Non-Coding RNA Biology: New Roles and Diversity (J6)
January 27-30, 2025
| Keystone Resort, Keystone, CO, United States
Sebastian Kadener, Irene Bozzoni and Luisa Cochella
Scholarship Deadline: Nov. 13, 2024 | Abstract Deadline: Jan. 7, 2025 | Early Registration Deadline: Dec. 11, 2024
| 4:00–8:00 PM |
Registration |
Longs Peak Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Longs Peak Foyer |
Tuesday, January 28, 2025
| 7:30–8:30 AM |
Breakfast |
Quandary Peak |
| 8:30–9:45 AM |
Welcome and Keynote Address (Joint) |
Longs/Grays Peaks |
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* Sebastian Kadener, Brandeis University
Session Chair |
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V. Narry Kim, Seoul National University Institute for Basic Science
Cellular Regulation of Exogenous Rnas: from Viral Rnas to Mrna Therapeutics |
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| 9:45–10:05 AM |
Coffee Break |
Longs Peak Foyer |
| 10:05–12:05 PM |
RNA Biology and Immune System Diseases (Joint) |
Longs/Grays Peaks |
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* Sun Hur, Harvard Medical School
Session Chair |
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Noam Stern-Ginossar, Weizmann Institute of Science
Viral Pathogenesis and RNAs |
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Schraga Schwartz, Weizmann Institute of Science
Charting the Ribosomal Epitranscriptome |
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Judy Lieberman, Boston Children's Hospital; Harvard University
RNA Therapeutics to Modulate Tumor Immunity |
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Max Lauring, Columbia University Medical Center
Short Talk: An Anti-Retrotransposon Silencing Mechanism Promotes Antibody Diversification |
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Ignacio Ruiz Fernández, Spanish National Centre for Cardiovascular Research
Short Talk: T Cell-derived miR-721 as a Key Player in Inflammaging and Age-related Diseases |
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| 10:20–10:25 AM |
Award Recipient Acknowledgement (Joint) |
Longs Peak Foyer |
| 12:00–1:00 PM |
Poster Setup |
Quandary Peak |
| 12:00–2:30 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Quandary Peak |
| 2:30–4:30 PM |
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions |
Longs Peak |
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* Andrea Ventura, Memorial Sloan Kettering Cancer Center
Session Chair |
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Philippe J Batut, Columbia University
Non-coding RNAs and Genome Organization Control the Dynamics of Gene Expression during Development |
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Jazmin Morales, Brandeis University
Investigating the Role of circMbl in Neural Function and Development |
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Joseph Rosenbluh, Monash University
Systematic Loss-of-function Screens Identify Pathway-specific Functional Circular RNAs |
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Debraj Manna, Indian Institute of Science
Regulation of the Expression of Ribosomal Proteins by Small Downstream ORFs |
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Jinbiao Ma, Fudan University
Cryo-EM Structures of IStron-encoded Group I Intron Reveal Molecular Mechanism of Antagonistic Conflict with TnpB Associated Guide RNA |
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Neve Auperin, Pasteur Institute
Soma-to-Germline miRNA Inheritance via Yolk Promotes Stress Resilience in Progeny |
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Karine G Le Roch, University of California, Riverside
Novel Insights into the Role of Long Non-coding RNA in the Human Malaria Parasite, Plasmodium Falciparum |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Non-Coding RNA and Chromatin |
Longs Peak |
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* Philippe J Batut, Columbia University
Session Chair |
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Donal O'Carroll, University of Edinburgh
Small RNAs and De Novo DNA Methylation |
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Yehu Moran, Hebrew University of Jerusalem
Characterization of the Antiviral RNAi in Cnidarians Sheds Light on Mechanistic Evolution and Diversity |
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Tim Hasenbein, Technical University of Munich (TUM)
Short Talk: X-linked Deletion of Crossfirre, Firre, and Dxz4 in vivo Uncovers Diverse Phenotypes and Combinatorial Effects on Autosomes |
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Claire Rougeulle, CNRS / Institut Curie
Non-coding RNAs Controlling X Chromosome Activity in Primates |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peak |
| 7:30–10:00 PM |
Poster Session 1 |
Quandary Peak |
Wednesday, January 29, 2025
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–11:00 AM |
Post-Transcriptional Control by Non-Coding RNAs |
Longs Peak |
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* Irene Bozzoni, University La Sapienza, Rome
Session Chair |
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Luisa Cochella, Johns Hopkins University School of Medicine
Quantitative microRNA-Mediated Repression in Animal Development |
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Joshua T Mendell, University of Texas Southwestern Medical Center
Regulation and Function of Mammalian Noncoding RNAs |
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Gaspare La Rocca, University of Palermo
Non-Coding RNAs in Cancer and Development |
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Peter Wang, MIT
Short Talk: The Structural Basis for RNA Slicing by Human Argonaute2 |
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Mariangela Morlando, Sapienza University of Rome
Short Talk: Functional Insights into circDlc1(2): A Key Regulator of microRNA Localization and Synaptic Translation in Neurons |
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Martin J Simard, CHU de Québec-Université Laval Research Center
Short Talk: Dipeptidyl Peptidase DPF-3 is a Gatekeeper of MicroRNA Argonaute Compensation in Animals |
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Francesca Briganti, UCSD
Short Talk: The Use of miRNA for the Identification of Etiology Specific Compensatory Mechanisms in Heart Disease |
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–1:00 PM |
Poster Setup |
Quandary Peak |
| 11:00–2:45 PM |
On Own for Lunch |
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| 1:00–2:30 PM |
Career Roundtable (Joint) |
Grays Peak |
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Damian Refojo, Max Planck Partner Institute - Buenos Aires
Principal Investigator |
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Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia
Professor |
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Emily M Anderson, Revvity, Inc.
