RNA Modifications in Health and Disease (J7)
December 12-15, 2023
| Fairmont Banff Springs, Banff, AB, Canada
Eric A. Miska, Ramesh S. Pillai and Eva Maria Novoa Pardo
Scholarship Deadline: Sep. 7, 2023 | Abstract Deadline: Sep. 25, 2023 | Early Registration Deadline: Oct. 12, 2023
Tuesday, December 12, 2023
| 4:00–8:00 PM |
Registration |
Van Horne Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Van Horne Foyer |
Wednesday, December 13, 2023
| 7:00–8:00 AM |
Breakfast |
Van Horne Ballroom C |
| 8:00–9:00 AM |
Welcome and Keynote Address (Joint) |
Van Horne A |
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* Eric A. Miska, University of Cambridge
Session Chair |
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* Mitchell Guttman, California Institute of Technology
Session Chair |
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Caroline Dean, John Innes Centre
Antisense-Mediated Chromatin Silencing |
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| 9:00–11:15 AM |
RNAs in Immune Defenses (Joint) |
Van Horne A |
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* Faezeh Jame-Chenarboo, University of Alberta
Session Chair |
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Sandra L. Wolin, NCI, National Institutes of Health
Nicked tRNAs: Surveillance and Roles as Regulatory RNAs |
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Stacy M. Horner, Duke University Medical Center
RNA Modifications at the Virus-host Interface |
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Christian Bellodi, Lund University
Short Talk: Short Talk: A New Role for the Pseudouridine Synthase 10 (PUS10) in Retrotransposon-driven Inflammation |
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Diana Dou, Stanford University
Short Talk: Short Talk: Xist Ribonucleoproteins Promote Female Sex-biased Autoimmunity |
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| 9:30–9:50 AM |
Coffee Break |
Van Horne Foyer |
| 11:15–1:00 PM |
Poster Setup |
President's Hall |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
President's Hall |
| 2:30–4:30 PM |
Workshop 1: Molecular Mechanisms |
Van Horne Ballroom A |
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* Federica Accornero, Brown University
Session Chair |
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Andre Verdel, INSERM - CNRS - UGA
YTH Protein Mmi1 Dimerization by Erh1 Drives Chromatin-associated Multimodal Gene Silencing |
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Aldema Sas-Chen, Tel Aviv University
Quantitative Cross-evolutionary Mapping Reveals Potential Roles for Dynamic RNA Acetylation in Thermostability |
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Jinbiao Ma, Fudan University
Molecular Mechanism and Regulation of RNA N6-Methylasdenosine Modification |
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Kira Holton, University of Michigan
Cellular Context for mRNA Substrate Selection by Pseudouridine Synthase 7 (PUS7) |
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P. Cody He, University of Chicago
Exon Junction Complexes and Exon Architecture Control m6A Methylation and Gene Expression |
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Gunter Meister, University of Regensburg
Autophagy Contributes to YTHDF Protein Regulation during Contact Inhibition |
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Julian Konig, Institute of Molecular Biology
RNA Stability Controlled by m6A Methylation Contributes to X-to-autosome Dosage Compensation in Mammals |
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| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Novel Technologies to Study RNA Modifications |
Van Horne Ballroom A |
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* Ainara Castellanos-Rubio, University of Basque Country
Session Chair |
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* Jean-Denis Beaudoin, University of Connecticut Health
Session Chair |
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Schraga Schwartz, Weizmann Institute of Science
The 100-nt Code Governing mRNA Methylation and mRNA Stability |
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Chengqi Yi, Peking University
Quantitative Mapping of mRNA Modifications in the Transcriptome |
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Kalon Overholt, MIT
Short Talk: Short Talk: RNA-mediated Genome Architecture Revealed by High Resolution Mapping of Chromatin Contacts |
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Amanda Whipple, Harvard University
Short Talk: Short Talk: Direct Mapping of snoRNA Interactions Identifies Targets of Orphan snoRNAs |
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Isabel Naarmann-de Vries, University Hospital Heidelberg
Short Talk: Short Talk: Detecting m6A at Single-molecular Resolution via Direct-RNA Sequencing and Realistic Training Data |
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Matthew Tegowski, Duke University
Short Talk: Short Talk: m6A Methylation Pattern in the Mammalian Cortex using Single-cell m6A Profiling |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Van Horne Ballroom C |
| 7:30–10:00 PM |
Poster Session 1 |
President's Hall |
Thursday, December 14, 2023
| 7:00–8:00 AM |
Breakfast |
Van Horne Ballroom C |
| 8:00–11:00 AM |
RNA Modifications in Development and Disease |
Van Horne Ballroom A |
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Eva Maria Novoa Pardo, Centre for Genomic Regulation
Remote Presentation: Epitranscriptome in Cancer at Single-Nucleotide Resolution |
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Ramesh S. Pillai, University of Geneva
RNA Modifications in Development and Disease |
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Alexander H. Dalpke, Universität Heidelberg
RNA Modification, Processing and Immune Recognition |
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Donal O'Carroll, University of Edinburgh
Safeguarding Germline Immortality |
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Victoria H. Cowling, Beatson Institute for Cancer Research
RNA Cap Regulation in Health and Disease |
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Anja Wagner, Medical University Vienna
