Cardiometabolism in Health and Disease (J6)
January 26-29, 2026
| Keystone Resort, Keystone, CO, United States
Daniel P Kelly, Rong Tian and William C. Sessa
Scholarship Deadline: Oct. 9, 2025 | Abstract Deadline: Jan. 6, 2026 | Early Registration Deadline: Nov. 25, 2025
| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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Tuesday, January 27, 2026
| 8:00–8:10 AM |
Welcome Remarks (Joint) |
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| 8:10–9:00 AM |
Keynote Address (Joint) |
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Richard D DiMarchi, Indiana University
The Chemical Evolution of Peptides To Transform Human Health |
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| 9:00–11:30 AM |
Beyond Weight Loss: New Directions for Obesity Therapeutics (Joint) |
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Rachel J. Roth Flach, Valo Health
Using Human Data & Machine Learning Techniques to Identify Heart Failure Phenogroups & Application to New Target Discovery & Validation |
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Susan Quaggin, Northwestern University
A United Vision for Kidney and Cardiovascular Disease Treatment |
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James Trevaskis, Eli Lilly
Incretins for MASH Treatment |
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Riccardo Panella, Aalborg University
Short Talk: From Fat Selectivity to Rebound Prevention: RES-010 As A Novel Backbone for Obesity Therapy |
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Taha Bugra Gungul, University of Virginia
Short Talk: A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs |
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| 9:30–9:50 AM |
Coffee Break |
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| 11:30–12:30 PM |
Meet the Editors (Joint) |
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* Rong Tian, University of Washington
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| 11:30–1:00 PM |
Poster Setup |
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| 11:30–2:30 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 2:30–4:30 PM |
Symposia Spotlight 1: Emerging Therapies, Lifestyle Interventions and AI Approaches (Joint) |
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Jiyuan Piao, University of Alberta
Discovery of Snail Molecule in Hibernating Snails that Rewires Fuel Sensing and Induces Quiescence in Mouse Fibroblasts and Cardioprotective Hibernation in Mice Hearts |
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Pieterjan Dierickx, Max Planck for Heart & Lung Research
Metabolic Regulation of Circadian Rhythmicity in the Aging Female Heart |
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Ashutosh Tomar, University Heidelberg
Disruption of CaMKII–HDAC4 Axis Protects Against Metabolic HFpEF |
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Trace Thome, University of Pennsylvania
SGLT2 Inhibitors Activate PANK1 in Human Hearts Augmenting Cardiac Metabolism |
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Michelle To, Svensson Lab, Stanford University
A BRINP3-Derived Peptide Drives Non-Aversive Appetite Suppression via PVH Circuits |
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Richard G. Kibbey †, Yale University
Small Molecule Activators of Pyruvate Kinase: Preserving Muscle while Treating Obesity |
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Brendan Gabriel †, University of Aberdeen
A Skeletal-Muscle Phospholipase That Governs Energy Expenditure, Muscle Mass, And Adiposity |
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Joanne Hsieh, Gordian Biotechnology
Parallelized In Vivo Screening in Visceral Adipocytes to Identify Novel Targets for Safe Weight Loss |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Metabolic Origins of Heart Health and Disease |
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Daniel P Kelly, University of Pennsylvania
Modulating Cardiac Maturation in the Failing Heart |
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Catherine Makarewich, Cincinnati Children's Hospital Medical Center
Microproteins as Targets in the Diseased Heart |
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David A Kass, Johns Hopkins Hospital
Integrated OMIC and Physiologic Interrogation of HFpEF |
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Lin Liu, Baylor College of Medicine
Short Talk: YAP Creates a Distinct Metabolic State to Regenerate the Heart |
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Natasha Maria James, The Ohio State University
Short Talk: Uncovering Heart–Adipose Tissue Crosstalk: Natriuretic Peptides and Their Role In BAT-Mediated Metabolic Health |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 7:30–10:00 PM |
Poster Session 1 |
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Wednesday, January 28, 2026
| 8:00–11:00 AM |
Metabolic Contributions to Vascular Health and Disease |
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Michael Simons, Yale University
Metabolic Control of Vascular Cell Fate |
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Katrien De Bock, Swiss Federal Institute of Technology
Metabolic Determinants of Angiogenesis in Disease States |
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Yajaira Suarez, Yale School of Medicine
Regulators of Macrophage or Endothelial Cell Functions in Atherosclerosis |
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Zoltan Arany, University of Pennsylvania
Metabolic Determinants of Vascular Function |
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Antentor O Hinton Jr., Vanderbilt University School of Medicine
Short Talk: DRP1 Dysregulation Couples Mitochondrial Dynamics, Lipid Droplet Remodeling, and Impaired Muscle Oxygenation in Peripheral Artery Disease |
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Mitchell E. Granade, Pfizer Inc.