Principal Scientist |
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Xiaoyi Yuan, UTHealth Houston
Assistant Professor |
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| 1:00–10:00 PM |
Poster Viewing |
Quandary Peak |
| 2:45–4:30 PM |
Panel: Methodologies to Study Non-Coding RNAs: Standards and Best Practices |
Longs Peak |
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* Luisa Cochella, Johns Hopkins University School of Medicine
Panelist |
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Roy R. Parker, HHMI/University of Colorado
Panelist |
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Yunsun Nam, University of Texas Southwestern Medical Center
Panelist |
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Donal O'Carroll, University of Edinburgh
Panelist |
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Yehu Moran, Hebrew University of Jerusalem
Panelist |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Granules and RNA Localization |
Longs Peak |
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* Scott G. Kennedy, Harvard Medical School
Session Chair |
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Irene Bozzoni, University La Sapienza, Rome
circRNA in the Control of Translation and RNA Trafficking |
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Roy R. Parker, HHMI/University of Colorado
Role of RNA in Granule Function and Structure |
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Marie Laure Baudet, University of Trento
Intracellular Distribution of RNA and Association with Different Organelles |
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Scott G. Kennedy, Harvard Medical School
Non-Templated Addition of a G-Quadruplex Structure Marks RNA for Small RNA Production |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peak |
| 7:30–10:00 PM |
Poster Session 2 |
Quandary Peak |
Thursday, January 30, 2025
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–11:00 AM |
Novel Functions of Non-Coding RNAs |
Longs Peak |
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* Mariangela Morlando, Sapienza University of Rome
Session Chair |
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Damian Refojo, Max Planck Partner Institute - Buenos Aires
The Influence of circTulp4 on Emotional Behavior and Synaptic Function |
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Christine Mayr, Memorial Sloan Kettering Cancer Center
The Location of Protein Synthesis Controls The Activity of Transcriptional Regulators in the Nucleus |
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Yunsun Nam, University of Texas Southwestern Medical Center
Structure Function Analysis of RNA Modifying Enzymes |
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Sebastian Kadener, Brandeis University
Molecular and Physiological Functions of circRNAs |
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Bodu Liu, Cold Spring Harbor Laboratory
Short Talk: A Casein Kinase 2 Interacting LncRNA Regulates Cellular Plasticity of Breast Cancer by Stabilizing c-Myc |
|
| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–12:00 PM |
Meet the Editors (Joint) |
Longs Peak |
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Mishtu Dey, Cell Chemical Biology, Cell Press
*Session Chair, Editor-in-Chief |
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Gail Teitzel, Cell Press
Deputy Editor |
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Iris Marchal, Springer Nature AG & Co. KG
Associate Editor, Reviews |
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Yehu Moran, Hebrew University of Jerusalem
Academic Editor, EMBO Press |
|
| 11:00–2:30 PM |
On Own for Lunch |
|
| 3:00–4:30 PM |
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions |
Longs Peak |
| |
* Yehu Moran, Hebrew University of Jerusalem
Session Chair |
|
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Yael Sarusi, Weizmann Institute of Science
CHASERR-targeting antisense oligonucleotides boost CHD2 levels and affect mouse behavior in a model of CHD2 haploinsufficiency |
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Jackson B Trotman, University of North Carolina at Chapel Hill
Xist Repeat A Coordinates an Assembly of SR Proteins to Mediate Gene Silencing |
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Guifeng Wei, University of Oxford
N6-methyladenosine and the NEXT complex direct Xist RNA turnover and X inactivation dynamics |
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Takahisa Furukawa, Osaka University
Single cell/nucleus RNA-Seq analysis revealed in vivo functional mechanisms of central nervous system-specific miR-124a in mouse development |
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Chelsea Drown, University of Colorado Boulder
Investigation of MeCP2-RNA Targets in Rett Syndrome Neurodevelopmental Disorder |
|
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–6:45 PM |
RNA and Therapeutics (Joint) |
Longs/Grays Peaks |
| |
* Uttiya Basu, Columbia University
Session Chair |
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Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia
RNA Regulation of Tumor Associated Macrophages |
|
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Trey Westbrook, Baylor College of Medicine
Targeting RNA Splicing in Cancer: From Synthetic Lethality to Immuno-Oncology |
|
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Michael G Kharas, Memorial Sloan Kettering Cancer Center
RNA Methylation and Control of Cellular Fate in the Blood |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Longs/Grays Peaks |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peak |
| 8:00–9:00 PM |
Trivia |
Longs Peak |
| 8:00–9:00 PM |
Cash Bar |
Quandary Peak |