Short Talk: Short Talk: Deciphering rRNA Modification Changes in Cellular and Organismal Aging by Direct RNA Sequencing |
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Shunya Kaneko, National Institute of Genetics
Short Talk: Short Talk: Mettl1-dependent m7G tRNA Modification is Essential for Maintaining Spermatogenesis and Fertility in Drosophila Melanogaster |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–1:00 PM |
Poster Setup |
President's Hall |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
President's Hall |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Van Horne A |
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Juan Alfonzo, Brown University
Professor of Molecular Biology, Cell Biology and Biochemistry |
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Sandra L. Wolin, NCI, National Institutes of Health
Chief and Senior Investigator, RNA Biology Laboratory |
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Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics
Senior Group Leader & Director |
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Gudrun Stengel, Alida Biosciences
CEO & Co-Founder |
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| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Cancer and RNA Modifications |
Van Horne Ballroom A |
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* Kathy Liu, University of Pennsylvania
Session Chair |
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Michaela Frye, Deutsches Krebsforschungszentrum
RNA Modifications in Cancer |
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Yunsun Nam, University of Texas Southwestern Medical Center
RNA Substrate Recognition by Modification Enzymes |
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Kathy Liu, University of Pennsylvania
Catalytic-independent and -dependent Roles of rRNA Modifying Enzymes in Leukemogenesis |
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Giuseppe Quarto, Université libre de Bruxelles
Short Talk: Short Talk: SRSF2 Plays an Unexpected Role as Reader of m5C on mRNA, Linking Epitranscriptomics to Cancer |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Van Horne Ballroom C |
| 7:30–10:00 PM |
Poster Session 2 |
President's Hall |
Friday, December 15, 2023
| 7:00–8:00 AM |
Breakfast |
Van Horne Ballroom C |
| 8:00–11:00 AM |
Translating RNA to Industry |
Van Horne Ballroom A |
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* Christopher Maher, Washington University
Session Chair |
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Eric A. Miska, University of Cambridge
Harnessing RNA Modifications for Therapeutics |
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Wendy V. Gilbert, Yale University
Decoding the Untranslated to Engineer Next-generation mRNA Therapeutics |
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Gudrun Stengel, Alida Biosciences
Short Talk: Short Talk: Mapping the Epitranscriptome Using a Multiplexed Barcoding Assay Platform |
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Ana Rita Poim, Universidade de Aveiro
Short Talk: Short Talk: Experimental Evolution and Dynamics of Adaptation of Yeast Lacking tRNA-Modifying Enzymes |
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Anindhya S Das, Brown University
Short Talk: Short Talk: AIMP3 is a Key Regulator of Cardiac Proteostasis |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Workshop 2: RNA Modifications and Therapeutics |
Van Horne Ballroom A |
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* Trushar R. Patel, University of Lethbridge
Session Chair |
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* Elena Piskounova, Weill Cornell Medicine
Session Chair |
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Cindy Ann Collins, Accent Therapeutics
Discovery of Small Molecule Inhibitors of ADAR1 |
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Louna Fruchard, Institut Pasteur
Aminoglycoside Tolerance in Vibrio Cholerae Engages Translational Reprogramming Associated to Queuosine tRNA Modification |
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Pedro J. Batista, NCI, National Institutes of Health
Rewiring of RNA Methylation by the Oncometabolite Fumarate in Renal Cell Carcinoma |
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Inna Ricardo-Lax, Rockefeller University
RNA Modification By M5c – Lessons from RNA Viruses |
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Kamil R. Kranc, The Institute of Cancer Research
Targeting mRNA Modifications to Eradicate Cancer Stem Cells in Acute myeloid Leukaemia |
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Christopher Lee Holley, Duke University
SnoRNAs Regulating Cardiovascular Disease |
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Carre Clement, Sorbonne University - CNRS - Institut de Biologie Paris Seine -
The Ribose Methylation Enzyme FTSJ1 has a Conserved Role in Neuron Morphology and Learning Performance |
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| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
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Ki-Jun Yoon, Korea Advanced Institute of Science and Technology
Session Chair |
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Eva Kowalinski, European Molecular Biology Laboratory
Structural Studies of tRNA Modification Complexes |
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Juan Alfonzo, Brown University
Dynamic Interplay Between tRNA Transport, Processing and Modifications |
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Tsutomu Suzuki, University of Tokyo
Glycosylation of Queuosine in tRNAs Contributes to Optimal Translation and Post-embryonic Growth in Vertebrates |
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JeanYves Roignant, CIG, University of Lausanne
Pseudouridine Synthase 7 Controls Aggressiveness through Modulation of Glycolysis |
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Elena Piskounova, Weill Cornell Medicine
Short Talk: Short Talk: The Role of Codon-biased Translation and tRNA Modifications in Melanoma Metastasis |
|
| 5:00–7:30 PM |
Non-Coding RNA Modifications |
Van Horne Ballroom A |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Van Horne Ballroom C |
Saturday, December 16, 2023