Short Talk: CD300LG Binds to Triglyceride-rich Lipoproteins and Facilitates Postprandial Lipid Clearance |
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–1:00 PM |
Poster Setup |
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| 11:00–3:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 1:30–2:45 PM |
Career Roundtable (Joint) |
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| 3:00–4:30 PM |
Panel Discussion: SGLT2 and GLP-1: Potential Mechanisms of Cardioprotective Actions |
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* Daniel P Kelly, University of Pennsylvania
Moderator |
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* William C. Sessa, Yale School of Medicine
Moderator |
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Justin H Berger, Washington University School of Medicine
Panelist |
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Zoltan Arany, University of Pennsylvania
Panelist |
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Murielle M Véniant-Ellison, Amgen Inc.
Panelist |
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Matthias H. Tschöp, Ludwig-Maximilians-Universität München (LMU)
Panelist |
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Susan Quaggin, Northwestern University
Panelist |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Mitochondria and Cardiometabolic Disease |
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Rong Tian, University of Washington
Mitochondria in HFpEF |
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E. Dale Abel, David Geffen School of Medicine and UCLA Health
Mitochondrial Dynamics and Cardiometabolic Disease |
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Yibin Wang, Duke-NUS, Singapore
Branched-Chain Amino Acid Metabolism in the Failing Heart |
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Jiuzhou Huo, Cincinnati Children's Hospital Medical Center
Short Talk: MCU-Dependent Alterations in Mitochondrial Calcium Dynamics Alters Metabolism and Fuel Selection in the Heart |
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Sumeet A Khetarpal, University of Virginia School of Medicine
Short Talk: PGC-1α–Driven Secretion of PLBD1 in the Heart Promotes Mitochondrial Function and Confers Cardioprotection |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 7:30–10:00 PM |
Poster Session 2 |
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Thursday, January 29, 2026
| 8:00–11:00 AM |
Emerging Therapies for Obesity and Cardiometabolic Diseases (Joint) |
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Matthias H. Tschöp, Ludwig-Maximilians-Universität München (LMU)
Dual and Triple Co-Agonists: From Discovery to Best-in-Class |
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Kirsten Raun, Novo Nordisk A/S
Amylin: The All-Inclusive Obesity Therapeutic |
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Thomas A Lutz, University of Zürich
Amylin Physiology and its Therapeutic Potential to Treat Metabolic Diseases |
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Murielle M Véniant-Ellison, Amgen Inc.
Unlocking the Power of GIPR and GLP-1R Targeting for Effective Weight Loss and Metabolic Improvement |
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Shan Parikh, Yale University
Short Talk: TLC-1180 Reverses Obesity, Improves Myocardial Insulin Sensitivity, and Enhances Cardiac Fitness in a Murine Model of Diet-Induced Obesity |
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Timo D Müller, Helmholtz Munich
Short Talk: An Unimolecular GIPR:GLP-1R:PPAR𝛼,𝛾,𝛿 Quintuple Agonist Eliminates Obesity and Insulin Resistance in Mice |
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–2:30 PM |
On Own for Lunch |
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| 1:00–2:00 PM |
Panel: Perspectives: Personalized Medicine & Patient-Centered Strategies (Joint) |
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Tiffany M Powell-Wiley, NHLBI, National Institutes of Health
Panelsit |
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Kevin Grove, Versant Ventures
Panelist |
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Roger D. Cone, University of Michigan
Panelist |
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| 2:30–4:30 PM |
Symposia Spotlight 2: Leveraging New Technologies, Experimental Approaches and AI for Cardiometabolic Research |
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Naoto Muraoka, Gordian Biotechnology
Identification of Therapeutic Targets in Heart Failure with Preserved Ejection Fraction Via In vivo Mosaic Screening |
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Spencer Haws, University of Wisconsin-Madison
Manipulating Cardiomyocyte Senescence via the Metabolism-Chromatin Axis |
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Lara E Celebi, University of Notre Dame
3D Model of Adipocyte Hypertrophy-Induced Atrial Dysfunction for Therapeutic Screening |
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Shinsuke Nirengi, Ohio State University Wexner Medical Center
9-HODE is an Exercise-Induced Adipokine that Improves Insulin Sensitivity |
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Short Talk(s) Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:45 PM |
Environmental and Social Modulators of CV Health and Disease |
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Martin E. Young, University of Alabama at Birmingham
Circadian Control of the Heart in Health and Disease |
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Danica Chen, University of California, Berkeley
Aging and Cardiovascular Health |
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Tiffany M Powell-Wiley, NHLBI, National Institutes of Health
Social Determinants of Obesity and Cardiovascular Risk |
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Hayley Barta, The Ohio State University
Short Talk: Glucocorticoids Disrupt Mitochondrial Quality Control Through Metabolic Reprogramming in the Heart |
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 PM |
Entertainment |
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