutes of Health
Shared and Distinct Mechanisms of UBA1 Inactivation Across Different Disease States |
|
| |
Xiaojing Sui, Northwestern University
Short Talk: Short Talk: The Functional Proteome Landscape Reveals Adaptive Regulation of the Proteasome in Aging |
|
| |
Carlos Castañeda, Syracuse University
Modulators of Ubiquilin Phase Separation: Implications for Protein Quality Control |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Red Cloud/Crestone |
| 7:30–10:00 PM |
Poster Session 2 |
Red Cloud/Crestone |
Wednesday, December 6, 2023
| 7:00–8:00 AM |
Breakfast |
Red Cloud/Crestone |
| 8:00–8:45 AM |
Keynote Address (Joint) |
Torreys/Shavano Peak |
| |
* Eric H. Baehrecke, University of Massachusetts Medical School
Session Chair |
|
| |
J. Wade Harper, Harvard Medical School
Principles of Organelle Quality Control by Autophagy |
|
| 8:45–11:15 AM |
Autophagy, Ubiquitin, Organelle Clearance and Disease (Joint) |
Torreys/Shavano Peak |
| |
* Christina Towers, The Salk Institute for Biological Studies
Session Chair |
|
| |
* Vojo Deretic, University of New Mexico Health Sciences Center
Session Chair |
|
| |
Sylvie Urbé, University of Liverpool
E3 Ligase and DUB Imposed Restrictions on Mitophagy |
|
| |
Anne Simonsen, University of Oslo
Regulation of Mitophagy and Cellular Bioenergetics by Lipid-binding Proteins |
|
| |
Alexandra Stolz, Goethe University Frankfurt
Short Talk: Short Talk: The Function of ER-phagy Receptors is Regulated through Phosphorylation-dependent Ubiquitination Pathways |
|
| |
Philippa Rosewell, University of Dundee
Short Talk: Short Talk: Hexokinase II Catalytic Activity Regulates Mitophagy |
|
| |
Richard J. Youle, NINDS, National Institutes of Health
STING Activation of LC3 Lipidation and Linear (M1) Ubiquitination in Innate Immune Signaling |
|
| 9:15–9:35 AM |
Coffee Break |
Shavano Foyer |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Workshop: Emerging Views on Structural, Molecular and Functional Aspects of Ub System |
Torreys Peak |
| |
* Alexandra Whiteley, University of Colorado, Boulder
Session Chair |
|
| |
* Sven M Lange, Harvard Medical School
Session Chair |
|
| |
Alexandra Whiteley, University of Colorado, Boulder
Probing a New Model of Ubiquilin Client Selection |
|
| |
Xiangyi (Susie) Wang, The Walter and Eliza Hall Institute of Medical Research (WEHI)
Deciphering the Molecular Mechanism of HOIL-1, an Unconventional Ubiquitin Ligase |
|
| |
Daniel Grabarczyk, Research Institute of Molecular Pathology
Antiviral Mechanism of the Non-canonical Ubiquitin Ligase ZNFX1 |
|
| |
Reina Iwase, Harvard University
Regulation of PTEN by Ubiquitination |
|
| |
Sven M Lange, Harvard Medical School
Decoding Ubiquitin Signals for Ciliary Trafficking |
|
| |
Ranabir Das, National Centre for Biological Sciences
Ubiquitin Dynamics at the Center of Host-pathogen Interactions |
|
| 4:30–5:00 PM |
Coffee Available |
Shavano Foyer |
| 5:00–6:45 PM |
Emerging Therapeutics Employing the Ubiquitin System |
Torreys Peak |
| |
* Michael Rape, University of California, Berkeley
Session Chair |
|
| |
* Judith A. Ronau, AbbVie, Inc.
Session Chair |
|
| |
Daniel K. Nomura, University of California, Berkeley
Reimagining Druggability using Chemoproteomic Platforms |
|
| |
Cristina Mayor-Ruiz, IRB Barcelona
Chasing Molecular Glue Degraders |
|
| |
Judith A. Ronau, AbbVie, Inc.
Short Talk: Short Talk: Innovative Approaches for Examining Ternary Complex Formation in TPD and Key Insights |
|
| |
Benika Pinch, Novartis Institutes for BioMedical Research
SOCS2: A Recruitable E3 Ligase for TPD with Disease-specific Expression |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Torreys Peak |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Red Cloud/Crestone |
| 8:00–9:00 PM |
Trivia |
Shavano Peak |
| 8:00–9:00 PM |
Cash Bar |
Red Cloud/Crestone |
Thursday, December 7, 2023
